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All Journal Jurnal Kedokteran Brawijaya The Journal of Experimental Life Sciences (JELS) Research Journal of Life Science Berkala Kedokteran Indonesian Journal of Cardiology Heart Science Journal JSMARTech : Journal of Smart Bioprospecting and Technology Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Journal of Nursing Science Update Indonesian Journal of Biomedicine and Clinical Sciences Brawijaya Journal of Urology
Mohammad Saifur Rohman
Department Of Cardiology And Vascular Medicine, Faculty Of Medicine, Universitas Brawijaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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The association of CDKNB-AS1 gene polymorphism and coronary artery calcification: A systematic review Tsuraya, Alfi; Miasih, Dewi Sekar; Ramadhani, Risa; Rohman, Mohammad Saifur; Raras, Tri Yudani Mardining
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.8

Abstract

BACKGROUND: Coronary artery calcification (CAC) is a robust, heritable marker of subclinical atherosclerosis. Among genetic loci identified by genome-wide association studies (GWAS), 9p21 locus, particularly the CDKN2B-AS1 (ANRIL) region, has emerged as a key determinant of coronary artery disease (CAD). However, whether this signal generalizes to CAC across ancestries remains unresolved because the evidence is scattered and analytically heterogeneous, with certain populations underrepresented. OBJECTIVES: This systematic review was conducted to synthesize findings across studies that assessing CDKN2B-AS1 variants and CAC within populations. METHODS: We conducted a search in PubMed, BioMed Central, Wiley, ScienceDirect, and Cochrane from January 2010 to June 2025. Fourteen eligible studies were included in total. The JBI Critical Appraisal Checklist for Observational Studies was utilised to assess the risk of bias. Data were synthesised through a narrative approach. RESULTS: This systematic review integrates multi-ethnic evidence showing that rs1333049 and rs4977574 exhibit strong, reproducible associations with CAC severity in European and Admixed American populations, but weaker or absent effects in African and East Asian groups. In East Asia population, particularly Korean, rs10757272 shows the strongest influence. CONCLUSION: Overall, CDKN2B-AS1 functions as an important, ancestry-dependent in coronary calcification, emphasizing the need for fine-mapping and diverse cohort inclusion to achieve globally equitable genetic risk assessment.
In Silico Approach of Predicting The Interaction of Epigallocatechin-3 Gallate and Chlorogenic Acid on E47 and THOC5 in Macrophage Differentiation: In Silico Study of EGCG and CGA on Macrophage Differentiation Rohman, Mohammad Saifur; Izzatur Rochmah, Evalina; Abdullah, Fuad; Alvianoes Guterez Hose, Victor
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 7 No. 1 (2026): Vol. 7 No. 1 (2026): JSMARTech Volume 7, No 1, 2026
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2026.007.01.24

Abstract

Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia and glucose intolerance. Vascular hyperglycemia triggers the release of inflammatory mediators, which can increase monocyte differentiation into macrophages. Compounds such as epigallocatechin-3 gallate (EGCG) from green tea and chlorogenic acid (CGA) from green coffee are known to have anti-inflammatory effects. This study aimed to analyze the effect of EGCG and CGA on macrophage differentiation markers by assessing their binding activity with THOC5 and E47 proteins. An in silico assessment was conducted using metformin, which is widely used as a first-line antidiabetic drug, as the control ligand. Pharmacokinetic and drug-likeliness predictions were carried out. Additionally, molecular docking and molecular dynamics analysis were performed on the active residues of the proteins to assess the binding affinity and complex stability. The results obtained demonstrate that the binding affinity energy of EGCG and CGA to THOC5 and E47 was more favorable than that of metformin, yet their bioavailability value was poor. Molecular dynamics simulation showed that EGCG had a more stable complex compared to CGA and metformin. In conclusion, EGCG and CGA could potentially be effective as anti-inflammatory agents in diabetes mellitus.
Correlation Analysis of Mortality and Length of Stay in Sepsis Cases Among Heart Failure Patients with Low Ejection Fraction at Dr. Saiful Anwar General Hospital, East Java, Indonesia Pradhika Perdana Sakti; Setyasih Anjarwani; Mohammad Saifur Rohman; Indra Prasetya; Cholid Tri Tjahjono
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.24597

