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All Journal Jurnal Kesehatan Andalas Global Medical and Health Communication The Indonesian Biomedical Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) AcTion: Aceh Nutrition Journal Jurnal Kesehatan Medika Saintika Jurnal Kreativitas PKM Majalah Kedokteran Andalas Indonesian Journal of Kidney and Hypertension Human Care Journal Contagion: Scientific Periodical Journal of Public Health and Coastal Health Jurnal Ners Nusantara Hasana Journal Open Access Indonesian Journal of Medical Reviews Daengku: Journal of Humanities and Social Sciences Innovation Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Multidisciplinary Science Scientific Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Sciences of Pharmacy Eduvest - Journal of Universal Studies Jurnal Katalisator Jurnal Penyakit Dalam Indonesia Sriwijaya Journal of Internal Medicine Oshada Media Penelitian dan Pengembangan Kesehatan Proceeding International Health Conference

Harun Harnavi

Universitas Andalas

Author-ID : 3367942

Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Chronic Kidney Disease Related to Cognitive Disorders in the Elderly: A Narrative Literature Review Ajat Sudrajat; Drajad Priyono; Harnavi Harun; Roza Kurniati; Roza Mulyana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 14 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i14.663

Chronic kidney disease (CKD) is characterized by progressive and irreversible kidney damage, leading to the inability of the kidneys to perform their functions. Chronic kidney disease causes hypertension, anemia, vascular dysfunction, uremia, proteinuria, systemic inflammation, and oxidative stress associated with cognitive impairment. Age is a population group aged 60 years or more at risk of experiencing health problems and the consequences associated with CKD. One of the common comorbidities experienced by elderly patients with CKD is cognitive impairment. Current treatment options for CKD with cognitive impairment aimed at common risk factors, including angiotensin converting enzyme inhibitors (ACEI) and, angiotensin receptor blockers (ARBs), SGLT-2 inhibitors., GLP-1 RA, and DPP-4 inhibitors. Other interventions, such as erythropoietin (EPO) compensation and reduction of inflammation and oxidative stress, can help improve patients' clinical symptoms. This literature review aims to describe the relationship between chronic kidney disease and cognitive disorders that occur in the elderly.

Correlation of Serum Fibroblast Growth Factor 23 With Left Ventricular Diastolic Function in Chronic Kidney Patients Harun Harnavi; Febrianti Ika Kurnia; Kam Alexander
Eduvest - Journal of Universal Studies Vol. 2 No. 9 (2022): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Chronic Kidney Disease (CKD) is one of most common world’s health problems with constantly increasing prevalence and many complications, and cardiovascular is one of them. The earliest cardiovascular damage that can be seen is left ventricular diastolic dysfunction. In patients with CKD, there will be mineral metabolism disorders, including phosphate. Persistently increased phosphate in CKD will cause rising in Fibroblast Growth Factor 23 (FGF23) that regulates phosphate in the circulation. High level of FGF23 will directly damage the heart and stimulates cardiac remodeling that will result in cardiomyocyte damage, atherosclerosis and intramyocardial cells fibrosis. This will cause myocardial stiffness and diastolic dysfunction. The purpose of the study is to discover correlation between Fibroblast Growth Factor 23 (FGF23) serum and left ventricle diastolic function in patients with chronic kidney disease. This is an observational study with cross-sectional methods. The sample is 30 patients diagnosed with chronic kidney disease (CKD). Patients are evaluated for Fibroblast Growth Factor 23 (FGF23) level in their serum, assessed the left ventricle diastolic function by measuring early diastolic velocity of the left ventricle (lateral e’) using echocardiography.There is significantly increased of FGF23 serum levels and decreased of lateral e’ value in chronic kidney disease case. There’s also a strong correlation between FGF23 serum and filtration glomerulus rate (LFG) (p<0.05), and a strong correlation between FGF23 serum level with lateral e’ as a component of left ventricle diastolic function. There’s a strong correlation between FGF23 with left ventricle diastolic function in patients with CKD.

