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Antihyperuricemic Effect of the Combination of Eleutherine bulbosa and Syzygium polyanthum Extracts on Uric Acid Reduction in Hyperuricemic Mice Indriani, Amanda; Hujjatusnaini, Noor; Nurindahsari, Lilin Ika
Jurnal Medika Veterinaria Vol 19, No 2 (2025): J.Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v19i2.48281

Abstract

Hyperuricemia is a metabolic disorder characterized by elevated serum uric acid levels, which may lead to gout and other related complications. Long-term pharmacological treatments often cause adverse effects, making natural products a promising alternative therapy. This study aimed to evaluate the antihyperuricemic activity of a combined extract of Eleutherine bulbosa (Dayak onion) and Syzygium polyanthum (bay leaf) in hyperuricemic mice (Mus musculus). The experiment employed a post-test only control group design using 28 male Balb/c mice induced with a high-purine diet to establish hyperuricemia. Treatments included single and combined extracts of E. bulbosa and S. polyanthum at doses of 100, 200, and 300 mg/kg body weight with a ratio of 1:2, alongside a positive control (allopurinol). Phytochemical analysis revealed the presence of flavonoids, tannins, and saponins, which act as xanthine oxidase inhibitors and synergistic antioxidants. Statistical analysis using one-way ANOVA indicated a significant effect of the extract combination on reducing serum uric acid levels (p = 0.016). Further Duncans post-hoc test identified the 200 mg/kg dose (1:2 ratio) as the most effective, exhibiting a response comparable to allopurinol. These results suggest that the combination of E. bulbosa and S. polyanthum extracts possesses significant antihyperuricemic potential and may serve as a candidate for the development of stable phytopharmaceutical formulations for hyperuricemia therapy
Clinical Test of Herbal Product Formulation of Combination of Ageratum conyzoides, Mussaenda frondosa, Curcuma longa and Uncaria gambir as Postpartum Antibacterial Hujjatusnaini, Noor; Purwanti, Devi Yuni; Nirmalasari, Ridha; Dwi Rini Kurnia Fitri; Astuti Muh Amin; Mila
JURNAL KEBIDANAN Vol. 15 No. 2 (2025): October 2025
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v15i2.11219

Abstract

Indonesia is a maritime country with tropical forests that possess various natural resources utilized to fulfill needs in clothing, shelter, and medicine. Certain medicinal plants such as Ageratum conyzoides, Mussaenda frondosa, Curcuma longa, and Uncaria gambir have medicinal properties, including antibacterial effects for postpartum infections. The limited knowledge among the public regarding the benefits of traditional medicinal plants is due to restricted dissemination of information through digital media, among other factors.  Therefore, it is crucial that information about the clinical trials of herbal products containing a combination of Ageratum conyzoides, Mussaenda frondosa, Curcuma longa, and Uncaria gambir as postpartum antibacterials is conveyed to the younger generation, especially millennials, and those unfamiliar with the diversity of plants. A non-parametric research design method was employed, testing the pharmacological effects of the herbal product formulation through preliminary data. Data collection involved obtaining responses from 50 participants who used the herbal product, including 15 with vaginal discharge, 10 postpartum individuals, 10 with dysmenorrhea, 5 with postpartum infections, 5 unmarried healthy individuals, and 5 married healthy individuals, using the Wilcoxon test. The research results indicate that the combined herbal formulation significantly affected the test groups with indicators such as vaginal discharge, postpartum without infection, postpartum with infection, dysmenorrhea, and married and healthy individuals, with a significance level of 0.01. These results suggest positive potential. Further analysis reveals that the group without infection complaints did not show a significant impact. In conclusion, the combination formulation demonstrates positive effectiveness in groups with specific complaints related to infection and reproductive disorders. However, the response to the formulation may vary depending on initial health conditions and the characteristics of the target group.
Pemeriksaan Kadar Gula Darah dan Sosialisasi Bahaya Diabetes di SMA Muhammadiyah 1 Palangka Raya Penia Penia; Noor Hujjatusnaini
ARDHI : Jurnal Pengabdian Dalam Negri Vol. 3 No. 6 (2025): Desember: ARDHI : Jurnal Pengabdian Dalam Negri
Publisher : Asosiasi Riset Pendidikan Agama dan Filsafat Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/ardhi.v3i6.1621

