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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Alchemy : Journal of Chemistry The Journal of Pure and Applied Chemistry Research Jurnal Agroekoteknologi CHEMPUBLISH JOURNAL JOURNAL ONLINE OF PHYSICS Jurnal Teknologi Laboratorium Chimica et Natura Acta Indonesian Food Science and TechnologyJournal Pharmacology and Clinical Pharmacy Research Jambura Journal of Chemistry PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal IPTEK Bagi Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan International Journal of Hydrological and Environmental for Sustainability Makara Journal of Science Jurnal Pengabdian Pada Masyarakat Molekul: Jurnal Ilmiah Kimia Journal of The Indonesian Society of Integrated Chemistry Jurnal Sains dan Kesehatan
Madyawati Latief
Prodi Kimia Fakultas Sains dan Teknologi Universitas Jambi
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Encapsulation of Ethanol Extract Perepat Leaves (Sonneratia alba) with Maltodextrin Coating as an Antioxidant Functional Food Candidate Heriyanti, Heriyanti; Putri, Yunika Eka; Irawan, Hengky; Raza'i, Tengku Said; Tarigan, Indra Lasmana; Kartika, Elis; Ichwan, Budiyati; Latief, Madyawati
Indonesian Food Science and Technology Journal Vol. 7 No. 2 (2024): Volume 7. Number 2, July 2024 |IFSTJ|
Publisher : Department of Technology of Agricultural product (THP) Jambi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/ifstj.v7i2.34013

Abstract

Phytochemistry and Antidiabetic Evaluation in-vitro and in-vivo of Ethyl Acetate Fractions from Sungkai Leaves (Peronema canescens Jack) Aini, Qurrota; Latief, Madyawati; Tarigan, Indra Lasmana; MASRURI, Masruri
The Journal of Pure and Applied Chemistry Research Vol. 13 No. 2 (2024): Edition May-August 2024
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2024.013.02.700

Abstract

The paper reports the in vivo and in vitro antidiabetic activity of bioactive compounds composed of ethyl acetate fractions from Sungkai (Peronema canescens Jack). The fractions are obtained from vacuum liquid chromatography (F1, F2 and F3). Phytochemicals screening, UV-Vis and FTIR spectrometry analysis is applied to detect secondary metabolite composed of the fractions. In addition, in vitro antidiabetic capability is measured inhibiting a-amylase activity, and in vivo evaluation is conducted using diabetic rat's model induced by alloxan. It was found that fraction collected as a white precipitate. The phytochemical analysis indicated positive for flavonoid. UV-Vis and FTIR spectra support the data. Moreover, capability of the fractions to inhibit a-glucosidase activity in the range 5-100 ppm does not show the activity. Conversely, the in vivo evaluation from fraction 2 at concentration 600 mg/Kg of body weight has antidiabetic in 50.16%. This result comparable to that of glibenclamide as a control. This finding lead to further evaluation for structural elucidation.
In Silico Study of Bioactive Compounds of Putat Leaf Extract (Planchonia valida) as Anti-Cancer Against the VEGFR2 Receptor Bela, Anisa; Farid, Faizar; Nelson; Dewi, Tribuana Tungga; Prabawa, Satria; Khatib, Alfi; Yusnaidar, Yusnaidar; Latief, Madyawati; Tarigan, Indra Lasmana
Journal of The Indonesian Society of Integrated Chemistry Vol. 16 No. 1 (2024): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v16i1.32049

Abstract

Cancer is the process of forming new tissue that is abnormal and malignant. Efforts to discover anti-cancer drug compounds continue to be made to minimize the toxic effects of chemotherapy, so it is necessary to look for other alternatives to treat cancer. This research aims to determine the anti-cancer activity of putat plant bioactive compounds through identification of receptor targets and interaction studies using the molecular docking method against the VEGFR2 (Vascular endothelial growth factor receptor-2) receptor. The results showed that in the test of eight putat plant bioactive compounds the best results were obtained for the compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with a binding free energy value of -9.86 kcal-mol-1 with an inhibition constant value of 1.47 Micromolar. The best docking result has an inhibition constant value that is higher than the native ligand and has a binding free energy that is almost close to the binding free energy of the native ligand with an inhibition constant value of 42.38 Micromolar and a binding free energy value of 10.06 kcal-mol-1. Therefore, the results of the docking of the bioactive compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with the VEGFR-2 receptor are considered capable of being an alternative as a candidate for anti-cancer drugs.
LC-MS Based Metabolite Profiling of Ethanol Extract From the Sungkai (Peronema canescens Jack) and In Silico Prediction of Antidiabetic Activity With α-Glucosidase Latief, Madyawati; Arum, Dewi; Nurjannah, Sofia; Tarigan, Indra Lasmana; Khatib, Alfi; Yusnaidar, Yusnaidar
Molekul Vol 19 No 3 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.3.8806

