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Helmi Ismunandar
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Gangguan Muskuloskeletal Akibat Kerja: Epidemiologi, Faktor Risiko, Gejala Klinis, Tatalaksana dan Pencegahan Indika Poloriani Tunang; Winda Trijayanthi Utama; Helmi Ismunandar
Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Vol. 9 No. 2 (2022): Jurnal Kesehatan dan Agromedicine
Publisher : Fakultas Kedokteran Universitas Lampung

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Abstract

Peringkat kedua untuk penyakit penyebab disabilitas di dunia adalah gangguan muskuloskeletal akibat kerja. Faktor yang berperan dalam timbulnya keluhan muskuloskeletal berasal dari individu pekerja maupun lingkungan kerja, yang meliputi faktor biomekanik dan faktor biokimia. Berbagai keluhan yang dirasakan pekerja berupa manifestasi nyeri sampai sulit untuk digerakkan pada bagian otot rangka yang melibatkan otot, ligamen, sendi, dan saraf. Lokasi gangguan muskuloskeletal yang paling sering dikeluhkan adalah pada tubuh bagian atas yang disebabkan karena beban statis dengan frekuensi berulang. Penanganan awal pada pusatkesehatan layanan primer sangat berperan dalam hal efisiensi di lingkungan kerja. Peran terapis okupasi dalam tatalaksana farmakologi maupun non-farmakologi merupakan bagian yang tak kalah penting dalam perawatan pada gangguan muskuloskeletal akibat kerja. Penilaian ergonomi melalui rekayasa stasiun dan alat kerja, serta dengan pengaturan organisasi kerja yang baik, mampu mencegah terjadinya gangguan muskuloskeletal pada pekerja akibat pajanan dari pekerjaan.  Kata kunci: Keluhan Muskuloskeletal, Kesehatan Kerja, Risiko Ergonomi  
Potensi Daun Binahong (Anredera cordifolia (Ten) Steen.) Terhadap Penyembuhan Luka Insisi: Tinjauan Pustaka Yusnita Eka Rahayu; Helmi Ismunandar; Hanna Mutiara
Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Vol. 10 No. 1 (2023): Jurnal Kesehatan dan Agromedicine
Publisher : Fakultas Kedokteran Universitas Lampung

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Abstract

Kulit merupakan organ terbesar pada tubuh yang menyusun 16% dari total berat badan manusia dengan berat rata-rata sekitar 4 kg dan luas permukaan sekitar 1,8m2. Luka didefinisikan sebagai rusaknya integritas epitel suatu jaringan. Kerusakan ini juga  dapat melibatkan jaringan subepitel termasuk dermis, fasia, dan otot. Luka dapat disebabkan olehtrauma fisik seperti terobek, tersayat, atau tertusuk (luka terbuka) dan oleh trauma benda tumpul yang akan menyebabkan memar (luka tertutup). Meskipun terdapat banyak pilihan obat kimia seperti antibiotik, anti-inflamasi, maupun analgesik yang tersedia untuk pengobatan luka, sebagian besar pengobatan tersebut sering menimbulkan efek samping yang tidak diinginkan sehingga sangat dianjurkan untuk beralih  menggunakan pilihan bahan alami sebagai pengobatan luka. Daunbinahong (Anredera cordifolia (Ten) Steenis) merupakan salah satu tanaman herbal yang dapat digunakan sebagai penyembuh luka dengan berbagai macam sediaan WIJAYANTI. Kandungan ekstrak daun binahong yang berpengaruh terhadap penyembuhan luka adalah saponin, tanin, terpenoid, alkaloid, dan flavonoid.Kata Kunci: Binahong, Penyembuhan Luka, Luka Insisi
Efek Iyengar Yoga terhadap Keseimbangan Dinamis pada Populasi Lanjut Usia: Tinjauan Pustaka Jasmine Putri Nabila; Helmi Ismunandar; Arif Yudho Prabowo; Ahmad Fauzi
Jurnal Ilmiah Manusia Dan Kesehatan Vol. 9 No. 1 (2026): Jurnal Ilmiah MANUSIA DAN KESEHATAN
Publisher : FAKULTAS ILMU KESEHATAN UNIVERSITAS MUHAMMADIYAH PAREPARE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31850/makes.v9i1.4222

