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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmaseutik GHIDZA: Jurnal Gizi dan Kesehatan Jurnal Ilmiah Kesehatan FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Majalah Farmasetika Jurnal Farmamedika (Pharmamedica Journal) Jurnal Ilmiah Farmako Bahari Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Insan Farmasi Indonesia Ruang Cendekia : Jurnal Pengabdian Kepada Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Media Bina Ilmiah Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Journal of Natural Product for Degenerative Diseases Indonesian Journal of Jamu

Deni Rahmat

Fakultas Farmasi Universitas Pancasila, Jakarta Selatan, 12640

Author-ID : 3249194

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Formulasi dan Aktivitas Gel yang Mengandung Nanopartikel Ekstrak Temulawak sebagai Antiacne Anastasya Anastasya; Deni Rahmat; Anarisa Budiati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Javanese turmeric is one of the Indonesia’s authentic plant that has many beneﬁts, antimicrobial eﬀect is one of them. Curcuminoid and xanthorrhizol contents are responsible for it's antimicrobial activity. Acne vulgaris is one of skin’s disorder that caused by bacteria, the major cause is Propionibacterium acnes. This study aimed to compare antimicrobial activity diﬀerence between nanoparticle and extract gel. Javanese turmeric was extracted and then formulated into nanoparticles. Javanese turmeric extract and it's nanoparticles were then formulated in gel preparation. Gel preparations were evaluated physically (organoleptic, homogeinity, spreadibility, and viscosity and rheology), chemically (pH value), and tested for their antimicrobial activity. Gel evaluations showed that both formula (nanoparticle and extract gel formula) did not show any discoloration and still homogeny. Extract gel formula had viscosity about 1540–1600 Ps, while nano extract gel had viscosity in the range of 487.63–501.01Ps. Extract gel formula had spreadability in the range of 51.75-53.35 mm, while nano extract gel has viscosity in the range of 65.125-72.75 mm. Extract gel formula had pH value in the range of 5.98–6.02, while nano extract gel had pH value in the range of 5.88–5.93. Extract gel formula has inhibition zone in the range of 10.0 mm–10.3 mm, while nanoextract gel has inhibition zone in the range of 13.0 mm–13.4 mm. Based on statistical paired sample t-test analysis, nano extract gel formula was signiﬁ cantly diﬀerent from extract gel formula in antimicrobial activity.

Pengembangan Kromatografi Cair Kinerja Tinggi yang Sederhana untuk Analisis Kurkumin dalam Plasma Manusia In-Vitro Novi Yantih; Endah Giyah Wahyuningsih; Deni Rahmat; Yunahara Farida
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.947

Curcumin has antioxidant, antiinfl ammatory, antitumor, apoptotic-inducing, andantiangiogenesis eff ects. In order to study the pharmacokinetics of curcumin, a method for analysisof curcumin in plasma levels is required. The aim of this study was developing of a simple HighPerformance Liquid Chromatography (HPLC) for analysis curcumin in human plasma in-vitro. TheHPLC system was using isocratic technique in column reversed phase of C18 (Reliant® RP-18ecolumn (4.6x250 mm; 5 μm)) and mobile phase of acetonitrile–acetic acid–aquabidest (60:1:39) at fl owrate of 1.0 mL/min. Irbesartan was used as an internal standard. Detector was performed at a wavelengthof 428 nm for curcumin and 270 nm for irbesartan. Linearity test shown linear results with a correlationcoeffi cient (r) of 0.9970. LLOQ value was 0.0196 μg/mL with a diff erentiation value of 10.48-18.09%.The accuracy and precision of this method met requirement with a diff erentiation value and relativestandard deviation of between -5.51-3.04 % and 1.04-1.86 %, respectively. Recovery of this method was94.74-103.12%. This method provides good selectivity for the analysis curcurmin in human plasma.The developed of HPLC was a simple and valid method for analysis curcumin in human plasma.

Hewan Model Kanker Ovarium untuk Studi Preklinik dan Pengembangan Obat Kanker Ovarium Ni Made Dwi Sandhiutami; Puspita Eka Wuyung; Wawaimuli Arozal; Melva Louisa; Deni Rahmat
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Treatment for ovarian carcinoma is still far from optimal, animal models are still needed to study human epithelial ovarian cancer. Animal models of ovarian cancer are very important for understanding the pathogenesis of the disease and for testing new treatment strategies. Ovarian carcinogenesis models in mice have been modified and repaired to produce preneoplastic lesions and neoplastic ovaries that are pathogens resembling human ovarian cancer. Although spontaneous ovarian tumors in mice have been reported, some of the shortcomings of existing studies preclude their use as animal models of ovarian cancer. Because of this, many efforts have been made to develop animal models that are relevant for ovarian cancer. Experimental animal models are developed accurately to represent cellular and molecular changes associated with the initiation and development of human ovarian cancer. Accurate experimental models have significant potential in facilitating the development of better methods for early detection and treatment of ovarian cancer. Several animal models of ovarian cancer have been reported, including manipulation of various reproductive factors or exposure to carcinogens. The latest advance in ovarian cancer modeling is using genetically engineered mice.