Abstract

Sungkai (Peronema canescens Jack) is a medicinal plant in the Verbenaceae family that is known to have antidiabetic activity. The secondary metabolite content found in sungkai leaves is in the form of alkaloids, flavonoids, triterpenoids, steroids, phenolics, and saponins. This research aimed to identify the biological activity of compounds in sungkai plants as antidiabetic agents using α-glucosidase inhibitors in silico. Sungkai leaf extract with ethanol solvent was identified using a Liquid Chromatography Mass Spectrometer (LC-MS/MS). There are 15 compounds resulting from LC-MS/MS analysis which will then predict antidiabetic activity using molecular docking. Molecular docking was carried out using AutoDock Tools software and visualized with Discovery Studio. The highest scoring result obtained from the molecular docking test was the compound C13H23N6S with a free bond energy result of -7.31 and an inhibition constant value of 4.41 μM, which binds three hydrogen bonds in GLU 78, ALA 75, and GLU 198. Keywords: In sillico, metabolite profilling, Peronema canescens
Pelatihan Masyarakat Desa Setiris, Kecamatan Muaro Sebo dalam Mengolah Tumbuhan Sungkai Menjadi Minuman Herbal Bermanfaat Teh Sungkai Natasya, Dian; Oktavioni, Marsella; Warni, Tri; Bulan, Catherine Putri; Sinurat, Julius Alvin Novensius; Sari, Tika; Latief, Madyawati; Tarigan, Indra Lasmana
Jurnal Pengabdian Pada Masyarakat Vol 9 No 4 (2024): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/jppm.v9i4.862

Abstract

Sungkai (Peronema canescens Jack) merupakan tumbuhan obat yang banyak dimanfaatkan secara tradisional oleh masyarakat sebagai obat luka, diare, obat kumur dan malaria. Kegiatan pengabdian ini bertujuan untuk memberikan pemahaman khasiat daun sungkai secara saintifik melalui pelatihan pemanfaatan daun sungkai sebagai minuman herbal. Kegiatan pendampingan dimulai dari sosialisasi dan edukasi untuk peningkatan pemahaman serta pelatihan pengolahan daun sungkai menjadi teh berstandar dengan penambahan herbal lainnya guna meningkatkan keterampilan masyarakat dan diakhiri dengan survei untuk evaluasi kegiatan. Teh daun sungkai dibuat dalam empat variasi: variasi 1 (daun sungkai + gula aren + kayu manis), variasi 2 (daun sungkai + gula aren + lemon), variasi 3 (daun sungkai + kayu manis + madu) dan variasi 4 (daun sungkai + lemon + madu). Hasil observasi dan survei terhadap masyarakat terkait variasi teh sungkai, ditemukan bahwa masyarakat menyukai variasi teh sungkai mencapai 87 – 94% dengan tingkat preferensi 25% pada masing-masing varisi 1, 2, 3, dan 4. Kegiatan ini meningkatkan pengetahuan dan keterampilan masyarakat mencapai 95%. Sungkai (Peronema canescens Jack) is a medicinal plant traditionally used by the community as a medicine for caterpillars, diarrhea, mouthwash, and malaria. This activity aims to provide an understanding of the scientific efficacy of sungkai leaves through training in the use of sungkai leaves as herbal drinks. The mentoring activity begins with socialization and education to increase understanding and training in processing sungkai leaves into standardized tea with the addition of other herbs to improve community skills. It ends with a survey to evaluate the activity. Sungkai leaf tea is made in four variations: variation 1 (sungkai leaves + palm sugar + cinnamon), variation 2 (sungkai leaves + palm sugar + lemon), variation 3 (sungkai leaves + cinnamon + honey), and variation 4 (sungkai leaves + lemon + honey). The results of observations and surveys of the community regarding variations of sungkai tea found that the community liked the variation of sungkai tea, reaching 87 - 94% with a preference level of 25% for each variation 1, 2, 3, and 4. This activity increased community knowledge and skills by 95%.
ANALISIS LC-MS/MS SENYAWA METABOLITE EKSTRAK DAUN PUTAT (Planchonia valida) DAN PREDIKSI POTENSINYA SEBAGAI KANDIDAT OBAT ANTIKANKER Dewi, Tribuana Tungga; Bela, Anisa; Prabawa, Satria; Latief, Madyawati; Tarigan, Indra Lasmana
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.1629

