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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kesehatan Andalas Global Medical and Health Communication Biomedical Journal of Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Penelitian Pendidikan IPA (JPPIPA) Window of Health : Jurnal Kesehatan Majalah Kedokteran Andalas Majalah Patologi Indonesia Majalah Kedokteran Neurosains Human Care Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ners Science Midwifery Nusantara Hasana Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Journal of Pharmaceutical and Sciences. Neurona Jurnal Sains, Teknologi dan Kesehatan Jurnal Ilmu Psikologi dan Kesehatan Indonesian Journal of Global Health Research
Yuliarni Syafrita
Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Hubungan Kadar Protein S100B Serum dengan Volume Perdarahan dan Tingkat Keparahan Pasien Perdarahan Intraserebral Spontan Fadrian Herjunio; Syarif Indra; Restu Susanti; Yuliarni Syafrita; Dedi Sutia; Reno Bestari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1662

Abstract

Spontaneous intracerebral hemorrhage is a hemorrhagic stroke with high mortality and morbidity rates. Hemorrhage volume and the degree of neurological severity are important factors influencing prognosis. Brain tissue damage due to hemorrhage triggers the release of biomarkers such as S100B protein, which is secreted by astrocytes. This study aims to determine the relationship between serum S100B protein levels and the volume of bleeding and severity in patients with spontaneous intracerebral hemorrhage. This observational, analytical, cross-sectional study was conducted on 47 patients with primary spontaneous intracerebral hemorrhage aged ≥18 years with onset within 0–24 hours, admitted to Dr. M. Djamil Padang General Hospital between August 2025 and February 2026 and confirmed by head CT scan. Serum S100B protein levels were measured using an enzyme-linked immunosorbent assay (ELISA), hemorrhage volume was assessed using the Broderick method, and severity was assessed using the NIHSS score. Statistical analysis used the Mann-Whitney and Kruskal-Wallis tests. A total of 30 patients (63.8%) had a bleeding volume <30 cc and 27 patients (57.4%) had moderate neurological deficits. The median serum S100B protein level was 0.049 µg/L. There was a significant median difference between serum S100B protein levels and hemorrhage volume (p=0.047), but not with clinical severity based on the NIHSS (p=0.173). Serum S100B protein levels differed significantly between the small and large hemorrhage volume groups, but not across clinical severity groups based on the NIHSS.
Co-Authors Abdul Razak Adang Bachtiar Adila, Qanita Afriyeni Sri Rahmi Ahmad, Baihaqi Alya Ramadhini Amel Yanis Andi Fadilah Yusran Andy, Marfri Anggi Anugerah Basir ATTIYA ISTARINI Basjiruddin Ahmad Cintya Agreayu Dinata Darwin Amir Darwin Amir Darwin Amir, Darwin Dhiang Mulia Syofiadi Dicky Lesmana Djong Hon Tjong Dwi Sri Rejeki Dwitya Elvira Dwitya Elvira, Dwitya Effy Huriyati Elsi Rahmadhani Hardi Elvia Fataya Ennesta Asri Erdanela Setiawati Eva Chundrayetti Eva Decroli Fadel Muhammad Fadrian Herjunio Fadrian, Fadrian Fanny Adhy Putri Fanny Adhy Putri Fanny Adhy Putri Fitra Ermila Basri Gunawan Septa Dinata Gunawan Septa Dinata Haiga, Yuri Harun Harnavi Hauda El Rasyid Hendra Permana Hendra Permana Hendra Permana Husni Minanda Fikri Iffah Dzakiyyah Ifmi Ilmiawati, Ilmiawati Indra, Syarif Iqbal Al Rasyid Istiqomah Karina Prasasti Helhid Kurniawan, Yoga Setia Lesti Marliana Lydia Susanti, Lydia M Hasan Machfoed Marfri Andy Mayetti Akmal Meldayeni Busra Mubarak, M. Dzaky Muhammad Farhan Khadaffi Mustafa Noer Nela Novita Sari Netti Suharti Nora Fitri Nora Fitri Novi Yudia Novia Riza Lestari Nur Indrawati Lipoeto Nur Indrawaty Lipoeto Nurhayati Nurhayati Nurvalinda Nurvalinda Pitra, Dian Ayu Hamama Rahmatini . Rahmi Ulfa Rasyid, Hauda El Ratna D Siregar Rauza Sukma Rita Reno Bestari Reno Bestari Reno Bestari Reno Bestari Restu Susanti Ridho Ahmad Jabbar Rika Susanti Rika Susanti Rince Restiviona Rini Gusya Liza, Rini Gusya Rizanda Machmud Rizki Muhammad Rananda RR. Ella Evrita Hestiandari Russilawati, Russilawati Sahputra, Roni Eka Salmiah Agus Sonia Hardianti Sukri Rahman Susila Sastri Susila Sastri Sutia, Dedi Syahrul, Muhammad Zulfadli Syandrez Prima Putra Syarif Indra Syarif Indra Syarif Indra Syarif Indra Syarif Indra Trya Mia Intani Widia Rahmawati Yantri Maputra Yanwirasti Yanwirasti Yaumi Faiza Yoga Setia Kurniawan Yulia Trisna Zahra Zafira