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Sosialisasi Pemanfaatan Tanaman Herbal sebagai Obat Akternatif Penyakit Radang Sendi Desak Made Malini; Tia Setiawati; Kartiawati Alipin
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 6, No 4 (2023): Volume 6 No 4 April 2023
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v6i4.9682

Abstract

ABSTRAK Radang sendi atau Osteoartritis (OA) merupakan salah satu penyakit kronis yang paling sering terjadi pada orang dewasa. Penyakit ini termasuk penyakit degeneratif yang dapat menyebabkan nyeri, kekakuan dan kehilangan mobilitas pada sendi.  Pengobatan konvensional meliputi penggunaan obat antiinflamasi nonsteroid (NSAID) diketahui memiliki efek samping yang tidak diinginkan dan dapat mempengaruhi kualitas hidup pasien. Pengobatan dengan tanaman herbal telah menjadi alternatif yang menarik untuk pengobatan konvensional. Tujuan dilakukan kegiatan Pengabdian Pada Masyarakat (PPM) adalah meningkatkan pengetahuan masyarakat mengenai pemanfaatan tanaman herbal sebagai obat alterhatif OA sehingga dapat meningkatkan kualitas kesehatan masyarakat.  Kegiatan pengabdian yang dilakukan berupa penyuluhan dengan pre test dan post test, penyebaran kuisioner dan skriining kesehatan pada 40 orang wanita yang berumur 40-70 tahun. Berdasarkan hasil evaluasi pretest dan post test dari kegiatan ini terdapat peningkatan terkait pengetahuan responden tentang pemanfaatan tanaman herbal (100%), minat menggunakan tanaman herbal (97%) dan budidaya tanaman herbal (100%) obat alternative OA.  Sedangkan hasil skriining kesehatan menunjukkan bahwa nilai IMT (71%), tekanan darah (71%), kadar glukosa(55%), kolesterol (61%) dan Asam urat (40%) menunjukkan nilai rata-rata diatas normal. Dapat disimpulkan bahwa kegiatan PPM efektif untuk meningkatkan pengetahuan masyarakat  tentang pemanfaatan tanaman herbal sebagai obat OA dan masyarakat  juga menjadi lebih waspada akan kesehatannya. Kata Kunci: Sosialisasi, Radang Sendi, Tanaman Herbal  ABSTRACT Arthritis or Osteoarthritis (OA) is one of the most common chronic diseases in adults. This disease is a degenerative condition that can cause pain, stiffness, and loss of mobility in the  joints. Conventional treatment involves the use of nonsteroidal anti-inflammatory drugs (NSAIDs) which are known to have unwanted side effects and can affect the patient's quality of life. Treatment with herbal plants has become an attractive alternative to conventional treatment. The purpose of this Community Service activity is to increase public knowledge about the use of herbal plants as an alternative medicine for OA, thus improving the quality of public health. The community service activities carried out were in the form of counseling with pre-test and post-test, distribution of questionnaires, and health screening on 40 women aged 40-70 years. Based on the pre-test and post-test evaluation results of this activity, there was an increase in respondents' knowledge about the use of herbal plants (100%), interest in using herbal plants (97%), and herbal plant cultivation (100%) as an alternative medicine for OA. Meanwhile, the health screening results showed that the BMI (71%), blood pressure (71%), glucose levels (55%), cholesterol (61%), and uric acid (40%) values were above the normal average. It can be concluded that the community service activity was effective in increasing public knowledge about the use of herbal plants as an alternative medicine for OA, and the public also became more aware of their health. Keywords: Socialization, Arthritis, Herbs   
Citarum River Water Pollution and Stress Responses in The Tolerant and Sensitive Fish Sunardi Sunardi; Kabul Fadilah; Nadia Istiqomah; Miranti Ariyani; Desak Made Malini; Syifa Yolanda; Azalea Putri; Nining Ratningsih
Indonesian Journal of Limnology Vol. 2 No. 1 (2021): Indonesian Journal of Limnology
Publisher : Indonesian Society of Limnology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3906.437 KB) | DOI: 10.51264/inajl.v2i1.10

