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Noor Hujjatusnaini
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Journal : Pharmascience

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Efek Antimikroba Kombinasi Ektrak Daun Isotoma longinflora (L). C. Presl dan Bunga Clitoria ternatea terhadap S. aureus dan Fusarium sp. sebagai Faktor Pemicu Resiko Infeksi Konjungtiva secara In Vitro Hujjatusnaini, Noor; Nirmalasari, Ridha; Amin, Astuti Muh; Mila, Nor; Rahman, Luthfi Aulia; Marshanda, Utin Tria; Awaluddin, Annisa Maharani; Putri, Ayu Tiara; Najwa, Fatri; Mila, Mila
Jurnal Pharmascience Vol 12, No 1 (2025): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i1.18409

Abstract

Infeksi konjungtiva sering disebabkan oleh berbagai mikroorganisme patogen, termasuk Staphylococcus aureus dan Fusarium sp. Isotoma longiflora dan Clitoria ternatea diketahui mengandung senyawa metabolit sekunder yang berpotensi sebagai agen antimikroba. Penelitian ini bertujuan untuk menguji efek antimikroba dari kombinasi ekstrak Isotoma longiflora dan Clitoria ternatea terhadap Staphylococcus aureus dan Fusarium sp., yang berpotensi menyebabkan infeksi konjungtiva secara in vitro. Kombinasi ekstrak kedua tanaman dibuat dalam formulasi 1:1, dengan mencampurkan 50% ekstrak Isotoma longiflora dan 50% Clitoria ternatea. Formulasi kombinasi ini diuji pada konsentrasi 50%, 60%, 70%, 80%, dan 90%, dengan waktu pengamatan selama 72 jam. Hasil uji statistik menggunakan One-Way ANOVA menunjukkan pengaruh signifikan dari kombinasi ekstrak terhadap pertumbuhan kedua mikroba (p=0,001; p<0,05). Kombinasi ekstrak Isotoma longiflora dan Clitoria ternatea memiliki efektivitas penghambatan lebih tinggi terhadap Staphylococcus aureus dibandingkan Fusarium sp., terutama pada konsentrasi 50%. Diduga dipengaruhi kandungan senyawa seperti flavonoid, tanin, dan saponin yang merusak dinding sel dan membran bakteri. Sebaliknya, efektivitas penghambatan terhadap Fusarium sp. relatif lebih rendah karena struktur dinding sel jamur yang lebih kompleks. Simpulan bahwa efek kombinasi ekstrak Isotoma longiflora dan Clitoria ternatea lebih besar sebagai antibakteri bakteri Gram-positif seperti S. aureus, dibandingkan terhadap Fusarium sp., sehingga diperlukan penelitian lanjutan untuk memvalidasi temuan dalam penelitian ini. Kata Kunci: Clitoria ternatea, Isotoma longinflora, S. aureus, Fusarium sp. Conjunctival infections are often caused by various pathogenic microorganisms, including Staphylococcus aureus and Fusarium sp. Isotoma longiflora and Clitoria ternatea are known to contain secondary metabolites with potential as antimicrobial agents. This study aimed to test the antimicrobial effects of a combined extract of Isotoma longiflora and Clitoria ternatea against Staphylococcus aureus and Fusarium sp., which can potentially cause conjunctival infections, in vitro. The combined extract of the two plants was formulated in a 1:1 ratio, mixing 50% Isotoma longiflora extract and 50% Clitoria ternatea. This combination was tested at concentrations of 50%, 60%, 70%, 80%, and 90%, with an observation period of 72 hours. Statistical testing using One-Way ANOVA showed a significant effect of the combined extract on the growth of both microorganisms (p=0.001; p<0.05). The combined extract of Isotoma longiflora and Clitoria ternatea exhibited a higher inhibitory effect against Staphylococcus aureus than Fusarium sp., especially at the 50% concentration. This effect is thought to be influenced by compounds such as flavonoids, tannins, and saponins that can damage bacterial cell walls and membranes. Conversely, the inhibition effect on Fusarium sp. was relatively lower, possibly due to the more complex structure of fungal cell walls. In conclusion, the combined extract of Isotoma longiflora and Clitoria ternatea demonstrates a stronger antibacterial effect against Gram-positive bacteria like Staphylococcus aureus compared to Fusarium sp., indicating a need for further research to validate these findings.
Co-Authors Aín, Latifah Nur Adiansyah, Romi Afriliani, Hesti Agriana, Brenda Mila ahmad yani Ahmad, Dony Ajiza, Pratisa Defiera Ajiza, Pratisa Deifirera Alia, Rahmah Alya Meiana, Nurma Amelia Fitriani, Amelia Amin, Astuti Muh Anggraeni, Cici Ramadhan Artani Hasbi Astina Astina Astina Astina, Astina astuti muh amin Awaluddin, Annisa Maharani Ayatusa'adah, Ayatusa'adah Ayu Handayani Ayu Tiara Putri, Ayu Tiara Azzahra, Jahida Bilal Firdizky, Rafli Bismillah, Alif Bunga Nur Siammukaromah, Jamalika Dalila, Aupi Damayanti, Annisa Darma, Rizki Novia Dina Nur Khalisa Dwi Rini Kurnia Fitri Erawaty, Yenny Fatimah Febrianty, Riafany Hadi Kusuma, Muhammad Prayoga Hamid, Nasim Hidayati, Maulidia Ihsan, Afifi Raima Ika Nurindahsari, Lilin Indriani, Amanda Jamalika Bunga Nur Siammukaromah Jarkani, Muhammad Jubaidah, Jubaidah Jumrodah Jumrodah Jumrodah Jumrodah, Jumrodah Karlina, Siti Karmila, Fitriyah Kartika, Cindy Khotimah, Ayu Husnul LINTAL MUNA M, Mila Maisyarah, Annisa Maradona, Maradona Marshanda, Utin Tria Marsiah, Marsiah Maulana, Muhammad Akmal Maulida Maulida, Elyami Mega Selfia Mila Mila mila Mila, Nor Mufaddilah, Fira Muh Amin , Astuti Muh.Amin, Astuti Muhammad Ridho Muhammad Syaiful Anwar Muhammad Yusuf Mukhlis Rohmadi Nada, Ara Aulia Nadi, Nadi Najwa, Fatri Nasution, Aulia Fajrurramadhina Nirmalasari, Ridha Nisa, Zahratun Noor, Muhammad Arifin Nur Annisa Nur Indah Sari, Lilin Ika Nur Siammukaromah, Jamalika Bunga Nurindahsari, Lilin Ika Nurohman, Farkhan Nursalina, Nursalina Nurul Septiana, Nurul Penia Penia Pitria, Pitria Purwanti, Devi Yuni Purwita Sari, Purwita Puteri Maharani, Septia Rahmadini, Lika Rahmadiyah, Novia Rahman, Luthfi Aulia Ramadhan, Ahmad Ananda Ramadhanti, Noor Raniah, Nor Reski Saputra, Reski Respi, Respi Rita Sukaesih Rita, Ambar Sari, Lilin Ika Nur Indah SARI, MITA Sasmita Sasmita Sa’adah, Ayatus Septianingrum, Dwi Dian Setyowati, Ais Rantauni Siti Maysaroh Sonia Sukmawati, Erviana Swestyani, Sondra Tenani, Miya Tuanfareena, Tuanfareena Tumini Tumini, Tumini Uswatun Khasanah, Purnama Wati, Helda Widya Ningsih, Sri Indah Widyadana, Rafif Ibnu Winanto, Aldi Wulandari, Noor Sari Yantiah Yantiah Yuliyana, Via Ziya, Kholida