Abstract

Secondary metabolite compounds contained in plants are bioactive substances related to the chemical content in plants, so that some plants can be used as medicinal materials. Putat (Planchonia valida) is a medicinal plant that has bioactive compounds that have potential as anticancer. Compound analysis of LC-MS test results has been carried out which shows several metabolite compounds contained in putat. The method used is analyzing compounds obtained from LC-MS results, screening compounds using pchembl and chemspider websites. And using the pChEMBL webserver to find out the bioactivity of these compounds. The purpose of this study is to determine and predict the potential bioactivity of the compounds contained therein as new drug candidates. The results obtained from this study are metabolite compounds in putat have the potential as anticancer based on the screening results carried out using the pChEMBL webserver by looking at the highest pIC50 value, obtained the highest pIC50 value of 8.18 with target proteins namely Serine/threonin mTOR and Cholinesterase which are target proteins that have anticancer activity.
Pengembangan Ekonomi Kreatif Masyarakat melalui Pengolahan Limbah Kulit Kopi Liberika di Desa Jatimulyo: The Development of Economy Creative through Liberica Coffee Waste Processing in Jatimulyo Village Latief, Madyawati; Heriyanti, Heriyanti; Tarigan, Indra Lasmana; Bemis, Restina; Puspitasari, Ratih Dyah
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 3 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i3.5562

Abstract

Coffee pulp is a by-product of coffee cherry processing. It has the potential to be used as a source of antioxidant activity. The dried coffee pulp is commonly referred to as cascara tea, which can be used as a functional drink. The coffee pulp contains caffeine, phenols, and chlorogenic acid that has antioxidant activity. Cascara tea can be fermented into kombucha as a functional drink that contains probiotics. In Jatimulyo Village, coffee cultivation and processing have been developed, but coffee skin waste is not used. Seeing the potential for processing coffee pulp waste into cascara and kombucha cascara tea products can provide added value (value added) to coffee pulp waste. The existence of added value to a product can increase the selling price in the market. The processing of coffee pulp waste into a product that is useful and has a sale value can be used as an effort to develop a creative economy. The results achieved from this activity are increasing the knowledge and skills of Jati Mulyo Village residents in utilizing coffee pulp waste into food products that are useful and have economic selling value.
Synthesis of Carboxymethyl Cellulose from Nypa fruticans for Coating Metformin on Zn-Based Metal-Organic Framework Nanohybrid as a Bionanocomposite Drug Delivery System Delviani, Delviani; Maharani, Viola Giary Rizkillah; Shadrina, Putri Nur; Warni, Tri; Azizah, Regina Wan; Tarigan, Indra Lasmana; Latief, Madyawati
Makara Journal of Science
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes is a common and rapidly spreading disease that affects 6.6% of the world’s population. Metformin hydrochloride (HCl) is an effective oral pharmacological treatment for type 2 diabetes mellitus (T2DM) patients because of its capability to reduce glucose levels and the risk of hypoglycaemia. However, gastrointestinal sensitivities to this drug can cause diarrhoea, nausea, vomiting and stomach ache. An alternative is controlled release technology by coating metformin with carboxymethyl cellulose (CMC) and zinc-metal-organic framework (Zn-MOF) through the encapsulation method. Therefore, this study aimed to coat metformin formulations using CMC in a Zn-MOF to control release into the body and minimise the side effects related to doses. The results showed that CMC/metformin@Zn-MOF encapsulation had a controlled blood sugar lowering effect and stable healing effectiveness even at a low concentration of 1:10 of local metformin. In vitro, the released concentrations from local metformin tablets and CMC/Metformin@Zn-MOF were 199.50 ppm of 500 ppm and 42.182 ppm of 50 ppm, with release percentages of 39.90% and 84.364%, respectively. This study found that metformin masking using CMC and Zn-MOF maximally produced a modified release formula along the intestine by reducing the concentration to increase tolerability in lowering blood sugar effectively for T2DM patients with minimal side effects.
Flavonoid Compounds from Ethanol Extract of Sungkai Leaves (Peronema canescens. Jack) and Antibacterial Activity Test Against Staphylococcus epidermidis and Escherchia coli Susanto, Nindita Clourisa Amaris; Ardhica, Jammes; Nelson; Latief, Madyawati
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41653

