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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kesehatan Andalas Global Medical and Health Communication Biomedical Journal of Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Penelitian Pendidikan IPA (JPPIPA) Window of Health : Jurnal Kesehatan Majalah Kedokteran Andalas Majalah Patologi Indonesia Majalah Kedokteran Neurosains Human Care Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ners Science Midwifery Nusantara Hasana Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Journal of Pharmaceutical and Sciences. Neurona Jurnal Sains, Teknologi dan Kesehatan Jurnal Ilmu Psikologi dan Kesehatan Indonesian Journal of Global Health Research
Yuliarni Syafrita
Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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The Association between NLR and TGF-β with Acute Ischemic Stroke Severity with and without Thrombolysis Lesti Marliana; Syarif Indra; Dedi Sutia; Yuliarni Syafrita; Restu Susanti; Fanny Adhy Putri
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.49866

Abstract

Acute ischemic stroke is a leading cause of mortality worldwide. Thrombolysis is the main treatment in the acute phase; however, clinical outcomes remain variable. Inflammatory markers such as the NLR and TGF-β1 may reflect inflammatory activity and tissue repair, yet their relationship with stroke severity is not fully established. This study aimed to evaluate the association of NLR and TGF-β1 with acute ischemic stroke severity in patients with and without thrombolysis. A cross-sectional study was conducted in the neurology ward of Dr. M. Djamil General Hospital, Padang. Patients with acute ischemic stroke, either treated with thrombolysis or not, were included. NLR and TGF-β1 were measured at 24 hours after onset, while stroke severity was assessed using the NIHSS at 24 hours. A total of 25 thrombolyzed and 25 non-thrombolyzed patients were enrolled. The results showed no significant association between NLR and stroke severity in either the thrombolysis (p=0.123) or non-thrombolysis group (p=0.257). In contrast, TGF-β1 was significantly associated with stroke severity in both groups (p<0.001 and p=0.002, respectively). In conclusion, TGF-β1 correlates with acute ischemic stroke severity regardless of thrombolysis, while NLR shows no significant association.
Characteristics of Tuberculous Meningitis Patients at M.Djamil Padang Hospital in 2024 Fanny Adhy Putri; Yuliarni Syafrita; Djong Hon Tjong; Dwitya Elvira; Nurvalinda Nurvalinda
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.50224

Abstract

Tuberculous meningitis (TBM) is the most severe form of extrapulmonary TB, causing high morbidity and mortality. The Global TB 2022 report estimates that there are at least 100,000 people with MTB each year. In 2021, there were at least 13,400 MTB cases in Indonesia, or about 8% of the global estimate. To determine the characteristics of tuberculous meningitis patients at M. Djamil Padang Hospital in 2024. A descriptive study with cross-sectional method. The sampling technique used was purposive sampling by collecting medical record data of TBM patients at Dr. M. Djamil Padang Hospital in 2024. The number of samples that met the inclusion and exclusion criteria was 45 sample. Data were analyzed using SPSS. Univariate analysis was used to assess the characteristics of patient and presented in the form of a frequency distribution table. The average age of TBM patients in this study was 31 years, dominated by male gender (55.6%). Most of the TBM patients had normal nutritional status (64.4%) and only 17.8% of patients were underweight. Only 13.3% of TBM patients had a history of TB and 6.7% of patients had positive HIV status. Around 4.76% and 11.1% of patients had comorbid DM and hypertension. Most patients were in stage II BMRC (71.1%). Hydrocephalus was the most common CT Scan finding, which was 46.7%. Only 26.7% of patients died during treatment. Tuberculous meningitis is more common in men, with stage II BMRC, has hydrocephalus, and more than a quarter of MTB patients died during treatment.
The Relationship Between Serum Calprotectin Levels and Severity in Myasthenia Gravis Patients at Dr. M. Djamil Hospital Padang Novia Riza Lestari; Lydia Susanti; Yuliarni Syafrita; Restu Susanti; Reno Bestari; Dedi Sutia
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.51684

