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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Alchemy : Journal of Chemistry The Journal of Pure and Applied Chemistry Research Jurnal Agroekoteknologi CHEMPUBLISH JOURNAL JOURNAL ONLINE OF PHYSICS Jurnal Teknologi Laboratorium Chimica et Natura Acta Indonesian Food Science and TechnologyJournal Pharmacology and Clinical Pharmacy Research Jambura Journal of Chemistry PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal IPTEK Bagi Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan International Journal of Hydrological and Environmental for Sustainability Makara Journal of Science Jurnal Pengabdian Pada Masyarakat Molekul: Jurnal Ilmiah Kimia Journal of The Indonesian Society of Integrated Chemistry Jurnal Sains dan Kesehatan
Madyawati Latief
Prodi Kimia Fakultas Sains dan Teknologi Universitas Jambi
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IDENTIFIKASI KANDUNGAN TANAH DI KECAMATAN PEMAYUNG KABUPATEN BATANG HARI PROVINSI JAMBI Samsidar, Samsidar; maison, Maison; Ermadani, Ermadani; Latief, Madyawati; Fendriani, Yoza; Alrizal, Alrizal; Resta, Ichy Lucya; Riany, Hesti; Pebralia, Jesi
JOURNAL ONLINE OF PHYSICS Vol. 10 No. 3 (2025): JOP (Journal Online of Physics) Vol 10 No 3
Publisher : Prodi Fisika FST UNJA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jop.v10i3.47051

Abstract

Informasi akan kandungan tanah penting diketahui sebagai dasar pengolahan pertanian. Pada Kabupaten batang Hari kecamatan pemayung Provinsi Jambi terdapat dua jenis tanah yang sering dimanfaatkan sebagai lahan pertanian yaitu tanah Ultisol dan Inseptisol. Dalam pemanfaatan sebagai lahan pertanian terhadap kedua jenis tanah tersebut umumnya pelaku pertanian melakukan penanaman langsung sehingga sering kali mendapatkan hasil yang kurang optimal akibat ketidaksesuaian jenis tanaman dan pupuk yang digunakan, untuk itu pada penelitian ini dilakukan karakterisasi terhadap tanah tersebut. Sampel tanah diambil dari 6 titik lokasi dengan ukuran 1km x 2km, selanjutnya dilakukan preparasi untuk pengukuran unsur logam dengan menggunakkan X-Ray Fluorescence (XRF), uji kandungan C-Organik dan pH. Hasil pengujian XRF menunjukkan bahwa daerah aluvial (Inseptisol) memiliki kandungan Mg dan C-organik lebih tinggi daripada tanah Ultisol dimana rata-rata kandungan Mg >18% dan C-Organik >14% serta memiliki kandungan Al dan Si lebih rendah, dimana Al <20% dan Si <25%. Untuk nilai C- Organik tanah inseptisol (aluvial) memiliki C-organik lebih tinggi (>14%) dan pH lebih rendah (<5) dibandingkan dengan tanah ultisol. Dari hasil pengujian kandungan tanah diharapkan pelaku pertanian pada daerah tersebut dapat mengetahui gambaran kandungan tanah dengan cara melakukan pencocokan pendekatan terhadap sampel tanah yang telah dilakukan pengujian pada penelitian ini.
In-silico of Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Inhibitors of Seven Bioactive Compounds from Sonneratia alba Latief, Madyawati; Melani, Fitria; Yusnaidar, Yusnaidar; Tarigan, Indra Lasmana
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.59525

Abstract

Cancer is a disorder resulting from genetic changes, abnormal growth, and spread to other parts of the body. Cancer treatment is commonly administered through chemotherapy, which often results in adverse side effects. Therefore, research is essential to identify safer alternative cancer therapies. This study aims to identify potential bioactive compound ligand receptor targets from Sonneratia alba as anticancer candidates in silico by identifying VEGFR target proteins based on their pharmacophores and studying their interactions through the reverse docking method. Docking simulations between the native ligand (Tivozanib) and the receptor yielded promising results, with a free energy value of -12.76 kcal/mol and an inhibition constant of 440.70 μM. Among the seven bioactive compounds, Meperidine (C15H21NO2) exhibited favorable outcomes, showing a free energy value of -7.39 kcal/mol and an inhibition constant of 3.83 μM. Additionally, the meperidine and gibberellin A7 compounds formed three and four hydrogen bonds, respectively, including one with Ala866, and interacted with 15 and 18 amino acid residues, such as Glu917, Cys919, Glu885, and Asp1046. The presence of active sites on the ligand or test compounds that bind to the target receptor indicates a potential for comparable affinity in inhibiting VEGFR-2 receptor activity.
Metabolomic Profiling LC-MS Based Bioactive Compound of Sonneratia alba, Antioxidant Activities and Its In-silico molecular docking Studies Tarigan, Indra Lasmana; Latief, Madyawati; Anshori, Jamaludin Al; Melani, Fitria; Putri, Silvi Ayudiah; Husna, Naimul; Warni, Tri; Ramadhan, Ilham Ifandi; Yusnaidar, Yusnaidar; Sutrisno, Sustrisno
Molekul Vol 20 No 2 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.2.13578