Aktivitas Senyawa Sargassum sp. sebagai Anti-aterosklerosis dengan Pembandingan Ligan-Reseptor HMG-CoA Reduktase- Simvastatin (1HW9) dan Uji Toksisitas secara In-Silico Sarah Zaidan; Syamsudin Abdillah; Deni Rahmat; Ratna Djamil; Esti Mumpuni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Introduction:Sargassum.sp is one of the marine biota published as antiaterosclerosis, but compound toxicity data need to be explored for safety. Method: Virtual screening has been done with MVD software from active compounds contained in sargassum where has activity as antiaterosclerosis with the mechanism of hypolipidemic effects. Test compounds in sargassum include: fucoidan, rhamnose, fucose, galactose, fucoxantin, alginate, phlorofucofuroeckol A, phloroglucinol, phlorotannin, with HMG-COA Reductase-Simvastatin adenosine receptors with a 1HW9 /PDB code. Its toxicity is predicted using pkCSM (online). Results: The value RS, RMSD value as a result of the docking simulation carried out on said compounds, the following results are obtained: fucoidan (-110,420; 1,478), rhamnose (-72,081; 1,629), fucose (-98,408; 1,546), galactose (-95,757; 5,187), fucoxantin (-106,297; 2,161), alginate (-84,674; 2,897), phlorofucofuroeckol A (-106.701; 2,809), phloroglucinol (-103,140; 2,142), phlorotannin (-48,826; 7,750). The prediction results of toxicity showed fucoidan, rhamnose, fucose, galactose, fucoxantin, alginate, phlorofucofuroeckol A, phloroglucinol and phlorotannin not toxic with LD50 0.95-2.482g / kg. Conclusion:Based on RS values, fucoidan, fucoxantin and phlorofucofuroeckol A compounds contained in brown seaweed were predicted to have activity as antiaterosclerosis. Compounds in brown seaweed can also be predicted to be relatively non-toxic with a value of LD50 0.95-2.482g / kg.

Uji Aktivitas Antiinflamasi Nanopartikel Ekstrak Etanol Rimpang Temulawak (Curcuma xanthorrhiza Roxb.) dengan Metode Penghambatan Denaturasi Protein Yunahara Farida; Deni Rahmat; Agi Widia Amanda
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Javanese turmeric rhizome (Curcuma xanthorrhiza Roxb.) has been known to have many health benefits as antibacterial, anti-inflammatory, antidiabetic and anticancer. The purpose of this study was to compare the anti-inflammatory activity of temulawak rhizome extract with its nanoparticles. Temulawak rhizome extract was obatained by maceration using 96% (v/v) ethanol as a solvent. The extracts were made into nanoparticles by ionic gelation method which used chitosan and tripolyphosphate. The results of antiinflammatory activity test using a method of inhibiting protein denaturation showed the persentage of inhibition of protein denaturation (IC50) of the extract of temulawak rhizome of 521.67±5.80 ppm while the IC50 of the nanoparticles was 398.02±1.78 ppm. Accordingly, the antiinflammatory activity of the nanoparticles was better than the extract of temulawak rhizome.

Antioxidant and Sunscreen Activity from Nanoparticles Extract of Temulawak Rhizome (Curcuma Xanthorrhiza Roxb.) And Formulation in The Form of A Cream Anarisa Budiati; Deni Rahmat; Zahirah Alwiyah
Jurnal Jamu Indonesia Vol. 6 No. 2 (2021): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v6i2.212

Temulawak (Curcuma xanthorrhiza Roxb.) is a medicinal plant for the raw material of traditional medicine in Indonesia. Temulawak can be a source of antioxidants and natural sunscreen because of its curcumin content. This study was conducted to determine antioxidant and sunscreen activity on Curcuma rhizome extract and nanoparticles extract and making cream preparations. Extraction using the maceration methods with 96% ethanol solvent, concentrated with a rotary evaporator and the thick extract of Curcuma rhizome was made into nanoparticles by ionic gelation methods. Spray drying methods dried the nanosuspension of Curcuma rhizome extract. The nanoparticles formed were evaluated for particle size, zeta potential and particle morphology. The dry powder nanoparticles and extract of Curcuma rhizome were tested for antioxidant activity by DPPH (2,2-diphenyl-1-picrylhydrazyl) methods and sunscreen using a UV-Vis spectrophotometer at λ = 290-340 nm. The antioxidant activity showed the IC50 value of the Curcuma rhizome extract was 78.30 μg/mL and nanoextract was 116.51 μg/mL. The sunscreen testing result showed that the SPF (Sun Protective Factor) value of Curcuma rhizome extract at a concentration of 0,012% was 14.14 and nanoextracts at a concentration of 0.04% was 7.73. Curcuma rhizome extract has relatively strong antioxidant activity, while the nanoextract was moderate. The sunscreen activity of Curcuma rhizome extract and nanoextract has maximum protection and extra protection.