Abstract

Myasthenia Gravis (MG) is an autoimmune disorder characterized by skeletal muscle weakness resulting from impaired neuromuscular transmission, primarily caused by autoantibodies directed against acetylcholine receptors. Excessive immune activation in MG triggers the release of inflammatory mediators, one of which is calprotectin — a protein complex of S100A8/A9 that is released by neutrophils and monocytes during the inflammatory process. Elevated levels of calprotectin have been reported in various autoimmune diseases; however, the relationship between serum calprotectin concentration and disease severity in MG, based on the Myasthenia Gravis Foundation of America (MGFA) classification, has not been extensively investigated. The objective of this study was to determine the association between serum calprotectin levels and disease severity in patients with MG. This study employed a cross-sectional design involving 23 MG patients receiving treatment at Dr. M. Djamil Hospital, Padang, from May to July 2025. Serum calprotectin levels were measured using the ELISA method, while MG severity was assessed using the MGFA scoring system. Statistical analyses were performed using SPSS version 27.0, with a significance level set at p < 0.05. The results of this study showed that serum calprotectin levels in patients with Myasthenia Gravis (MG) tended to be higher than in the healthy population; however, there was no significant association with the Myasthenia Gravis Foundation of America (MGFA) severity classification (p = 0.276).
Hubungan Kadar Glial Fibrillary Acidic Protein Serum dengan Skor Nihss dan Ich Score pada Pasien Stroke Hemoragik Dicky Lesmana; Syarif Indra; Restu Susanti; Yuliarni Syafrita; Dedi Sutia; Lydia Susanti
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.54075

Abstract

Hemorrhagic stroke, particularly intracerebral hemorrhage (ICH), is a major cause of mortality and morbidity and is associated with poorer outcomes than ischemic stroke. The severity of ICH is commonly assessed using the National Institutes of Health Stroke Scale (NIHSS) and the ICH score. Glial fibrillary acidic protein (GFAP) is an astrocytic protein released into the circulation as a result of glial tissue injury and is known to be elevated in various types of stroke, with generally higher concentrations in ICH. This study aimed to evaluate the potential of GFAP as an indicator of disease severity and clinical outcomes in ICH. This was an observational analytic study with a cross-sectional design conducted in patients with hemorrhagic stroke hospitalized at RSUP Dr. M. Djamil Padang from February to July 2025. Serum GFAP levels were measured using the ELISA method, while disease severity and mortality were assessed using the NIHSS and ICH score. Statistical analysis was performed using one-way ANOVA or the Kruskal–Wallis test to examine the relationship between GFAP and NIHSS, and Pearson or Spearman correlation tests to evaluate the relationship between GFAP and the ICH score. Most subjects had moderate stroke severity based on the NIHSS (48.57%). The median serum GFAP level was 3.41 ng/mL (1.75–17.7). Analysis showed a significant difference in GFAP levels across the three NIHSS severity categories (p = 0.001), particularly between the mild–severe (p = 0.002) and moderate–severe (p = 0.001) groups. Spearman correlation analysis demonstrated a significant positive correlation between GFAP levels and the ICH score (p = 0.000; r = 0.481). In addition, GFAP levels were significantly higher in patients with hemorrhage volumes >30 cc compared with those ≤30 cc (median 7.29 vs 3.24 ng/mL; p = 0.000). Serum GFAP levels were significantly associated with NIHSS score, ICH score, and hemorrhage volume in patients with hemorrhagic stroke. These findings support the use of GFAP as a biomarker for assessing severity and prognosis in hemorrhagic stroke.
Karakteristik Pasien BPPV di Rumah Sakit Universitas Andalas Tahun 2019-2024 Adila, Qanita; Permana, Hendra; Rahmatini; Huriyati, Effy; Syafrita, Yuliarni; Nofita, Eka
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 1 (2026): Maret 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i1.1723

