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All Journal Jurnal Kedokteran Brawijaya e-Journal Pustaka Kesehatan EQUILIBRIUM Majalah Kedokteran Gigi Indonesia Journal of Agromedicine and Medical Sciences UNEJ e-Proceeding Jurnal Ilmiah Kedokteran Wijaya Kusuma Health Notions Multidiciplinary Journal Medical Technology and Public Health Journal Jurnal Mekanova : Mekanikal, Inovasi dan Teknologi Jurnal MID-Z (Midwivery Zigot) Jurnal Ilmiah Kebidanan Indonesian Journal of electronics, electromedical engineering, and medical informatics Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar Journal of Telenursing (JOTING) Jurnal Surya Muda: Ilmu Keperawatan dan Ilmu Kesehatan AloHA International Journal of Health Advancement (AIJHA) GANESHA MEDICINA Hang Tuah Medical Journal Jurnal Pengabdian Pada Masyarakat Journal for Quality in Public Health Jurnal Manajemen dan Pendidikan Agama Islam Neurona

Al Munawir

Department Of Pathology, Faculty Of Medicine, University Of Jember, Jember, 68121 Indonesia

Author-ID : 325059

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Validity of Electronic Device-Based Application for Visual Acuity Examination: A Systematic Review Natasya Febrilia Yulianti; Al Munawir; Novan K. Adji
Indonesian Journal of Electronics, Electromedical Engineering, and Medical Informatics Vol 4 No 1 (2022): February
Publisher : Department of electromedical engineering, Health Polytechnic of Surabaya, Ministry of Health Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/ijeeemi.v4i1.7

Recent years, advances in the internet and communication technology have enabled the proliferation of digital medical devices with innovations in health applications, including for visual acuity examination. However, the validity of these applications remains unclear. The limited mobility and health service during the COVID-19 pandemic underscores the urgent need to conduct research that validates these electronic device-based applications. Thus, this study aims to critically analyze whether the electronic device-based application can provide a valid and high-quality visual acuity examination. A systematic review was conducted through studies searching PubMed, MEDLINE, Springer, and Cochrane Library using specific keywords. After the studies were selected through inclusion and exclusion criteria, extraction was carried out. Publications from 2011 to the end of 2021 were reviewed, yielding in 1409 studies, of which 19 were included. The results showed a lower systematic bias for distance visual acuity testing with electronic device-based applications than standard reference tests with a mean difference of -0.08 to 0.10 logMAR. The validity of the near visual acuity examination with the application shows better results than the distance examination, which is marked by smaller 95% limits of agreement range. The results of the analysis of Bland-Altman plots in all the studies reviewed showed that the accuracy of the examination results tended to increase in patients who had better visual acuity. In practice, the use of electronic device-based applications for visual acuity examination can increase the work effectiveness of medical personnel and the proliferation of digital medical devices. It can also be one of the breakthroughs in remote medical services and support the implementation of telemedicine policies.

Pengaruh Lama Perendaman terhadap Absorpsi Tetrasiklin pada Adsorben Limbah Sisik Ikan Gurami (Osphronemus Gouramy) Sabrina M Pratama; Ghiza J.K. Barqly; Retno Widyastuti; Rizka N Wardani; Dear F Sielma; Al Munawir
Majalah Kedokteran Gigi Indonesia Vol 1, No 2 (2015): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Influence of Immersion Length on Tetracycline Absorption on Gourami (Osphronemus Gouramy) Scales as Adsorbent. Gourami (Osphronemus Gouramy) scales are one of the natural sources of collagen. This fish scale’s collagen has functional properties, such as bio-degradable (easily decomposed), bio-compatible (compatible with surrounding tissue), and potential as bio-adsorbent. The absorbent properties of collagen are currently used as a transport material in local drug delivery for periodontal disease treatment, which is known as tetracycline chip. However, this chip is made of synthetic collagen so it is not absorbable by the body’s system. The price is also expensive. This study’s aim is to prove the potency of Gourami scales as a source of collagen in medical treatment, especially as a transport material of tetracycline for periodontal disease treatment. The gourami scale was obtained from seafood restaurant in Jember, Jawa Timur. About 500 mg of gourami scales was immersed into 20 ml tetracycline solution in beaker glass. About 200 μl solution from the beaker glass was taken with micropipette after 1-hour, 2-hour, 4-hour, 12-hour and 24-hour after immersed. After that, the solution was collected into an eppendorf for each time. The absorbance was measured with spectrophotometer at 450 nm wave length. This procedure was repeated five times. The lowest absorbance occured at 1-hour time (160,6 μg/μl). The result from light and inverted microscope examination shows a bond between collagen from gourami scales with tetracycline. Gourami scale has the ability to absorb the highest rate of tetracycline at 1-hour immersed time by forming a bond between collagen and tetracycline.

