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All Journal Journal of Food and Pharmaceutical Science Jurnal Penelitian Saintek Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Statistika Indonesian Journal of Cancer Chemoprevention Program Kreativitas Mahasiswa - Penelitian Indonesian Journal of Biotechnology Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY JURNAL BIOLOGI INDONESIA The Indonesian Biomedical Journal Jurnal Farmasi Sains dan Komunitas Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Majalah Farmaseutik Indonesian Journal of Chemistry Media Ilmu Kesehatan JPSCR : Journal of Pharmaceutical Science and Clinical Research JFIOnline INTEGRITAS : Jurnal Pengabdian Jurnal Farmasi Journal of Community Development Populer: Jurnal Penelitian Mahasiswa Jurnal Kedokteran Hewan Journal of Food and Pharmaceutical Sciences Agri Analytics Journal Jurnal Medika: Medika Indonesian Journal of Pharmacology and Therapy Jurnal Pengabdian Masyarakat Manage
Retno Murwanti
Departemen Farmakologi Dan Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Jurnal Ilmiah Farmasi

 1 
KETOKSIKAN AKUT TABLET EFFERVESCENT DARI EKSTRAK DAUN SIRIH (Piper betle L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR Farida Hayati; Retno Murwanti; Dwi Brilyani Sandy
Jurnal Ilmiah Farmasi Vol. 4 No. 2 (2007)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTA research on acute toxicity of effervescent tablet from Piper betle leaf extractum on wistaralbino male rats was done. This research aimed to determine acute toxicity potential ofeffervescent tablet from piper betle leaf extractum, evaluated clinical symptom that perhaps occurdue to the giving of effervescent tablet, single dosage orally on 24 hours to 15 days observation.The research uses male rats, which are divided into 5 groups. Group I was negative control withaquadest. Group II was given sample with 0,38 g/kgBW dosage. Then, succesively group III with1,03 g/kgBW dosage, group IV with 2,79 g/kgBW dosage and group V was given test sample withhighest dosage, that was 7,50 g/kgBW dosage. On the basis of data analysis result having beenperformed both quantitively and qualitatively, it could be said that in general, the giving ofeffervescent tablet from Piper betle leaf extractum single dosage orally on male rats from 0,38g/kgBW dosage to highest level (7,50 g/kgBW) or approximately 19,74 times of therapy dosage,didn’t cause toxic effect. It didn’t cause mortality on research animal. So we can determine thequasi LD50, that was bigger than 7,50 g/kgBW, according to Loomis criteria (1978), that acutetoxicity potential of effervescent tablet from piper betle extractum was practically not toxic category.Key words: acute toxicity, effervescent tablet, Piper betle
KEAMANAN PEMBERIAN BERULANG EKSTRAK KANGKUNG DARAT (Ipomoea reptans,Poir) TERSTANDAR TERHADAP FUNGSI GINJAL DAN HEPAR MENCIT BETINA Farida Hayati; Retno Murwanti; Ginna Zabrina
Jurnal Ilmiah Farmasi Vol. 10 No. 1 (2013): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol10.iss1.art1

Abstract

Kangkung darat terbukti memiliki aktifitas antihiperglikemia pada mencit betina galur swiss yang diinduksi streptozotosin. Penelitian ini dilakukan untuk mendapatkan kajian keamanan pemberian berulang ekstrak kangkung darat terstandar terhadap fungsi ginjal dan hepar pada mencit betina. Dua puluh hewan uji dibagi ke dalam 4 kelompok, yaitu kelompok kontrol (akuades 10 ml/ kg), dosis I (ekstrak etanolik kangkung darat 480 mg/ kg), dosis II (ekstrak etanolik kangkung darat 759 mg/ kg), dan  dosis III (ekstrak etanolik kangkung darat 1200 mg/ kg). Ekstrak etanolik kangkung darat diberikan 1 kali sehari secara p.o. selama 14 hari. Pengamatan gejala toksik dilakukan selama 3 jam setelah pemberian senyawa uji. Kelompok dosis 1200 mg/ kg mengalami efek sedasi, konstipasi, dan feses berwarna hitam selama pemberian ekstrak etanolik kangkung darat terstandar, sedangkan kelompok lainnya tidak mengalami gejala toksik. Data berat badan, pemeriksaan ALT, dan pemeriksaan AST dianalisis secara statistik. Berat badan rata-rata hewan uji kelompok dosis 759 mg/ kg mengalami penurunan yang paling banyak dibandingkan kelompok lainnya dan berbeda signifikan dengan kelompok kontrol dari hasil analisis statistik. Kadar AST dan ALT mengalami peningkatan setelah pemberian berulang ekstrak etanolik kangkung darat selama 14 hari, dari hasil analisis statistik kadar ALT dan AST kelompok dosis 759 mg/ kg dan dosis 1200 mg/ kg berbeda signifikan dengan kelompok kontrol (p<0,05). Hasil histopatologi organ ginjal dan hepar hewan uji setelah pemberian berulang ekstrak etanolik kangkung darat terstandar selama 14 hari menunjukkan tidak adanya perubahan yang membahayakan pada organ.
KETOKSIKAN AKUT TABLET EFFERVESCENT DARI EKSTRAK DAUM SIRIH ( Piper betle L.) PADA TIKUS PUTIH BETINA GALUR WISTAR Farida Hayati; Retno Murwanti; Wahyu Utaminingrum
Jurnal Ilmiah Farmasi Vol. 4 No. 1 (2007)
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