Abstract

Latar Belakang: Benign Paroxysmal Positional Vertigo (BPPV) adalah penyebab paling umum dari vertigo. BPPV merupakan suatu kondisi terjadinya gangguan sistem vestibular perifer, saat pasien merasakan sensasi pusing berputar dan berpindah ketika posisi kepala berubah terhadap gaya gravitasi akibat adanya gangguan di organ vestibular. Objektif: Penelitian ini bertujuan untuk mengetahui karakteristik pasien BPPV di Rumah Sakit Universitas Andalas Tahun 2019-2024. Metode: Penelitian ini merupakan penelitian deskripitif menggunakan data sekunder rekam medis pasien di Rumah Sakit Universitas Andalas. Penelitian menggunakan metode total sampling dengan jumlah sampel penelitian sebanyak 53 sampel. Hasil: Berdasarkan hasil penelitian didapatkan karakteristik pasien sebagai berikut: dari 53 pasien, 41 orang (77,4%) terkena kanalis semisirkularis posteriornya. Pasien paling banyak didiagnosis pada rentang usia 50-59 tahun yaitu 20 orang (34,7%). Terdapat 35 orang pasien perempuan (66,0%) dan 18 orang pasien laki-laki (34,0). Pasien BPPV dengan hipertensi stage 1 berjumlah 20 orang (37,7%) dan obesitas berjumlah 21 orang (39,6%). Pilihan terapi yang paling banyak digunakan adalah antivertigo sebanyak 39 pasien  (73,6%), disusul  gabungan canalith repositioning procedure (CRP) dan antivertigo pada 13 pasien (24,5%), serta CRP pada 1 pasien (1,9%). Kesimpulan:  Kesimpulan dari penelitian ini adalah pasien BPPV umunya terkena kanalis semisirkularis posteriornya. Pasien kebanyakan berusia 50-59 tahun pada saat didiagnosis, berjenis kelamin perempuan dengan tekanan darah 140-159/ 90-99 mmHg, dan status gizi obesitas. Pilihan terapi yang paling banyak digunakan adalah terapi obat-obatan antivertigo.
Hubungan Kadar Delta Like Ligand 1 (DLL-1) Serum dan Cairan Serebrospinal (CSS) Terhadap Derajat Keparahan Meningitis Tuberkulosis Abdul Razak; Syarif Indra; Restu Susanti; Yuliarni Syafrita; Reno Bestari; Gunawan Septa Dinata
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1514

Abstract

Tuberculous meningitis (TBM) is an infection caused by Mycobacterium tuberculosis (M.tb) affecting the meninges, characterized by high morbidity rates. The prognosis of TBM is partially determined by clinical severity, classified according to the British Medical Research Council (BMRC) scale. Delta Like Ligand 1 (DLL-1) is a transmembrane protein that plays a role in the formation of lipid cells, which are essential for the survival, virulence, and defense of M.tb against the host immune system. DLL-1 expression can be induced by the stimulation of M.tb cell walls in response to the human immune system. This study aims to analyze the correlation between DLL-1 levels in the serum and cerebrospinal fluid (CSF) with the clinical severity of TBM patients. A cross-sectional study was conducted involving 30 TBM patients treated at M. Djamil Central General Hospital, Padang, from October 2025 to January 2026. Serum and CSF DLL-1 levels were measured using the enzyme-linked immunosorbent assay (ELISA) method, while TBM severity was assessed based on the BMRC criteria. Data analysis was performed using SPSS version 26.0 with a significance level of p < 0.05. The results of the analysis showed no significant difference in serum DLL-1 levels (p = 0.129) or CSS DLL-1 levels in relation to the severity of TBM (p = 0.097).
FAKTOR-FAKTOR YANG MEMPENGARUHI KEJADIAN DEPRESI PADA PASIEN PENYAKIT GINJAL KRONIK YANG MENJALANI HEMODIALISIS DI RSUP DR. M. DJAMIL PADANG Zahra Zafira; Yuliarni Syafrita; Amel Yanis
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 3 No. 2 (2026): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Juni 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v3i2.2611