Abstract

Severe river pollution creates a stressful environment for aquatic organisms, causing disturbances to their health and leading to their extinction. Thus, in this study, the stress responses of tolerant (Oreochromis niloticus) and sensitive (Cyprinus carpio) fish to river pollution in the Citarum River, Indonesia were investigated. The two groups of fish were exposed to varying levels and lengths of water pollution, their blood was sampled, and stress responses were identified. The red blood cells (RBC) count, haemoglobin (HGB), haematocrit (HCT), white blood cells (WBC) count, blood glucose levels, and derived haematological indices such as mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC), were measured. Significant changes in these indices, with tendential changes in RBC and HCT, were observed, indicating that stress responses had occurred in both groups of fish. The sensitive fish recorded more pronounced changes in their haematological activities, with greater amounts of blood parameters being altered in response to water pollution exposure. This result suggested that the sensitive fish were more susceptible to environmental stressors and were, therefore, more vulnerable to extinction in a polluted natural environment.
Noni simplistic effect with Chicken Shank Gelatin Film on White Rat Spleen Exposed to Dexamethasone Virita Rossa Pratiwi; Yasmi Purnamasari Kuntana; Ruly Budiono; Desak Made Malini; Joko Kusmoro
Jurnal Veteriner Vol 24 No 1 (2023)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2023.24.1.122

Abstract

Dexamethasone is a corticosteroid drug belong to glucocorticoid group. Dexamethasone is immunosuppressant and anti-inflammatory in various inflammatory conditions. Side effects of its use can cause cell apoptosis in various organs such as the spleen. The immunosuppressant effect of dexamethasone can reduce and inhibit peripheral lymphocytes and macrophages until the death of lymphoid cells in the white pulps of the spleen. The simultaneous effect of administering chicken shank gelatin and noni has the potential to improve the structure of the spleen. This study was aimed to prove and obtain effective and safe dose of chicken shank gelatin and noni on the spleens of rats exposed to dexamethasone. The research was carried out experimentally in the laboratory with a completely randomized design (CRD). A total of 25 heads male rats were grouped into five treatments and each treatment consist of five repetitions. There was a treatment group P1 as a negative control, P2 as a positive control (dexamethasone 5 mg/kg BW), P3-P5 (dexamethasone 5 mg/kg + gelatin 1.585 mg/kg + noni simplicia 50; 112; 250 mg/kg BW). The results of the study showed an increase in the area of white pulps and a decrease in the percentage of necrotic cells in the spleen, however, it did not increase the relative weight of the spleen and serum albumin levels (P>0.05). In conclusion, the effective and safe dose for the spleen organs of rats exposed to dexamethasone is 250 mg/kg BW.
Pengaruh Subletal Nanosuspensi Lantana camara Linnaeus dalam Menghambat Perkembangan dan Lolos Hidup Larva Croccidolomia pavonana Fabricius (Lepidoptera: Crambidae) Melanie, Melanie; Hermawan, Wawan; Rustama, Mia Miranti; Malini, Desak Made; Husodo, Teguh; Panatarani, Camellia; Joni, I Made
Agrikultura Vol 34, No 1 (2023): April, 2023
Publisher : Fakultas Pertanian Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/agrikultura.v34i1.43164