Abstract

ABSTRACT. Mangrove Perepat (Sonneratia alba) plants have various potentials that need to be utilized optimally because they have varying bioactive compound content. A comprehensive exploration of secondary metabolite compound content and plant bioactivity based on metabolomics and in-silico molecular docking is needed to see the effects of single or multiple compounds. This study aimed to obtain a profile of medicinal compounds from Perepat leaves as antioxidants. Extraction was carried out using five gradients of Ethanol: Water concentration. EP1 (water), EP2 (25% Ethanol), EP3 (50% Ethanol), EP4 (75% Ethanol), EP5 (100% Ethanol). The research was carried out through extraction, antioxidant determination, metabolomics, and molecular docking. Exploration data showed that increasing ethanol concentration increased phenolics, flavonoids, and antioxidant activity. EP5 has the highest total phenolics and flavonoids of 24.978 mgGAE/g and 42.97 mgQE/g, respectively, with an IC50 value of 8.263 ppm. Docking analysis of 37 test compounds identified 12 compounds with low binding energy, ranging from -7 to -9 kcal/mol, with the NADPH oxidase protein receptor (PDB ID: 2CDU). These compounds include kaempferol-3-rhamnoside, meperidine, apigenin-7-O-glucoside, 2-keto benzothiazole 54, methyl propanoic acid, salicyloylaminotriazole, salicylihalamide A, and gibberellin A7. Our findings suggest that S. alba extract holds potential for further exploration as a natural antioxidant source. Keywords: Antioxidant; In-silico; Metabolomics; S. alba
Analisis Aktivitas Imunomodulator dan Antiinflamasi Senyawa Bioaktif Fraksi Daun Sungkai (Peronema canescens Jack) Secara In Silico: Analysis of Immunomodulatory and Anti-inflammatory Activities of Bioactive Compounds of Sungkai Leaf Fractions (Peronema canescens Jack) In Silico Maharani, Viola Giary Rizkillah; Delviani, Delviani; Latief, Madyawati; Tarigan, Indra Lasmana
Jurnal Sains dan Kesehatan Vol. 7 No. 4 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i4.2481

Abstract

The immune system recognizes and responds to various pathogens to protect the body. An imbalance in the immune system can lead to uncontrolled inflammation that causes inflammation. The discovery of new agents as immunomodulators and anti-inflammatories is very important in the search for effective drugs for long-term use. Sungkai is a plant with immunomodulatory and anti-inflammatory effects. The purpose of this study is to predict the potential of compounds in sungkai that act as immunomodulators and anti-inflammatory through an in silico approach with molecular docking method. Based on the results of molecular docking of test ligands with COX 1 anti-inflammatory receptor in the form of prostaglandin H2 synthase-1, the best ligands were obtained in the form of 3?-acetoxy-6-nitrocholest-5-ene, Squalen, Quercetin and Apigenin with binding free energy (?G) values of -12.48; -8.26; -8.09; and -7.95 kcal/mol, respectively. Meanwhile, between the test ligands and the IL-6 immunomodulatory receptor in the form of Human Interleukin-6, the best ligands were obtained in the form of 3?-acetoxy-6-nitrocholest-5-ene, Apigenin, Quartzetin and Squalen with binding free energy values (?G) of -5.80; -5.05; -4.70; and -2.81 kcal/mol. Keywords:          Immunomodulator, Anti-inflammatory, In Silico, Sungkai   Abstrak Sistem kekebalan tubuh merupakan bentuk pengenalan dan respons berbagai patogen dalam melindungi tubuh. Ketidakseimbangan sistem kekebalan dapat menyebabkan inflamasi tidak terkontrol yang menimbulkan peradangan. Penemuan agen baru sebagai imunomodulator dan antiinflamasi sangat penting dalam pencarian obat  efektif untuk penggunaan jangka panjang. Sungkai merupakan tumbuhan dengan efek imunomodulator dan antiinflamasi. Tujuan penelitian ini adalah untuk memprediksi potensi senyawa dalam sungkai yang berperan sebagai imunomodulator dan antiinflamasi melalui pendekatan secara in silico dengan metode molecular docking. Berdasarkan hasil molecular docking ligan uji dengan reseptor antiinflamasi COX 1 berupa prostaglandin H2 synthase-1 diperoleh ligan terbaik berupa 3?-acetoxy-6-nitrocholest-5-ene, Squalen, Kuarsetin dan Apigenin dengan nilai energi bebas pengikatan (?G) masing- masing -12.48; -8.26; -8.09; dan -7,95 kkal/mol. Sedangkan antara ligan uji dengan reseptor imunomodulator IL-6 berupa Human Interleukin-6 diperoleh ligan terbaik berupa 3?-acetoxy-6-nitrocholest-5-ene, Apigenin, Kuarsetin dan Squalen nilai energi bebas pengikatan (?G) yaitu  -5.80; -5.05; -4.70; dan -2.81 kkal/mol. Kata Kunci:         Imunomodulator, Antiinflamasi, In Silico, Sungkai
Studi In Silico Senyawa Bioaktif Kopi Arabika (Coffea Arabica) Sebagai Kandidat Antikanker terhadap Reseptor PI3K p110-delta subunit Melani, Fitria; Putri, Silvi Ayudiah; Zulnita, Anis; Latief, Madyawati; Sutrisno, Sustrisno; Tarigan, Indra Lasmana
ALCHEMY:Journal of Chemistry Vol 13, No 1 (2025): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v13i1.28636