Pengaruh Induksi Racun Ubur-Ubur (Physalia utriculus) terhadap Fungsi Oksigenasi dari Eritrosit pada Mencit Jantan Vita Alfiatul Hasanah; Al Munawir; Erfan Efendi
Pustaka Kesehatan Vol 4 No 1 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Jellyfish is one of the animals that is responsible for poisoning in human. The poisoning jellyfish commonly found is Physalia utriculus. Jellyfish poison is potential to cause hemolysis on blood. The purpose of this study was to determine the influence of jellyfish (Physalia utriculus) poisoning induction toward the oxygenation function of the male mice erythrocytes. The method was true experimental design with post test only control group design. Eight male mice were devided into two groups: control and treatment groups with a dose of jellyfish poison 30 mg/kgBW. The observation was conducted by using a pulse oxymeter. The result showed average level of oxygen saturation in the control group minute 0; 15; 30; 60; 120; 240; 480; 720; 1440 were 55%; 54%; 63,75%; 70%; 65,25%; 67,5%; 65,75%; 72%; 55%, respectively. While in the treatment group were 61,25%; 62,75%; 59,75%; 58,5%; 51,75%; 58%; 57%; 75,75%; 47%, respectively. The statistical bivariate correlation test has a correlation coefficient value (r) 0,383. The significance value is (p) 0,309 (p>0,05). The conclusions of this study was jellyfish (Physalia utriculus) poisoning induction has no significant effect toward the change of oxygenation function of the male mice erythrocytes. Keywords: jellyfish, jellyfish poison (Physalia utriculus), erythrocytes, oxygen saturation

Aktivitas Membran Bakiko (Bayam-Kitosan-Kolagen) terhadap Ekspresi Matriks Metaloproteinase-9 pada Luka Bakar Derajat II Hazmi Dwinanda Nurqistan; Al Munawir; Ika Rahmawati Sutejo
Pustaka Kesehatan Vol 7 No 1 (2019): Volume 7 No. 1, 2019
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v7i1.17593

Matrix metalloproteinase-9 (MMP-9) plays an important role in regulating the degradation and deposition extracellular matrix (ECM) that are important for wound reepithelization. However, excessive protease activity can lead to delayed wound healing. Kaemferol in spinach can inhibit the activity of MMP-9. Chitosan and collagen can help tissue growth and have an antimicrobial effect. Chitosan-collagen membranes have been widely used for wound healing but, the results are unsatisfactory. Therefore, the researcher wanted to know the activity of bakiko (Spinach-Chitosan-Collagen) membrane to MMP-9 expression on second degree burn with immunohistochemical method. This research was true-experimental laboratories design with post test only control group design. The experimental animals used were 36 white wistar rats (Rattus novergicus) male, divided into 4 groups ie control group, negative control, positive control (bioplacenton), and treatment (bakiko membrane). Data were obtained by calculating MMP-9 using ImageJ software. The analysis using anova test showed that p value less than 0.05 indicated a significant difference. This study showed that there was a decrease in MMP-9 activity by bakiko membrane in grade II burn with immunohistochemical method in wistar rats.

