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All Journal Jurnal Kedokteran Brawijaya Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Reproduksi Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Universa Medicina Jurnal Gizi Klinik Indonesia Majalah Farmaseutik Indonesian Contemporary Nursing Journal (ICON Journal) Window of Health : Jurnal Kesehatan Jurnal Kesehatan Reproduksi Molekul: Jurnal Ilmiah Kimia Media Karya Kesehatan Journal of Community Empowerment for Health JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Jurnal Tumbuhan Obat Indonesia Indonesian Journal of Pharmacology and Therapy
Mae Sri Hartati Wahyuningsih
*) Department Of Pharmacology And Therapy, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada; *) Herbal Medical Center, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Antikeloid Activity and Irritation Test of Combination Extract of Tithonia diversifolia A. Gray and Nerium indicum Mill in vivo Yuliani, Fara Silvia; Wahyuningsih , Mae Sri Hartati
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2046

Abstract

Keloids, marked by overgrowth of fibrous tissue beyond wound boundaries, present therapeutic challenges due to recurrence and the side effects of current treatments. Conventional methods, including surgery and radiotherapy are often costly and carry risks such as recurrence, pain, and infection. This has led to increasing interest in natural alternatives. This study investigates the antikeloid potential of a combination extract from Nerium indicum Mill (N. indicum) and Tithonia diversifolia A. Gray (T. diversifolia) in an in vivo rabbit ear hypertrophic scar model. The efficacy of the extract was evaluated using the Scar Elevation Index (SEI), while irritation tests assessed its potential for localized skin reactions. Five groups were tested: three groups receiving different doses of the combination extract, a negative control (aquadest), and a positive control (triamcinolone acetonide). The results showed that SEI values in all treatment groups were significantly reduced compared to the negative control (p<0.05), indicating reduced scar prominence. The Draize test further classified the extract as a minimal irritant, supporting its safety for topical application. These findings suggest that the combination extract of N. indicum and T. diversifolia is a promising, safer, and natural alternative for keloid treatment, particularly in managing hypertrophic scars.  
Piper Crocatum Ruiz and Pav as A Commonly Used Typically Medicinal Plant From Indonesia: What Do We Actually Know About It? Scoping Review Setyawati, Andina; Wahyuningsih, Mae Sri Hartati; Nugrahaningsih, Dwi Aris Agung; Effendy, Christantie; Ibeneme, Sam
Indonesian Contemporary Nursing Journal (ICON Journal) Vol. 7 No. 2 (2023): Volume 7 No. 2 Februari 2023
Publisher : Faculty of Nursing, Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/icon.v7i2.23891

Abstract

Aims: Piper crocatum Ruiz & Pav (P. crocatum) has been widely used medicinally among ethnic communities in Indonesia to treat a variety of diseases through various preparation- application techniques, duration, and frequency of use. Since research on the benefits of P. crocatum is still limited, our scoping review aimed to identify the key findings resulting from experimental studies regarding the medicinal uses of P. crocatum. Methods: We conducted a scoping review using the framework developed by Arksey and O’Malley. Databases were searched using CAB Direct, ProQuest, ScienceDirect, SpringerLink, and Google Scholar. Data were extracted and tabulated using Microsoft Office Excel 2013. Results: Sixteen articles fulfilled were included in the scoping review. Three key concepts were emerged from this scoping review: 1) Study characteristics indicated the most prevalent type of research was in vivo experiment (n=14) with the highest number of preparations using ethanol extracts (n=8) and P. crocatum sample were mostly sourced from Indonesia (n=9); 2) Seventeen screened metabolites were reported and the most frequently identified were steroids and flavonoids, followed by polyphenols and saponins; and 3) Eight potential activities of P. crocatum were reported as follows: anti-inflammatory, pro-wound healing, antibacterial, antioxidant, anti-necrotic, antitumoral, hepatoprotective, and anti-hyperglycaemic. Conclusion: P. crocatum has various metabolites that might influence the reported potential therapeutic activities with different preparation-application techniques, uses, and duration, yet the scientific evidence conducted in clinical study is still limited. Future research needs to perform testing standardized preparations of P. crocatum to be developed as novel therapeutic agents in wounds, infective diseases, cancers, diabetes, and liver diseases.
The Effect of Rosella (Hibiscus sabdariffa Linn) on Insulin Resistance in Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial Sarbini, Dwi; Huriyati, Emy; Sadewa, Hamim; Wahyuningsih, Mae Sri Hartati
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1429