A research on acute toxicity of effervescent tablet from Piper betle leaf extractum on wistar albino female rats was done. This research aimed to determine acute toxicity potential of effervescent tablet from piper betle leaf extractum, evaluated clinical symptom that perhaps occur due to the giving of effervescent tablet, single dosage orally on 24 hours to 15 days observation. The research uses female rats, which are divided into 5 groups. Group I was negative control with aquadest. Group II was given sample with 0,38 g/kgBW dosage. Then, succesively group III with 1,03 g/kgBW dosage, group IV with 2,79 g/kgBW dosage and group V was given test sample with highest dosage, that was 7,50 g/kgBW dosage. On the basis of data analysis result having been performed both quantitively and qualitatively, it could be said that in general, the giving of effervescent tablet from Piper betle leaf extractum single dosage orally on female rats from 0,38 g/kgBW dosage to highest level (7,50 g/kgBW) or approximately 19,74 times of therapy dosage, didn't cause toxic effect which causing damage on lung, liver, kidney, heart, spleen, stomach and intestine. It didn't cause mortality on research animal. So we can determine the quasi LD^, that was bigger than 7,50 g/kgBW, according to Loomis criteria (1978), that acute toxicity potential of effervescent tablet from piper betle extractum was practically not toxic category. Thus based on ANOVA result with 95 % significance level, it could be said that the giving of effervescent tablet from piper betle leaf extractum didn't show significant differences to average body weight changes and organ weight.
Co-Authors Abdul Rohman Adam Hermawan Agung Endro Nugroho Agung Endro Nugroho Ahmad Marzuki Alexxander, . Alexxander, . Amalia, Latifa Anami Riastri Andayana Puspitasari Gani Andayana Puspitasari Gani Andayana Puspitasari Gani Annisa, Siti Nur Anselma Ivanawati Arief Nurrochmad Arief Nurrochmad Arief Nurrochmad Arief Nurrochmad Arief Rahman Hakim Arifka, Vigha Ilmanafi Ariska Deffy Anggarany, Ariska Deffy Ashfannada, Nuqya Asri Mega Putri Azizah Amin Azizah, Ulfah Laily Azmi Rahmadani Bambang Sulistiyo Ari Sudarmanto Bani Adlina Shabrina Bayu Irawan, Muhamad Bayu Prio Septiantoro Beni Lestari Budastra, Wayan Cintya Ganes Cahyo Nurani, Sekar Cindy Puspita Sari Devina Martina Devita Anggraeni Devita Anggraeni Devyanto Hadi Triutomo Dhania Novitasari Dhirgo Adji Dhirgo Adji Diana Rachma Ningsih Dwi Brilyani Sandy Dwi Salim, Rozin Dyah Afritasari Dyah Aryani Perwitasari Dyaningtyas Dewi Pamungkas Putri Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Effendi, Adha Maula Erna Prawita Setyowati Erna Prawita Setyowati Fikriansyah Fikriansyah Fita Rahmawati Fitri, Dafina Aisya Fitriana Hayyu Arifah Gagas Pradani Nur Ilmawati Gani, Andayana Puspitasari Ginna Zabrina Hayati, Farida Hendri Wasito Herwandhani Putri Hidayah, Alifia Brilliani Hilyatul Fadliyah I Gusti Ngurah Agung Dewantara Putra Ida Ayu Putu Sri Widnyani Idlohatud Dilalah Ika Puspita Sari Illian, Didi Nurhadi Imono Argo Donatus, Imono Argo Iren Wati Siahaan Jenie, Riris Istighfari Juang Juansa Khafi, Muhammad Khasanah, Aisyah Nur Kustanto, Satya Prima Layung Sekar Sih Wikanthi Ledi, Ledi Klarismawati Lodyta Nawang Tika lubis, muhammad fauzan Lukman Hakim Luthfiyyah, Annisa Tiara Maharani, Astrid Martien , Ronny Mentari Widiastuti Miftahus Sa&#039;adah Muharom, Luthfi Ali Mustofa Mustofa Naisbitt Iman Hanif, Naisbitt Iman Nanda Saifullah Sulaiman, Teuku Ngurah Agung Dewantara Putra, I Gusti Nindi Wulandari Nindya Budiana Putri Nindya Budiana Putri Ningsih, Diana Rachma Norita Citra Yuliarti, Norita Citra Novrizal Abdi Sahid , Muhammad Nunung Yuniarti Nursani, Rabila Nurul Mukhlisa Pratiwi, Rima Dwi Prawitasari, Saptya Prisnu Tirtanirmala Probowulan, Diyah Purnomo, Kurnia Rahayu Purwantiningsih Purwantiningsih Rahmawati, Desty Restia Rahmawaty Rachmady Rahmayani, Almira Retno S. Sudibyo Retno Sunarminingsih Sudibyo Riandari , Teti Mariam Rima Munawaroh Riris Istighfari Jenie Risa Umari Yuli Aliviyanti Ritmaleni, Ritmaleni Rizkita, Anggraini Ihza Rohmad Yudi Utomo Rohman, Abdul Rommy Sagala, Reynelda Juliani Sardjiman . Sari Haryanti Sari Haryanti Sari, Laras Ratna Shofa Annur Siswadi Siswadi Sri Susilowati Sri Tasminatun Sri Wahdaningsih Subagus Wahyuono Sudarsono Sudarsono Sugeng Riyanto Sugiyanto . Sugiyanto . Sulaiman, T.N Saifullah Sumaiyah, Sumaiyah Susi Ari Kristina Suwijiyo Pramono Suwijiyo Pramono Tamhid, Hady Anshory Tampubolon, Keshia Thoriq Ziyad, Thoriq Tiffany, Ghea Rachella Triana Candraningrum Triana Hertiani Triawan Adi Cahyanto Ulfa Afrinurfadhilah Darojati Wahyu Utaminingrum Widya Leontin Susanti Wulandari, Febri Yance Anas Yoce Aprianto Yosi Bayu Murti Yundari, Yundari Zahrotul Ulum Ziana Walidah, Ziana