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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kesehatan Andalas Global Medical and Health Communication Biomedical Journal of Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Penelitian Pendidikan IPA (JPPIPA) Window of Health : Jurnal Kesehatan Majalah Kedokteran Andalas Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Majalah Kedokteran Neurosains Human Care Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ners Science Midwifery Nusantara Hasana Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Neurona
Yuliarni Syafrita
Department Of Neurology, Faculty Of Medicine, Universitas Andalas, Padang, Indonesia.
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Relationship of Serum Tau Levels with Cognitive Functions and Factors Affecting The Cognitive Function Decrease in Parkinson's Disease Patients Meldayeni Busra; Yuliarni Syafrita; Hendra Permana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i6.317

Abstract

Introduction: Cognitive impairment is a non-motor symptom of Parkinson's disease (PD) which occurs as the disease progresses and affects quality of life. Many efforts have been developed in early detection of cognitive disorders, one of which is the examination of tau protein biomarkers, where the tau protein that undergoes pathological changes to form neurofibrillary tangles (NFTs) is found in Alzheimer's disease and PD and plays a role in cognitive impairment. However, the role of tau in PD is still controversial. This study aims to assess the relationship between serum tau levels and cognitive function and the factors that affect cognitive function in PD patients. Methods: This cross-sectional design was conducted at the RSUP DR. M Djamil Padang. During the period March to August 2020, 62 research subjects were obtained. Cognitive function examination was carried out by using the MoCA-Ina test and examination of serum tau levels using the Elisa method. The relationship between categorical variables was tested by Chi square and differences in serum tau levels in the group with and without cognitive impairment were tested with the Mann Whitney test, considered statistically significant if the p value <0.05. Results: With Moca Ina examination, it was found that 67.7% of patients had impaired cognitive function. The mean serum tau level was 198.004 ± 162.69 ng / L.There was a significant relationship between education level and degree of disease with cognitive function (p <0.05) and there was no difference in mean serum tau levels between groups with and without cognitive impairment. Conclusion: There is a significant relationship between education level and degree of disease with cognitive function and there is no difference in mean serum tau protein levels between the cognitive impaired group and the cognitive normal group.
Analysis of Neuron Specific Enolase Serum Levels in Traumatic Brain Injury Yuliarni Syafrita; Nora Fitri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 4 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i4.413

Abstract

Background : Traumatic brain injury is still the main cause of death and disability in productive age. Assessment the level of consciousness and imaging examinations after a brain injury can not always describe the severity of damage in the brain, this is because the pathological process is still ongoing due to secondary brain injury. Therefore, it is necessary to examine biomarkers that can describe the severity of the pathological process that occurs. The purpose of this study was to assess serum neuron-specific enolase (NSE) levels and their relationship to the severity and outcome of a traumatic brain injury. Methods : A cross sectional design was conducted in the emergency department of DR M Djamil Hospital, Padang. There were 72 patients who met the inclusion criteria. A Glasgow Coma Scale examination was performed to assess the severity of brain injury and examination of NSE serum levels at 48 hours post- injury using ELISA technique and assess the Glasgow outcome scale (GOS) at 6 weeks post-injury. Data analysis using SPSS 22 program, the results are significance if the p value <0.05 Results : The average NSE level was higher in severe brain injuries than moderate and mild brain injuries and this difference was statistically significant (p<0.05). The NSE serum levels were higher in poor outcomes than in good outcomes and this difference was statistically significant (p<0.05). Conclusion : High NSE serum levels in the acute phase were associated with the severity of the brain injury and poor outcome 6 weeks after the brain injury.
FAKTOR YANG BERHUBUNGAN DENGAN DEPRESI PADA PASIEN PENYAKIT PARKINSON DI KOTA PADANG Reno Bestari; Yuliarni Syafrita
HUMAN CARE JOURNAL Vol 5, No 1 (2020): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v5i1.655