Plasma Galectin-3 Biomarkers in Chronic Kidney Disease Annesa Fadella; Harnavi Harun; Drajad Priyono; Deka Viotra
Indonesian Journal of Multidisciplinary Science Vol. 2 No. 5 (2023): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Assessment of renal function is based on determination of serum creatinine and creatinine-based equations to assess GFR. However, this marker is not perfect or accurate, especially for longitudinal monitoring of kidney function in Chronic Kidney Disease (CKD patients). Decreased kidney function can be slowed or even anticipated with early detection, so as to avoid secondary complications. So it is important to find new biomarkers that can identify individuals at risk as early as possible. Plasma galectin-3 is a ?-galactoside-binding lectin expressed in monocytes, which plays an important role in inflammation, immunity, cancer, and is involved in the pathogenesis of atherosclerosis, diabetes, renal fibrosis and asthma. Higher galectin-3 levels were associated with reduced eGFR in a cross-sectional study. Galectin-3 is essential in various biological activities including cell growth, cell proliferation, differentiation, apoptosis, pre-mRNA splicing, transformation, angiogenesis, inflammation, fibrosis, fibrogenesis and host defense. Galectin-3 is a stable biomarker and is not associated with age, body mass index or sex. Galectin-3 is also useful for detecting the early stages of some diseases. Galectin-3 shows no circadian variation and increases slightly after exercise, returning to normal levels after 1-3 hours. Higher concentrations of galectin-3 may be associated with CKD development, indicating the potential for new mechanisms related to galectin-3 expression that may contribute to CKD development. Galectin-3 has also been reported to play an important role in renal interstitial fibrosis. Thus, galectin-3 inhibition may be a promising therapeutic strategy to prevent kidney disease progression.

The Relationship between Nutritional Status and the Incidence of Hypertension in the Elderly at the Working Area of the Lubuk Pinang Health Center, North Bengkulu Amelia Rinita; Diana Melida; Sjaaf Fidiariani; Harun Harnavi
Jurnal Penelitian Pendidikan IPA Vol 9 No 3 (2023): March
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i3.3407

Hypertension may occur primarily or is idiopathic. Where the causative factor cannot be identified or can occur secondarily as a result of a particular disease. This study aims to determine the relationship between nutritional status and the incidence of hypertension in the Elderly Work Area of the Lubuk Pinang Health Center, Muko-Muko Regency, North Bengkulu. The type of research used is analytical observational research with a cross-sectional approach. The affordable population in this study was the elderly who were registered for treatment at the Lubuk Pinang Health Center, Muko-Muko Regency, North Bengkulu, with 36 samples using the total sampling technique. Univariate data analysis is presented in frequency and percentage distribution and bivariate analysis using the spearman correlation test and data processing using the computerized IBM SPSS program version 24.0. The results of this study show that the highest age was 60-70 years, namely 28 people (77.8%), and the most gender was female, namely 31 people (86.1%). The most nutritional status was overweight, 15 people each (41.7%), the most hypertension was stage II, namely 25 people (69.4%), and there was a relationship between nutritional status and the incidence of hypertension in the Elderly Work Area of the Lubuk Pinang Health Center, Muko-Muko Regency, North Bengkulu (p=0.031). This research concludes that the highest age is 60-70 years. The most gender is female, the most nutritional status is overweight, the most hypertension is stage II, and there is a relationship between nutritional status and the incidence of hypertension in the Elderly Work Area of the Lubuk Pinang Health Center, Muko-Muko Regency, North Bengkulu

The Role of Nutritional Therapy in Inhibiting the Progression of Chronic Kidney Disease: A Narrative Literature Review Harnavi Harun; Genta Pradana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 3 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i3.789

The need for proper nutrition and diet is fundamental in every stage of chronic kidney disease. The principle of nutritional therapy is slowing the progression of chronic kidney disease, delaying patients with CKD (chronic kidney disease) from getting kidney replacement therapy. In CKD patients, there is a disturbance of protein homeostasis, disturbance in metabolism protein, acid-base disorders, and hormonal dysfunctions. As the progression of CKD increases, nitrogen-containing products accumulate, causing a decrease in appetite. In CKD patients, intestinal absorption is also impaired because uremia causes microbiota disturbance and damage to the intestinal epithelium. These various things cause nutritional status to become often irregular, and protein energy wasting frequently occurs, thus requiring dietary adjustments in patients with CKD. In conclusion, each individual with CKD has a different nutritional therapy approach depending on the disease conditions and nutritional status of the individual. Appropriate nutritional therapy in CKD patients can reduce disease progression.

