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Journal : eJournal Kedokteran Indonesia

The Expression of LFA-1, MMP-9, and Dicer1 in The Histological Grading of Colorectal Cancer Wahyuniari, Ida Ayu Ika; Sumadi, I Wayan Juli; Darwinata, Agus Eka; Linawati, Ni Made; Ratnayanti, I Gusti Ayu Dewi; Sugiritama, I Wayan; Wiryawan, I Gusti Nyoman Sri; Komalasari, Ni Luh Gede Yoni; Arijana, I Gusti Kamasan Nyoman; Ganesha, I Gde Haryo
eJournal Kedokteran Indonesia Vol. 13 No. 2 (2025): Vol 13, No. 2 - Agustus 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1076.1

Abstract

Colorectal cancer (CRC) remains one of the most common cancers in many Asian countries, alongside lung and breast cancer. Tumor dissemination to the organs, particularly the liver, contributed to the mortality of this disease. The β2 subunit of lymphocyte function-associated antigen-1 (LFA-1) was revealed to cause impairments in liver endothelial activation, cytokines release, and tumor cell retention in the liver of CRC in the in vivo study. Epigenetic and matrix metalloproteinase (MMP)-9 are essential for CRC progression and poor prognosis. Tumor differentiation grade correlates with TNM staging, prognostic factors, patient survival, and lymph node metastasis. This study aimed to investigate the expression of the β2 subunit of LFA-1, MMP-9, and Dicer1 in the histological grading of CRC. A total of 38 formalin-fixed paraffin-embedded (FFPE) CRC samples were classified into low-grade, high-grade, and histology variants. Tissue samples were processed for qRT-PCR to examine the β2 subunit of LFA-1 expression and immunohistological staining to evaluate Dicer1 and MMP-9 expression. The results show that the expression of LFA-1 was significantly higher in high-grade compared to low-grade (p<0.05), except for mucinous type adenocarcinoma. In contrast, no significant difference was found in Dicer1 and MMP-9 expressions of all grades of CRC (p>0.05). In addition, no significant correlation (p>0.05) was found between Dicer1 expression and LFA-1 and MMP-9. In conclusion, the expression of LFA-1 is upregulated in high-grade tumors; however, Dicer1 and MMP-9 expressions are not correlated with the histological grade.
Co-Authors A.A.A. Biantari Apsari Trinaya ADNYANA PUTRA, I GEDE AGUS DIVA Adnyana, I Made Diatmika Agus Eka Darwinata Ali Djamhuri Amaral, Meriana Barreto Anak Agung Ngurah Subawa Arijana, I G Kamasan Nyoman Arijana, I Gusti Nyoman Kamasan Arijana, I.G Kamasan Nyoman Arijana, IGK Nyoman Bagus Komang Satriyasa Dakshayani Vijayan Dewa Agung Gina Andrini Dewa Ayu Agus Sri Laksemi Dewa Ayu Agus Sri Laksmi Dewa Putu Gede Purwa Samatra Dewi, Pande Putu Ayu Patria Etik Nurhidayati Eugenia Meidy Farmananda, Irsandi Rizki Fedik Abdul Ratam Gede Wirata Harinder Kaur I Dewa Gede Angga Triadi Nata I Dewa Made Agus Paramarta Putra I Gde Haryo Ganesha I Gusti Ayu Dewi Ratnayanthi I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Dewi Ratnayanti I Gusti Kamasan Arijana I Gusti Kamasan Nyoman Arijana I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Mayun I Gusti Nyoman Sri Wiryawan I Gusti Nyoman Sri Wiryawan I Gusti Nyoman Sri Wiryawan I Ketut Tunas I Made Jawi I Made Krisna Dinata I MADE MULIARTA . I Made Niko Winaya I Made Sudarmaja I Made Sudarmaja I Nyoman Wande I Nyoman Wande I Putu Dema Prasetya I Wayan Juli Sumadi I Wayan Putu Sutirta Yasa I Wayan Rai Widarta I Wayan Sugiritama I Wayan Sugiritama I Wayan Sugiritama I Wayan Sumardika I.A.A. Widhiartini Ida Ayu Ika Wahyuniari Ida Bagus Putra Manuaba Intan Syahirah Bt Abdul Rauap Irmawan Farindra Jaspreet Kaur Juven Luvianto Ketut Ariawati Komang Ayu Trisnadewi Luh Made Indah Sri Handari Adiputra Luh Made Mas Rusyati Luh Putu Ratna Sundari Luvianto, Juven Muhammad Ashhabul Kahfi Mathar Mulianti, Rizki N. Adiputra Ni Eka Dewi Ambarawati Ni Eka Dewi Ambarawati Ni Kadek Ayu Satya Dewanti Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni Ni Luh Rustini Ni Made Mertaniasih Ni Nyoman Sri Budayanti Ni Putu Candra Paramita Nuril Hidayah Nyoman Intan Cahaya Pertiwi Nyoman Pratiwi Hapsari Dewi Putu Ayu Asri Damayanti Putu Ayu Sita Saraswati Putu Diah Pratiwi Radjibu, Gabriela Anastasya Viorezky Rastika, I Gede Agus Ratnayanthi, I Gusti Ayu Dewi Ratnayanti, Gusti Ayu Dewi Raymond Elbert Budianto Riezky Januar Pramitha Ruthirar Kalaichelvam Sawitri, Anak Agung Sagung Sianny Herawati Sidauruk, Dona Uli Sugijanto - Sugijanto - Susy Purnawati Tjokorda Gede Oka Tohjiwa, G. Raditya Vania Lannisa Haestidyatami Wahyuddin, Wahyuddin Wicaksana, I Dewa Agung Gede Oka Dwi Widianti, I Gusti Ayu Widiyanti, I Gusti Ayu Wijaya, Debby Chesilya Wilianto Wilianto Yusuf Nasirudin