Abstract

Depresi merupakan gejala non-motor terbanyak pada pasien Parkinson yang sangat mempengaruhi kualitas hidup, namun pada praktek klinis sering terabaikan. Tujuan penelitian ini adalah untuk melihat angka kejadian depresi dan faktor apa saja yang berhubungan dengan depresi pada pasien penyakit Parkinson dengan menggunakan Montgomery Asberg Depression Rating Scale (MADRS). Desain penelitian adalah cross sectional. Penelitian dilakukan pada pasien penyakit Parkinson yang berobat ke Poliklinik RS Dr. M. Djamil dan beberapa rumah sakit di Kota Padang. Didapatkan 62 pasien penyakit Parkinson (56,5% laki-laki) dengan rentang usia 35-78 tahun. Berdasarkan kuisioner MADRS didapatkan 34 pasien (54,8%) mengalami depresi, dimana 24 pasien depresi ringan (71%) dan 10 pasien depresi sedang (29%). Depresi pada pasien penyakit Parkinson cukup tinggi, dimana lebih setengah dari pasien penyakit Parkinson dalam penelitian ini mengalami depresi.   
FAKTOR-FAKTOR YANG MEMPENGARUHI SUBTIPE GEJALA MOTORIK PENYAKIT PARKINSON Attiya Istarini; Yuliarni Syafrita; Restu Susanti
HUMAN CARE JOURNAL Vol 5, No 1 (2020): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v5i1.649

Abstract

Background: Parkinson's disease (PD) is a chronic neurodegenerative disease that manifests as movement disorders. Based on motor symptoms, PD is classified into subtypes of tremor and postural instability gait disorders (PIGD). The motor symptoms subtype is a predictor of disease progression, therapeutic response, and quality of life for Parkinson's patients. The purpose of this study is to identify some  factors that influence motor symptoms in Parkinson's disease.Methods: This research use cross sectional design. Samples were selected by consecutive sampling method that met the inclusion and exclusion criteria. Research subjects were 58 people. Statistical analysis using SPSS. p values <0.05 were considered statistically significant.Results: This research include 58 patients, 55.2% were men with range of age 63.5 ± 8.5 years old. The mean age at onset was 57.9 ± 9.5 years and duration of disease 6.1 ± 4.6 years. Motor symptoms 53.4% dominant tremor. There was a significant relationship between disease stage and motor symptom subtypes (p <0.001). There is no relationship between the patient's age, age at onset and duration of the disease with motor symptom subtypes.Conclusions: There is a relationship between disease stage and motor symptom. The patient's age, age at onset and duration of the disease are not related to the motor symptoms of Parkinson's patients.
FAKTOR-FAKTOR YANG MEMPENGARUHI FUNGSI KOGNITIF PADA PASIEN DIABETES MELITUS TIPE 2 Yaumi Faiza; Yuliarni Syafrita
HUMAN CARE JOURNAL Vol 5, No 1 (2020): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v5i1.654

Abstract

Background :The number of Dementia is increasing year by year, and it will be 3.980.000 in 2050 In Indonesia, as well as the world. Dementia can be triggered by Diabetes Mellitus type 2. Long hyperglycemia can induce beta amiloid in brain, that declines the cognitive function. Besides, some factors can influence cognitive function such as age, sex, level of education and duration of DM type 2. The aim of this study is to review the faktors that influence cognitive function of DM type 2.Methods: The study design was cross sectional, with 56 subjects.  The collective data were age, sex, level of education, duration of DM type 2,  and cognitive function which is determined by using MoCA Ina The variables associated were tested by using Chi-Square Test, and the association is significant if p<0,05.Results: From 56 research subjects,32 (57,14%) subjects are female,, high level of education is 76,79 %, and 57,14 % subjects are suffering from DM for 5-<10 years. The average MoCA Ina value was 23 + 3.47. There are 37 (66.1 %) subjects with cognitive decline. There is no significant associations between age, sex,level of education, duration of DM and cognitive function (p>0,05).
HUBUNGAN LAMA MENDERITA DM TIPE 2 DENGAN KEJADIAN NEUROPATI DIABETIK Afriyeni Sri Rahmi; Yuliarni Syafrita; Restu Susanti
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 10 No. 1 (2022): Jambi Medical Journal: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (336.661 KB) | DOI: 10.22437/jmj.v10i1.18244