Effect of Ramadan Fasting on DNA Repair, Immune System, Inflammation and Cognitive Function in Chronic Kidney Disease Patients: A Systematic Literature Review Drajad Priyono; Harnavi Harun; Deka Viotra; Zaki Mahmudi Dasril
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 4 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i4.809

Background: There have been many studies that say Ramadan fasting has a positive effect on reducing BMI, blood sugar, inflammatory factors, and DNA Repair. However, there are still no guidelines for fasting in patients with chronic kidney disease (CKD) both nationally and internationally. This study aimed to conduct a review to explore the effects of Ramadan fasting against chronic kidney disease, specifically on DNA repair, Immune System, Inflammation, and Cognitive Function in patients with chronic kidney disease. Methods: This study is a systematic literature review (SLR) with sources obtained from various reputable journal databases such as PubMed, Cochrane Library, EBSCO, and Elsevier using relevant keywords. The selected articles have passed the inclusion and exclusion criteria. A total of 39 articles that discuss fasting were obtained from Ramadan in chronic kidney disease patients on metabolic response and inflammatory markers in the body. Results: Ramadan fasting has a positive effect on the response to anti-inflammatory, expression of protective genes, markers of kidney and liver function, protective proteome, and oxidative stress. Conclusion: Ramadan fasting may provide a short-term protective effect against levels of systemic inflammation.

The Role of Monocyte Chemoattractant Protein-1 (MCP-1) in Diabetic Kidney Disease Deddy Canceria Suka Rahmatsyah; Harnavi Harun; Deka Viotra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 9 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i9.861

Monocyte chemoattractant protein-1 plays an important role in kidney disease. In several studies, the role of MCP-1 as a urine biomarker has been extensively studied. In many kidney diseases, there are elevated levels of MCP-1 in the kidney tissue and this is an important cause of monocyte infiltration in the pathogenesis of kidney damage. Elevated urinary MCP-1 levels have been able to predict outcome in proliferative kidney diseases such as lupus nephritis. However, in several studies it was also found that there was an increase in MCP-1 in diabetic kidney disease. Macrophages have even appeared early in diabetic kidney disease and are associated with the progression of kidney disease. Urinary MCP-1 levels are related to the degree of leukocyte infiltration in the tubulointerstitial. This supports inflammatory factors as part of the pathogenesis of diabetic kidney disease.

Symmetric Dimethylarginine as a Biomarker for Chronic Kidney Disease Khairat AS; Harnavi Harun; Deka Viotra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 9 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i9.866

Symmetric dimethylarginine (SDMA), is a post-translationally stable catabolic product of arginine-methylated proteins that plays an important role in basic cellular metabolism. SDMA is an endogenous biomarker of kidney function that has been widely used in veterinary medicine. Symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA) are 2 constant products of L-arginine proteolysis that undergo methylation. SDMA is almost completely excreted by the kidneys after filtration making SDMA an ideal GFR biomarker candidate. Apart from that, SDMA has several advantages as a biomarker of kidney function, namely that it is not affected by non-renal factors that influence creatinine and cystatin C. Apart from that, SDMA also increases earlier than other biomarkers.

The Difference of Survival Rate COVID-19 in Patients with Initiated Hemodialysis and Regularly Hemodialysis Deka Viotra; Harnavi Harun; Drajad Priyono; Fauzar; Roza Kurniati; Alexander Kam; Abdul Alim Rahimi; Jersivindo Ranazeri; Zaki Mahmudi Dasril
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 10 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i10.877

Background: Since December 2019, a novel coronavirus called SARSCoV-2 (severe acute respiratory syndrome coronavirus) has caused an international outbreak of respiratory illness described as COVID-19. This study aimed to describe the difference in the survival rate of COVID-19 induced AKI with hemodialysis and COVID-19 in patients with CKD on hemodialysis in Dr. M Djamil General Hospitals. Also, in this review, we provide a comprehensive overview of data on the factors that may be affected by COVID-19 survival rates in patients with COVID-19 induced AKI with hemodialysis and COVID-19 in patients with CKD on hemodialysis. This study was conducted to analyze the survival of COVID-19 with initiated or regular HD patients in Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This study was conducted from January 2021 to July 2021 in Dr. M. Djamil General Hospital, Padang, West Sumatera, Indonesia. Data for this study was collected through medical records of patients admitted for COVID-19 with CKD in hemodialysis and acute renal failure induced by COVID-19 to show the demographics, comorbidities, and survival rates of the patients who underwent hemodialysis. Results: Factors associated with survival in COVID-19 with hemodialysis were COVID-19 severity and abnormal potassium serum level (Table 3). Moderate COVID-19 patients tend to survive than severe COVID-19 patients (OR 60; 95% CI 16.034 – 224.525). There was no significant difference in survival between initiated and regular HD (p = 0.829). Conclusion: There is no difference in clinical outcome from patients with COVID-19 who initiated hemodialysis or regularly HD to the survival rates.