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by elevated blood glucose levels. This condition includes several types, such as type 1 and type 2 diabetes. It occurs when the body is unable to produce enough insulin, experiences impaired insulin function, or faces a combination of both. As a result, glucose cannot be effectively absorbed by the body’s cells and accumulates in the bloodstream, leading to high blood sugar or hyperglycemia. If this condition persists, the buildup of glucose can cause various disorders in different organs. Without proper management, diabetes may lead to severe and life-threatening complications. Chronic hyperglycemia in diabetic patients is associated with long-term damage, dysfunction, and even failure of vital organs such as the eyes, kidneys, nerves, heart, and blood vessels. In this activity, percentage-based methods and demonstrations of blood glucose testing were used as educational tools for students. The results showed that students’ awareness of the dangers of elevated blood sugar levels remains low. Many of them are still unfamiliar with the importance of regular blood glucose monitoring and maintaining a healthy lifestyle to prevent diabetes. Therefore, continuous efforts are needed to provide education and outreach on the prevention and early management of diabetes mellitus.
Pelatihan Pembuatan Deobalm Alami ‘Nature Deobalm’ di Laboratorium Entrepreneurship UIN Palangka Raya Noor Hujjatusnaini
Jurnal Pelayanan Masyarakat Vol. 2 No. 4 (2025): Desember:Jurnal Pelayanan Masyarakat
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/jpm.v2i4.2587

Abstract

This community service program aims to enhance students’ knowledge and awareness regarding natural cosmetic formulations through training on the development of a natural deodorant balm, “Nature DeoBalm.” The activity was conducted at the Entrepreneurship Laboratory of UIN Palangka Raya and involved fifth-semester students of the Biology Education Department as participants. The training integrates promotive and applicative approaches, combining theoretical education on the risks of synthetic deodorants with direct observation of the production process for natural deodorant balm. The program emphasized the use of safe, plant-based ingredients such as beeswax, coconut oil, shea butter, vitamin E, and essential oils, which are known for their antibacterial, moisturizing, and skin-protecting properties. The implementation included several stages: preparation, material presentation, demonstration of the formulation process, product observation, evaluation, and documentation. Results showed that students demonstrated increased understanding of natural cosmetic components, formulation techniques, and the benefits of natural deodorants. They also developed a heightened awareness of environmentally friendly personal care products and showed interest in exploring entrepreneurial opportunities in herbal-based cosmetics. This program highlights the importance of introducing natural cosmetic innovation in higher education environments as a way to build scientific literacy, practical skills, and entrepreneurial competence. Overall, the activity successfully provided meaningful learning experiences and promoted the utilization of natural ingredients as sustainable alternatives to synthetic deodorant products.
Antimicrobial activity of Etlingera elatior leaf extract in Staphylococcus aureus-induced cystitis: an in vivo study Ridha Nirmalasari; Hujjatusnaini, Noor; Sari, Mita; Wahyuni Nurqadriyani Bustan
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.24470

Abstract

Background: Etlingera elatior has been reported to possess antimicrobial properties; however, its therapeutic effects in bacterial cystitis, particularly those caused by Staphylococcus aureus (S. aureus), remain inadequately explored in vivo. Objective: This study aimed to evaluate the antimicrobial and anti-inflammatory effects of Etlingera elatior leaf extract in an experimental model of S. aureus cystitis. Methods: A true experimental posttest-only design was conducted using 28 male BALB/c mice induced with S. aureus. The animals were allocated into control and treatment groups receiving Etlingera elatior leaf extract at concentrations of 40%, 50%, 60%, 70%, and 80%. Therapeutic outcomes were assessed based on urinary tract mucosal fluid secretion and bacterial colony counts. Data were analyzed using one-way ANOVA followed by post hoc testing. Results: Treatment with Etlingera elatior leaf extract significantly reduced cystitis severity compared with the infected control group (p < 0.05). The extract demonstrated both antimicrobial and anti-inflammatory effects, as indicated by reductions in bacterial load and mucosal secretion. Among the tested concentrations, the 40% extract showed the most consistent therapeutic effect, with outcomes comparable to ciprofloxacin. Conclusions: Etlingera elatior leaf extract exhibits potential as an alternative therapeutic agent for bacterial cystitis. Its antimicrobial and anti-inflammatory properties support its further development as a complementary treatment for urinary tract infections.
The Potential Of Purple Leaves Ethanol Extract (Graptophyllum pictum L.) Against The Growth Of Staphylococcus aureus and Candida albicans Noor Hujjatusnaini; Yunia Dwi Friska; Ayatus saadah; Astuti Muh. Amin
JURNAL AGRONOMI TANAMAN TROPIKA (JUATIKA) Vol. 3 No. 2 (2021): Volume 3 No.2 July 2021
Publisher : LPPM UNIVERSITAS ISLAM KUANTAN SINGINGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36378/juatika.v3i2.1325