Abstract

Aplikasi insektisida sintetik pada tanaman kubis seringkali mendapatkan kendala, salah satunya karena insektisida tidak dapat merekat dengan baik pada permukaan daun kubis yang mengandung lapisan lilin. Penelitian ini dilakukan dengan tujuan untuk mendapatkan formulasi nanosuspensi bioinsektisida yang dapat digunakan untuk mengendalikan larva Crocidolomia pavonana pada tanaman kubis. Nanosuspensi Fraksi Etil Asetat (FEA) daun Lantana camara telah diketahui berpotensi sebagai antifidan terhadap larva C. pavonana. Formula nanosuspensi dengan rasio surfaktan (SOR 9, 11, 12, dan 14) di formulasikan dalam media air menggunakan metode emulsi sederhana energi rendah ditambah dengan interferensi ultrasonikasi. Uji bioassay dilakukan untuk menentukan kategori toksisitas dan bioaktivitas nanosuspensi pada konsentrasi subletal terhadap perkembangan larva hingga pupa C. pavonana. Formula nanosuspensi FEA L. camara  dengan variasi SOR 11 (D= 76,6 nm; PI= 0,589; Z = -4,4 mV) diketahui terdispersi dalam media air yang terbaik diantara variasi komposisi formula lainnya. Hasil uji toksisitas menunjukkan bahwa efek subletal nanosuspensi (SOR 11) LC50 48 jam (2.948 ppm) dan LC50 72 jam (3.897 ppm) dikategorikan sebagai toksikan sedang, dan secara nyata menghambat perkembangan dan lolos hidup larva C. pavonana instar 3 menuju pre-pupa (P<0,05), dengan rata-rata waktu perkembangan terlama 6,5 hari (SOR 11), dan persentase lolos hidup terendah instar 4 menuju fase pupa pada perlakuan SOR 11 (13,33%). Pupa diketahui tidak mampu berkembang ke tahap imago pada semua variasi SOR, yang diindikasikan melalui cacat dan kematian pupa. Dengan demikian, toksisitas nanosuspensi FEA L. camara  yang rendah menjadikannya formula yang efektif dan berpotensi utuk mencegah resistensi C. pavonana.
Perbaikan Profil Kolesterol dan Histologis Jantung Tikus Model Diabetes dengan Nanopartikel Poly(Lactic-Co-Glycolic Acid) -Ekstrak Etanol Kulit Buah Jengkol desak made Malini; Firda Mohammad Firdous; Madihah Madihah; Wawan Hermawan
Jurnal Veteriner Vol 24 No 2 (2023)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2023.24.2.238

Abstract

Diabetes mellitus merupakan penyakit kelainan metabolisme glukosa akibat defisiensi atau penurunan efektivitas insulin. Kondisi ini memicu terjadinya hiperlipidemia yang ditandai dengan kadar low density lipoprotein (LDL) yang tinggi dan high density lipoprotein (HDL) rendah serta meningkatkan risiko terkena penyakit jantung. Penelitian ini bertujuan untuk menguji efektivitas nanopartikel poly(lactic-co-glycolic acid) atau PLGA-ekstrak etanol kulit buah jengkol (EEKBJ) dalam memperbaiki profil kolesterol dan kerusakan struktur histologis jantung tikus (Rattus Norvegicus) Wistar model diabetes. Tikus yang digunakan sebanyak 30 ekor yang dibagi menjadi enam kelompok yaitu satu kelompok normal dan lima kelompok diabetes. Induksi model tikus diabetes dilakukan dengan injeksi intravena streptozotocin (STZ) dosis 65 mg/kg BB. Perlakuan yang diberikan adalah KN (Carboxy Methyl Cellulose (CMC) 0,5%), kontrol positif (KP) (STZ+CMC 0,5%), pembanding (Pb) (STZ+Glibenklamid dosis 10 mg/kg BB), P1 (STZ+EEKBJ 770 mg/kg BB), P2 (STZ+EEKBJ 110 mg/kg BB), dan P3 (STZ+nanopartikel PLGA-EEKBJ 110 mg/kg BB) selama 14 hari berturut-turut. Parameter yang diamati adalah kadar kolesterol HDL dan LDL, jumlah sel nekrosis, dan derajat kerusakan pada sel miokardium (degenerasi hidropik, degenerasi lemak, dan infiltrasi sel radang). Uji analisis statistika menggunakan sidik ragam, dilanjutkan dengan uji Kruskal Wallis dan uji jarak berganda Duncan. Hasil penelitian menunjukkan bahwa pemberian nanopartikel PLGA-EEKBJ menurunkan kadar LDL, jumlah sel nekrosis, derajat kerusakan histologis dan meningkatkan kadar kolesterol HDL secara signifikan (p>0,05), Simpulan dari penelitian ini adalah nanopartikel PLGA-EEKBJ dosis 110 mg/kg BB efektif memperbaiki profil kolesterol dan struktur histologis jantung tikus model diabetes.
PERBANDINGAN ANATOMI INSANG IKAN BERDASARKAN HABITAT YANG BERBEDA Malini, Desak Made; Octaviani, Regita; Rosada, Keukeu Kaniawati
BIOTIKA Jurnal Ilmiah Biologi Vol 21, No 1 (2023): BIOTIKA JUNI 2023
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/biotika.v21i1.46178