Edukasi Manfaat Probiotik Susu Kambing Etawa dalam Percepatan Penurunan Prevalensi Stunting di Kota Padang Panjang Rinita Amelia; Yusti Siana; Ruhsyahadati Ruhsyahadati; Dian Puspita; Ira Suryanis; Harnavi Harun; Yudha E. Pratama
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 6, No 11 (2023): Volume 6 No 11 2023
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v6i11.12376

ABSTRAK Stunting adalah suatu kondisi dimana anak mengalami gangguan pertumbuhan, sehingga tinggi badan anak tidak sesuai dengan usia nya (stunted), sebagai akibat dari masalah gizi kronis yaitu, kekurangan asupan gizi dalam waktu yang lama. Data Riset Kesehatan Dasar (Riskesdas) tahun 2018 menunjukkan prevalensi stunted di Indonesia sebesar 30,8%. Prevalensi stunted balita untuk tahun 2022 adalah 24,1% di Indonesia, 23,3% di Sumatera Barat, dan 20% di Kota Padang Panjang (Kemenkes 2022). Stunting melibatkan multifaktorial seperti ekonomi, nutrisi, pola asuh yang salah, pendidikan, pengetahuan dan lain- lain. Stunting dapat memperlambat perkembangan motorik dan mental serta akan meningkatkan resiko terhadap penyakit degeneratif dan Infeksi. Metode yang dipakai pada pengabdian kepada masyarakat ini adalah memberikan edukasi dan pelatihan kepada 15 kader TP-PKK Padang Panjang dari 15 Kelurahan tentang pembuatan minuman sehat “yodiwa (yogurt dadiah Etawa) sebagai makanan high protein untuk anak stunting dengan penggunaan starter bakteri halal yang berasal dari dadiah. Selain itu juga diberikan edukasi pentingnya pemberian menu seimbang dan bahaya Stunting. Hasil yang didapatkan adalah peserta edukasi yang terbanyak pada usia 30-50 tahun (60%) dengan tingkat pendidikan terakhir Sekolah Menengah Atas/SMA sebanyak 73%. Terjadi peningkatan penegetahuan kader dengan score Baik dari 7% menjadi 33%. Pada kegiatan pelatihan pembuatan produk Inovasi yogurt yang berasal dari susu kambing dengan penambahan starter makanan lokal dadiah menghasilkan kader yang dapat mandiri membuat minuman yodiwa dan memiliki rencana dalam usaha untuk membantu meningkatkan perekonomian keluarga khususnya dan perekonomian daerah umumnya. Kata Kunci: Yogurt, Susu Kambing Etawa, Dadiah, Probiotik, Stunting ABSTRACT Stunting is a condition where a child experiences growth disorders, so that the child's height does not correspond to his age (stunting), as a result of chronic nutritional problems, namely, lack of nutritional intake for a long time. Basic Health Research (Riskesdas) data for 2018 shows that the prevalence of stunting in Indonesia is 30.8%. The prevalence of stunting under five in 2022 is 24.1% in Indonesia, 23.3% in West Sumatra, and 20% in Padang Panjang City (Ministry of Health 2022). Stunting involves multifactorial factors such as economics, nutrition, wrong parenting patterns, education, knowledge and others. Stunting can slow down motor and mental development and increase the risk of degenerative diseases and infections. The method used in this community service is providing education and training to 15 TP-PKK Padang Panjang cadres from 15 sub-districts on making the healthy drink "yodiwa (dadiah etawa yoghurt) as a high-protein food for stunted children using halal bacterial starter originating from Dadiah. Apart from that, education was also provided on the importance of providing a balanced menu and the dangers of stunting. The results obtained were that the majority of educational participants were aged 30-50 years (60%) with the highest level of education being high school/high school at 73%. There was an increase in knowledge of cadres with a Good score from 7% to 33%. In the training activity for making innovative yogurt products made from goat's milk with the addition of the local food starter dadiah, it produces cadres who can independently make yodiwa drinks and have business plans to help improve the family economy in particular and the regional economy in general. Keywords: Yogurt, Etawa Goat Milk, Dadiah, Probiotics, Stunting