Abstract

In Indonesia, heart failure (HF) prevalence reaches 5%, contributing to over 1.8 million annual hospitalizations, accompanied by a 29% readmission rate and a 30-day mortality rate of 17%. The burden of infectious diseases, notably sepsis, further complicates the clinical landscape. Patients with sepsis residing in tropical regions often exhibit mortality rates surpassing global averages. Sepsis-associated coagulopathy (SAC) serves as a significant complication in this context. This study investigates the correlation between SAC, indicated by international normalized ratio (INR) levels, and outcomes in patients with heart failure with reduced ejection fraction (HFrEF) who develop sepsis. Utilizing a retrospective cohort approach, we analyzed medical records from Saiful Anwar Regional General Hospital, Malang, East Java, involving adult HFrEF patients who underwent INR testing. Purposive sampling was applied. Statistical analyses, including the Mann-Whitney Test, Kaplan-Meier Analysis, Log-Rank Test, Cox Proportional Hazards Regression, and Multiple Linear Regression, were conducted employing SPSS software. Results revealed a mean survival of 7.69 days in the Non-SAC group compared to 6.78 days in the SAC group, though the difference was not statistically significant (p=0.080). Notably, additional clinical complications predominantly influenced survival outcomes. This study elucidates that elevated INR levels, indicative of SAC, correlate with increased mortality and decreased survival in HFrEF patients with sepsis. Furthermore, the exacerbating effect of clinical complications on mortality highlights the imperative for early SAC detection and management of cardiovascular implications to enhance patient prognosis.
Predictor for premature coronary artery disease (PCAD) in Asian populations: a meta‑analysis Baskoro, Shalahuddin Suryo; Adelathifa Rahma, Oktivani; Arthalia, Virra Dennisa Rahmandasari; Maulana, Muhammad Zacky Hafiyyan; Waranugraha, Yoga; Rohman, Mohammad Saifur
Heart Science Journal Vol. 7 No. 3 (2026): Predicting Restenosis in Coronary Artery Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.03.5

Abstract

Background: Premature coronary artery disease (PCAD) is a major cause of heart disease in Asian populations, where coronary events happen at younger ages than in Western populations. Evidence concerning PCAD risk factors is inconsistent, in part due to variability in comparator selection among studies. Objective: To assess clinical and metabolic risk factors linked to PCAD in Asian populations through comparator-specific meta-analysis Method: According to the PRISMA 2020 guidelines, we did a systematic review and meta-analysis. We searched PubMed/MEDLINE, Cochrane, Scopus, and Web of Science for studies published from 2020 onwards. We included studies that looked at risk factors for PCAD in Asian groups with either non-CAD or older/later-onset CAD comparators. We used random-effects models to combine mean differences for continuous variables and odds ratios for categorical variables. We used I² statistics, funnel plots, and Egger's regression test to look at publication bias and heterogeneity. Results: Sixteen studies comprising 187,591 participants, including 28,943 patients with PCAD, were included. In pooled analyses, smoking (OR 2.18, 95% CI 1.74–2.72; p<0.001) and family history of premature cardiovascular disease (OR 2.11, 95% CI 1.74–2.55; p<0.001) were significantly associated with PCAD, while hypertension (OR 0.75, 95% CI 0.63–0.90; p=0.002) showed an inverse association. In the non-CAD comparator subgroup, stronger associations were observed for smoking (OR 2.56, 95% CI 1.83–3.58; p<0.001), hypertension (OR 2.34, 95% CI 1.63–3.35; p<0.001), male sex (OR 1.90, 95% CI 1.34–2.69; p<0.001), and family history (OR 3.99, 95% CI 1.10–14.51; p=0.040). HDL levels were consistently lower (MD −4.34 mg/dL and −9.52 mg/dL in both comparator groups), while triglycerides and non–HDL-C were higher. Elevated fasting blood glucose and C-reactive protein were observed only in non-CAD comparisons. LDL-C showed no significant difference across analyses. Conclusion: Predictors linked to PCAD in Asian populations differ based on the choice of comparators. Traditional cardiovascular risk factors, especially smoking and familial history, exhibit the most significant correlations, underscoring the necessity of early risk detection and prevention in younger populations.
Determinants of in-stent restenosis in coronary artery disease patients after percutaneous coronary intervention in Dr Saiful Anwar General Hospital, Malang Pramudya, Astrid; Rohman, Mohammad Saifur; Novi, Kurnianingsih; Djanggan, Sargowo; Setyasih, Anjarwani
Heart Science Journal Vol. 7 No. 3 (2026): Predicting Restenosis in Coronary Artery Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.03.9