Optimasi Proses Hidrolisis Protein Dari Limbah Bulu Ayam Pangestu Bowo; Teti Indrawati; Deni Rahmat
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 8 No. 1 (2021)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v8i1.5171

Limbah bulu ayam yang mengandung protein keratin telah direkomendasikan sebagai sumber nutrisi alternatif yang dapat digunakan untuk pakan ternak, industri kosmetik, dan industri pupuk. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh konsentrasi NaOH terhadap kualitas hidrolisat bulu ayam. Penelitian dilakukan dengan optimasi proses hidrolisis limbah bulu ayam dengan metode basa menggunakan NaOH (rasio 1:6) dengan variasi konsentrasi 5%, 7,5% dan 10% selama 4 jam pada suhu 80ºC. Penentuan rendemen hidrolisat bulu ayam paling optimum dilakukan dengan analisis total protein menggunakan metode Kjeldahl, analisis asam amino dengan menggunakan Amino Acid Analyzer (AAA) dan identifikasi profil protein menggunakan metode Static light scattering (SLS). Hasil optimasi proses hidrolisis dapat disimpulkan bahwa hidrolisat bulu ayam dengan konsentrasi pelarut NaOH 5% menunjukkan hasil optimum dengan rendemen sebesar 70,24% , total protein 62,66 %, total asam amino bebas 39.126 % dan masa molekul protein dengan metode SLS menunjukkan hasil 4,31 kDa.

Nilai Antioksidan dan Spf dari Kombinasi Minyak Biji Wijen (Sesamum indicum L.) dan Minyak Biji Bunga Matahari (Helianthus annuus L.) Yanthy Susanti; Anny Victor Purba; Deni Rahmat
Majalah Farmaseutik Vol 16, No 1 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Minyak wijen dan minyak biji bunga matahari yang mengandung Vitamin E dan β-Karoten dilaporkan memiliki aktivitas antioksidan dan tabir surya. Penelitian aktivitas tabir surya pada minyak wijen memberi hasil nilai SPF sebesar 1,77. Tujuan penelitian ini adalah untuk mendapatkan kombinasi minyak wijen dan minyak biji bunga matahari yang memiliki aktivitas antioksidan dan nilai SPF yang optimal. Metode yang digunakan untuk mengukur aktivitas antioksidan dengan metode peredaman radikal bebas, nilai SPF diperoleh dengan menghitung harga AUC kurva hubungan antara panjang gelombang dengan serapan yang dihasilkan. Hasil penelitian menunjukkan minyak wijen memiliki aktivitas antioksidan (IC50) sebesar 267 µg/mL dan nilai SPF sebesar 1,46 pada konsentrasi 125µg/mL, minyak biji bunga matahari memiliki aktivitas antioksidan (IC50) sebesar 88,37 µg/mL dan nilai SPF 1,14 pada konsentrasi 125µg/mL, kombinasi kedua minyak memiliki aktivitas antioksidan sebesar (IC50) sebesar 118,04 µg/mL dan nilai SPF 1,78 pada konsentrasi 125µg/mL.

Nilai Antioksidan dan SPF dari Kombinasi Minyak Biji Nyamplung (Calophyllum inophyllum L) dan Minyak Kelapa Sawit (Elaeis guineensis) Indri Astuti Handayani; Anny Victor Purba; Deni Rahmat
Majalah Farmaseutik Vol 16, No 2 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Minyak biji nyamplung dilaporkan memiliki kandungan vit E 2,05% dan β karoten sebesar 8,44mg/100g, minyak kelapa sawit dilaporkan memiliki kandungan vit E 27,6mg/100g dan β karoten 505mg/kg sehingga dapat berfungsi sebagai antioksidan dan tabir surya. Tujuan penelitian ini adalah mengetahui peningkatan atau penurunan nilai antioksidan dan SPF dari kombinasi minyak antara minyak biji nyamplung dengan minyak kelapa sawit. Metode untuk mengukur aktivitas antioksidan adalah peredaman radikal bebas, nilai SPF diukur menggunakan metode perhitungan nilai absorbansi menggunakan spektrofotometer UV-Vis. Hasil penelitian menunjukkan minyak biji nyamplung, minyak kelapa sawit dan kombinasi minyak (2:3) memiliki aktivitas antioksidan (IC50) secara berturut-turut sebesar 192,77; 140, 89 ; dan 237,26 µg/mL. Nilai SPF dari minyak biji nyamplung, minyak kelapa sawit dan kombinasi minyak (2:3) pada konsentrasi 125 µg/mL sebesar 6,69, 1,33 dan 6,54.