Abstract

The rapid aging of Indonesia’s population has significantly increased fall risk among older adults, underscoring the need for safe, effective non-pharmacological interventions to improve dynamic balance. This systematic literature review aimed to evaluate current evidence (2020–2025) on the effects of Iyengar yoga on dynamic balance in older adults. Following PRISMA 2020 guidelines, a Scopus search identified four studies meeting inclusion criteria from an initial 46 records; these were subsequently analyzed using the PICOS framework. Results consistently demonstrated that Iyengar yoga significantly enhanced postural stability, muscle strength, flexibility, proprioception, balance confidence, and cognitive functions (attention and working memory), while indirect benefits through stress reduction further strengthened motor coordination. The intervention proved highly safe, exhibited excellent adherence, and was successfully delivered online. However, its direct impact on fall prevention remained variable. Iyengar yoga is therefore confirmed as an effective holistic intervention for improving multiple components of dynamic balance in older adults. It is recommended that programs be enriched with multidirectional reactive exercises and fall-prevention education to optimize real world fall reduction outcomes. Keywords: Iyengar Yoga; Dynamic Balance; Seniors; Eldely People
Perkembangan Strategi Pengobatan β-Thalassemia Santhi, Komang Ria Yuliana; Sangging, Putu Ristyaning Ayu; Jausal, Anisa Nuraisa; Ismunandar, Helmi
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1663

Abstract

β-thalassemia is an inherited blood disorder caused by mutations in the β-globin gene that reduce or eliminate β-globin chain synthesis, leading to hypochromic microcytic anemia and significant morbidity worldwide. The disorder is prevalent in South Asia, Southeast Asia, the Mediterranean, the Middle East, India, and Africa, with approximately 1.5% of the global population identified as carriers. Severe complications, including iron overload, skeletal deformities, heart failure, and multi-organ damage, contribute to its substantial global health burden. This narrative literature review synthesizes evidence from PubMed, Cochrane, and Google Scholar to examine conventional and emerging therapeutic strategies for β-thalassemia, with particular emphasis on recent advances in gene therapy. Standard management relies on regular blood transfusions and iron chelation, which remain supportive and are associated with long-term complications. Hematopoietic stem cell transplantation is the only established curative treatment, especially effective in pediatric patients with matched HLA donors, although its availability is limited. Novel pharmacologic agents, such as luspatercept and mitapivat, have demonstrated reductions in transfusion requirements and improvements in hemoglobin production. Additional approaches, including fetal hemoglobin induction and modulation of iron metabolism, show encouraging potential. A major breakthrough is CRISPR-based gene therapy using exagamglogene autotemcel (Casgevy), approved by the FDA and EMA in 2024, with phase 3 trials reporting transfusion independence in more than 90% of patients and significant quality-of-life improvements. Despite persistent challenges related to cost, access, and long-term safety, these advances indicate a paradigm shift toward precision medicine with curative potential for β-thalassemia.
Diagnosis dan Tatalaksana Fraktur Klavikula: Tinjauan Pustaka Waton, Hisbul; Ismunandar, Helmi
Medula Vol 16 No 1 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i1.1735

Abstract

Clavicle fracture is one of the most common fractures of the upper extremity, resulting from either direct or indirect trauma to the shoulder with the arm positioned alongside the body. This injury is more frequently observed in young adult males, commonly due to traffic accidents, while in the elderly population it is often caused by falls. Clavicle fractures typically present with severe pain, swelling, shoulder deformity, and may be accompanied by neurovascular impairment, necessitating comprehensive clinical evaluation. Physical examination includes inspection, palpation, assessment of shoulder range of motion, and neurovascular evaluation such as the Allen test to assess collateral blood flow. Diagnostic confirmation is supported by imaging modalities including standard anteroposterior radiographs, 30° cephalad tilt view, apical oblique view, and computed tomography scan for complex fracture patterns and preoperative planning. The management of clavicle fractures aims to reduce pain, prevent disability, restore upper limb function, and consider cosmetic outcomes. Treatment options include nonoperative management using an arm sling or figure-of-eight brace for stable fractures, as well as operative management for unstable fractures or those associated with neurovascular complications. Post-treatment rehabilitation plays a crucial role in gradually restoring shoulder range of motion and functional recovery.
The The Role of Glucosamine and Chondroitin Supplementation in the Management of Osteoarthritis. Febriantara, M.Kaisar; Pestalozi, George; Ismunandar, Helmi
Medula Vol 16 No 2 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i2.1808

