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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Biomedical Journal of Indonesia Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Journal of Islamic Nursing Jurnal Kreativitas PKM SRIWIJAYA JOURNAL OF MEDICINE Jurnal Kesehatan Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Pengabdian Masyarakat: Humanity and Medicine Indonesian Community Empowerment Journal International Archives of Medical Sciences and Public Health International Journal of Islamic and Complementary Medicine Journal of Child, Family, and Consumer Studies Mega Buana Journal of Innovation and Community Service (JICS) Jurnal Profesi Guru Indonesia
Evi Lusiana
Department Of Pharmacology, Faculty Of Medicine, Sriwijaya University, Palembang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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The Effectiveness of Asiatic Acid, Asiaticoside, and Madecassocide in Centella Asiatica, (Linn), Urb. on the Healing Process of Infected Wounds in Experimental Animals: Systematic Literature Review Kessyy Widowati; Evi Lusiana; Theodorus; Debby Handayati Harahap; Nita Parisa; Abda Arif
Sriwijaya Journal of Medicine Vol. 7 No. 3 (2024): Vol 7, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i3.282

Abstract

A wound is a condition where body tissue is damaged as a result of sharp objects, chemicals, animal bites, electric shocks, and so on. Good and correct wound management can prevent wounds from becoming infected. In general, for infected wounds, aminoglycoside antibiotic ointments are used which are effective against gram-negative and gram-positive bacteria, such as gentamicin. Where the use of gentamicin ointment is still the "Drug of Choice" for infected wounds. However, due to several side effects that can be caused such as allergic reactions that will cause discomfort in patients with hypersensitivity to antibiotics in this group and the possibility of resistance to the use of this type of antibiotic, other alternative therapies have emerged for treating wounds with ingredients that have minimal side effects, one of which is by using traditional medicine from nature. One of the herbal medicines that is believed to be able to treat skin wounds is the Gotu Kola plant or Centella asiatica. The gotu kola plant or Centella asiatica contains several active substances that are useful in accelerating wound healing, namely Asiatic acid, Madecassocide, and Asiaticoside. This study aims to determine and assess the activity of these substances in Centella asiatica which play a role in the healing process of infected wounds in experimental animals. This research is a review article, by searching data from Google Scholar, PubMed, and NCBI databases with keywords used such as, "Effectiveness of Centella, Active Ingredients of Centella, Centella on Wounds". Many articles appear, but those used in this article that fit the inclusion criteria are 6 articles. The results of the 6 articles stated that Centella asiatica has the potential to heal infected wounds because it contains triterpenoid compounds which have antibacterial activity against Staphylococcus aureus and Escherichia colli. This review article concludes that the active substances found in pegagan leaves, namely Asiatic acid, Madecassocide, and Asiaticoside, have benefits in healing infected wounds in experimental animals.
EFFECTIVENESS OF ANTHOCYANIN AS A HEPATOPROTECTOR: A SYSTEMATIC LITERATURE REVIEW Amanda Putri, Khairunnisa Rizqika; Lusiana, Evi; Theodorus; Rosdah, Ayeshah Augusta; Harahap, Debby Handayati; Larasati, Veny
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 1 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i1.453

Abstract

Exposure to free radicals can cause hepatotoxicity in liver cells. Hepatoprotectors are needed to prevent free radicals. The flavonoid group anthocyanin compounds, which give many plants purple, blue, and red colors, have antioxidant activity as hepatoprotectors. This study uses a systematic literature review to review the effectiveness of various plants containing anthocyanins as hepatoprotectors. Articles were searched using Google Scholar, PubMed, and NCBI with keywords such as "Anthocyanin compounds and Hepatoprotective effects" that met the inclusion and exclusion criteria. The results obtained from 7 review articles show that several plants contain anthocyanins, such as bilberry and blackberry, Rosella, purple cabbage, butterfly pea flower, Aronia melanocarpa Elliot (AMA), red cabbage, and radish. The mechanisms in plants containing anthocyanins as hepatoprotective include antioxidant activity, inhibition of cytochrome enzymes, inhibition of inflammation, protein expression, and modulation of the apoptotic signal pathway. This review concludes that plants containing anthocyanins are effective as natural hepatoprotectors with various mechanisms.
Cycle Threshold Value as A Death Predictor of COVID-19 Patients Oktariana, Desi; Saleh, Irsan; Banun, Syahri; Rahadiyanto, Kemas Ya’kub; Liana, Phey; Rahmawati, Eny; Hafizzanovian, Hafizzanovian; Lusiana, Evi; Tamzil, Nia Savitri; Prasasty, Gita Dwi; Aseptianova, Aseptianova
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2390