Abstract

Latar belakang: Neuropati diabetik merupakan salah satu komplikasi yang sering muncul pada pasien Diabetes Melitus Tipe 2 (DMT2), diperkirakan setengah dari penderita DM mengalami komplikasi neuropati. Neuropati diabetik (ND) didefinisikan sebagai tanda dan gejala disfungsi saraf perifer pada pasien DM setelah mengesampingkan penyebab lain. Studi menunjukkan bahwa prevalensi ND adalah 8% pada pasien DM yang baru terdiagnosis dan lebih tinggi ditemukan pada pasien yang sudah lama menderita DM yaitu 50%. Tujuan: Tujuan penelitian ini mengetahui hubungan antara waktu menderita DMT2 dengan angka kejadian neuropati diabetik. Metode: Penelitian ini merupakan penelitian analitik observasional dengan desain cross-sectional pada pasien DMT2 di Poliklinik Penyakit Dalam dan Neurologi RSUP Dr. M. Djamil Padang dari bulan November 2021 sampai Maret 2022. Pengambilan sampel dilakukan dengan metode konsekutif sampling. Hasil: Total responden pada penelitian ini berjumlah 44 orang berdasarkan kriteria inklusi dan eksklusi. Sebagian besar pasien DMT2 yang menderita neuropati diabetik rata-rata menderita DM ≥ 5 tahun (92.1%). Analisis statistik Chi-square mendapatkan p value = 0.003 (<0.05) yaitu terdapatnya hubungan yang signifikan antara waktu menderita DMT2 dengan angka kejadian neuropati diabetik. Simpulan: Berdasarkan analisis data disimpulkan bahwa terdapat hubungan antara waktu menderita DMT2 dengan angka kejadian neuropati diabetik. Keyword: DM tipe 2,waktu menderita, Neuropati Diabetik
Hubungan Kadar Magnesium Serum Dan Hba1c dengan Severitas Neuropati Diabetik Andi Fadilah Yusran; Yuliarni Syafrita; Hendra Permana
Jurnal Ilmu Kedokteran Vol 16, No 1 (2022): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v16i1.2022.22-29

Abstract

Low magnesium levels are known to be associated with increased risk of diabetes mellitus and its complications. In addition, HbA1c levels are also known to have a correlation with further diabetes complications such as diabetic neuropathy. Diabetic neuropathy is the most common microvascular complication in diabetes mellitus, whose incidence is associated with disability and mortality rates in diabetic patients. This study aimed to assess the correlation between serum magnesium levels and HbA1c with the severity of diabetic neuropathy. This was a cross-sectional study. Severity of diabetic neuropathy is classified according to the Baba's Diabetic Neuropathy Classification (BDC). All subjects were examined for serum magnesium and HbA1C levels. This study consisted of 46 diabetes mellitus subjects, with 69.6% of the subjects suffering from diabetic neuropathy. The average magnesium level in this study was 1.87 mg/dl ± 0.245 and the median HbA1c level was 8.6 %. There was no significant correlation between serum magnesium levels and HbA1c with the incidence and severity of diabetic neuropathy (p>0.05). However, there was a significant negative correlation between magnesium levels and HbA1c levels in diabetic neuropathy patients.
Gambaran Gangguan Tidur pada Pasien Pasca Stroke Iskemik Alya Ramadhini; Yuliarni Syafrita; Russilawati Russilawati
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 3 (2020): November 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1276.117 KB) | DOI: 10.25077/jikesi.v1i3.75

