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All Journal International Journal of Public Health Science (IJPHS) Sainteks JURNAL GIZI INDONESIA AGROTEKBIS Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Farmasi Sains dan Komunitas Jurnal Penelitian Pendidikan IPA (JPPIPA) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JPI Jurnal Kesehatan Komunitas JECCE (Journal of Early Childhood Care and Education) JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Diklat Review : Jurnal manajemen pendidikan dan pelatihan SCAFFOLDING: Jurnal Pendidikan Islam dan Multikulturalisme Jurnal Abdi Insani JURNAL AKUNTANSI Jurnal Wahana Pendidikan Jurnal Ilmiah Pharmacy Journal of Agri-Food Science and Technology (JAFoST) Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Journal of Halal Science and Research Jurnal Primagraha Jurnal Dedikasi untuk Negeri Pharmacy Genius JIMPI: Jurnal Inovatif Manajemen Pendidikan Islam Journal of Public Health and Pharmacy Jurnal Pengabdian Kompetitif Asian Journal of Social and Humanities
Nurkhasanah Nurkhasanah
Universitas Ahmad Dahlan
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Phytochemical Constituents and Pharmacological Effects of Baeckea Frutescens: A Review Abdul Wahid Suleman; Nurkhasanah Mahfudh; Nanik Sulistyani
Jurnal Penelitian Pendidikan IPA Vol 11 No 12 (2025): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i12.13476

Abstract

Baeckea frutescens is a medicinal species widely used in traditional practices and known for its rich phytochemical diversity, yet its pharmacological profile remains fragmented across multiple studies. This systematic review aims to integrate current evidence on the phytochemical constituents and pharmacological activities of B. frutescens, focusing on anti-inflammatory, antimicrobial, antioxidant, anticancer, wound-healing, and insecticidal effects. A literature evaluation was conducted using previously compiled research comprising 16 studies from China, Indonesia, Malaysia, and Southeast Asia, covering chemical isolation, essential oil analysis, in vitro assays, in vivo experiments, and computational approaches. The results indicate that B. frutescens contains meroterpenoids, phloroglucinol derivatives, flavonoids, phenolics, and terpenes that collectively contribute to significant modulation of NF-κB, MAPK, TLR4–MyD88, and COX-related pathways. Essential oils and polar extracts exhibit broad antimicrobial and antioxidant activities, while cytotoxic and wound-healing assays demonstrate promising therapeutic potential. Insecticidal studies further highlight ecological relevance through antifeedant and repellent properties. Overall, the review confirms B. frutescens as a pharmacologically versatile species with strong prospects for drug discovery and functional applications. However, further mechanistic and in vivo investigations are needed to strengthen its translational value.
Analisis Bibliometrik dan Penambangan Teks terhadap Penelitian Obat Herbal dengan Aktivitas Anti-Inflamasi Wawasan dari Data PubMed (2015–2025) Daipadli, Daipadli; Nurkhasanah, Nurkhasanah; Yuliani, Sapto
Pharmacogenius Journal Vol 5 No 1 (2026): Pharmacy Genius
Publisher : Yayasan Inspirasi El Burhani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/pharmgen.v5i1.921