Co-Authors -, Sari Setiarini Abdul Alim Rahimi Abdul Alim Rahimi Adang Bachtiar Adang Bachtiar Ade Asyari Ade Sukma Ade Teti Vani Afdhol Falah Afrah Diba Faisal Ajat Sudrajat Akmal M Hanif Alexander Kam Alexander Kam Alexander Kam Alvarino Alvarino Amelia, Rinita Anandia Putriyuni Andikha Putra Annesa Fadella Arief Rinaldy Arina Widya Murni Arina Widya Murni Arnelis Arnelis Asir, Taufik Rizkian Athasya Aulia Mufidah Athif Abyaz Khalil Putra ayu pathya Bayu Arief Hartanto Dasman, Hardisman Deddy Canceria Suka Rahmatsyah Deka Viotra Deka Viotra Deka Viotra Deka Viotra Deka Viotra Deka Viotra Deka Viotra Dela Hangri Jalmas Dessy Abdullah Dewi, Amelia Fitria Dian Puspita Diana Melida Dinda Aprilia Dional Setiawan Drajad Priyono Drajad Priyono Drajad Priyono Dwitya Elvira Efrida Efrida Eryati Darwin Ety Yerizel Evelin Veronike Evelin Veronike Evelin Veronike Evelin Veronike Fadrian, Fadrian Faheri, Eifel Fauzar Fauzar Fauzar Fauzar Fauzar Fauzar Fauzar, Fauzar Faza Yasira Rusdi Febrianti Ika Kurnia Festi Eliza Finny Fitry Yani Garri Prima Decroli Garri Prima Decroli Genta Pradana gina ariani Hanifa Alyu Hannie Qalbina Syaiful Hardisman Dasman Husna Yetti Ilmiawati Ilmiawati, Ilmiawati Indra, Syarif Indrapriyatna, Ahmad Syafruddin Ira Suryanis Irena Fathin Amelia Jalmas, Dela Hangri Jen Hendriman Jersivindo Ranazeri Jersivindo Ranazeri Kam Alexander Kam, Alexander Karmia, Rofila Dita Khairat AS Khairil Faiz Amir Kino Kino Ligat Pribadi Sembiring Meri Wulandari Miftah Irramah Muhammad Ridhwan Fatharanifurqan Murni, Arina W Nadia Purnama D Najirman Najirman Najirman, Najirman Naufal Fathi Ashari Nur Indrawaty Lipoeto Nursyirwan Effendi, Nursyirwan Pratama, Yudha Endra Priyono, Drajad Puti Anggun Sari Putra, Mindy Pasuma Putri Lisna Radias Zasra Radias Zasra Rangga Lunesia Rapida Saragih RAVEINAL RAVEINAL Restu Susanti Rezki Sadeli Rini Yulia Rinita Amelia Rinita Amelia Rivai, Muhammad Iqbal Rivani Sintia Suratman Rizkianto Imannual Rose Dinda Martini Roslaini Roslaini Roza Kurniati Roza Kurniati Roza Kurniati Roza Kurniati Roza Mulyana Ruhsyahadati Ruhsyahadati Ruhsyahadati, Ruhsyahadati Rusdi, Faza Yasira Russilawati Selfi Renita Rusjdi Siana, Yusti Simajuntak, Rohayat Bilmahdi Sjaaf Fidiariani SM Rezvi Sofiani, Dinda Putri Sri Puji Rahayuningsih Suchitra, Avit Syaiful Azmi Syaiful Azmi Syaiful Azmi Syaiful Azmi Syaiful, Hannie Q Vendry Rivaldy Veronike, Evelin Vesri Yoga Vidiansyah, Achmad Wahyudi, Adefri Yanuar Surya Saputra Poedjijo Yerizal Karani Yudha E. Pratama Yudha Endra Pratama Yugo Berri Putra Rio Yulia Devi Putri Yulia Devi Putri Yuliarni Syafrita Yulistia Asmi Yusti Siana Zaki Mahmudi Dasril Zaki Mahmudi Dasril Zaki Mahmudi Dasril

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