Abstract

Background: In-stent restenosis (ISR) is common complication found following percutaneous coronary intervention. It can be caused by multifactorial such as patient related, lesion related and procedure related. Methods: A retrospective cohort study in Saiful Anwar general Hospital to know what are the characteristic of patient with ISR stated from clinical, lesion and procedural related. Result: From 3335 patients underwent PCI in our hospital, the incidence of ISR after PCI was 9.3%. Stent overlapped as one of the significant predictors of ISR (p=0.024). Multivariate analyses found significant correlation between Multivessel disease (OR = 1.76, 95%; [CI] [1.61 – 1.91], P 0.003), LAD lesion (OR=3.46, 95% CI [2.22 – 5.38], P<0.001), osteal lesion (OR=3.97, 95% CI [2.42-6.52], P<0.001], bifurcation lesion (OR=5.14, 95% CI [2.52-10.49], P<0.001), Calcified lesion (OR=1.86, 95% CI [1.62-2.15], P<0,001), LM disease (OR=2.16, 95% CI [1.36-3.41], P 0.001), Stent overlapped (OR 1.96, 95% CI [1.27-3.02], P 0.03), Stent length (OR=2.08, 95% CI [2.02-3.19] P 0.001). The multi-factor logistic regression analysis suggested that LAD lesion (p<0.001), stent overlapped (p 0.024) and calcified lesion (p<0.001) were independent risk factors for ISR. We evaluate subclinical analysis for stent length cut off >33.5 mm increased the risk of ISR with fair sensitivity but less specificity. Patient with DM type II had 3.013 times folded to become ISR rather than non DM group (1.995 – 4.552, 95% CI). By using ROC Curve, we evaluate subclinical analysis for HbA1C cut off <7.45 % with high sensitivity (81.2 %) and specificity (85.5 %). Conclusion: DM type 2, LAD lesion, stent overlapped and calcified lesion were the determinant of ISR.
Co-Authors Abdullah, Fuad Achmad Rudijanto Adelathifa Rahma, Oktivani Adhika Prastya Wikananda Adi, Andi Wahjono Aditha Satria Maulana Afifuddin, Mokhammad Ahsan Ahsan Ainan, Shafa Akbar, Naufal Zulfikar Alfata, Fandy Hazzy Alvianoes Guterez Hose, Victor Anditri Weningtyas Anita Surya Santoso Anjarwani, Setyasih Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Annisa Hasanah Ardhani Galih Prakoso Ardhino, Ardhino Ardian Rizal Ardian Rizal Ardian Rizal Arief Wibisono Arif Wicaksono Arina Madjidi Arthalia, Virra Dennisa Rahmandasari Ashari, Yordan Wicaksono Astiawati, Tri Aulanni'am Aulanni'am Ayu Asri Devi Ayu Asri Devi Adityawati Aziz, Indra Jabbar Bagus H Kuncahyo Bahar, Mokhamad Aswin Bambang Kusbandono Bambang Rahardjo Baskoro, Shalahuddin Suryo Bayu Aji Bayu Lestari Budi Satrijo Budi Satrijo Budi Satrijo Caesario, Fahreza Catelya, Laras Gaby Cholid Tri Tjahjono Cholid Tri Tjahjono Cholid Tri Tjahjono Candra Chomsy, Indah Nur Christine, Anastasia Citra Tarannita Dadang Hendrawan Dea Arie Kurniawan Dedy Irawan Dhani, Fauzan Kurniawan Dian Nugrahenny Dian