Abstract

For several years, COVID-19 has been a major problem in human health and also caused a global socio-economic crisis. However, the impact of viral load on patient mortality has not been thoroughly investigated. This study analyzes the association between CT value and the mortality of COVID-19 patients in inpatients at Mohammad Hoesin Hospital. This study used observational analysis with a longitudinal retrospective design. This study had 280 subjects. Fifty-four of the 280 patients died (19.3%) 33% had a CT <22.93; 16.7% had a CT 22.93-29.93; 31.5% had a CT 29.94-34.9, 18.5% had a CT >35 with p-value >0.05 for patient mortality. Analysis of age, comorbidities, and clinical severity of patient mortality showed a p-value <0.05. Meanwhile, gender analysis of patient mortality showed a p-value >0.05. These results indicate that the CT value cannot predict patient mortality. Patients with older age, comorbidities, and admission with severe clinical severity have a higher risk of death.
Edukasi swamedikasi obat herbal yang rasional pada kelompok ibu rumah tangga di Kelurahan Karya Baru Rosdah, Ayeshah Augusta; Adenina, Masayu Syarinta; Parisa, Nita; Harahap, Debby Handayati; Lusiana, Evi; Fatmawati, Fatmawati
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 6 No 1 (2025): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V6I1.169

Abstract

Indonesian Health Survey reported that more than half of the population in South Sumatera utilizes herbal medicine to alleviate disease symptoms. The survey also indicated that factors such as lower-middle income levels and the female gender are relatively more likely to utilize medicinal plants compared to higher-income levels and the male gender. The findings from this health survey strongly support the characteristics of the target audience for this community service, specifically the residents of Karya Baru Village represented by the women in Majelis Taklim Al-Kahfi. Initial interviews with several members of this group revealed a tendency to self-treat sick family members, particularly using herbal remedies, as they are perceived to have no side effects compared to modern medications (synthetic drugs). These findings indicate a potential irrational use of herbal medicine in self-medication practices. Self-medication refers to the efforts made by individuals to determine treatments for their disease symptoms. For self-medication practices to be safe and effective, it is essential for the community to be equipped with adequate knowledge about the rational use of herbal medicines. Therefore, a community service initiative is necessary to enhance public knowledge regarding the types of herbal medicines and promote rational behaviors on self-medication practice of herbal medicines within the community.
The Use of Wordwall-Based Educational Games to Improve Student Learning Outcomes in Islamic Education Learning in MI Negeri 2 Solok Farida; Lusiana, Evi
Jurnal Profesi Guru Indonesia Vol. 1 No. 2 (2024): JUNE 2024
Publisher : MANDAILING GLOBAL EDUKASIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62945/jpgi.v1i2.681