Abstract

The Potential of Purple Leaves Ethanol Extract (Graptophyllum pictum L.) against Staphylococcus aureus and Candida albicans. This study is an experimental study with a comparative approach, aimed at analyzing the potential of purple leaves (Graptophyllum pictum L.) by using in vitro method against Staphylococcus aureus and Candida albicans. The clear zone was formed between the outer sides of the paper disc containing the ethanolic extract of the purple leaves (Graptophyllum pictum L.) and the S. column. gold and C. albicans colonies are growth indicators. The growth of S. aureus and C. albicans were measured at incubation time 24, 48, and 72 hours, which were then analyzed by analysis with Anava's one-way statistical test and continued with Duncan's 1%. The research found that the purple leaves ethanol extract (Graptophyllum pictum L.) has the growth inhibition of Staphylococcus aureus and Candida albicans, which is indicated by the comparison results of the optimal concentrations of S. aureus and C. albicans, were 50% and 90%, so that the purple leaf ethanol extract could recommended as an antibacterial.
Co-Authors Aín, Latifah Nur Adiansyah, Romi Afriliani, Hesti Agriana, Brenda Mila ahmad yani Ahmad, Dony Ajiza, Pratisa Defiera Ajiza, Pratisa Deifirera Alia, Rahmah Alya Meiana, Nurma Amelia Fitriani, Amelia Amin, Astuti Muh Anggraeni, Cici Ramadhan Artani Hasbi Astina Astina Astina Astina, Astina astuti muh amin Astuti Muh. Amin Awaluddin, Annisa Maharani Ayatus saadah Ayatusa'adah, Ayatusa'adah Ayu Handayani Ayu Tiara Putri, Ayu Tiara Azzahra, Jahida Bunga Nur Siammukaromah, Jamalika Dalila, Aupi Damayanti, Annisa Darma, Rizki Novia Dwi Rini Kurnia Fitri Erawaty, Yenny Fatimah Febrianty, Riafany Hadi Kusuma, Muhammad Prayoga Hamid, Nasim Hidayati, Maulidia Ihsan, Afifi Raima Indriani, Amanda Jamalika Bunga Nur Siammukaromah Jarkani, Muhammad Jubaidah, Jubaidah Jumrodah Jumrodah Jumrodah Jumrodah, Jumrodah Karlina, Siti Karmila, Fitriyah Kartika, Cindy Khotimah, Ayu Husnul LINTAL MUNA M, Mila Maisyarah, Annisa Maradona, Maradona Marshanda, Utin Tria Marsiah, Marsiah Maulana, Muhammad Akmal Maulida Maulida, Elyami Mega Selfia Mila Mila mila Mila, Nor Mufaddilah, Fira Muh Amin , Astuti Muh.Amin, Astuti Muhammad Ridho Muhammad Syaiful Anwar Muhammad Yusuf Mukhlis Rohmadi Nada, Ara Aulia Nadi, Nadi Najwa, Fatri Nasution, Aulia Fajrurramadhina Nirmalasari, Ridha Nisa, Zahratun Noor, Muhammad Arifin Nur Annisa Nur Indah Sari, Lilin Ika Nur Siammukaromah, Jamalika Bunga Nurindahsari, Lilin Ika Nurohman, Farkhan Nursalina, Nursalina Nurul Septiana, Nurul Penia Penia Pitria, Pitria Purwanti, Devi Yuni Purwita Sari, Purwita Puteri Maharani, Septia Rahmadini, Lika Rahmadiyah, Novia Rahman, Luthfi Aulia Ramadhan, Ahmad Ananda Ramadhanti, Noor Raniah, Nor Reski Saputra, Reski Respi, Respi Ridha Nirmalasari Rita Sukaesih Rita, Ambar Sari, Lilin Ika Nur Indah SARI, MITA Sasmita Sasmita Sa’adah, Ayatus Septianingrum, Dwi Dian Setyowati, Ais Rantauni Sonia Sukmawati, Erviana Swestyani, Sondra Tuanfareena, Tuanfareena Tumini Tumini, Tumini Uswatun Khasanah, Purnama Wahyuni Nurqadriyani Bustan Wati, Helda Widya Ningsih, Sri Indah Widyadana, Rafif Ibnu Wulandari, Noor Sari Yantiah Yantiah Yuliyana, Via Yunia Dwi Friska Ziya, Kholida