Abstract

The rise of antibiotic-resistant bacteria has intensified the global search for alternative antimicrobial agents, particularly from natural sources. Traditional medicinal plants have been widely recognized for their therapeutic potential, and Peronema canescens Jack is well-known to contain bioactive compounds. Among its pharmacological properties, its antibacterial potential has drawn scientific interest. Secondary metabolites such as flavonoids, tannins, and phenolics are believed to contribute to its antimicrobial activity. However, the specific antibacterial compounds in P. canescens remain largely unidentified. This study seeks to isolate and characterize antibacterial compounds from the ethanol extract of Sungkai leaves, aiming to discover new natural antibacterial agents. The research objectives include isolating antibacterial compounds using maceration extraction and fractionation, conducting phytochemical screening to identify metabolite classes, assessing antibacterial activity using the paper disc diffusion method, and characterizing bioactive isolates through UV-Vis spectrophotometry and FTIR analysis. The results indicate that the ethyl acetate fraction of the ethanol extract of P. canescens leaves exhibits significant antibacterial activity, particularly at concentrations of 500 and 1000 ppm. UV-Vis spectrophotometric analysis identified flavonoid compounds, including apigenin, flavones, and flavonols, based on characteristic absorption peaks. FTIR analysis confirmed the presence of functional groups associated with flavonoids, supporting their antibacterial potential. These findings highlight P. canescens as a promising source of natural antibacterial agents. Further studies focusing on compound purification and in vivo antibacterial testing are recommended to explore its pharmaceutical applications.
Formulation and Characterization of Microencapsules Containing Ethanol Extract of Sungkai Leaves (Peronema canescens Jack) Tarigan, Indra Lasmana; Farah, Farah; Puspitasari, Ratih Dyah; Saharin, Siti Munirah; Latief, Madyawati
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.43042

Abstract

The Sungkai plant (Peronema canescens Jack) is a widely recognized medicinal plant in Indonesia, with its leaves recently gaining attention for their potential health benefits. This study explores the microencapsulation of ethanol extract from Sungkai leaves using three different coating materials—maltodextrin, inulin, and Arabic gum—at varying concentrations. The aim of this study was to identify the optimal microencapsulation formulation using these materials. Microencapsulation was performed using the extrusion method, and the best formulation was characterized by evaluating its physicochemical properties, morphology, and infrared (IR) spectrum. Antioxidant activity was measured using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The results showed that microencapsulant formulation A1 exhibited superior physicochemical properties compared to other formulations. Scanning electron microscopy (SEM) analysis of sample A1 revealed a smooth surface with a slightly rounded shape and minimal wall folds or cracks, suggesting good stability. Fourier-transform infrared (FTIR) analysis confirmed effective encapsulation of the ethanol extract. While the crude extract demonstrated the highest antioxidant activity, microencapsulation slightly reduced this activity. Among the microencapsulated samples, formulation A1 (using Arabic gum) retained the most antioxidant potential. In conclusion, formulation A1, utilizing Arabic gum as the coating material, was found to be the optimal microencapsulation formulation for the ethanol extract of Sungkai leaves.
Co-Authors -, Maison Addion Nizori Ahmad Fadhil, Ahmad Alfi Khatib, Alfi Alrizal, Alrizal Amanda, Dwi Rahma Amanda, Hilda Ardhica, Jammes Arum, Dewi Azizah, Regina Wan Bela, Anisa Budiyati Ichwan Bulan, Catherine Putri Delviani, Delviani Dewi, Tribuana Tungga Elis Kartika Ermadani Ermadani Faizar Farid Farah, Farah Fisesa, Anggun Tri Helmina Mandalahi, Helmina Hengky Irawan, Hengky Heriyanti Heriyanti, Heriyanti Husna, Naimul Indra Lasmana Tarigan Jamaludin Al-Anshori Kharisma, Tiara Lince Muis Lizawati Lizawati Lucky Zaehir Maulana Maharani, Viola Giary Rizkillah Marbun, Sarah Aknesia Masruri Masruri Melani, Fitria Muhaimin Muhaimin Nabila, Annisa Candra Natasya, Dian Nelson Nurjannah, Sofia Nurul Huda Oktavioni, Marsella Pebralia, Jesi Prabawa, Satria Prahandika, Graha Puspitasari, Ratih Dyah Putri Maya Sari Putri, Silvi Ayudiah Putri, Yunika Eka qurrota aini Rahayu, Rosi Rahmasari, Nadia Ramadhan, Ilham Ifandi Razai, Tengku Said Resta, Ichy Lucya Restina Bemis, Restina Riany, Hesti Saharin, Siti Munirah Samsidar Samsidar Sari, Tika Shadrina, Putri Nur Silvi Leila Rahmi Sinurat, Julius Alvin Novensius Suci, Ulan Susanto, Nindita Clourisa Amaris Sutrisno, Sustrisno Sutrisno, Sutrisno Tambunan, Betharia Juli Mas Tarigan, Indra L. Uce Lestari Warni, Tri Wulan Safitri, Wulan Yoza Fendriani Yulianti, Nike Desvi Yusnaidar, Yusnaidar Yusof, Yus Aniza Zulnita, Anis