Abstract

This research aims to improve student learning outcomes in learning Islamic religious education by using wordwall-based educational games. This research is a classroom action research that uses four steps, namely planning, action, observation and reflection. The subjects of this research are primary school madrasah students. The data of this research was obtained with test and observation techniques. Tests are used to measure learning outcomes and observations are used to analyze the learning activities of teachers and students. The data analysis technique used in this research is descriptive statistics by comparing the results obtained with research success indicators. The results of the research show that wordwall-based educational games can improve student learning outcomes in Islamic religious education. This can be seen from the increase in the percentage of student learning completion in each cycle with details of the precycle 45.01%, the first cycle 79.39% and in the second cycle it increased to 91.16%. Thus, the use of wordwall-based educational games can be used as an alternative to improve student learning outcomes in Islamic religious education.
SIDE EFFECTS OF SECOND-LINE ANTITUBERCULOSIS DRUGS IN MULTI-DRUG RESISTANCE (MDR) TUBERCULOSIS PATIENTS Tamzil, Nia Savitri; Lorenza, Geofanny; Andriani, R.A. Linda; Theodorus, Theodorus; Sudarto, Sudarto; Lusiana, Evi; Harahap, Debby Handayati; Oktariana, Desi; Prasasty, Gita Dwi
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 2 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i2.483

Abstract

Multidrug-resistant tuberculosis (MDR TB) is caused by Mycobacterium tuberculosis strains resistant to isoniazid and rifampicin—the most potent anti-TB drugs. Prolonged treatment duration and complex drug regimens often lead to poor adherence, contributing to high MDR TB incidence and low treatment success rates, particularly in Indonesia. This study analyzed drug utilization patterns in 52 MDR TB patients at Dr. Mohammad Hoesin Hospital Palembang, using total sampling based on medical records from October 2018 to December 2019. Data were analyzed descriptively with SPSS v25. The most common side effects reported were weakness, nausea, and vomiting (84.6%), followed by arthralgia, hyperuricemia, and hearing loss (42.3%). Severe side effects were more prevalent in the short-term regimen group (40.4%) compared to the long-term group (7.7%). Weakness, nausea, and vomiting were the most frequently observed side effects in MDR TB patients.
THE IMPACT OF HEALTH EDUCATION USING FOCUS GROUP DISCUSSION ON BREAST SELF-EXAMINATION (BSE) BEHAVIOR AMONG FEMALE STUDENTS AT SMAN 14 MAKASSAR Ratna sari; Mikawati; Evi lusiana; Muaningsih; Rizky pratiwi
Journal of Child, Family, and Consumer Studies Vol. 4 No. 1 (2025): Journal of Child, Family, and Consumer Studies
Publisher : Department of Family and Consumer Sciences, Faculty of Human Ecology, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jcfcs.4.1.40-50

Abstract

Breast cancer poses a significant global threat to women's health, yet awareness and practice of its most accessible early detection method—Breast Self-Examination (BSE)—remain low among adolescent girls, especially high school students. This study aims to examine the impact of health education using the Focus Group Discussion (FGD) method on BSE behavior among 11th-grade female students at SMAN 14 Makassar in 2023. A pre-experimental research design with a one-group pretest-posttest approach was employed. A total of 51 female students were selected through probability sampling. Data were collected using a standardized questionnaire assessing both knowledge and attitudes toward BSE. The Wilcoxon test revealed a significant increase in knowledge following the intervention (p = 0.001), indicating a meaningful difference between pretest and posttest scores. In contrast, although there was an increase in attitude scores post-intervention, the result was not statistically significant (p = 0.239). These findings suggest that while the health education intervention effectively improved knowledge about BSE, its influence on attitude change was not statistically confirmed. Nevertheless, the upward trend in attitude scores implies potential for long-term impact. In conclusion, health education through FGD proved to be effective in enhancing students’ knowledge of BSE and may contribute to fostering more positive attitudes over time. This highlights the importance of integrating structured health education programs into school curricula to promote early breast cancer prevention among adolescents.
IMPACT OF FAMILY AND NURSE SUPPORT ON SELF-CARE BEHAVIOR IN DIABETES MELLITUS PATIENTS Gita angrini; Mikawati; Evi lusiana; Julianus ake; Hidayati ismail
Journal of Child, Family, and Consumer Studies Vol. 4 No. 1 (2025): Journal of Child, Family, and Consumer Studies
Publisher : Department of Family and Consumer Sciences, Faculty of Human Ecology, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jcfcs.4.1.1-11

