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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kesehatan Andalas Global Medical and Health Communication Biomedical Journal of Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Penelitian Pendidikan IPA (JPPIPA) Window of Health : Jurnal Kesehatan Majalah Kedokteran Andalas Majalah Patologi Indonesia Majalah Kedokteran Neurosains Human Care Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ners Science Midwifery Nusantara Hasana Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Journal of Pharmaceutical and Sciences. Neurona Jurnal Sains, Teknologi dan Kesehatan Jurnal Ilmu Psikologi dan Kesehatan Indonesian Journal of Global Health Research
Yuliarni Syafrita
Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Association between Serum Alpha-Synuclein Levels and Parkinson's Disease Stage Yuliarni Syafrita; Restu Susanti
Global Medical & Health Communication (GMHC) Vol 10, No 2 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (81.728 KB) | DOI: 10.29313/gmhc.v10i2.9271

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's. It is chronically progressive with the main symptoms of resting tremor, rigidity, bradykinesia, and postural disturbances. Lewy's body and Lewy's neurite are the main findings in brain biopsies of patients with PD. The main component is alpha-synuclein, a misfolding protein that plays an essential role in the pathogenesis of PD. This study aims to determine the association between serum alpha-synuclein levels during the PD stage and compare the levels between PD patients and healthy populations of the same age. A case-control study was conducted on 62 people with PD and 20 normal subjects as controls in the outpatient Department of Neurology of Dr. M. Djamil General Hospital and Ibnu Sina Islamic Hospital, Padang, from March to September 2020. The ELISA method examined serum alpha-synuclein examination, and the PD stage was assessed according to Hoehn and Yahr stages. The differences in alpha-synuclein levels between cases and controls and between stages of PD were analyzed by the Mann-Whitney test. Alpha-synuclein levels in PD patients were higher than in controls, and this difference was statistically significant (p<0.05). On the other hand, alpha-synuclein levels were higher in the severe stage than in the mild stage but not statistically significant (p>0.05). In conclusion, there was no association between alpha-synuclein levels and the stage of Parkinson's disease. Still, serum alpha-synuclein levels in PD patients were significantly higher than in the healthy population.
Serum Vitamin D Levels Related to Cognitive Function in Chronic Kidney Disease Patients Elsi Rahmadhani Hardi; Yuliarni Syafrita; Syarif Indra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.640

Abstract

Background: Vitamin D acts as a neuroprotector and modulator in the central nervous system. Hypovitaminosis is a risk factor for cognitive dysfunction. Hypovitaminosis D and impaired cognitive function are common in patients with chronic kidney disease. Impaired cognitive function is comorbid that can increase the morbidity and mortality of patients with chronic kidney disease. This study aims to assess the relationship between serum vitamin D levels and cognitive function in patients with chronic kidney disease. Methods: This research is an observational study with a cross-sectional approach. A total of 60 research subjects participated in this study. Sociodemographic data, cognitive function, and vitamin D levels were analyzed in this study. Data analysis was performed with SPSS 25 to perform univariate and bivariate tests. Results: The impaired cognitive function was found in 56.7% of CKD patients. The median serum vitamin D level of patients with chronic kidney disease with impaired cognitive function was 30.80 ng/mL and without impaired cognitive function 42.98 ng/mL. There was a significant relationship between serum vitamin D levels and impaired cognitive function (OR=4.125, p=0.035). The cut-off point of serum vitamin D levels associated with impaired cognitive function in CKD patients was 34.8 ng/mL (sensitivity 64.7% and specificity 69.2%). Conclusion:There is a significant relationship between serum vitamin D levels and the incidence of cognitive dysfunction in patients with chronic kidney disease. The cut-off point for serum vitamin D levels associated with impaired cognitive function in chronic kidney disease is 34.8 ng/mL.
Relationship of Parathyroid Hormone Levels with Uremic Neuropathy in Chronic Kidney Disease Patients Rizki Muhammad Rananda; Yuliarni Syafrita; Restu Susanti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.697