Abstract

Insulin resistance in Type 2 Diabetes Mellitus (T2DM) is indicated with high fasting blood glucose level, fasting insulin and HOMA-IR. The long-time consume of diabetes drugs would bring harm. Rosella can be used as a complementary drug to improve insulin resistance and prevent T2DM complications. This study seeks the effect of consuming Rosella on fasting blood glucose, fasting insulin and HOMAIR in T2DM patients.The study design used double-blinded & placebo-controlled randomized clinical trial with intervention (placebo and Rosella) for 8 weeks. The sample consisted of 52 T2DM outpatients at Health Office Yogyakarta City. Measurement of fasting blood glucose was conducted through GOD-PAP method, fasting insulin was measured by MEIA, HOMA-IR was calculated with HOMA Calculator 2.2.3 Version. Analysis of the influence of Rosella on fasting blood glucose, fasting insulin and HOMA-IR level in one group were tested with the Wilcoxon Signed Test and the effect between groups were tested through Mann Whitney with a significance level of 95%.Rosella consumption can reduce fasting blood glucose, fasting insulin and HOMA-IR levels. There was a significant effect of Rosella administration on decreasing fasting blood glucose level in T2DM patients (p=0.001) but there were no significant effect on decreasing fasting plasma insulin level and HOMA-IR levels (p=0.932 and p=0.368). Rosella can improve insulin resistance by reducing fasting blood glucose levels, fasting insulin levels and HOMA-IR values.
Tamarindus indica increases the stability of jamu kunyit-asam herbal suspension over Citrus aurantifolia wicaksono, arko jatmiko; Rakhmawati, rita; Wahyuningsih, Mae Sri Hartati; Syarif, Rul Afiyah; Prasetyo, Yacobus Christian
Indonesian Journal of Pharmacology and Therapy Vol 5 No 2 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.11818

Abstract

Rapid shelf-life of traditional supplementary drink still becomes major issue for herbal production in household industries. In this study the stability formula of an herbal suspension, so called as jamu kunyit-asam, was investigated. The jamu kunyit-asam Formula-1 (F1) contains combination of Citrus aurantifolia and Curcuma longa. While the Formula-2 (F2) is consisted by mixture of Tamarindus indica and C. longa. The two formulas were compared to justify better stability between preparations. No preservatives were added, in order to comply with the local regulation. To simulate the real situation, all samples were stored in 4 different conditions: opened bottle (room temperature), closed bottle (room temperature), closed bottle (refrigerator), and freeze-thaw condition. To evaluate the stability profile, an organoleptic testing and pH alteration were frequently checked for 12 consecutive days. Several parameters including color changing, sting odor, and microscopic appearance were looked over. As the results, mold, precipitation and pungent odor were formed faster from the F1 (C. aurantifolia combined with C. longa). These findings indicates that jamu kunyit-asam herbal drink suspensions containing C. longa has less stability in combination with the C. aurantifolia (F1) compared to the T. indica (F2).
Improving literacy about the cultivation and utilization of family medicinal plants in Blunyahrejo Village, Yogyakarta City Wahyuningsih, Mae Sri Hartati; Najiyati, Ifa; Wastutiningsih, Sri Peni; Purwono, Setyo; Padmawati, Retna Siwi
Journal of Community Empowerment for Health Vol 8, No 2 (2025)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.82763

