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All Journal Journal of Dentistry Indonesia ODONTO Dental Journal Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Dentino: Jurnal Kedokteran Gigi Padjadjaran Journal of Dentistry Molecular and Cellular Biomedical Sciences (MCBS) Dentin An-Nadaa: Jurnal Kesehatan Masyarakat Bubungan Tinggi: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Ilung (Inovasi Lahan Basah Unggul) Jurnal Pengabdian Sumber Daya Manusia Denta: Jurnal Kedokteran Gigi Makara Journal of Science Odonto dental journal Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia Global Medical and Health Communication
Utami, Juliyatin Putri
Departemen Biomedik, Fakultas Kedokteran Gigi, Universitas Lambung Mangkurat
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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DIFFERENCES IN DMF-T INDEX OF PDAM WATER AND RIVER WATER USERS IN THE BLACKSMITH INDUSTRY AREA Nida, Raihatun; Wardani, Ika Kusuma; Diana, Sherli; Putri Utami, Juliyatin; Sarifah, Norlaila
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22198

Abstract

Background: Caries is a disease of the oral cavity that affects the hard tissues of the teeth, enamel, dentin, and cementum. Caries is a multifactorial disease or is caused by many factors. One factor that influences the incidence of caries is the water used for daily purposes. Water containing high concentrations of metals can affect the incidence of caries, one of which is iron. Ferrum or iron contained in water can cause caries by increasing H + ions and then continuing to decrease pH, resulting in a demineralization or dissolution process of hydroxyapatite. Caries occurrence can be measured using the DMF-T index. Purpose: This study aims to determine the difference in the DMF-T index of students using PDAM water and river water in the iron industry area of Sungai Pinang Village. Methods: The method used was analytic observational with a cross-sectional design. Respondents in this study were 36 for each group, with a total of 72 respondents. Results: The results of the unpaired T-Test test showed a significance value of 0.00 <0.05, so HO was rejected. Conclusion: There is a significant difference in the DMF-T index of river water PDAM water users in the blacksmith industrial area of Sungai Pinang Village.
In Silico Model of Musa acuminata Stem as an Anticancer on Oral Squamous Cell Carcinoma against EGFR Rachmayani, Nevrila Dewi; Carabelly, Amy Nindia; Firdaus, I Wayan Arya Krishnawan; Apriasari, Maharani Laillyza; Utami, Juliyatin Putri
Journal of Dentistry Indonesia Vol. 33, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Oral squamous cell carcinoma (OSCC) is characterized by overexpression of the epidermal growth factor receptor (EGFR). Citral, eucalyptol, and caffeic acid phenethyl ester (CAPE), which are derived from Musa acuminata, have shown anticancer activity. This study evaluated the potential of citral, eucalyptol, and CAPE from Musa acuminata as anticancer agents for OSCC by targeting EGFR using an in silico approach. Methods: Potential biological activity was predicted using Prediction of Activity Spectra for Substances (PASS) Online. Molecular docking was conducted with AutoDock Vina, and BIOVIA Discovery Studio was used to analyze binding affinity, interaction types, and bond distances between the compounds and active-site residues of EGFR. Results: CAPE showed the strongest binding affinity (-8.6 kcal/mol), whereas citral and eucalyptol each showed a binding affinity of -5.4 kcal/mol. CAPE formed a conventional hydrogen bond with CYS775 at 2.65 Å and hydrophobic interactions with PHE856, LEU777, and MET766, through π-alkyl and π-π T-shaped interactions. These interaction distances were within the effective range of <3.5 Å, indicating a stable ligand-protein complex. Conclusions: These in silico findings suggest that CAPE derived from Musa acuminata is a promising anticancer candidate for OSCC through its interaction with EGFR.
Glomerular-Bowman’s Space Correlation in Obese Rats Treated with Citrus amblycarpa Extract Lena Rosida; Roselina Panghiyangani; Maria Ulfah; Dewi Indah Noviana Pratiwi; Siti Wasilah; Ika Kustiyah Oktaviyanti; Juliyatin Putri Utami; Rizki Aprian; Andi Muthia Azizah Tenri Bali
Global Medical & Health Communication (GMHC) Vol. 14 No. 1 (2026): Accredited Sinta 2
Publisher : UPT Publikasi Ilmiah Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v14i1.7865