Nugrahenny Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan, Sargowo Dwi Adi Nugroho Dwi Adi Nugroho Dwi Adi Nugroho Dwi Sarbini Dwigustiningrum, Nur Kaputrin Efris Kartika Sari, Efris Kartika Endah Kusuma Rastini Evit Ruspiono Fahmi Rusnanta Fahmy Rusnanta Fahmy Rusnanta Fajar, Jonny Karunia Fandy Hazzy Alfatta Faris Wahyu Nugroho Filano, Marco Firdaus, Achmad Jauhar Firdaus, Dylan Hanny Fitranti Suciati Laitupa Ghazyarda Aqilah Setya H Hendarto Harumsari, Stefani Haryati, Lina Hendrawati Hendrawati Heny Martini Hidayat Sujuti Hikmawan Wahyu Sulistomo Hose, Victor Alvianoes Guterez Husnul Khotimah Ika Setyo Rini Ikhwan Handirosiyanto Imelda Krisnasari Imelda Krisnasari Indra Prasetya Indra Prasetya Indra Prasetya Inggita Kusumastuty Irma Kamelia Pratiwi Izzatur Rochmah, Evalina Kahadi, Cik Karolina, Wella Krishna Ari Nugraha Kuhn, Corinna Maria Kurnianingsih, Novi KURNIAWAN, ARY Laitupa, Fitranti Suciati Laukkanen, Noora Julia Lenny Kartika Lestari, Bayu Lestari, Puspa Liemena Harold Adrian Lowry Yunita Lukitasari, Mifetika Martini, Heny Maulana, Muhammad Zacky Hafiyyan Maulidiyatun Nuril Faizah Miasih, Dewi Sekar Mifetika Lukitasari Mifetika Lukitasari Mifetika Lukitasari Mifetika Lukitasari Millisani, Hayla Iqda Mohammad Aris Widodo Muchammad Dzikrul Haq Karimullah Muhamad Bayu Aji Muhammad Rizki Fadlan Muhammad Rizki Fadlan Muhammad Rizki Fadlan Nashi Widodo Nashi Widodo Noverike, Nikhen Novi Kurnianingsih Novi Kurnianingsih Novi Kurnianingsih Novi, Kurnianingsih Nugraha, Krishna Ari Nugraha, Yudha Tria Nugrahanti Prasetyorini Nugroho, Ira Vori Nur Ida Panca Nugraheini Nur Ida Panca Nugrahini Nur Permatasari Oktafin Srywati Pamuna Olivia Handayani Olivia Handayani Pamuna, Oktafin Srywati Pande Made Dwijayasa Pawik Supriadi Pawik Supriadi Pradhika Perdana Sakti Pramudya, Astrid Purbaningroom, Dian Laila Putri Annisa Kamila Putri Annisa Kamila Putri, Valerinna Yogibuana Swastika Rahimah, Anna Fuji Rahma, Oktivani Adelathifa Rahmi, Koyuki Atifa Ramadhani, Risa Ratih Kusuma Wardani Ratna Pancasari Ratna Pancasari Renny Suwarniaty Rislan Faiz Muhammad Riswati, Harnanik Puji Riza, Mochamad Faishal Rizal , Ardian Rizal, Ardian Rochmawati, Icmi Dian Rohman, Ibrahim Abdur Salvatore Di Somma Sasmojo Widito Satrijo, Budi Seprian Widasmara Setiawan, Dion Setyasih Anjarwani Setyasih Anjarwani Setyasih, Anjarwani Setyowati, Danti Utami Suprayoga, Imam Mi'raj Suryanto Taufieq Ridlo Makhmud Taufiq Nur Budaya Teguh Aryanugraha Teguh Wahyu Sardjono Titi A W Tonny Adriyanto Tri Yudani MR Tsuraya, Alfi Veny Kurniawati Veny Kurniawati Wella Karolina Widito, Sasmojo Widodo Nashi Widodo Widodo Wikananda, Adhika Prastya Wira Kimahesa Anggoro Wira Kimahesa Anggoro Wiwit Nurwidyaningtyas, Wiwit Yoga Waranugraha Yoga Waranugraha Yoga Waranugraha Yogibuana, Valerinna Yoseph Budi Utomo Yusuf Arifin Zhao, Zihan