Abstract

Osteoarthritis (OA) is a chronic degenerative disease characterized by progressive damage to articular cartilage and surrounding joint tissues, clinically manifesting as pain, deformity, and disability. The main risk factors include aging, joint injury or overuse, and obesity. According to the Global Burden of Disease Study in 2020, approximately 595 million people worldwide were living with osteoarthritis. In Indonesia, data from the 2018 Basic Health Research report indicated that osteoarthritis affected about 55 million individuals, with the highest prevalence among those aged over 61 years, accounting for 65%. Pathophysiologically, osteoarthritis develops due to cartilage thinning, leading to biomechanical changes, reduced synovial fluid, and increased inflammatory processes associated with aging. Inflammatory cells, particularly macrophages, release mediators that accelerate cartilage degradation and exacerbate joint pain. Radiological assessment of osteoarthritis severity is commonly performed using the Kellgren–Lawrence classification. Management of osteoarthritis frequently involves nonsteroidal anti inflammatory drugs, although long term use is associated with adverse effects. Therefore, adjunctive therapies such as glucosamine and chondroitin have been widely studied. Glucosamine and chondroitin exhibit anti inflammatory and chondroprotective effects and play roles in inhibiting cartilage degradation while supporting anabolic processes in cartilage tissue. Several studies have demonstrated that supplementation with glucosamine and chondroitin improves pain scores, slows joint space narrowing, and enhances joint function in patients with osteoarthritis. These findings suggest that glucosamine and chondroitin may serve as beneficial adjunctive therapies in the management of osteoarthritis.
Literature Review : Efektivitas Pemberian Antibiotik Profilaksis dalam Mencegah Infeksi Luka Operasi pada Bedah Ortopedi Dewi, Hanifah Tiara; Junando, Mirza; Fitra W.S, Muhammad; Ismunandar, Helmi
Sains Medisina Vol 4 No 2 (2025): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v4i2.869

Abstract

Infeksi luka operasi (ILO) merupakan salah satu komplikasi yang paling sering terjadi setelah tindakan bedah ortopedi dan dapat meningkatkan morbiditas, lama rawat inap, serta biaya perawatan pasien. Upaya pencegahan ILO melalui pemberian antibiotik profilaksis telah menjadi standar praktik di berbagai rumah sakit, namun masih terdapat variasi dalam jenis, waktu, dan durasi pemberian yang dapat memengaruhi efektivitasnya. Kajian literatur ini bertujuan untuk menelaah bukti ilmiah mengenai efektivitas antibiotik profilaksis dalam mencegah ILO pada bedah ortopedi. Penelitian ini menggunakan metode literature review dengan cara menelaah, mengidentifikasi dan menganalisis dari berbagai literature yang diperoleh melalui pencarian artikel ilmiah yang dipilih berdasarkan kriteria inklusi dan eksklusi. Hasil telaah terhadap berbagai penelitian menunjukkan bahwa pemberian antibiotik profilaksis yang tepat waktu, yaitu 30–60 menit sebelum insisi, serta dengan durasi pendek (single dose atau kurang dari 24 jam), terbukti efektif menurunkan risiko infeksi tanpa meningkatkan kejadian resistensi antibiotik. Sefazolin direkomendasikan untuk operasi ortopedi bersih karena efektif terhadap flora kulit penyebab infeksi, dan penggunaan yang rasional sesuai pedoman mendukung keselamatan pasien serta pencegahan resistensi antibiotik. Hal ini dapat disimpulkan bahwa antibiotik profilaksis efektif dalam mencegah infeksi luka operasi pada bedah ortopedi jika diberikan tepat waktu, memiliki spektrum antibiotik yang sempit, dan berdurasi <24 jam.
Effectiveness of various leg muscle training methods on increasing leg muscle strength M. Frans Surya Pradana; Setiorini, Anggi; Agustina Daulay, Suryani; Ismunandar, Helmi
Jurnal Keolahragaan Vol. 13 No. 2: September 2025
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jk.v13i2.92125