Abstract

Background: Parathyroid hormone is known as one of the main uremic toxicants, which, if the amount increases in plasma, will affect motor conduction in patients with chronic kidney disease. This study aims to determine the relationship between Parathyroid hormone levels with uremic neuropathy in patients with chronic kidney disease. Methods: This study was an analytic observational study with a cross-sectional approach, where as many as 42 subjects participated in this study. Data analysis was performed using SPSS using univariate and bivariate, with p<0.05. Results: There was a difference in the average thyroid hormone levels in neuropathy and without neuropathy, but statistically, it was not different p>0.05. Conclusion: There is no relationship between parathyroid hormone and uremic neuropathy in patients with chronic kidney disease.
Development of the Erdanela model for stroke prevention in the elderly: Effectiveness Test Erdanela Setiawati; Nur Indrawaty Lipoeto; Yuliarni Syafrita; Adang Bachtiar
Jurnal Penelitian Pendidikan IPA Vol 8 No 5 (2022): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v8i5.2507

Abstract

A new stroke-prevention service (ERDANELA model) has been developed at nursing homes by empowering elderly caregivers to become service-implementing cadres. The aim of this study is to investigate the effect of empowerment on the knowledge, attitude, skill, and behavior of elderly caregivers about stroke-prevention services in nursing homes. A quasi-experimental study was conducted on 52 elderly caregivers who were working at 3 nursing homes in West Sumatra Province, Indonesia. The questionnaire design consists of knowledge, attitudes, skills, and behavior variables. Intervention in the form of training was carried out for three days, using pre-test and post-test methods. The results of this research are the majority of caregivers are 40-49 years old (34.60%), male (51.9%), have middle school education (48.10%), have monthly income bigger than the RMW (75.00%), worked in nursing home>5 years (67.30%), and never attended training while working at nursing-home (73,10%). Caregivers knowledge, attitude, skill, and behavior mean was 18.23±1.89, 7.65±1.22, 6.75±1.37 and 6.00±0,91 respectively before training, and significantly it has increased to 25.48±3.38, 10.15±.09, 9.10±0.96, and 7.06±1.43 respectively after training with sig=0.000<0.05. Empowerment has succeeded in increasing the knowledge, attitudes, skills, and behaviors of elderly caregivers to become service-implementing cadres of the new stroke-prevention service at nursing homes
The Relationship between Serum Cystatin-C Levels and Impaired Cognitive Function in Patients with Chronic Kidney Disease Anggi Anugerah Basir; Yuliarni Syafrita; Syarif Indra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.777

Abstract

Background: Cystatin-C acts as a neuroprotector in the central nervous system at normal levels, but high serum cystatin-C levels are associated with impaired cognitive function. Serum cystatin-C levels increase in impaired renal function, and cognitive impairment are comorbidities that can increase the morbidity and mortality of chronic kidney disease patients. This study aimed to assess the relationship between serum cystatin-C levels and cognitive function in chronic kidney disease patients. Methods: This study used a cross-sectional design with 73 samples of non-hemodialysis chronic kidney disease patients. Cognitive function was assessed using the MoCa-Ina. Serum cystatin-C levels of all samples were measured by the ELISA method. Data analysis was carried out using SPSS. Results: Impaired cognitive function in CKD patients was found to be 76.7%. The median serum cystatin-C level of CKD patients with impaired cognitive function (n=56) was 1.015 mg/dL, and without cognitive impairment (n=17) was 0.929 mg/dL. There was no significant relationship between serum cystatin-C levels (cut-off point 0.98 mg/dL) and impaired cognitive function (OR : 2.05, 95% CI : 0.680-6.175, p= 0.198). Conclusion: There is no relationship between serum cystatin-C levels and cognitive function impairment in non-hemodialysis chronic kidney disease patients.
The Relationship between Dickkopf-Related Protein-1 (DKK-1) Plasma Levels and Impaired Cognitive Function in HIV Patients Yulia Trisna; Yuliarni Syafrita; Restu Susanti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.780

