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Journal : JURNAL PHOTON

SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KALKON TURUNAN 2’-HIDROKSIASETOFENON DAN HALOBENZALDEHID Ihsan Ikhtiarudin; Lelani -; Adel Zamri; Hilwan Yuda Teruna; Yuharmen -
Sistem Informasi Vol 5 No 1 (2014): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v5i1.194

Abstract

Kalkon merupakan senyawa metabolit sekunder golongan flavonoid yang terdapat pada beberapa jenis tumbuhan. Senyawa ini dikenal memiliki berbagai bioaktivitas yang menarik. Dalam bidang sintesis, senyawa ini digunakan untuk mensintesis berbagai macam senyawa heterosiklik seperti benzodiazepin, pirazolin, flavanon, flavonol, dan senyawa turunan kalkon lainnya yang juga memiliki bioaktivitas yang menarik. Oleh karena itu, senyawa ini banyak dijadikan sebagai molekul target untuk keperluan pencarian senyawa-senyawa aktif sebagai kandidat obat, salah satunya adalah sebagai obat antikanker. Pada penelitian ini, tiga analog kalkon turunan 2’-hidroksiasetofenon dan halobenzaldehid telah disintesis menggunakan metode stirer dengan katalis KOH dan pelarut PEG-400. Struktur setiap produk dikarakterisasi dengan spektroskopi UV-Vis, FTIR, 1H NMR, 13C NMR, dan HRMS. Uji toksisitas dilakukan menggunakan metode Brine Shrimp Lethality Test (BSLT). Berdasarkan hasil uji BSLT, ketiga senyawa tersebut berpotensi sebagai senyawa antikanker dengan nilai LC50<200 μg/mL.
EKSTRAKSI DAN OPTIMASI VITAMIN E DARI FRAKSI NON POLAR CRUDE PALM OIL (CPO) Rahmiwati Hilma; Anggi Fisi Anggita; Ihsan Ikhtiarudin
Sistem Informasi Vol 9 No 1 (2018): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v9i1.1077

Abstract

Vitamin E has many benefits for human health. Besides being known as supplements, vitamin E is known to have activities as an anticancer compound, preventing premature aging, preventing cardiovascular diseases and other degenerative diseases. In this study carried out the extraction and optimization process of vitamin E from sample non-polar fraction of fresh CPO. The extraction process was carried out by saponification reaction, vitamin E optimization was carried out on the non-polar fraction with the addition of methanol, then to the oil fraction added 2-propanol (1%) in hexane. From the fresh CPO samples used, it was seen that the samples met the quality standards of fresh CPO. From the results of extraction and optimization of vitamin E, it was found that the yield was quite large (52.77%). Characterization results with TLC and analyzed with UV light at a wavelength of 254 and 366 nm seen vitamin E still has 2 stains, the possibility was tocopherol and tootrienol which was usually components contained in vitamin E.
Sintesis dan Potensi Aktivitas Tabir Surya Senyawa Analog Kalkon Turunan 3’-Hidroksiasetofenon dan 4-Metoksibenzaldehid Ihsan Ikhtiarudin; Nesa Agistia; Tria Harlianti; Adel Zamri
Sistem Informasi Vol 10 No 1 (2019): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v10i1.1541

Abstract

Chalcone analogues have attracted the attention of researchers due to their various biological activities. In this study, a chalcone analogue, (E)-1-(3-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-on has been synthesized under microwave irradiation and its sunscreen activity has been evaluated by in vitro assay using 96-well microplate reader. Based on the in vitro assay, at concentration of 100-500 µg/ml, the compound showed potential sunscreen activity with %Te value of 5.49 – 0.04 % (extra protection – sunblock), %Tp value of 0.51-0.05 % (sunblock) and SPF value of 18.20 – 32.91 (ultra protection). The assay result showed that the (E)-1-(3-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-on has a potency to be developed as active ingredient in sunscreen product.
Sintesis C-dots dari Gula Pasir dan Asam Sitrat untuk Deteksi Logam Berat Yanto, Yanto; Dona, Rahma; Ikhtiarudin, Ihsan
Photon: Jurnal Sain dan Kesehatan Vol. 14 No. 1 (2023): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v14i1.4214

Abstract

Heavy metal contamination is one of the problems in pharmaceutical products. Carbon dots are a practical and economical method of heavy metal detection to reduce heavy metal contamination in pharmaceutical products. Carbon dots have been successfully synthesized by microwave irradiation from sugar table doped with urea fertilizer (CD-GU) and citric acid doped with urea fertilizer (CD-AU). The success of the synthesis of carbon dots can be seen from their properties that produce a blue to green luminescence when excited with a 405 nm laser and an orange to red luminescence when excited with a 532 nm laser. When excited with a 405 nm laser, CD-GU produces a strong light blue luminescence, while CD-AU produces a strong green luminescence. CD-GU and CD-AU also exhibit orange luminescence when excited with a 532 nm laser. The intensity of luminescence of carbon dots will decrease when interacting with heavy metals so that it can be applied for heavy metal detection. The results of this study revealed that CD-GU and CD-AU can be used to detect heavy metals.