Abstract

Patients with Chronic Kidney Disease (CKD) require hemodialysis due to a decrease kidney function. This hemodialysis procedure can have psychological impacts, one of which is depression. Suspected contributing factors include age, gender, education, duration of hemodialysis, comorbidities, and socioeconomic status. This observational analytical study utilized a cross-sectional design involving 47 CKD patients in the Hemodialysis Unit of Dr. M. Djamil Padang Hospital. The sample was selected using consecutive sampling. Depression screening was assessed with Patient Health Questionnaire (PHQ-9). Results indicate 61.7% of CKD patients experience depression, notably prevalent in individuals aged over 51 years (62%), females (55.17%), with lower education (51.1%), undergoing hemodialysis for over 6 months (75.85%), with hypertension comorbidity (86.2%), without diabetes mellitus comorbidity (96.55%), and with low socioeconomic status (75.86%). Chi-square analysis identified age (p=0.018) is a significant factor, while gender (p=0.432), education level (p=0.693), duration of hemodialysis (p=1.000), hypertension comorbidity (p=0.692), diabetes mellitus comorbidity (p=1.000), and socioeconomic status (p=0.455) are not significantly related. This study concluded that age is a significant factor related to the occurrence of depression in CKD patients, while gender, education level, duration of hemodialysis, comorbidities, and socioeconomic status do not have a significant relationship with the occurrence of depression in CKD patients.
The Effect of Probiotic Bacteria Lactobacillus Spp. And Bifidobacterium Spp. as A Novel Effective Therapy for Seizures in Epilepsy: A Systematic Review of Preclinical Study Designs Rince Restiviona; Cimi Ilmiawati; Mayetti Akmal; Yuliarni Syafrita
Indonesian Journal of Global Health Research Vol. 7 No. 6 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i6.619

Abstract

Epilepsy is a chronic neurological disorder characterized by recurrent seizures due to abnormal electrical activity in the brain. The seizure mechanism involves neurotransmitter imbalance, oxidative stress, and neuroinflammation. Recent studies highlight the role of the gut–brain axis, emphasizing probiotics such as Lactobacillus spp. and Bifidobacterium spp., which potentially stabilize the nervous system through microbiota modulation and anti-inflammatory effects. This review aims to systematically assess preclinical evidence on the efficacy of Lactobacillus spp. and Bifidobacterium spp. as adjunctive therapies to reduce seizures in epilepsy through molecular and gut–brain axis mechanisms. This systematic review followed PRISMA guidelines, with literature searches performed in Google Scholar, PubMed, Taylor & Francis, and ScienceDirect, including publications from 2015 to 2025 (1576 articles to 13 articles), and inclusion criteria based on the PICOS framework. Risk of bias was assessed using Sycle’s risk of bias tool. A total of 13 in vivo preclinical studies of Lactobacillus spp. and Bifidobacterium spp. reported significant effectiveness in reducing seizure symptoms and regulating excitatory–inhibitory neurotransmitter balance in rat models of induced epilepsy. Probiotics have potential as effective alternative therapies in modulating seizure reduction and maintaining neurotransmitter balance during epilepsy. They may be developed in the future as non-pharmacological therapeutics based on microbiota.
Faktor Risiko Hernia Nukleus Pulposus Pada Pasien Nyeri Punggung Bawah Iffah Dzakiyyah Ifmi; Roni Eka Sahputra; Yuliarni Syafrita; Hendra Permana; Syandrez Prima Putra
Jurnal Ilmu Psikologi dan Kesehatan | E-ISSN : 3063-1467 Vol. 3 No. 1 (2026): April - Juni
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jipk.v3i1.1679

Abstract

This study aimed to analyze the association between age, sex, occupation, smoking status, and body mass index (BMI) with the incidence of lumbar disc herniation (LDH) among patients with low back pain. This analytical observational study used a cross-sectional design with medical record data from 69 patients attending the Orthopedic and Traumatology Clinic at Dr. M. Djamil General Hospital, Padang, from 2020 to 2021. The results showed that 63.8% of patients were diagnosed with LDH. Smoking status (p=0.043; OR=3.21) and BMI (p=0.035; OR=3.39) were significantly associated with LDH, while age, sex, and occupation showed no significant relationship. These findings indicate that smoking and elevated BMI are important modifiable risk factors for LDH, highlighting their role in prevention strategies.
Hubungan Kadar Matrix Metalloproteinase-9 pada Cairan Serebrospinal dan Serum terhadap Derajat Keparahan dan Luaran Pasien Meningitis Tuberkulosis Sonia Hardianti; Yuliarni Syafrita; Fanny Adhy Putri; Syarif Indra; Restu Susanti; Reno Bestari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1632

