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All Journal Althea Medical Journal Jurnal Penelitian Hutan dan Konservasi Alam Al-Ahkam JITRO (Jurnal Ilmiah dan Teknologi Peternakan Tropis) Journal of Agromedicine and Medical Sciences Al-Ta'rib: Jurnal Ilmiah Program Studi Pendidikan Bahasa Arab IAIN Palangka Raya JURNAL ILMIAH INFORMATIKA JMM (Jurnal Masyarakat Mandiri) JURNAL PENDIDIKAN TAMBUSAI Jesya (Jurnal Ekonomi dan Ekonomi Syariah) Buletin Ilmiah Nagari Membangun Istinbath: Jurnal Hukum dan Ekonomi Islam Jurnal Ilmiah Administrasi Bisnis dan Inovasi Jurnal Administrasi dan Manajemen Jurnal Respirasi (JR) JIMF (JURNAL ILMIAH MANAJEMEN FORKAMMA) Jurnal Mnemonic JATI (Jurnal Mahasiswa Teknik Informatika) Journal of Telenursing (JOTING) Akubis: Jurnal Akuntansi dan Bisnis Buletin Poltanesa Zona Laut : Jurnal Inovasi Sains dan Teknologi Kelautan Journal of Educational Administration and Leadership (JEAL) Jurnal Aplikasi Pelayaran dan Kepelabuhanan Wewarah: Jurnal Pendidikan Multidisipliner Journal of Comprehensive Science JURNAL SAINS DAN TEKNOLOGI MARITIM Populer: Jurnal Penelitian Mahasiswa Jurnal Pelayanan dan Pengabdian Masyarakat Indonesia Ekalaya: Jurnal Pengabdian Kepada Masyarakat Indonesia Journal Community Service Consortium Jurnal Ilmiah Sistem Informasi FingeR: Journal of Elementary School Mindset : Jurnal Pemikiran Pendidikan dan Pembelajaran Pedagogi : Jurnal Pendidikan dan Pembelajaran Journal of Information Technology and Cyber Security Jurnal Indonesia Mengabdi Al I'tibar Jurnal Pendidikan Islam
Supangat Supangat
Medical Faculty University Of Jember
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Journal : Althea Medical Journal

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Subchronic Oral Exposure to Chlorpyrifos Decreases Butyrylcholinesterase in Wistar Rat Sakinah, Elly Nurus; Supangat, Supangat; Wisudanti, Desie Dwi; Abrori, Cholis; Mustika, Arifa; Wibsono, Sony; Athoillah, Nabil
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3133

Abstract

Background: Indonesia as an agricultural country has more than 33 million workers in the agriculture. Pesticides have an important role in agriculture because they function as powerful plant pest exterminators. However, its use is considered to cause various toxic effects, one of which is on the nervous system. This study aimed to evaluate the impact of pesticide exposure on cognitive impairment by assessing the butyrylcholinesterase biomarker in the blood of rats as experimental animals.Methods: This was a true experimental study conducted during September–November 2022 at the Pharmacology and Biochemistry Laboratory, Faculty of Medicine, University of Jember with a post-test only approach using Wistar rats which were divided into 1 control group and 4 treatment groups treated with chlorpyrifos 5 mg/kg orally. Serum butyrylcholinesterase enzyme levels were measured using the kinetic photometric method and then analyzed with a regression test in IBM SPSS® Statistics software.Results: The average value of butyrylcholinesterase was 920.23±145.27 (Control group); 904.48±91.6 (7 days after chlorpyrifos administration); 889.81±95.2 (14 days after chlorpyrifos administration); 457.84±69.5 (28 days after chlorpyrifos administration); 575.82±194.25 (56 days after chlorpyrifos administration). The results of the One-Way ANOVA test showed significant differences between groups as indicated by a significance test of 0.024 (p <0.05).Conclusions: There is a relationship between the duration of exposure to chlorpyrifos and butyrylcholinesterase levels in Wistar rats. This fact shows that the longer an organism is exposed to low doses of chlorpyrifos pesticides, the higher the level of neurological system toxicity that occurs in that organism.
Co-Authors Abdul Ghofur Ahmad Rosulana Ahmad Ulin Niam Akbar, M. Agung Al Munawir Aldri Frinaldi Alzitawi, Diaya Uddeen Deab Mahmoud Amir Tajrid Andika Saputra Angga Mardro Raharjo, Angga Mardro Anis Rahmawati Amna Annisa Annisa ansori ansori Arifa Mustika Aris Prasetyo Astri Ahmad, Wa Ode Athoillah, Nabil Azah Zumroh Baehaqi BJ Azmy As'ady Cholis Abrori, Cholis Cicih Komariah Dandi Dedy Mardiansyah Delastri , Lita Delastri, Ilta Desie Dwi Wisudanti Dwi Rohman Soleh, Dwi Rohman Dwisaraswati, Salma Aulia Dyah Pravitasari Dyah Pravitasari El Syam, Robingun Suyud Elly Nurus Sakinah, Elly Nurus ENNY SUSWATI Etty Nur Rahmawati Hairrudin Hairrudin HARJA, HARLINA Heri Triyanto, Heri Ida Srisurani Wiji Astuti Indey, Jennifer Florenzia Indey Ira Farazulika Jaelani, M Syahran Jamrizal, Jamrizal Januantoro, Ardy Jauhar Firdaus Jumanto Jumanto Justina Evy Tyaswati, Justina Evy Kasful Anwar Us, Kasful Anwar Khoiriyah, Ina Yatul Kristianningrum Dian Sofiana Kuncowati Kusumastuti, Inke Lailatul Fitriyah Laksmi Indreswari Listriyawati, Nyoman Marsudi, Sugeng Maulana Anwar Muhammad Rizki Afrizal Azhar Mukarromah, Laylatul Fitriyah Mukri, Anang Nelly Rustiati Ni Ketut Sujati Nor Kholidin NUR HASANAH Nurlita Dwi Oktavia Panji Kuncoro Hadi, Panji Kuncoro Pertiwi, Ratih Purnama Pralampita, Pulong Wijang Purnama Pertiwi, Ratih Raden Arfan Rifqiawan Raden Arfan Rifqiawan, Raden Arfan Rahmat, Indra Samudra Ratna Dewi, Tri Reny Ekawati Resti Septikasari Rismilda, Nela Aprilia Rochman, Mochamad Yovi Fatchur Rodin, Imam Rukmanah Rukmanah Rumastika, Nindya Shinta Rustiati, Nelly Sahidin . Samudra, Farel Rigel Sanad, Zakeya Saptia pratiwi, Mega septa surya wahyudi, septa surya Setiawan, Wahyu Danni Sheilla Rachmania, Sheilla Sholiq, M. Mudhafiq Siti Aisyah Sri Enggar Kencana Dewi Suhartono Suhartono Sukatin, Sukatin Sutaman, Sutaman Suwandi Suwandi Syaifullah, Firman Tri Ratna Dewi Ulum, M. Samsul Usman, Raihan Gymnastiar Usman Wibsono, Sony Widodo, Muhammad Rifqy Alvy Winarni, Dwi Putri Wiyono, S. Teguh yuliantoro, ahmad taufiq Zulkifli, Noor Fadzilah binti