Abstract

Introduction: During the COVID-19 pandemic, Indonesian society used family medicinal plants to prevent infection by enhancing immunity. Consumption of medicinal plants as herbal medicine should have scientific consideration so that the benefits can be proven and do not cause harmful side effects. Cultivation of medicinal plants is necessary to meet the needs of the family's medicinal plants independently.Methods: We designed a community-based education to improve literacy about the cultivation and utilization of family medicinal plants to farmer groups at Blunyahrejo, Yogyakarta. The study used a quasi-experimental research design with one group pre-post-test design. The group received an intervention in the form of training on the use and cultivation of medicinal plants. Community literacy was measured before and after participants attended the training. The 1st post-test has been conducted right after the training and the 2nd post-test was carried out after 3 months of intervention. The data were analyzed by a paired t-test.Results: The total number of participants who participated was 28 people. Observations have also been done during and after the training. The study showed that there was an increase in knowledge about the cultivation and utilization of family medicinal plants between the pre-test and 1st post-test, 1st post-test and 2nd post-test, and the pre-test and 2nd post-test (9.96%; 1.98%; 12.04%).Conclusion: The training improved the literacy about the cultivation and utilization of family medicinal plants of the farmer group in Blunyahrejo, Yogyakarta. Although the number of participants was quite small, participants showed a positive response during and after the training. Community leaders often reported the activities of farmer groups that showed enthusiasm for maintaining and continuing the cultivation of medicinal plants after the training.
Co-Authors Abdul Karim Zulkarnain Achmad Fudholi Adiguno Suryo W Adiguno Suryo W, Adiguno Suryo Akhmadi Akhmadi Alam, Gemini Amira Fawwaz Tsabitah Andina Setyawati, Andina Angga Anugerah Annisa Nurul Pratiwi Arfian Bela Mahardika Argo D, Imono Arief Budiyanto Arif Yusuf Wicaksana Arko Jatmiko Wicaksono, Arko Jatmiko Astuti, Puji Aurelia Priscilla Regita Putri Bayu Putra Beni Lestari Bolhuis RLH Christantie Effendy Damiana Sapta Candrasari Desyandri Desyandri Detty Siti Nurdiati Dewi Aryanti Dita Ayu Dewi Laras Sati Dwi Aris Agung Nugrahaningsih Dwi Aris Nugrahaningsih Dwi Sarbini Dwiki Yuliya Rahmawati Edy Meiyanto Elly Wahyudin Elly Wahyudin Elsi Dwi Hapsari Elvira Santi Emy Huriyati Emy Huriyati Eti Nurwening Sholikhah Farida Fitriyanti Farida Fitriyanti Firandi Saputra Firandi Saputra, Firandi Fitranto Arjadi Fudholi, Achmad - Gatot S. Lawrence Gatot S. Lawrence Hajid Rahmadianto Hajid Rahmadianto Mardihusodo Hajid Rahmadianto Mardihusodo, Hajid Rahmadianto Halimah, Wahyu Nur Hardyanto Soebono Hayati, Farida I Dewa Putu Pramantara Ibeneme, Sam Ibnu G Gandjar, Ibnu G Ibnu G. Gandjar Ibnu G. Gandjar Ibnu G. Ganjar, Ibnu G. Indwiani Astuti Indwiani Astuti Ishandono Dachlan Ita Fauzia Hanoum K. Nooter Ketut Shri Satya Wiwekananda KV Rao, KV Lisma Evareny, Mohammad Hakimi, Retna Siwi Padmawati M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Mark T Hamann, Mark T Mark T. Hamann Mia Munawaroh Mirianti A. Manggau Mirianti A. Manggau, Mirianti A. Mufidah Mufidah Mufidah Mufidah Mustofa Mustofa Mustofa Mustofa Najiyati, Ifa Ngatidjan Ngatidjan Nia Krisniawati Nina Salamah Nooter K Nungki Anggorowati Nur Arfian Nur Arfian, Nur Nur Falah Setyawati Nyoman Kertia Oostrum RG Pinus Jumariyatno Prasetyawati, Citra Prasetyo Tri Kuncoro Pratiwi, Woro Rukmi Probosuseno Probosuseno R.L.M. Bolhuis Rakhmi Aulia Ranti, Imaniar Rita Rakhmawati, Rita Rul Afiyah Syarif S Sulastri Sadewa, Hamim Sari, Dinar Setyo Purwono Sofia Mubarika Haryana Sri Kadarsih Soejono Sri Peni Wastutiningsih Sri Suharmi, Sri Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Sugiyanto . Sugiyanto Sugiyanto Sulastri, S Sunarti Sunarti Susetyowati Tatsuo Takeya, Tatsuo Teguh Aryandono Tri Baskoro T.Satoto Tri Baskoro Tunggul Satoto Tri Murini Tri Murini Tri Murini Tri Murini Venny Vidayanti Wahyu Nur Halimah Wahyuono, Subagus Wahyuono, Subagus Wasis Pujiati Widiartini, Catharina Woro Rukmi Pratiwi Woro Rukmi Prtiwi Yacobus Christian Prasetyo Yohanes Widodo Wirohadidjojo Yulia Fauziyah Yuliani, Fara Silvia Yuniyanti, Mia Munawaroh