Abstract

Background : Sleep disorder is common to be the complication in stroke patients and can be a risk factor for stroke. Sleep disorder in stroke patients decrease the quality of life. Objective : The purpose of this study was to find out the prevalence of sleep disorders in a post-ischemic stroke patient and the association between sleep disorders and stroke risk factors. Methods: A cross-sectional study was conducted on post-ischemic stroke at the neurology outpatient clinic of Ibnu Sina Islamic Hospital Padang. Information about stroke risk factors is obtained through patient data and guided questionnaires. Types of sleep disorders were assessed through the 2005 Specialized Center of Research Sleep Questionnaire. Results: We found out there were 57 post-ischemic stroke patients, in which 37 post-ischemic stroke patients (64.9%) had sleep disorder incidences, such as apnea, restless legs syndrome, insomnia, and narcolepsy (38.6%, 36.8%, 35.1%, and 15.8%; respectively). There was an association between age and insomnia (p = 0.034,CI = 95%). On the other hand, there was no association between other risk factors (gender, diabetes mellitus, dyslipidemia, heart disease, obesity, smoking, and alcohol consumption) and insomnia, apnea, narcolepsy, and restless legs syndrome. Conclusions : The conclusion of this study was more than half post-ischemic stroke patients have sleep disorder with the most common were apnea. There was an association between age and insomnia. Keywords: sleep disorder, apnea, ischemic stroke
Hubungan Usia Penderita Stroke Iskemik dengan Kadar Beta-amyloid Plasma Yuliarni Syafrita
Cermin Dunia Kedokteran Vol 42, No 10 (2015): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v42i10.954