Abstract

Diabetes mellitus is a metabolic disease characterized by increased blood glucose levels (hyperglycemia). This study aims to analyze the relationship between social support and nurse support with self-care behavior in diabetes mellitus patients in the working area of Samata Community Health Center, Gowa Regency. This research employs a quantitative approach with an analytical observational design using a cross-sectional study. The sample was selected using a non-probability sampling method with a purposive sampling approach, resulting in a total of 66 respondents. Data collection instruments included questionnaires for social support, nurse support, and the Summary of Diabetes Self-Care Activities (SDCA) for self-care behavior. The results showed that 89 percent of respondents received social support, 80 percent received nurse support, and 76% demonstrated self-care behavior. Statistical analysis using the Chi-square test, specifically the Continuity Correction test, yielded a p-value of 0.009 (p-value < α = 0.05). The findings indicate a significant relationship between social support and self-care behavior among diabetes mellitus patients in the working area of Samata Community Health Center, Gowa Regency. Additionally, nurse support was found to be significantly associated with self-care behavior, as nurses play a crucial role as educators by providing accurate information to diabetes mellitus patients. Future research is encouraged to explore other variables to expand the reference framework.
Upaya Penanganan Stunting Pada Balita di Desa Tanrara Suriyani, Suriyani; Mikawati, Mikawati; Lusiana, Evi; Muaningsih, Muaningsih; Pratiwi, Rizky
Mega Buana Journal of Innovation and Community Service Vol. 2 No. 1 (2023): Juli Tahun 2023
Publisher : LPPM Universitas Mega Buana Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59183/z3w91r19

Abstract

Gangguan pertumbuhan yang dialami oleh balita dapat mengakibatkan keterlambatan tumbuh kembang anak. Untuk itu pendidikan dan pengetahuan Ibu mengenai stunting sangatlah berkontribusi sehingga perlu diadakan pendidikan kesehatan maupun penyuluhan.Tujuan pengabdian masyarakat agar ibu-ibu termotivasi dalam melakukan pengasuhan pada anak sejak dini di Wilayah kerja Puskesmas Bontonompo Selatan Tahun 2022. Pelaksanan kegiatan ini dilakukan oleh dosen dan dibantu oleh mahasiswa Stikes Panakkukang. Metode pelaksanaannya dibagi menjadi tiga tahap. Pertama menyiapkan kegiatan dilokasi penyuluhan dan tahap kedua menyiapkan ibu –ibu yang memiliki anak usia balita bekerja sama dengan pihak puskesmas, pemerintahan desa dan ibu-ibu kader. Kegiatan ini dihadiri oleh 13 ibu yang memiliki balita. Dari hasil kegiatan ini disimpulkan bahwa pengetahuan sebagai orang tua sangatlah perlu mengetahui dan memantau kondisi kesehatan balita stunting untuk meminimalisir dampak yang akan muncul serta memberikan penanganan yang baik kepada balita stunting.
POTENTIAL OF DUTCH TEAK LEAVES (Guazuma ulmifolia) AS ANTIOXIDANTS AND ANTI-INFLAMMATORIES AGENT Smaradhna, Safira; Az Zahra, Zaviera; Maria Sidabutar, Carolina; Eskalatin, Khaira; Tamzil, Nia Savitri; Lusiana, Evi; Oktariana, Desi; Dwi Prasasty, Gita; Parisa, Nita
International Journal of Islamic and Complementary Medicine Vol. 4 No. 1 (2023): International Journal of Islamic and Complementary Medicine
Publisher : International Islamic Medicine Forum