Abstract

Background: Dickkopf-related protein – 1 (DKK-1) is an antagonist protein to the Wingless (Wnt)-β catenin signal. Dysregulation of Wnt-β catenin signaling by DKK-1 causes disruption of neuronal synapses, which can result in impaired cognitive function. Impaired cognitive function in people with HIV or HIV-associated neurocognitive disorder (HAND) is a spectrum of cognitive disorders related to HIV neuroinvasion and neuroinflammation, which significantly results in impaired cognitive function and daily activity. This study aimed to assess the relationship between plasma DKK-1 levels and impaired cognitive function in HIV patients. Methods: This study used a cross-sectional design, consisting of 84 HIV sufferers who went to the voluntary counseling and testing (VCT) polyclinic at Dr. M. Djamil General Hospital, Padang, Indonesia, in the period December 2022 - March 2023, who met the inclusion and exclusion criteria. Cognitive function was assessed using the Montreal Cognitive Assessment Indonesian version (MoCa-Ina), and daily activity function using the instrumental activity of daily living (IADL) examination. Plasma DKK-1 levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Results: The mean plasma DKK-1 level of HIV sufferers was 358.4 (+ 157.6) pg/mL. ANI type disorder was found in 78.6%, MND in 21.4%, and no HAD type. There was a significant relationship between plasma DKK-1 levels and impaired cognitive function in HIV patients (OR = 2.82, CI95% = 1.128-7.043, p = 0.025), but there was no significant difference in plasma DKK-1 levels between types of cognitive impairment ANI and MND (p = 0.858). Conclusion: Plasma DKK-1 levels are significantly associated with impaired cognitive function in HIV patients.
Characteristics of Adult Sepsis Patients Admitted to Department of Internal Medicine, Dr. M. Djamil General Hospital, Padang, Indonesia Elvia Fataya; Fadrian; Mustafa Noer; Dwitya Elvira; Yuliarni Syafrita; Netti Suharti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 3 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i3.791

Abstract

Background: Sepsis is a life-threatening organ dysfunction resulting from a dysregulated host response to infection. Septic shock is the most dangerous complication of sepsis, characterized by abnormalities in the circulatory and metabolic systems. This study aimed to determine the characteristics of adult sepsis patients admitted to the department of internal medicine of Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This research was a descriptive study and used secondary data from medical records. Samples in this study were medical record data from the medical record installation of Dr. M. Djamil General Hospital, Padang, Indonesia. The inclusion criteria were adult patients aged more than 18 years old, diagnosed with sepsis, and hospitalized in the department of internal medicine for the period of January 2020 to December 2021. Results: Most of the sepsis patients were mostly aged more than 60 years old (51.7%), female (57.2%), and had normal BMI scores (59.3%). The infections mainly originated from the lungs (80%), the most common comorbid disease was chronic kidney disease (26.4%), the most frequent causing microorganism was Escherichia coli (15.9%), the frequent degree of severity was a septic shock (60%), and cefepime was used as the initial empirical antibiotic (44.8%). Conclusion: Most sepsis patients were adults aged more than 60 years old and females, with the focus on infection originating from the lungs, degree of severity in the form of septic shock, and the most used initial empirical antibiotic, namely cefepime.
ASSOCIATION BETWEEN SPESIFIC ENOLASE SERUM LEVELS AND OUTCOME ACUTE ISCHEMIC STROKE ONSET 1-MONTH Yuri Haiga; Darwin Amir; Yuliarni Syafrita
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 25 No. 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1377

