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All Journal Jurnal Kedokteran Brawijaya The Journal of Experimental Life Sciences (JELS) Research Journal of Life Science Berkala Kedokteran Indonesian Journal of Cardiology Heart Science Journal JSMARTech : Journal of Smart Bioprospecting and Technology Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Journal of Nursing Science Update Indonesian Journal of Biomedicine and Clinical Sciences Brawijaya Journal of Urology
Mohammad Saifur Rohman
Department Of Cardiology And Vascular Medicine, Faculty Of Medicine, Universitas Brawijaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Regulatory RNAs and coronary artery calcification: A systematic review of clinical associations and biological insights Tsuraya, Alfi; Raras, Tri Yudani Mardining; Lestari, Bayu; Ramadhani, Risa; Hose, Victor Alvianoes Guterez; Rohman, Mohammad Saifur; Waranugraha, Yoga; Fajar, Jonny Karunia
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.7

Abstract

BACKGROUND: Regulatory RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have emerged as key regulators of vascular remodelling and coronary heart disease. However, their specific roles in coronary artery calcification (CAC) remain fragmented across diverse clinical studies. OBJECTIVES: This review aims to systematically synthesize human observational evidence on differentially expressed regulatory RNAs associated with CAC and their underlying molecular mechanisms. METHODS: We included clinical observational studies (case-control, cross-sectional, or cohort designs) that compared regulatory RNA expression in patients with and without CAC. We searched PubMed, BioMed Central, Wiley, ScienceDirect, and Cochrane between January 2010 and June 2025. Risk of bias was assessed using the JBI Critical Appraisal Checklist for Observational Studies. Data were synthesized narratively with stratification by RNA type, direction of expression, and biological mechanism. RESULTS: A total of 10 eligible studies were included. Several regulatory RNAs demonstrated potential as biomarkers or modulators of CAC. However, the diversity of regulatory RNAs highlights the complex and multifactorial nature of CAC, while also revealing opportunities for future investigation. CONCLUSION: Notably, circSmad4 demonstrated a favourable trend with a high AUC and a reasonably balanced mix of sensitivity and specificity, despite with relatively larger sample sizes.
The association of CDKNB-AS1 gene polymorphism and coronary artery calcification: A systematic review Tsuraya, Alfi; Miasih, Dewi Sekar; Ramadhani, Risa; Rohman, Mohammad Saifur; Raras, Tri Yudani Mardining
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.8

Abstract

BACKGROUND: Coronary artery calcification (CAC) is a robust, heritable marker of subclinical atherosclerosis. Among genetic loci identified by genome-wide association studies (GWAS), 9p21 locus, particularly the CDKN2B-AS1 (ANRIL) region, has emerged as a key determinant of coronary artery disease (CAD). However, whether this signal generalizes to CAC across ancestries remains unresolved because the evidence is scattered and analytically heterogeneous, with certain populations underrepresented. OBJECTIVES: This systematic review was conducted to synthesize findings across studies that assessing CDKN2B-AS1 variants and CAC within populations. METHODS: We conducted a search in PubMed, BioMed Central, Wiley, ScienceDirect, and Cochrane from January 2010 to June 2025. Fourteen eligible studies were included in total. The JBI Critical Appraisal Checklist for Observational Studies was utilised to assess the risk of bias. Data were synthesised through a narrative approach. RESULTS: This systematic review integrates multi-ethnic evidence showing that rs1333049 and rs4977574 exhibit strong, reproducible associations with CAC severity in European and Admixed American populations, but weaker or absent effects in African and East Asian groups. In East Asia population, particularly Korean, rs10757272 shows the strongest influence. CONCLUSION: Overall, CDKN2B-AS1 functions as an important, ancestry-dependent in coronary calcification, emphasizing the need for fine-mapping and diverse cohort inclusion to achieve globally equitable genetic risk assessment.
In Silico Approach of Predicting The Interaction of Epigallocatechin-3 Gallate and Chlorogenic Acid on E47 and THOC5 in Macrophage Differentiation: In Silico Study of EGCG and CGA on Macrophage Differentiation Rohman, Mohammad Saifur; Izzatur Rochmah, Evalina; Abdullah, Fuad; Alvianoes Guterez Hose, Victor
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 7 No. 1 (2026): Vol. 7 No. 1 (2026): JSMARTech Volume 7, No 1, 2026
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2026.007.01.24