Abstract

Obesity induces pro-inflammatory fat accumulation that impairs renal function, causing structural damage to the glomerulus and Bowman’s capsule. The anti-inflammatory properties of Citrus amblycarpa Hassk peel extract indicate its potential therapeutic role for these renal disorders. This study aimed to investigate the correlation between histological alterations in glomerular diameter and Bowman’s capsule width in high-fat diet-treated rats. The study used a post test control group. We divided rats into 6 groups: the normal diet (ND) group, the high-fat diet (HFD) group with orlistat, and groups receiving various doses of Citrus amblycarpa Hassk. Peels extract 200, 300, and 400 mg/kgBW. Hematoxylin and eosin (HE) stain was used for renal histological preparations. Glomerular diameter and Bowman’s capsule width were measured using a light microscope equipped with Optilab Viewer software (five microscopic fields). Glomerulus diameter was averaged from two outer-edge measurements, while Bowman’s capsule width was recorded at its widest point. Data were analyzed using Pearson’s correlation test to assess variable relationships. The mean glomerular (µm) of K1 = 89.99±5.68, K2 = 97.56±4.03, K3 = 89.99±3.91, K4 = 90.80±3.88, K5 = 86.09±4.22, K6 = 82.89±2.50 and mean Bowman’s capsule width (µm) K1 = 14.18±4.27, K2 = 9.98±2.24, K3 = 10.12±0.58, K4 = 8.87±2.85, K5 = 14.87±6.42, K6 = 15.39±4.21. The results demonstrated a significant negative correlation between increased glomerular diameter and reduced Bowman's capsule width in all experimental groups (p=0.018, r=−0.430), suggesting that glomerular enlargement is linked to structural shrinkage of the Bowman's capsule. In conclusion, a significant correlation exists between glomerular diameter changes and Bowman’s capsule width in high-fat diet rats treated with Citrus amblycarpa Hassk peel extract.
Co-Authors Adhiya, Geyanina Melda Agung Satria Wardhana Ainna Dewi Iriani Amalia, Aysca Fakhira Amy Nindia Carabelly Andi Muthia Azizah Tenri Bali Anisa Novia Farrasti Annisa Noviany Apriasari, Maharani Lailyza Aprilyani, Nur Arifin, Rahmad Aspriyanto, Didit At-Thoyyar, Aila Azminida, Dhiya Salma Baitullah, Muhammad Akbar Bambang Setiawan Bayu Indra Sukmana Beta Widya Oktiani Budiarman, Andi Azizah Maulidia Dewi Indah Noviana Pratiwi Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Dewi Nurdiana Dewi Purboningsih Dewi Puspitasari Dewi Puspitasari Diana Lyrawati Diana Wibowo Erika Norfitriyah Eriwati, Yosi Kusuma Erni Marlina Febriansyah, Muhammad Firda Damayanti Firdaus, I Wayan Arya Krishnawan Fransiska Uli Arta Panjaitan Gita Puspa Ningrum Hadi Waskito Haluanry Doane Santoso Hatta, Isnur Ichrom Nahzi, Muhammad Yanuar Idhafi, Nasrul Ika Kustiyah Oktaviyanti Ika Kusuma Wardani Jatmiko, Habibi Naufal Kelana, Adhytya Suryo Krishnawan Firdaus, I Wayan Arya Kurnianingsih, Nia Lena Rosida Lena Rosida Maghfirah, Yolanda Sajjida Maharani Laillyza Apriasari Maria Tanumihardja, Maria Maria Ulfah Maulida, Novi Dwi Melisa Budipramana, Melisa Milka Widya Sari Mira Hadistiana Monita Valentine Silalahi Muhammad Adeya Herdira Putra Muhammad Akbar Baitullah Muhammad Hasanu Reksi Muhammad Reza Faisal, Muhammad Reza Muhammad Rizal Bima Saputra Muhlisin, Mahmud Nahzi, Yanuar Ichrom Nanda Putri Arini Nia Kurnianingsih Nida, Raihatun Nisa Fachrizha Munier Nor Rahman Sugiarto Norfitriyah, Erika Novi Dwi Maulida Novia Damayanti Nur Tsaniya, Gusti Erysa Nurdiana Nurdiana Nurrahman, Tri Oktiani, Beta Widya Panghiyangani, Roselina Pramitha, Selviana Rizky Priyawan Rachmadi Rachmayani, Nevrila Dewi Rahmad Arifin Ramadhaniyah, Nur Rizki Aprian Roselina Panghiyangani Roselina Panghiyangani Safa Muzdalifah Salsabila, Namira Fathya Sandra Bhakti Mafriana Sari, Galuh Dwinta Sari, Milka Widya Sarifah, Norlaila Sherli Diana Silalahi, Monita Valentine Siti Wasilah Tri Putri, Deby Kania Wydiamala, Erida Yunike Christanti Yusrinie Wasiaturrahmah