Abstract

Pendahuluan: Stroke adalah masalah kesehatan global, karena penyebab kematian kedua dan kecacatan utama pada hampir seluruh negara di dunia. Penyakit ini memiliki dampak yang besar terhadap penderita, lingkungan sosial dan beban ekonomi. Sehingga diperlukan penanda spesifik yang berperan dalam menegakkan diagnosis, penentuan faktor risiko, serta tingkat keparahan stroke iskemik. Salah satu penanda yang diteliti adalah kadar NSE serum, yang diperkirakan dapat menggambarkan beratnya kerusakan otak pada pasien stroke.Metode: Penelitian ini menggunakan metode Cross sectional study pada 77 pasien stroke iskemik , dilaksanakan mulai Juli 2016 sampai Agustus 2017, di ruang rawat inap di Bagian Penyakit Saraf RS. DR. M. Djamil Padang. Setiap pasien dilakukan pemeriksaan kadar NSE serum dan  penilaian skor mRS pada bulan-1 setelah onset stroke iskemik. Dan dilakukan uji Spearmen untuk menilai korelasi antara dua variabel. Nilai p <0.05 dianggap signifikan secara statistikHasil: Berdasarkan jenis kelamin didapatkan laki-laki 42 orang (54.54%).  Median  usia 58.21 (16-88). Median kadar NSE  5.94 ( 2.77-36.75) µg/L. Skor  mRS onset bulan-1 dengan  median 3 (1-6). Terdapat hubungan antara kadar serum NSE dengan fungsi luaran stroke iskemik onset bulan-1 (r = 0.286, p value= 0.012, R2= +8.2%)Diskusi: Terdapat hubungan antara kadar serum NSE dengan fungsi luaran stroke iskemik onset bulan-1.Kesimpulan: Terdapat hubungan antara kadar serum NSE dengan fungsi luaran stroke iskemik onset bulan-1.
Perbedaan Kadar NSE Berdasarkan Derajat Perlukaan Menurut Aspek Medikolegal Pada Korban Trauma Kepala di IGD RSUP Dr. M. Djamil Padang Rika Susanti; Muhammad Farhan Khadaffi; Yuliarni Syafrita
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 3 (2023): September 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i3.1174

Abstract

Latar Belakang: Cedera otak traumatis (TBI) adalah penyebab utama kematian, terutama disebabkan oleh jatuh, kekerasan, dan kecelakaan lalu lintas. Dalam kasus kekerasan dan kecelakaan lalu lintas, polisi seringkali meminta visum et repertum, sebuah laporan tertulis yang menjelaskan luka korban dan diklasifikasikan menjadi tiga derajat luka. Namun, pemeriksaan ini kadang-kadang tidak akurat karena hanya melibatkan luka fisik yang terlihat. Oleh karena itu, pemeriksaan lebih lanjut diperlukan, seperti pemeriksaan biomarker, seperti neuron specific enolase (NSE) Objektif: Penelitian ini bertujuan mengetahui perbedaan kadar NSE berdasarkan derajat perlukaan pada korban trauma kepala. Metode: Ini adalah studi potong-lintang, dimana kadar NSE dinilai dengan Teknik ELISA, pada kunjungan korban trauma kepala di IGD. Derajat perlukaan diperoleh melalui catatan visum et repertum korban yang disimpan di bagian forensik dan medikolegal. Analisis bivariat dilakukan untuk mengetahui perbedaan kadar NSE berdasarkan derajat perlukaan. Hasil: Sebagian besar subjek penelitian adalah laki-laki (76,2%) dengan kelompok usia terbanyak di umur 12-45 tahun. Kadar NSE pada korban trauma kepala dengan derajat tiga lebih tinggi daripada korban trauma kepala dengan derajat dua. Tidak terdapat perbedaan yang signifikan kadar NSE pada korban trauma kepala dengan derajat dua atau tiga (p=0.642). Kesimpulan: Tidak ada perbedaan yang signifikan pada kadar NSE berdasarkan derajat perlukaan.
The Relationship between Plasma Glutamate Levels and Sleep Quality in HIV Patients Dhiang Mulia Syofiadi; Yuliarni Syafrita; Lydia Susanti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 11 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i11.884

