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All Journal BALI MEDICAL JOURNAL (BMJ) Jurnal Veteriner Microbiology Indonesia Indonesian Journal of Tropical and Infectious Disease UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Respirologi Indonesia J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Respirasi (JR) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Abdi Insani Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology Berkala Penelitian Hayati JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Journal of Halal Science and Research Journal of Clinical Microbiology and Infectious Diseases Jurnal Widya Medika Folia Medica Indonesiana
Ni Made Mertaniasih
Departement Of Medical Microbiology, Faculty Of Medicine Universitas Airlangga, Dr. Soetomo General Hospital Surabaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary Other

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Journal : Jurnal Veteriner

 1 
Perbedaan Gambaran Histopatologi Granuloma Paru Mencit Setelah Diinfeksi Mycobacterium tuberculosis dan atau Intervensi Silika (THE INFLUENCES OF TIME IN THE HISTOPATHOLOGY OF LUNG GRANULOMA IN MICE AFTER INFECTION OF MYCOBACTERIUM TUBERCULOSIS AND SILI Ni Made Linawati; I Gusti Ngurah Mayun; I Gusti Nyoman Sri Wiryawan; Nyoman Sri Budayanti; Ni Made Mertaniasih; Fedik Abdul Ratam; I Nyoman Wande; I Gusti Ayu Dewi Ratnayanti; Ida Ayu Ika Wahyuniari; I Wayan Sugiritama; I Gusti Kamasan Arijana
Jurnal Veteriner Vol 14 No 1 (2013)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

The characteristics of lung tuberculosis is granuloma, which is consisted of lymphocytes andmacrophages that show the interaction between immune cells and M.tb. Granuloma is the organizationprocess which is depend on lymphocytes invasion, adhesion molecules and chemokine fasilitation. Silicosiswhich is caused by silica, can influence granuloma in the lung. The features of granuloma is variationdepend on the elicited agent and immune reaction. The main purpose of this study was to prove thehistopathology differences of  mice lung granuloma caused by M.tb infection,  silica intervention and bothin 3th  and 7th weeks. It was 45 mice Balb-c strain, divided into 3 groups;  P1 got  M.tb infection with H37Rvstrain 105  perml,P2 got silica intervention with 60 micro litre and, P3 got both of M.tb infection and  silica intervention. Termination of each group were held on 3 and 7 weeks of intervention, continued byhistopathology examination. In the histopathology feature, we done semi-quantitative prosedure to measurelung damage by using Dormans scores; perivasculitis, peribronchiolitis, alveolitis and granuloma. Oneway anova to analysis the differences of histopathologycal result among these groups (P< 0,05).  Resultshowed the significant differences  among these group.  In the 3th weeks, we found  mild lung damage werehappened in all groups with granuloma, without necrosic (P1 and P2). In the 7th weeks we found  severe lungdamage in P3 with necrotic and fibrotic granuloma sign, with necrosis in P1, with fibrotic in P2.  Weconcluded the worst lung damage happened in 7th weeks in group which are got M.tb infection and silicaintervention, with granuloma characterictic of necrosic and fibrotic.
Co-Authors , Atika Abdul Rahman Bahmid Agnes Dwi Sis Perwitasari, Agnes Dwi Sis Aisah, Nurul Akirasena, Mayoori Alimsardjono, Lindawati Alvin Hartanto Kurniawan, Alvin Hartanto Ananda, I Gede Yogi Prema Andy Setiawan Asri Darmawati Atik Kurniawati Atika Ayu Lidya Paramita Ayu Lidya Paramitha Bagus Soebadi Budi Suprapti Budi Yanti Budi Yanti Catur Endra Arky, Catur Endra Deby Kusumaningrum Diah Savitri Ernawati Didik Didik Handijatmo, Didik Dimas Firman Hidayat Eko Budi Koendhori, Eko Budi Endraswari, Pepy Fedik Abdul Ratam Hanik Urifah, Hanik Hidayat, Dimas Firman I Gusti Ayu Dewi Ratnayanti I Gusti Kamasan Arijana I Gusti Ngurah Mayun I Gusti Nyoman Sri Wiryawan I Nyoman Wande I Wayan Agus Gede Manik Saputra I Wayan Sugiritama Idha Kusumawati Ikhwani, Irfan Arif Irfan Arif Ikhwani Irwanto Irwanto Isnaeni Isnaeni Isnaeni Isnin Anang Marhana Jayanti Putri, Jayanti Juita, Liza Puspa Senja Asmara Junus, Herisa Nataliana Kadariswantiningsih, Ika Kawilarang, Arthur Pohan Kusmiati, Tutik Kusmiati, Tutik Lestari, Aprilia Dwi Lyndia Effendy Maharani, Sekar Mahdani, Wilda Mangestuti Agil ManikRetno Wahyunitisari Maria Inge Lusida Marsha Maritsa, Olivia Mega Ferdina Suwito Mochamad Amin Mochammad Afif Ziaulhaq Muhammad Amin Muhammad Amin Mulyadi Mulyadi Ni Made Linawati Ni Nengah Dwi Fatmawati Ni Nyoman Sri Budayanti Nurrosyidah, Iif Hanifa Nurul Wiqoyah, Nurul Nuswantoro, Djohar Paramitha, Ayu Lidya Pepy Dwi Endraswari, Pepy Dwi Permatasari, Ariani Priyo Hadi Purwanta, Marijam Putranto, J.Nugroho Eko Raharjo, Dadik Rarome, Berlian Beatrix Ratna Kusumawati Ratna Kusumawati Rebekah Setiabudi, Rebekah Reiska Kumala Bakti Resti Yudhawati Retno Asih Setyoningrum Risa Etika, Risa S. Soedarsono Sakran, khawla Abdullah Salsabila, Sabila Sampurna, Mahendra Tri Arif Saputra, I Wayan Agus Gede Manik Sari, Trias Kusuma Sekar Maharani Setiawan, Firman Silvia Sutandhio Soedarsono Soedarsono SOETJIPTO . Soetjipto Soetjipto Sugeng Harijono, Sugeng Sulistyowati, Titiek Titiek Sulistyowati Titiek Sulistyowati Titiek sulistyowati VICTOR EKA NUGRAHAPUTRA Wayan Tunas Artama Widya, Alicia Margaretta Wilda Mahdani Wiwin Retnowati Yelvi Levani Yitijuatni Yudayanti, Elprania Credo