Uji Toksisitas Akut Ekstrak Buah Bruguiera gymnorrhiza pada Tikus (Rattus norvegicus) (Acute Toxicity Test of Bruguiera gymnorrhiza Fruit Extract In Rats (Rattus norvegicus)) Salman Al Farisi; Al Munawir; Zahrah Febianti
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Bruguiera gymnorrhiza (bakau) fruit has a great potency as a traditional medicine, but the safety has not known yet, therefore a test to determine the toxic effects of this fruit into living thing is needed. This research aimed to determine the acute toxicity effect of Bruguiera gymnorrhiza fruit extracts in rats based on Loomis criteria. This research was an experimental research laboratory with Post Test Only Control Group Design. Ten rats were divided into two groups. The control group was fed with a standard food while the treatment group was given Bruguiera gymnorrhiza (bakau) fruit extract at a dose of 5.000 mg/kg BB. After 24 hours, two groups were observed by calculating the number of the dead rats, if there was no dead rat, they were sacrificed for an autopsy for liver histopathological examination. The result of this research showed there was no dead rat during the treatment process . Histopathological examination of rat liver cells showed no necrosis, degeneration, inflammation, fibrosis, and cirrhosis. Conclusion of this research was Bruguiera gymnorrhiza (bakau) fruit had no toxic effects and could be clasified as “Practical Not Toxic” in Loomis criteria . Keywords: Bruguierra gymnorrhiza (bakau) fruit , the acute toxicity effect, rat

Efektivitas Chlorhexidine sebagai Inhibitor MMP-2 dan MMP-9 dalam Proses Dermonekrosis Akibat Racun Kumbang Tomcat (Paederus sp.) (The Effectiveness of Chlorhexidine as MMP-2 and MMP-9 inhibitor in Dermonecrotic Process due to Rove Beetles Toxin (Paederus sp.)) Putri Erlinda Kusumaningarum; Al Munawir
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Paederus dermatitis is dermonecrotic condition caused by Rove beetles (Paederus sp.). Paederin toxin come from endosymbiotic between rove beetles and Pseudomonas aeruginosa and can produces MMP-2 and MMP-9. Chlorhexidine is expected to be alternative therapy and prevention of dermatitis paederus due to it's MMP inhibitor and bacteriostatic effect. The study aimed to investigated the effectivity of chlorhexidine as MMP-2 and MMP-9 inhibitor in dermonecrotic process due to rove beetles toxin. Research groups consisted of negative control (paederin toxin), treatment 1 (paederin toxin + chlorhexidine 0,012%), treatment 2 (paederin toxin + chlorhexidine 0,06%), treatment 3 (paederin toxin + chlorhexidine 0,3%), and normal control (aquadest). As much as 9,3 µg paederin toxin and chlorhexidine are injected to the well of 8% acrylamide gel containing gelatin. Measuring of band density using ImageJ showed a decreasing of MMP-2 and MMP-9 band density. Negative control group was considered to have 1 of relative optical density. The result showed that chlorhexidine 0,06% can inhibits 21,6% MMP-2 activities and at 0,3% can inhibits 16,4% MMP-9 activities. One way ANOVA test show different significantly between negative control and treatment group (p<0,05). In conclusion chlorhexidine has potency as MMP-2 and MMP-9 inhibitor in dermonecrotic process due to Rove Beetles toxin. Keywords: Rove beetles(Paederus sp.), dermonrcrotic, MMP-2, MMP-9, chlorhexidine

Pengaruh Pemberian Gel Doksisiklin terhadap Jumlah Fibroblas pada Proses Penyembuhan Dermatitis Paederus akibat Racun Kumbang Tomcat (Paederus sp.) pada Mencit (The Effect of Doxycycline Gel on The Number of Fibroblast in Paederus Dermatitis Healing Silvi Ahmada Chasya; Al Munawir; Erma Sulistyaningsih
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Paederus dermatitis caused by rove beetle makes the tissue damage called dermonecrosis. The MMP on pederin toxins from the symbiosis of rove beetle (Paederus sp.) and Pseudomonas aeruginosa is supposed can delay the wound healing process. Doxycycline gel as a MMP inhibitor is believed can accelerate the healing process. The purpose of this study was to determine the effect of doxycycline gel on the healing process of Paederus dermatitis by observing the number of fibroblasts as an indicator. This study used 40 mice, were divided into four major groups, those were normal control group, the negative control, treatment groups with doxycycline gel 1% and 5%. Termination was performed on days 1, 3, 5, 7, and 15. Data was obtained by calculating the number of fibroblasts per field of view, then processed in ImageJ and tested statistically with comparation test of One Way Anova. The average number of fibroblasts per field of view in treatment groups was higher. The peak occurred on day 7 and decrease on day 15. It indicated that the topical administration of doxycycline gel on Paederus dermatitis can accelerate healing process, showed by the increasing in average number of fibroblasts per field of view. Keywords: doxycycline gel, fibroblast, paederus dermatitis