Pembuatan Fukosantin Nanospare dengan Metode Gelasi Ionik dan Uji Efektivitas Antioksidan Rizka Aisyah; Rachmaniar Rachmat; Deni Rahmat; Dedi Noviendri
Jurnal Ilmiah Kesehatan Vol 19 No 02 (2020): Jurnal Ilmiah Kesehatan terbitan Agustus Volume 19 Nomor 02 Tahun 2020
Publisher : STIKIM Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33221/jikes.v19i02.457

Fukosantin merupakan pigmen dari golongan karetenoid yang terdapat pada rumput laut coklat. Fukosantin memiliki sifat sebagai antioksidan, karena fukosantin mudah terdegredasi oleh pH, suhu dan cahaya. Untuk melindungi fukosantin dari degradasi tersebut maka dibuat menjadi sediaan nanospare. Penelitian ini bertujuan mendapakan senyawa fukosantin yang mempunyai efektivitas antioksidan yang baik dan stabil. Ekstraksi dengan metode maserasi dan mengisolasi fukosantin dengan menggunakan metode kromatografi kolom, fukosantin dianalisis menggunakan metode kromatografi cair kinerja tinggi dengan metode elusi gradien. Pembuatan fukosantin nanospare dengan metode gelasi ionic, metode ini dipilih karena tidak menggunakan energi panas yang bisa merusak efektivitas antioksidan fukosantin. Rendemen ekstrak kasar dan fukosantin, masing-masing 4,98 % dan 1,48 %, Fukosantin teridentifikasi dengan nilai Rf yaitu 0,5. Total kandungan fukosantin sebesar 0,919 mg/g. Gugus fungsi fukosantin terdiri dari alcohol, alkana, alkena, ester, metil dan alkena aromatik. Ukuran nanospare fukosantin yaitu 28,25 dan zeta potensial -5,76. Nilai IC50 nanospare fukosantin yaitu 98,24 masuk kategori kuat.

Co-Authors . Syamsudin . Syarmalina Agi Widia Amanda Agung Eru Wibowo Agung Eru Wibowo Agung Eru Wibowo Agung Eru Wibowo Aji Najihudin Anarisa Budiati Anarisa Budiati Anastasya Anastasya Anny Victor Purba Anny Victor Purba Asrul Muhamad Fuad Chaidir Chaidir Chaidir Dedi Noviendri Deny Wirawan Deny Wirawan Dian Eleveny Martha Flareyanti Dian Ratih Laksmitawati Dini Agustina Yuniaty Ema Hermawati Endah Giyah Wahyuningsih Esti Mumpuni Esti Mumpuni Fahleni Fahleni Faridah Faridah Fathiyah Ghina Greesty Finotory Swandiny Gumilar Adhi Nugroho Hadiyanti Hadiyanti Hidayatri, Nurul Indri Astuti Handayani Jenifer Sara Silalahi Kartiningsih Kartiningsih Liliek Nurhidayati Linawaty Lee Linda Fitriyani M. Ikhwan Setiawan Mantika Atiqah Baihaty Masneli Masri Meilda Ayu Bathini Melva Louisa Mindiya Fatmi Nadya Vresya Saputri Nenden Lilis Ni Made Dwi Sandhiutami Nilam Sari Maulidina Noviyantih, Noviyantih Nur Aji Pangestu Bowo Pra Panca Bayu Chandra Puspita Eka Wuyung Rachmaniar Rachmat Rachmaniar Rahmat Rahmaniar Rachmat Ratna Djamil Ratna Djamil RICKY KURNIAWAN Rina Hijayanti Risma Marisi Tambunan Riza Darma Putra Rizka Aisyah Ro’ufi Absor Safira Evani Rizki Anwar SARAH ZAIDAN Sarah Zaidan Sasanti Tarini D Setya, Ninik Shirly Kumala Stella Giovanny Stella Salim Sukmadjaya Asyarie Syamsudin Syamsudin Abdillah Syamsudin Abdillah Teti Indrawati Wawaimuli Arozal Yanthy Susanti Yesi Desmiaty, Yesi Yulius Evan Christian Yunahara Farida Zahirah Alwiyah Zahirah Alwiyah

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