Abstract

Latar Belakang: Ketidakseimbangan antara produksi, pemecahan, dan clearance beta-amyloid (Aβ) merupakan proses patofisiologi awal penumpukan beta-amyloid di jaringan otak. Tujuan penelitian ini adalah melihat hubungan antara usia dan kejadian stroke iskemik terhadap kadar beta-amyloid plasma. Metode: Penelitian cross-sectional bersifat observasional, membandingkan kadar beta-amyloid plasma di kelompok usia muda, usia lanjut sehat, dan usia lanjut yang mengalami stroke iskemik. Hasil: Kadar Aβ40 plasma pada usia muda lebih tinggi dibandingkan pada usia lanjut sehat (p=0,011). Kadar Aβ40 pada usia lanjut sehat lebih tinggi dibandingkan pada usia lanjut yang mengalami stroke (p<0,001). Kadar Aβ42 plasma pada usia muda lebih tinggi dibandingkan pada usia lanjut sehat (p=0,002). Kadar Aβ42 pada usia lanjut yang mengalami stroke jauh lebih tinggi dibandingkan pada usia lanjut sehat (p<0,001). Simpulan: Kadar Aβ40 dan Aβ42 plasma pada usia muda lebih tinggi dibandingkan pada usia lanjut sehat. Pada pasien usia lanjut dengan stroke iskemik usia lanjut, kadar Aβ40 plasma lebih rendah dan kadar Aβ42 plasma lebih tinggi dibandingkan pada usia lanjut sehat.Background: The imbalance of production, degradation, and clearance of beta-amyloid is an early pathophysiological process responsible for the accumulation of beta-amyloid in the brain tissue. The purpose of this study is to find out the association between age and events of ischemic stroke, and plasma beta-amyloid. Methods: Observational cross-sectional study to compare beta-amyloid plasma levels among younger age, healthy elderly, and the elderly suffering from ischemic stroke. Results: The plasma level of Aβ40 in the younger age is significantly higher than in the healthy elderly (p=0.011). The plasma level Aβ40 in the healthy elderly is significantly higher than in the post ischemic stroke elderly (p <0.001). The plasma level of Aβ42 in younger age is higher than in the healthy elderly (p=0.002). The plasma level of Aβ42 in the elderly who experienced stroke is higher than in the healthy elderly (p<0.001). Conclusion: The plasma level Aβ40 and Aβ42 are higher in younger age compared to the healthy elderly. In the elderly with ischemic stroke, the plasma level of Aβ40 was lower and level of Aβ42 was higher compared to the healthy elderly.
Differences in Anxiety Levels of Menopausal Women Before and After Given Psychoeducation and Relaxation Fitra Ermila Basri; Yuliarni Syafrita; Yantri Maputra
Science Midwifery Vol 9 No 2 (2021): April: Science Midwifery
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Menopause is a transitional period in a woman's life that shows that the ovaries have stopped producing eggs, menstrual activity decreases and finally stops.. One of the treatments for this complaint is non-pharmacological therapy, namely psychoeducation and relaxation. The research objective was to determine the differences in the anxiety levels of menopausal women before and after psychoeducation and relaxation. This research is a quasy experiment with one group pretest and posttest design. The research was conducted at the Elderly Posyandu in the working area of ​​the Dadok Tunggul Hitam Community Health Center to 54 menopausal women who were divided into a treatment group and a control group. The results showed that most respondents in the treatment and control groups prior to psychoeducation and relaxation were in the mild anxiety level category. After doing psychoeducation and relaxation, there was a decrease in anxiety levels in the treatment group.Based on the t test, the p-value is less than 0.05, it can be concluded that there are differences in the level of anxiety in menopausal women before and after psychoeducation and relaxation. (p =0.001). The conclusion of this study is that there are differences in the decrease in anxiety levels after psychoeducation and relaxation.
Co-Authors Adang Bachtiar Afriyeni Sri Rahmi Alya Ramadhini Andi Fadilah Yusran Andy, Marfri Anggi Anugerah Basir ATTIYA ISTARINI Basjiruddin Ahmad Cintya Agreayu Dinata Darwin Amir Darwin Amir Darwin Amir, Darwin Dedi Sutia Dhiang Mulia Syofiadi Djong Hon Tjong Dwi Sri Rejeki Dwitya Elvira, Dwitya Elsi Rahmadhani Hardi Elvia Fataya Ennesta Asri Erdanela Setiawati Eva Chundrayetti Eva Decroli Fadel Muhammad Fadrian, Fadrian Fanny Adhy Putri Fitra Ermila Basri Gunawan Septa Dinata Haiga, Yuri Harun Harnavi Hauda El Rasyid Hendra Permana Husni Minanda Fikri Indra, Syarif Iqbal Al Rasyid Isnu Lucky Riandini Istiqomah Jabbar, Ridho Ahmad Karina Prasasti Helhid Kurniawan, Yoga Setia Lydia Susanti Lydia Susanti Lydia Susanti Lydia Susanti M Hasan Machfoed Marfri Andy Marliana, Lesti Meldayeni Busra Mubarak, M. Dzaky Muhammad Farhan Khadaffi Mustafa Noer Nela Novita Sari Netti Suharti Nora Fitri Nora Fitri Novi Yudia Nur Indrawati Lipoeto Nur Indrawaty Lipoeto Nurhayati Nurhayati Nurvalinda, Nurvalinda Pitra, Dian Ayu Hamama Putri, Fanny Adhy Rahmi Ulfa Rahmi Ulfa Rasyid, Hauda El Ratna D Siregar Rauza Sukma Rita Reno Bestari Reno Bestari Reno Bestari Restu Susanti Rika Susanti Rika Susanti Rini Gusya Liza, Rini Gusya Rizanda Machmud Rizki Muhammad Rananda RR. Ella Evrita Hestiandari Russilawati, Russilawati Salmiah Agus Susila Sastri Susila Sastri Sutia, Dedi Syahrul, Muhammad Zulfadli Syarif Indra Syarif Indra Syarif Indra Trya Mia Intani Widia Rahmawati Yantri Maputra Yanwirasti Yanwirasti Yaumi Faiza Yoga Setia Kurniawan Yulia Trisna