Abstract

Lower limb muscle strength is crucial for functional human activities, providing body stabilization, maintaining posture, and enabling various movements. Insufficient training can hinder muscle protein synthesis, leading to diminished strength in the lower limbs. Regular training, particularly resistance exercises, is essential for improving this strength. Numerous training methods have been developed, such as resistance training, plyometric exercises, bodyweight exercises, isolation training, movement-based practices, and technology-assisted techniques, though their relative effectiveness remains a topic of ongoing evaluation. This literature review aims to assess the effectiveness of various lower limb strength training methods across diverse populations, including adolescents, athletes, and older adults. The review involved a systematic search of PubMed and Google Scholar, using defined inclusion and exclusion criteria, resulting in 16 eligible studies. The effectiveness of each training method was analyzed by comparing study findings, which incorporated different research designs. All included studies indicated significant improvements in lower limb strength, although the magnitude of the improvements varied based on training intensity, duration, and participant characteristics. Compound and resistance training demonstrated comprehensive strength gains, plyometric exercises improved explosive power, and isolation training was particularly effective for strengthening specific muscle groups. Among older adults, combined training proved to be the most effective, enhancing both strength and balance, as well as functional mobility. These results highlight that no single training method is universally superior, underscoring the importance of customizing exercise programs to meet individual needs and objectives.
Co-Authors Ad-Dhuha, Rahmah Maziyah Agustina Daulay, Suryani Ahmad Fauzi Aisyah Lubis, Aisyah Alyzah Nabila Miranda Andrifianie, Femmy Ari Wahyuni Ari Wahyuni Arif Yudho Prabowo Asyifa, Takhfa Nur Devi, Maria Dewi, Hanifah Tiara Dhipayasa Adirinarso Dwi Indria Anggraini Elvara Fatimah Muzaki Ety Apriliana Fadhilah, Fuad Fatkhul Rizqi, Khoirul Febriantara, M.Kaisar Febrianti, Arlin Firsandini, Firsandini Fitra W.S, Muhammad Fitria Saftarina Frauprades, Kaltihennah Oktavia George Pestalozi Ghifari, Ghaza Ahmad Al Gigaramadan Sema Giska Tri Putri Hakim, Ganesha Rahman Hanna Mutiara Hisbul Waton Ihsanti Dwi Rahayu Ilhamy, Satria Rizqi Indika Poloriani Tunang Indri Windarti Intanri Kurniati Jasmine Putri Nabila Jausal, Anisa Nuraisa Junando, Mirza Junita, Aulia Khairun Nisa M. Aqmal Hidayah M. Frans Surya Pradana Muhammad Maulana Muhartono Muhartono Mukhlis Imanto Novita Carolia Oktadoni Saputra Oktoba, Zulpakor Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Ratna, Maya Ganda Risal Wintoko Risti Graharti Sangging, Putu Ristyaning Ayu Santhi, Komang Ria Yuliana Setiorini, Anggi Shafia, Anindya Sihaloho, Yohanna Christiani Soraya Rahmanisa Supriyadi, Satrio Darma Suryadiwansa Harun Susanti, Andani Dewanti Sutarto Sutarto Syazili Mustofa T. Adjeng, Andi Nafisah Tiffani Dinda Ashar Tri Umiana Soleha Waton, Hisbul Winda Trijayanthi Utama, Winda Trijayanthi Wiwi Febriani Yanuar Burhanuddin Yoyos Dias Ismiarto Yusnita Eka Rahayu