Abstract

Pendahuluan: Inflamasi kronis yang tidak terkontrol berkontribusi signifikan terhadap patogenesis berbagai penyakit degeneratif, seperti artritis dan gangguan kardiovaskular. Meskipun efektif, penggunaan jangka panjang obat anti-inflamasi konvensional (NSAID dan kortikosteroid) sering menimbulkan efek samping serius, seperti iritasi gastrointestinal dan nefrotoksisitas. Obat herbal, dengan kandungan senyawa bioaktif seperti flavonoid dan terpenoid, menawarkan alternatif terapi yang menjanjikan dengan menekan mediator proinflamasi (TNF-α, IL-6, NF-κB) serta memodulasi stres oksidatif dengan profil keamanan yang lebih baik. Mengingat pesatnya pertumbuhan literatur di bidang ini, analisis bibliometrik diperlukan untuk memetakan arah penelitian global. Tujuan: Penelitian ini bertujuan untuk memvisualisasikan dan menginterpretasikan lanskap penelitian obat herbal terkait aktivitas anti-inflamasi menggunakan perangkat lunak VOSviewer, guna mengidentifikasi tren utama, evolusi topik, dan kesenjangan penelitian. Metode: Data bibliometrik dikumpulkan dari basis data PubMed dengan kata kunci “herbal medicine” AND “anti-inflammation” untuk periode publikasi tahun 2015 hingga 2025. Data diproses menggunakan VOSviewer versi 1.6.20 dengan metode full counting berdasarkan co-occurrence kata kunci, dengan ambang batas minimal kemunculan lima kali untuk menyaring istilah yang relevan. Hasil: Analisis memetakan lima klaster tematik utama: (1) suplementasi dan intervensi gaya hidup; (2) efikasi klinis pada pasien; (3) mekanisme molekuler dan penyakit modern (termasuk COVID-19); (4) jalur sitokin dan sinyal seluler; serta (5) formulasi sediaan lokal. Visualisasi overlay menunjukkan evolusi tren dari fokus awal pada biomarker klinis (seperti CRP) menuju pemahaman mekanisme molekuler yang lebih dalam dan imunomodulasi. Visualisasi densitas menegaskan bahwa topik seputar pasien dan pengobatan merupakan area riset yang paling padat. Kesimpulan: Terdapat peningkatan minat global terhadap pengembangan obat herbal sebagai agen anti-inflamasi yang bergerak dari studi empiris menuju validasi mekanistik molekuler dan integrasi klinis. Penelitian ini menyoroti potensi besar obat herbal sebagai terapi komplementer yang aman, sekaligus menekankan perlunya standardisasi dan uji klinis berkelanjutan.
Co-Authors A'Yun, Qurotul AA Sudharmawan, AA Abdul Rahman Wahid Abdul Wahid Suleman Ade Irawan Adiba, Thoriq Ahmad, Aunillah Albab, Farah Qistih Alif Muarifah Amalya Nurul Khairi Amini, Nurul Fajar Anisah, Retnani Anjani, Arlian Sherly Aprilia, Kartini Arie Kurniawan Aryastuti, Nurul Athifah Candra Dewi Ayu Shabrina Baroroh, Erli Carmel Meiden Chasanah, Hikmah Rochimatul Daipadli Daipadli Deni Firmansyah Dianingsig, Dianingsih Elya Zulfa, Elya Endang Wuryandini, Endang Farah Qistih Albab Fitrilya Mustikahati Yusuf, Fitrilya Mustikahati Flora Pasaru Hamzah Karim, Siti Aminah Harni, Harni Humaya, Humaya I Made Sudana Ika Dyah Kumalasari Ika Kumalasari Irawati, Riana Jailani, Muhammad Taufiq Bin Mohd Jayadinata, Asep Kurnia Jihad Lukis Panjawa Kariza, Alifia Ninda karmila karmila Kautsar, Akhmad Khairi, Amalya Nurul Laela Hayu Nurani Lengkong, Siti Nur Asyura Lola Angelita Lolita Sary Lovrina Rahmi Zulkarmen Mahdi, Lukman Maknun, Lu'lu'ul Meta Safitri Moch. Saiful Bachri Muhammad Amiruddin Muhammad Syakbani Murinto Murinto Nada, Rafa Nanik Sulistyani Neni Fidya Santi Nihayati, Nihayati Ningsih, Nur Cahyati Nofa Risma Azis Nugroho, Bondan Nur Ahmad, Nur Nuranisa, Nuranisa Nurul, Amalya Ofa Suzanti Betha Pramudianti, Ulfa Rahma Puri, Putri Ratna Rabiatul Adawiyah Rahman, Ika Ristia Ramadani, Cahya Ricke Desyratnaputri Rizka Indri Arfianti Rizky H. Mawardi Rostika, Rostika Sabrina Dahlizar Sapto Yuliani Saputri, Ginanjar Zukhruf Sepitriani, Sepitriani Siti Pandanwangi TW Siti Pandawangi TW Siti Sarifah Soedjono Soedjono Tokay, Anwar Tri Yanuarto Tri Yanuarto Utami, Zhazha Zetira W, Ratna Kurnia Wiwin Lismidiati Wulandari, Dita yesi budiarti, yesi Yuni Anggraeni Yunni Arnidha, Yunni Zuniarto, Ahmad Azrul