Abstract

Each year, 9.6 million people lose their lives to cancer, making it the world's second worst killer. Cancer is a disorder that results from genetic changes and has abnormal growth and spreads to other parts of the body. Cancer treatment is currently done with chemotherapy which has unfavorable side effects, so research needs to be done to determine safer alternatives to cancer treatment. This study aims to determine the activity of bioactive compounds in Arabica coffee beans that have potential as anticancer through identification of target receptors and interaction studies using molecular docking methods against PI3K p110-delta subunit receptors. The results showed that of the 21 compounds, five compounds gave good results, namely compounds 4-O-feruloylqunic acid, 4-O-caffeoylqunic acid, gluconic acid, 3-O-feruloylqunic acid and 3-O-caffeoylqunic acid with bond energy (ΔG) and inhibition constant values of -5.47; -5.33; -4.73; -4.69; -4.40 kcal/mol and 98.02; 123.62; 340.97; 363.82; 591.97 μM, respectively. So that these test ligands/compounds can have potential as PI3K receptor inhibitors in cancer treatment
Pendampingan Ibu PKK Mengolah Kulit Pisang Menjadi Cookies Untuk Mendukung Pencegahan Stunting Fadhil, Ahmad; Rahmasari, Nadia; Tambunan, Betharia Juli Mas; Marbun, Sarah Aknesia; Rahayu, Rosi; Latief, Madyawati; Tarigan, Indra Lasmana
Jurnal IPTEK Bagi Masyarakat Vol 5 No 1 (2025)
Publisher : Ali Institute of Research and Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55537/j-ibm.v5i1.1267

Abstract

Indonesia merupakan salah satu negara penghasil pisang terbesar, namun kulit pisang yang kaya nutrisi sering kali terbuang sebagai limbah. Di sisi lain, stunting masih menjadi permasalahan kesehatan yang signifikan, terutama di wilayah Jambi. Kegiatan pengabdian ini bertujuan untuk memberdayakan ibu-ibu PKK Desa Simpang Limo dalam mengolah kulit pisang menjadi cookies sehat sebagai upaya alternatif mendukung pencegahan stunting. Program dilaksanakan selama tiga bulan (Agustus-November 2024) dengan melibatkan tiga puluh peserta. Metode yang digunakan meliputi observasi, sosialisasi, pelatihan pembuatan tepung kulit pisang, dan praktik pembuatan cookies berbasis kulit pisang. Hasil survei pasca-pelatihan menunjukkan tingkat pengetahuan yang sedang namun minat yang tinggi, di mana 36,9% responden menyatakan kesediaan memproduksi cookies kulit pisang dan 15,4% menilai inovasi ini sebagai langkah positif dalam pengurangan limbah. Produk cookies yang dihasilkan memperoleh respon positif, masyarakat menilai rasa enak, tekstur renyah dan aroma yang khas. Kegiatan ini menunjukkan bahwa pemanfaatan kulit pisang berpotensi menghasilkan produk pangan bergizi dan bernilai ekonomi, sekaligus meningkatkan keterampilan ibu PKK serta berpotensi mendukung upaya penurunan stunting.
Isolasi Senyawa Metabolit Sekunder dari Ekstrak Etil Asetat Daun Sungkai (Peronema canescens jack.) dan Uji Aktivitas Imunomodulator Safitri, Wulan; Latief, Madyawati; Susanto, Nindita Clourisa Amaris
Jambura Journal of Chemistry Vol 6, No 2 (2024): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v6i2.15506