Abstract

Ikan telah mengembangkan beragam adaptasi anatomi insang agar dapat berfungsi secara efisien dalam habitatnya. Penelitian ini bertujuan untuk mengetahui perbedaan anatomi insang ikan yang meliputi morfologi dan morfometrik organ insang dari tiga jenis ikan yang hidup di habitat yang berbeda. Sampel ikan yang digunakan adalah Ikan Nila (Oreochromis niloticus), Ikan Lele (Clarias batrachus) dan Ikan Kembung (Rastrelliger sp.) masing-masing sebanyak lima ekor dengan bobot badan 100 sampai 300 g dan panjang tubuh 20 sampai 40 cm yang diperoleh dari pasar tradisional. Bagian insang yang diamati adalah membran branchiostegal, arcus branchialis, filamen branchialis, dan branchiospinalis. Hasil penelitian menunjukkan bahwa Ikan Kembung memiliki berat relatif insang lebih besar dibandingkan Ikan Nila dan Ikan Lele yaitu masing-masing 4,85 + 0,38%; 3,43 + 0,23%; dan 2,46 + 0,31%. Terdapat perbedaan morfologi insang dari ketiga spesies ikan yang diamati yaitu pada warna insang, bentuk membran branchiostegal, arcus branchialis, dan branchiospinalis. Pada morfometrik terdapat perbedaan berat relatif insang, rasio panjang arcus branchialis, rasio panjang filamen branchialis, jumlah filamen branchialis, kerapatan filamen branchialis, dan kerapatan branchiospinalis. Dapat disimpulkan bahwa terdapat perbedaan anatomi insang antara Ikan Nila (O. niloticus), Ikan Lele (C. batrachus) dan Ikan Kembung (Rastrelliger sp.) yang hidup pada habitat yang berbeda.   
Histological Structure of Male Wistar Rats’ Stomach Fed with Yam Tuber Flour Supplementation Permana, Andre Dian; Kuntana, Yasmi Purnamasari; Malini, Desak Made
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 8, No 3 (2023): October 2023
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v8i3.7166

Abstract

A residential rat might harm human health because it acts as a disease reservoir. It has been many efforts to control this rate using synthetic rodenticide. Nevertheless, synthetic rodenticides broke the environment and made rats resistant. Yam (Dioscorea hispida) tube application on rat’s bite could solve the problem. This study evaluated the histology of male Wistar rats (Rattus norvegicus) fed with bite block supplemented with different yam tuber flour concertation to control residential rat populations. Five different treatments were applied with five replications. The treatments were negative control and brodifacoum 0.005% (positive control), 30%, 50%, and 70% of yam tuber flour. The results show that yam tuber supplementation caused damage to male Wistar rat stomachs, as indicated by mucosal erosion and the presence of inflammatory cells. The statistical test indicated that stomach damage significantly differed among treatments, with the severest damages caused by 50% yam tuber supplementation. It could be concluded that the rat’s bite containing yam tuber flour caused stomach damage, and the feed bite containing 70% yam tuber flour was the most effective. This result proved that yam tuber has good potential as a natural rodenticide to control residential rat populations.
Perbandingan Morfometrik Sistem Pencernaan Ikan Lele (Clarias batrachus), Ikan Nila (Oreochromis niloticus), dan Ikan Kembung (Rastrelliger sp.) Malini, Desak Made; Putri, Deviana Aulia; Setiawati, Tia
MANILKARA: Journal of Bioscience Vol 3 No 1 (2024): Agustus
Publisher : LPPM Universitas Terbuka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33830/manilkara.v3i1.9811.2024