Abstract

Background: Disturbance sleep quality is often found in sufferers of human immunodeficiency virus (HIV). Disturbed sleep quality can affect immunity, which ultimately can increase patient morbidity and mortality. Impaired sleep quality in HIV sufferers is related to neurotoxicity due to the HIV virus, which damages sleep architecture. HIV infection can cause an increase in brain extracellular glutamate. Elevated glutamate plays a role in neuronal and glial damage and death. This study aimed to assess the relationship between plasma glutamate levels and sleep quality in HIV sufferers. Methods: The research uses a cross-sectional design. The samples were HIV sufferers in a polyclinic voluntary counseling test (VCT) internal medicine of Dr. M. Djamil General Hospital Padang, who met the inclusion and exclusion criteria. Samples are selected by consecutive methods. Sleep quality was assessed using a questionnaire called the Pittsburgh sleep quality index (PSQI). Plasma glutamate levels were measured using the ELISA method. Statistical analysis using SPSS with a p-value <0.05 was considered statistically significant. Results: The research sample consisted of 82 people. The median plasma glutamate level was 16.39 µg/mL. Impaired sleep quality was found in 45 (54.9%) HIV sufferers. There was no significant relationship between plasma glutamate levels (p= 0.506), age (p=0.795), gender (p=0.547), education (p=0.358), occupation (p=0.255), disease duration (p=0.348), stage (p=0.309) and type of ARV therapy (p=0.791) with sleep quality in HIV sufferers. From this research, a significant relationship was found between sleep quality, body mass index (BMI) (p= 0.015), and marital status (p= 0.039). Conclusion: There is no relationship between plasma glutamate levels and sleep quality in HIV sufferers. There are other factors that influence sleep quality, namely BMI and marital status.
Co-Authors Abdul Razak Adang Bachtiar Adila, Qanita Afriyeni Sri Rahmi Ahmad, Baihaqi Alya Ramadhini Amel Yanis Andi Fadilah Yusran Andy, Marfri Anggi Anugerah Basir ATTIYA ISTARINI Basjiruddin Ahmad Cintya Agreayu Dinata Darwin Amir Darwin Amir Darwin Amir, Darwin Dhiang Mulia Syofiadi Dicky Lesmana Djong Hon Tjong Dwi Sri Rejeki Dwitya Elvira Dwitya Elvira, Dwitya Effy Huriyati Elsi Rahmadhani Hardi Elvia Fataya Ennesta Asri Erdanela Setiawati Eva Chundrayetti Eva Decroli Fadel Muhammad Fadrian Herjunio Fadrian, Fadrian Fanny Adhy Putri Fanny Adhy Putri Fanny Adhy Putri Fitra Ermila Basri Gunawan Septa Dinata Gunawan Septa Dinata Haiga, Yuri Harun Harnavi Hauda El Rasyid Hendra Permana Hendra Permana Hendra Permana Husni Minanda Fikri Iffah Dzakiyyah Ifmi Ilmiawati, Ilmiawati Indra, Syarif Iqbal Al Rasyid Istiqomah Karina Prasasti Helhid Kurniawan, Yoga Setia Lesti Marliana Lydia Susanti, Lydia M Hasan Machfoed Marfri Andy Mayetti Akmal Meldayeni Busra Mubarak, M. Dzaky Muhammad Farhan Khadaffi Mustafa Noer Nela Novita Sari Netti Suharti Nora Fitri Nora Fitri Novi Yudia Novia Riza Lestari Nur Indrawati Lipoeto Nur Indrawaty Lipoeto Nurhayati Nurhayati Nurvalinda Nurvalinda Pitra, Dian Ayu Hamama Rahmatini . Rahmi Ulfa Rasyid, Hauda El Ratna D Siregar Rauza Sukma Rita Reno Bestari Reno Bestari Reno Bestari Reno Bestari Restu Susanti Ridho Ahmad Jabbar Rika Susanti Rika Susanti Rince Restiviona Rini Gusya Liza, Rini Gusya Rizanda Machmud Rizki Muhammad Rananda RR. Ella Evrita Hestiandari Russilawati, Russilawati Sahputra, Roni Eka Salmiah Agus Sonia Hardianti Sukri Rahman Susila Sastri Susila Sastri Sutia, Dedi Syahrul, Muhammad Zulfadli Syandrez Prima Putra Syarif Indra Syarif Indra Syarif Indra Syarif Indra Syarif Indra Trya Mia Intani Widia Rahmawati Yantri Maputra Yanwirasti Yanwirasti Yaumi Faiza Yoga Setia Kurniawan Yulia Trisna Zahra Zafira