Abstract

Sungkai (Peronema canescens Jack.) is a plant native to Indonesia that is traditionally used for dehumidifiers, treating malaria and increasing endurance. This study aims to isolate the compounds in the ethyl acetate extract of sungkai leaves and test the immunomodulatory activity of these compounds. Sungkai leaves were carried out stratified maceration using n-hexane, ethyl acetate and methanol solvents, then phytochemical screening of ethyl acetate extract of sungkai leaves, followed by an isolation process using the KVC method and isolates were obtained on F3. Phytochemical screening of F3 isolates contains steroid compounds. Immunomodulatory activity tests showed that in EEADS 50 mg/Kgbb, 150 mg/Kgbb, 450 mg/Kgbb, K+ and isolates there was an increase in the number of leukocytes and % macrophage activity compared to K-. The EEADS treatment of 50 mg/Kgbb, 150 mg/Kgbb and isolates of 0.7 mg/Kgbb did not differ markedly from K- but differed markedly from the EEADS treatment of 450 mg/Kgbb and K+. At a dose of 450 mg/Kgbb there was an increase in leukocytes and the highest % macrophage activity which was almost close to K+ (Imboost 0.7 mg/Kgbb). The UV-Vis spectrum of the F3 isolate shows a maximum absorption peak at 267 nm indicating the presence of a nonconjugation double bond. The FTIR spectrum shows isolates have groups O-H (3381.13cm-1), aliphatic C-H (2939.10cm-1), C=C (1631.44cm-1), C-H (1449.42-1362.82cm-1), and C-O (1022.32cm-1). Based on the literature comparison, the pattern of the UV-Vis spectrum and FTIR of F3 isolates has similarities with the UV-Vis and FTIR spectrum of steroid group compounds, namely β-Sitosterol.
Co-Authors -, Maison Addion Nizori Ahmad Fadhil, Ahmad Alfi Khatib, Alfi Alrizal, Alrizal Amanda, Dwi Rahma Amanda, Hilda Ardhica, Jammes Arum, Dewi Azizah, Regina Wan Bela, Anisa Budiyati Ichwan Bulan, Catherine Putri Delviani, Delviani Dewi, Tribuana Tungga Elis Kartika Ermadani Ermadani Faizar Farid Farah, Farah Fisesa, Anggun Tri Helmina Mandalahi, Helmina Hengky Irawan, Hengky Heriyanti Heriyanti, Heriyanti Husna, Naimul Indra Lasmana Tarigan Jamaludin Al-Anshori Kharisma, Tiara Lince Muis Lizawati Lizawati Lucky Zaehir Maulana Maharani, Viola Giary Rizkillah Marbun, Sarah Aknesia Masruri Masruri Melani, Fitria Muhaimin Muhaimin Nabila, Annisa Candra Natasya, Dian Nelson Nurjannah, Sofia Nurul Huda Oktavioni, Marsella Pebralia, Jesi Prabawa, Satria Prahandika, Graha Puspitasari, Ratih Dyah Putri Maya Sari Putri, Silvi Ayudiah Putri, Yunika Eka qurrota aini Rahayu, Rosi Rahmasari, Nadia Ramadhan, Ilham Ifandi Razai, Tengku Said Resta, Ichy Lucya Restina Bemis, Restina Riany, Hesti Saharin, Siti Munirah Samsidar Samsidar Sari, Tika Shadrina, Putri Nur Silvi Leila Rahmi Sinurat, Julius Alvin Novensius Suci, Ulan Susanto, Nindita Clourisa Amaris Sutrisno, Sustrisno Sutrisno, Sutrisno Tambunan, Betharia Juli Mas Tarigan, Indra L. Uce Lestari Warni, Tri Wulan Safitri, Wulan Yoza Fendriani Yulianti, Nike Desvi Yusnaidar, Yusnaidar Yusof, Yus Aniza Zulnita, Anis