Abstract

Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia and glucose intolerance. Vascular hyperglycemia triggers the release of inflammatory mediators, which can increase monocyte differentiation into macrophages. Compounds such as epigallocatechin-3 gallate (EGCG) from green tea and chlorogenic acid (CGA) from green coffee are known to have anti-inflammatory effects. This study aimed to analyze the effect of EGCG and CGA on macrophage differentiation markers by assessing their binding activity with THOC5 and E47 proteins. An in silico assessment was conducted using metformin, which is widely used as a first-line antidiabetic drug, as the control ligand. Pharmacokinetic and drug-likeliness predictions were carried out. Additionally, molecular docking and molecular dynamics analysis were performed on the active residues of the proteins to assess the binding affinity and complex stability. The results obtained demonstrate that the binding affinity energy of EGCG and CGA to THOC5 and E47 was more favorable than that of metformin, yet their bioavailability value was poor. Molecular dynamics simulation showed that EGCG had a more stable complex compared to CGA and metformin. In conclusion, EGCG and CGA could potentially be effective as anti-inflammatory agents in diabetes mellitus.
Co-Authors Abdullah, Fuad Achmad Rudijanto Adhika Prastya Wikananda Adi, Andi Wahjono Aditha Satria Maulana Afifuddin, Mokhammad Ahsan Ahsan Ainan, Shafa Akbar, Naufal Zulfikar Alfata, Fandy Hazzy Alvianoes Guterez Hose, Victor Anditri Weningtyas Anita Surya Santoso Anjarwani, Setyasih Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Annisa Hasanah Ardhani Galih Prakoso Ardhino, Ardhino Ardian Rizal Ardian Rizal Ardian Rizal Arief Wibisono Arif Wicaksono Arina Madjidi Ashari, Yordan Wicaksono Astiawati, Tri Aulanni'am Aulanni'am Ayu Asri Devi Ayu Asri Devi Adityawati Aziz, Indra Jabbar Bagus H Kuncahyo Bahar, Mokhamad Aswin Bambang Kusbandono Bambang Rahardjo Bayu Aji Bayu Lestari Budi Satrijo Budi Satrijo Budi Satrijo Caesario, Fahreza Catelya, Laras Gaby Cholid Tri Tjahjono Cholid Tri Tjahjono Cholid Tri Tjahjono Candra Chomsy, Indah Nur Christine, Anastasia Citra Tarannita Dadang Hendrawan Dea Arie Kurniawan Dedy Irawan Dhani, Fauzan Kurniawan Dian Nugrahenny Dian Nugrahenny Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Dwi Adi Nugroho Dwi Adi Nugroho Dwi Adi Nugroho Dwi Sarbini Dwigustiningrum, Nur Kaputrin Efris Kartika Sari, Efris Kartika Endah Kusuma Rastini Evit Ruspiono Fahmi Rusnanta Fahmy Rusnanta Fahmy Rusnanta Fajar, Jonny Karunia Fandy Hazzy Alfatta Faris Wahyu Nugroho Filano, Marco Firdaus, Achmad Jauhar Firdaus, Dylan Hanny Fitranti Suciati Laitupa Ghazyarda Aqilah Setya H Hendarto Harumsari, Stefani Haryati, Lina Hendrawati Hendrawati Heny Martini Hidayat Sujuti Hikmawan Wahyu Sulistomo Hose, Victor Alvianoes Guterez Husnul Khotimah Ika Setyo Rini Ikhwan Handirosiyanto Imelda Krisnasari Imelda Krisnasari Indra Prasetya Indra Prasetya Indra Prasetya Inggita Kusumastuty Irma Kamelia Pratiwi Izzatur Rochmah, Evalina Kahadi, Cik Karolina, Wella Krishna Ari Nugraha Kuhn, Corinna Maria Kurnianingsih, Novi KURNIAWAN, ARY Laitupa, Fitranti Suciati Laukkanen, Noora Julia Lenny Kartika Lestari, Bayu Lestari, Puspa Liemena Harold Adrian Lowry Yunita Lukitasari, Mifetika Martini, Heny Maulidiyatun Nuril Faizah Miasih, Dewi Sekar Mifetika Lukitasari Mifetika Lukitasari Mifetika Lukitasari Mifetika Lukitasari Millisani, Hayla Iqda Mohammad Aris Widodo Muchammad Dzikrul Haq Karimullah Muhamad Bayu Aji Muhammad Rizki Fadlan Muhammad Rizki Fadlan Muhammad Rizki Fadlan Nashi Widodo Nashi Widodo Noverike, Nikhen Novi Kurnianingsih Novi Kurnianingsih Novi Kurnianingsih Nugraha, Krishna Ari Nugraha, Yudha Tria Nugrahanti Prasetyorini Nugroho, Ira Vori Nur Ida Panca Nugraheini Nur Ida Panca Nugrahini Nur Permatasari Oktafin Srywati Pamuna Olivia Handayani Olivia Handayani Pamuna, Oktafin Srywati Pande Made Dwijayasa Pawik Supriadi Pawik Supriadi Purbaningroom, Dian Laila Putri Annisa Kamila Putri Annisa Kamila Putri, Valerinna Yogibuana Swastika Rahimah, Anna Fuji Rahma, Oktivani Adelathifa Rahmi, Koyuki Atifa Ramadhani, Risa Ratih Kusuma Wardani Ratna Pancasari Ratna Pancasari Renny Suwarniaty Rislan Faiz Muhammad Riswati, Harnanik Puji Riza, Mochamad Faishal Rizal , Ardian Rizal, Ardian Rochmawati, Icmi Dian Rohman, Ibrahim Abdur Sakti, Pradhika Perdana Salvatore Di Somma Sasmojo Widito Satrijo, Budi Seprian Widasmara Setiawan, Dion Setyasih Anjarwani Setyasih Anjarwani Setyowati, Danti Utami Suprayoga, Imam Mi'raj Suryanto Taufieq Ridlo Makhmud Taufiq Nur Budaya Teguh Aryanugraha Teguh Wahyu Sardjono Titi A W Tonny Adriyanto Tri Yudani MR Tsuraya, Alfi Veny Kurniawati Veny Kurniawati Wella Karolina Widito, Sasmojo Widodo Nashi Widodo Widodo Wikananda, Adhika Prastya Wira Kimahesa Anggoro Wira Kimahesa Anggoro Wiwit Nurwidyaningtyas, Wiwit Yoga Waranugraha Yoga Waranugraha Yoga Waranugraha Yogibuana, Valerinna Yoseph Budi Utomo Yusuf Arifin Zhao, Zihan