Efek Antiangiogenik Ekstrak Etanol Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) pada Membran Korio Alantois (CAM) Embrio Ayam Roat Yeti Mustafida; Al Munawir; Rosita Dewi
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Angiogenesis is the growth of new blood vessels that are used to supply nutrients and oxygen including cancer cells. Phaleria macrocarpa contains tannin, saponin, alkaloid, and flavonoid, known as an antiangiogenesis. This study determined the antiangiogenic effects of ethanolic extract of Phaleria macrocarpa on chorio allantoic membrane of chicken embryos. The antiangiogenesis trials used chorio allantoic membrane of 9 days chicken embryos. There were 5 groups, negative control group [K(-)] and 4 treatment groups (P), each group containing 4 eggs. K(-) group using aquadest and tween 80%; P groups with ethanolic extract of Phaleria macrocarpa at a concentration 10 ug/µL, 40 ug/µL, 80 ug/µL, 160 ug/µL for P1, P2, P3, dan P4 respectively. The number of new blood vessels on chorio allantoic membrane were K(-): (42.5 ± 14.57), P1: (28.25 ± 3.59), P2: (28.5 ± 1.73), P3: (15 ± 4.32), and P4: (6.5 ± 1.73). In conclusion, the ethanolic extract of phaleria macrocarpa has an antiangiogenic effect on chorio allantoic membran by decreasing the number of new blood vessels.Keywords: angiogenesis, Phaleria macrocarpa, ethanolic extract, chorio allantoic membrane

Hubungan antara Kadar LDL dan HDL terhadap Kejadian Kaki Diabetik pada Pasien DM Tipe 2 di Poli Interna RSD dr. Soebandi: Penelitian Case Control (Relationship between LDL and HDL Levels and Diabetic Foot Incidende in DM Type 2 Patients at the Internal M Nadia Putri Yurianto; Ali Santoso; Al Munawir
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Diabetic foot is a complication of type 2 DM that happen because of atherosclerosis, which one of the risk factor is dyslipidemia. The LDL and HDL are the indicator of dyslipidemia. The purpose of this study was to investigate the relationship between LDL, HDL and ratio of LDL/HDL levels on diabetic foot complication of type 2 DM patients at the dr. Soebandi hospital. This was a case control study. The total sample was 61 patients. The result showed that there were no correlation between LDL levels and diabetic foot (p = 0,59) as well as the LDL / HDL ratio (p = 0,5). There was no correlation between HDL and diabetic foot (p = 0.063), but they had a clinical relationship because there were over 20% proportion differences. The OR value between HDL levels and diabetic foot was 6.75. In conclusion, there were no relationship between LDL levels and ratio of LDL/HDL on diabetic foot, but there is clinical relationship between HDL levels on diabetic foot. Keywords: diabetic foot, type 2 DM, LDL, HDL, ratio of LDL/HDL

Pengaruh Induksi Toksin Ubur-ubur (Physalia physalis) terhadap Gambaran Histopatologi Paru-paru Tikus Wistar Sayyidah Auliany Aminy; Al Munawir; Erfan Efendi
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Physalia physalis adalah salah satu jenis ubur-ubur beracun yang dapat menimbulkan dyspnea setelah tersengat. Hal ini menunjukkan adanya efek pneumotoxic toksin Physalia physalis. Penelitian ini bertujuan untuk mengetahui efek pneumotoxic protein toksin ubur-ubur Physalia physalis secara in vivo pada tikus Wistar. Penelitian menggunakan sampel tikus galur Wistar jantan dengan berat rata-rata 150 gram dengan 1 kelompok kontrol (K) dan 3 kelompok perlakuan (P), masing-masing kelompok terdiri atas 6 ekor tikus. Kelompok K diinjeksi dengan larutan PZ; P1, P2 dan P3 masing-masing diinjeksi protein toksin ubur-ubur Physalia physalis dengan dosis 10 mg/KgBB, 20 mg/KgBB dan 30 mg/KgBB. Setelah 6 jam organ paru-paru tikus diambil dan direndam dengan formalin 10% dan dilakukan pembuatan preparat histologi, kemudian dilakukan pengamatan secara mikroskopik dan ditentukan tingkat perubahan histopatologi paru-paru dengan menggunakan skor. Hasil penelitian menunjukkan terjadinya perubahan histopatologi pada paru-paru tikus Wistar berupa infiltrasi sel radang, edema paru, degenerasi dan apoptosis sel-sel penyusun paru. Hasil uji statistik Kruskal-wallis menunjukkan data memiliki perbedaan signifikan (p=0,001). Terdapat perbedaan yang signifikan pada perubahan histologi paru-paru antara kelompok K dengan P1, P2 dan P3. Dapat disimpulkan bahwa toksin ubur-ubur Physalia physalis mempengaruhi gambaran histopatologi paru-paru tikus Wistar. Kata kunci: Toksin, ubur-ubur, Physalia physalis, Histopatologi, paru- paru.