Abstract

Tuberculous meningitis (TBM) is a severe form of tuberculosis associated with high mortality and neurological morbidity. Disease severity strongly influences outcome; however, reliable biological predictors remain limited. Matrix metalloproteinase-9 (MMP-9) is a proteolytic enzyme involved in neuroinflammation and blood-brain barrier disruption, and it has been reported to be elevated in both the cerebrospinal fluid (CSF) and serum of TBM patients. This study aimed to evaluate the relationship between MMP-9 levels and the severity and outcome of TBM patients. This was an analytical observational study with a cross-sectional design involving TBM patients treated at Dr. M. Djamil General Hospital, Padang, from January to December 2024. CSF and serum MMP-9 levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Disease severity was assessed using the British Medical Research Council (BMRC) criteria, and outcomes at 14 and 60 days were assessed using the Glasgow Outcome Scale. A total of 41 TBM patients were included in the study. The mean CSF MMP-9 level was 2,034.40 ng/L, while the median serum MMP-9 level was 1,490.14 ng/L. The analysis showed no significant association between CSF MMP-9 levels and disease severity (p = 0.276), 14-day outcome (p = 0.269), or 60-day outcome (p = 0.375). Serum MMP-9 levels were likewise not associated with disease severity (p = 0.248), 14-day outcome (p = 0.224), or 60-day outcome (p = 0.138), but they still showed an increasing pattern in patients with a fatal outcome. CSF and serum MMP-9 levels had no significant association with the severity and outcome of TBM patients. These findings suggest that a single MMP-9 measurement is insufficient as a clinical predictor, so a multibiomarker and longitudinal approach should be considered.
Co-Authors Abdul Razak Adang Bachtiar Adila, Qanita Afriyeni Sri Rahmi Ahmad, Baihaqi Alya Ramadhini Amel Yanis Andi Fadilah Yusran Andy, Marfri Anggi Anugerah Basir ATTIYA ISTARINI Basjiruddin Ahmad Cintya Agreayu Dinata Darwin Amir Darwin Amir Darwin Amir, Darwin Dhiang Mulia Syofiadi Dicky Lesmana Djong Hon Tjong Dwi Sri Rejeki Dwitya Elvira Dwitya Elvira, Dwitya Effy Huriyati Elsi Rahmadhani Hardi Elvia Fataya Ennesta Asri Erdanela Setiawati Eva Chundrayetti Eva Decroli Fadel Muhammad Fadrian Herjunio Fadrian, Fadrian Fanny Adhy Putri Fanny Adhy Putri Fanny Adhy Putri Fitra Ermila Basri Gunawan Septa Dinata Gunawan Septa Dinata Haiga, Yuri Harun Harnavi Hauda El Rasyid Hendra Permana Hendra Permana Hendra Permana Husni Minanda Fikri Iffah Dzakiyyah Ifmi Ilmiawati, Ilmiawati Indra, Syarif Iqbal Al Rasyid Istiqomah Karina Prasasti Helhid Kurniawan, Yoga Setia Lesti Marliana Lydia Susanti, Lydia M Hasan Machfoed Marfri Andy Mayetti Akmal Meldayeni Busra Mubarak, M. Dzaky Muhammad Farhan Khadaffi Mustafa Noer Nela Novita Sari Netti Suharti Nora Fitri Nora Fitri Novi Yudia Novia Riza Lestari Nur Indrawati Lipoeto Nur Indrawaty Lipoeto Nurhayati Nurhayati Nurvalinda Nurvalinda Pitra, Dian Ayu Hamama Rahmatini . Rahmi Ulfa Rasyid, Hauda El Ratna D Siregar Rauza Sukma Rita Reno Bestari Reno Bestari Reno Bestari Reno Bestari Restu Susanti Ridho Ahmad Jabbar Rika Susanti Rika Susanti Rince Restiviona Rini Gusya Liza, Rini Gusya Rizanda Machmud Rizki Muhammad Rananda RR. Ella Evrita Hestiandari Russilawati, Russilawati Sahputra, Roni Eka Salmiah Agus Sonia Hardianti Sukri Rahman Susila Sastri Susila Sastri Sutia, Dedi Syahrul, Muhammad Zulfadli Syandrez Prima Putra Syarif Indra Syarif Indra Syarif Indra Syarif Indra Syarif Indra Trya Mia Intani Widia Rahmawati Yantri Maputra Yanwirasti Yanwirasti Yaumi Faiza Yoga Setia Kurniawan Yulia Trisna Zahra Zafira