Abstract

Fish have a diversity of habitats and the types of food they consume, resulting in differences between species, especially in the morphology and morphometrics of their internal organs. One part of the fish that has significant differences is the digestive system. These differences allow fish to optimize their digestion to suit environmental conditions and the type of food they consume, thus ensuring better survival and reproduction. The aim of the study was to compare morphometrics in the digestive system organs of catfish (Clarias batrachus), tilapia (Oreochromis niloticus), and mackerel (Rastrelliger sp.). The research stages included sampling, anatomical preparation of fish, measurement of weight and length of digestive organs, measurement of Gastro Somatic Index (GaSI), measurement of Intestine Somatic Index (ISI), measurement of Gut Lengths (RGL), measurement of Relative Intestine Lengths (RIL), and measurement of Hepatosomatic Index (HSI). Analysis used one-way variance (oneway Anova) utilizing Statistical Package for the Social Sciences (SPSS) 22 software and Duncan's multiple range test. The results showed that GaSI, RGL, RIL, and HSI values of the three fish species were significantly different, while ISI values were not significantly different.  It was concluded that there were morphometric differences in the digestive system organs of tilapia, mackerel, and catfish.
The analysis of natural forage of blue swimming crab (Portunus pelagicus Linnaeus, 1758) on the east coast of Pangandaran, West Java Sofia Dorothy; Malini, Desak Made
Bioma Vol. 20 No. 1 (2024): Bioma
Publisher : LPPM Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/Bioma20(1).2

Abstract

Continuous use of blue swimming crab (Portunus pelagicus) without any control can cause population decline which leads to damage to the stability of the marine ecosystem, especially in East Coast Pangandaran, therefore cultivation is needed. In aquaculture, it is necessary to provide the right feed by knowing its natural diet. This study aimed to determine the natural diet of blue swimming crabs. The method used was descriptive analysis. The parameters observed were carapace width, gastric weight, the composition of natural diet. The relationship between the carapace width and gastric weight was analyzed by simple regression while the main type of natural diet was known by calculating the percentage of food composition. The relationship between carapace width and gastric weight was positive. Based on the composition found in crab gastric, there were 5 types of natural foods consisting of crustaceans (28.35%), meat (25.37%), mollusk (18.65%), fish (15.67%), and undefined material (UM) (4.47%). It is revealed that crabs are carnivores and scavengers, pose significant relationship between their size and gut content weight. It was also found that the composition of female crab feed was generally higher than that of males.
The Gonadal Maturity and Gene Expressions of Female Giant Freshwater Prawn (Macrobrachium rosenbergii) after Dietary Administration of Medroxyprogesterone Acetate Anggraeni, Fajar; Malini, Desak Made; Damanhuri, Joni Haryadi; Syahputra, Khairul; Sopian, Asep; Khasani, Ikhsan; Imron, Imron; Krettiawan, Hary
Jurnal Ilmiah Perikanan dan Kelautan Vol. 16 No. 1 (2024): JURNAL ILMIAH PERIKANAN DAN KELAUTAN
Publisher : Faculty of Fisheries and Marine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jipk.v16i1.43499