Co-Authors . Zulfan Abd, Miswar Achmad, Fariz Ade Ananta Pratiwi Adelia Handoko Adinningtyas Intansari Agung Sudrajat Agung_Sudrajat Agung Aini Hidayati Ali Santoso Alimas Jonsa Alloysius Vendhi Prasmoro, Alloysius Vendhi Anang Dwi Atmoko Ancah Caesarina Novi Marchianti Anhar Fazri Asti Nuris ASTUTI, IDA SRI SURANI WIJI Ayik Nikmatul Laili Azka Darajat Bachtiar, Dandi Bagus Indra Kusuma Dear F Sielma Desi Maulida Desy Tariustanti Desy Tariustanti Dewi Rokhmah dian febrianti Edy Kurniawan Elfian Zulkarnain Elfian Zulkarnain, Elfian Erfan Efendi Erma Sulistyaningsih Farida Wahyu Ningtyias, Farida Wahyu Farida Wahyuningtiyas Farizal, Teuku Futri Syam Ghiza J.K. Barqly Hadi Prayitno Hartati, Rita Hasdi, Syaiful Hazmi Dwinanda Nurqistan Hendri, Afrizal Herdi Susanto Herri Darsan Hilda Khairinnisa I Gusti Ngurah Agung Darma Putra Ida Srisurani Wiji Astuti Ika Rahmawati Sutejo Ikmala, Riskita Isa Marufi ISLAMI, SHOFI IQDA Jayadi, Farid Jumanto Jumanto Kiky Martha Ariesaka kustin uds Laili, Ayik Nikmatul laili, Ayik Nikmatul Laksmi Indreswari Luluk Faridatul Mukaromah Mahmuddin Marbun Maidi Saputra Masykur, Masykur Meylis Safriani Mirza Adia Nova Muazar, Muazar Mudzakkir Taufiqurrahman Muflikhatun, Khanif Muhammad Abrar Muhammad Aqib Husni Fadhli Muhammad Arif Nasution Muhammad Herizal Ihza Muhendra, Rifki Murhaban Murhaban Murtadho Ridwan Muzakkir Muzakkir N. Nazaruddin Nadia Putri Yurianto Nafolion Nur Rahmat, Nafolion Nur Nanda Prima Natasya Febrilia Yulianti Novan K. Adji Pandan, Pandan wangi Pipiet Wulandari Putri Erlinda Kusumaningarum Putri Kemala Sari Putri, Gusfita Trisna Ayu Raudhatun Nafisah Retno Widyastuti Riskita Ikmala Rita Fazlina Rizka N Wardani Rizki, Julia Roat Yeti Mustafida Romadhon, Nadia Jean Rosita Dewi Rudy Gunawan Sabrina M Pratama Safrirullah Safrirullah Saiful Bukhori Saiful Bukhori, Saiful Bukhori Salman Al Farisi Sarwendah Siswi Winasis Sayyidah Auliany Aminy Sekar Arum Srigati septa surya wahyudi, septa surya SHOFI IQDA ISLAMI Sihaan, Josua Cornel Roni Silvi Ahmada Chasya Solihin Solihin Solihin, Solihin Solihin Sri Wahyu Handayani Sugiyanta Sugiyanta Sukhairi, Teuku Ariessa Supangat Supangat Supangat Supangat Supangat Syahrul Fathi Syari, Zammiq Utami, Nastiti Bekti Vita Alfiatul Hasanah Wahyu Dian Puspita Widyantoro, Murwan Wiqodatul Ummah Yasrizal Zahrah Febianti Zakir Husin Zarah Puspita Zarah Puspitaningtyas Zuhrizal Fadhly Zulfadhli Zulfadhli Zulfan Adi Putra

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