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55116/IJICM.V4I1.57

Abstract

Oxidative stress is an imbalance in the quantity of reactive species and antioxidant activity that is often associated with inflammatory diseases. Inflammation is the main cause of morbidity in most of the world's population. Inflammation occurs when there is an invasion of foreign bodies and pathogenic agents such as bacteria, parasites, and viruses that cause activation of the immune system. The protective effect of the inflammatory process is actually very good under normal circumstances. However, in chronic inflammation, tissue damage becomes uncontrollable and can lead to various diseases such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, psoriasis and neoplastic transformation. For inflammatory therapy, steroids and non-steroidal drugs (NSAIDs) are usually used, but the use of these drugs can have serious long-term effects. Therefore, the development of anti-inflammatory agents from natural sources such as certain plant species that are safe, efficacious, biocompatible and cost-effective is a rational strategy that can be used to treat inflammatory diseases. One of its species, Guazuma ulmifolia or Dutch teak plant, is widely used in traditional medicine because it contains bioactive compounds, especially proanthocyanidins and flavonoids which have anti-oxidant and anti- microbial properties. The leaves and flowers of Guazuma ulmifolia can be used in fever, gastrointestinal disease, kidney disease and diabetes. Guazuma ulmifolia can protect the gastric mucosa against the harmful effects of NSAIDs through anti-inflammatory and anti-oxidant mechanisms. The extract of Dutch teak leaves (Guazuma ulmifolia) was also effective in reducing the expression of myeloperoxidase in the pulmonary tissue of Wistar white rats with pulmonary contusions .
Co-Authors Abda Arif Aisyah Fristania Ditamor Amanda Putri, Khairunnisa Rizqika Amira Azra Arisa Putri Andriani, R.A. Linda Ardesy Melizah Kurniati Aseptianova Aseptianova Ayeshah A Rosdah Az Zahra, Zaviera Azizah, Aida Nur Banun, Syahri Debby Handayati Harahap Debby Handayati Harahap Debby Handayati Harahap Debby Handayati Harahap Desi Oktariana Desi Oktariana Desi Oktariana Eny Rahmawati, Eny Ernawati Sinaga Eskalatin, Khaira Farida Fatmawati, Fatmawati Fifa Argentina Fifa Argentina Fifa Argentina Gita angrini Gita Dwi Prasasty Gita Dwi Prasasty Gita Dwi Prasasty Hafizzanovian, Hafizzanovian Indri Seta Septadina Islami, Arya Putera Ismail, Hidayati Julianus Ake Kemas Ya’kub Rahadiyanto Kessyy Widowati Khairunnisa Rizqika Amanda Putri Komar, Muhammad Hafidh Legiran Legiran Lorenza, Geofanny Luthfiah, Qonita M. T. Kamaluddin Manawan, Efman E.U. Maria Sidabutar, Carolina Mgs. Irsan Saleh, Mgs. Irsan Mikawati Mikawati, Mikawati Muaningsih Muaningsih, Muaningsih Muh. Zukri Malik Muhammad Irsan Saleh Muhammad Reagan Muhammad, Fadhil Nafrah Ardita Nashif, Arkan Abdullah Nia Savitri Tamzil Nia Savitri Tamzil Nita Parisa Nita Parisa Nita Parisa Oktariana, Desi pariyana, Pariyana Phey Liana Phey Liana Pratiwi, Rizky Qonitah, Zahrah Aliyah Rahadiyanto, Kemas Ya’kub Rahardiyanto, Kemas Ya’kub RATNA SARI Resty Ryadinency Ricardo Simanjuntak Rivani, Erizka Rizky Pratiwi Rofflin, Eddy Rosdah, Ayesha Augusta Sabrina, Tia Saleh, M. Irsan Saleh, Muhammad Irsan Sindy Bintang Permata Smaradhna, Safira Sudarto Sudarto Suriyani Suriyani, Suriyani Sutandar, Vivi Hendra Syarinta Adenina Theodorus Theodorus Theodorus Theodorus Theodorus Turridho, Aisya Veny Larasati Wicaksono, Bonanza Abi Wildan Dwi Putra Widodo Zanaria, Rima Zen Hafy