Abstract

Abstract One of the problems in giant prawn cultivation is female giant prawns laying eggs during rearing. They will incubate their eggs for three weeks so that the energy from the expected feed for growth is used for egg development and other reproductive activities. Giving MPA hormone to giant prawns either by injection or oral could inhibit gonadal maturation and increase growth rate. The maturation process of the prawn ovary consists of the activation of some complex cellular mechanisms involving genes that regulate the stages of oocyte development. This study aimed to evaluate the response of gonadal maturity and the expression of the MrvWD-Kazal gene in giant prawns fed with a diet containing MPA hormone. The design used in this study was a completely randomized design with four treatments and five replications. The treatments were feeding a diet added with MPA with a concentration of 0 mg.kg-1 feed as control (K), 50 mg.kg-1 feed (P1), 100 mg.kg-1 feed (P2), and 150 mg.kg-1 feed (P3). MPA hormone at a concentration of 50-150 mg/kg feed could inhibit the gonadal maturation of female prawns. In 100 mg/kg of feed concentration showed the lowest gene expression level, indicating an inhibition of gonadal maturation molecularly. The administration of MPA hormone through the feed is a recommended method of aquaculture because it is more applicable and effective than by injection, even though it has a non-uniform impact on each individual. Highlight Research Administration of MPA hormone through the feed to female giant freshwater prawns can inhibit the level of gonad maturity. Expression of von Willebrand factor D (vWD) – Kazal gene were analyzed in different levels of prawn maturity Gonadosomatic index and gonadal histology confirmed that different levels of administration of MPA hormone through the feed could affect the gonad development. The administration of MPA hormone through the feed is a recommended method for aquaculture because it is more applicable and effective to inhibit early maturation of prawns.
Co-Authors . SUNARDI Adam Robisalmi, Adam Adnin Laila Amalia Shalihah Andi Perdana Anggraeni, Fajar ANNISA JOVIANI ASTARI Artati, Diah Asep Sopian Azalea Putri Bisri Mustofa Camellia Panatarani Damanhuri, Joni Haryadi Dea Rahman Khairunnisa Dita Aprila Khoirunnisa Dwi Rahmi Dzikrina Syahidah, Dzikrina Elsa Dwi Fauzany Emay Maulani Emilie Nuraida Erawan Fajar Anggraeni Fajar Anggraeni Firda Mohammad Firdous Hary Krettiawan Hikmat Kasmara I Made Joni Iin Supartinah Ikhsan Khasani Imron Imron Imron Imron, Imron Indriani Sasmita Johan Iskandar Joko Kusmoro Joko Kusmoro Kabul Fadilah Kamilawati, Fitri Kartiawati Alipin KEUKEU KANIAWATI Keukeu Kaniawati Rosada Khairul Syahputra, Khairul Kuntana, Yasmi Purnamasari Listiyowati, Nunuk Madihah Madihah Madihah Madihah Madihah Madihah Madihah Madihah Madihah Madihah Madihah Madihah, Madihah Melanie Melanie Melanie Melanie, Melanie Mia Miranti Rustama Miranti Ariyani Muliani, Reni Muliani, Reni Nadia Istiqomah Nana Media Nia Rossiana Nining Ratningsih Nining Ratningsih Nining Ratningsih Nining Ratningsih Nurullia Fitriani Octaviani, Regita Perdana, Andi Permana, Andre Dian Putri, Deviana Aulia Rani Maharani Reni Muliani Resty Agustin Ruly Budiono Sairandri Dyah Harjanti, Sairandri Dyah Sofia Dorothy SRI WULANDARI sunardi sunardi Supartinah, Iin Syifa Yolanda TEGUH HUSODO TEGUH HUSODO Tia Setiawati Tia Setiawati Tia Setiawati Tri Dewi K. P Tri Dewi Kusumaningrum Pribadi Tri Mayanti Virita Rossa Pratiwi Vita Novianti Wahyu Pamungkas Wawan Hermawan Wawan Hermawan Wawan Hermawan Wawan Hermawan Wawan Hermawan Wildanul Furqon Yasmi Purnamasari Kuntana