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The Role of Urinary Potassium Examination on the Progressivity of Chronic Kidney Disease: A Narrative Literature Review Rezki Sadeli; Harnavi Harun; Drajad Priyono; Deka Viotra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 12 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i12.636

Kidneys play an important role in potassium homeostasis. The important role of the kidneys in maintaining potassium balance is reflected in the high level of potassium disturbances in patients with decreased kidney function, especially patients with severely decreased renal function and patients who have comorbidities, such as diabetes, hypertension, or heart failure. Chronic kidney disease is characterized by abnormalities of kidney structure or function that persist for more than 3 months, have many complex causes, and have a major impact on global health status. There are several methods to measure the amount of potassium intake consumed, including a food frequency questionnaire, dietary recall, temporary urine potassium examination, and 24-hour urine potassium examination. The standard gold measurement for evaluating urinary potassium excretion is through 24-hour urine collection. This literature review aims to describe the role of urinary potassium excretion in assessing the progression of chronic kidney disease.

Chronic Kidney Disease Related to Cognitive Disorders in the Elderly: A Narrative Literature Review Ajat Sudrajat; Drajad Priyono; Harnavi Harun; Roza Kurniati; Roza Mulyana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 14 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i14.663

Chronic kidney disease (CKD) is characterized by progressive and irreversible kidney damage, leading to the inability of the kidneys to perform their functions. Chronic kidney disease causes hypertension, anemia, vascular dysfunction, uremia, proteinuria, systemic inflammation, and oxidative stress associated with cognitive impairment. Age is a population group aged 60 years or more at risk of experiencing health problems and the consequences associated with CKD. One of the common comorbidities experienced by elderly patients with CKD is cognitive impairment. Current treatment options for CKD with cognitive impairment aimed at common risk factors, including angiotensin converting enzyme inhibitors (ACEI) and, angiotensin receptor blockers (ARBs), SGLT-2 inhibitors., GLP-1 RA, and DPP-4 inhibitors. Other interventions, such as erythropoietin (EPO) compensation and reduction of inflammation and oxidative stress, can help improve patients' clinical symptoms. This literature review aims to describe the relationship between chronic kidney disease and cognitive disorders that occur in the elderly.

The Role of Urinary Potassium Examination on the Progressivity of Chronic Kidney Disease: A Narrative Literature Review Rezki Sadeli; Harnavi Harun; Drajad Priyono; Deka Viotra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 12 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i12.636

Kidneys play an important role in potassium homeostasis. The important role of the kidneys in maintaining potassium balance is reflected in the high level of potassium disturbances in patients with decreased kidney function, especially patients with severely decreased renal function and patients who have comorbidities, such as diabetes, hypertension, or heart failure. Chronic kidney disease is characterized by abnormalities of kidney structure or function that persist for more than 3 months, have many complex causes, and have a major impact on global health status. There are several methods to measure the amount of potassium intake consumed, including a food frequency questionnaire, dietary recall, temporary urine potassium examination, and 24-hour urine potassium examination. The standard gold measurement for evaluating urinary potassium excretion is through 24-hour urine collection. This literature review aims to describe the role of urinary potassium excretion in assessing the progression of chronic kidney disease.

Chronic Kidney Disease Related to Cognitive Disorders in the Elderly: A Narrative Literature Review Ajat Sudrajat; Drajad Priyono; Harnavi Harun; Roza Kurniati; Roza Mulyana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 14 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i14.663

Chronic kidney disease (CKD) is characterized by progressive and irreversible kidney damage, leading to the inability of the kidneys to perform their functions. Chronic kidney disease causes hypertension, anemia, vascular dysfunction, uremia, proteinuria, systemic inflammation, and oxidative stress associated with cognitive impairment. Age is a population group aged 60 years or more at risk of experiencing health problems and the consequences associated with CKD. One of the common comorbidities experienced by elderly patients with CKD is cognitive impairment. Current treatment options for CKD with cognitive impairment aimed at common risk factors, including angiotensin converting enzyme inhibitors (ACEI) and, angiotensin receptor blockers (ARBs), SGLT-2 inhibitors., GLP-1 RA, and DPP-4 inhibitors. Other interventions, such as erythropoietin (EPO) compensation and reduction of inflammation and oxidative stress, can help improve patients' clinical symptoms. This literature review aims to describe the relationship between chronic kidney disease and cognitive disorders that occur in the elderly.

Correlation of Serum Fibroblast Growth Factor 23 With Left Ventricular Diastolic Function in Chronic Kidney Patients Harun Harnavi; Febrianti Ika Kurnia; Kam Alexander
Eduvest - Journal of Universal Studies Vol. 2 No. 9 (2022): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Chronic Kidney Disease (CKD) is one of most common world’s health problems with constantly increasing prevalence and many complications, and cardiovascular is one of them. The earliest cardiovascular damage that can be seen is left ventricular diastolic dysfunction. In patients with CKD, there will be mineral metabolism disorders, including phosphate. Persistently increased phosphate in CKD will cause rising in Fibroblast Growth Factor 23 (FGF23) that regulates phosphate in the circulation. High level of FGF23 will directly damage the heart and stimulates cardiac remodeling that will result in cardiomyocyte damage, atherosclerosis and intramyocardial cells fibrosis. This will cause myocardial stiffness and diastolic dysfunction. The purpose of the study is to discover correlation between Fibroblast Growth Factor 23 (FGF23) serum and left ventricle diastolic function in patients with chronic kidney disease. This is an observational study with cross-sectional methods. The sample is 30 patients diagnosed with chronic kidney disease (CKD). Patients are evaluated for Fibroblast Growth Factor 23 (FGF23) level in their serum, assessed the left ventricle diastolic function by measuring early diastolic velocity of the left ventricle (lateral e’) using echocardiography.There is significantly increased of FGF23 serum levels and decreased of lateral e’ value in chronic kidney disease case. There’s also a strong correlation between FGF23 serum and filtration glomerulus rate (LFG) (p<0.05), and a strong correlation between FGF23 serum level with lateral e’ as a component of left ventricle diastolic function. There’s a strong correlation between FGF23 with left ventricle diastolic function in patients with CKD.

Plasma Galectin-3 Biomarkers in Chronic Kidney Disease Annesa Fadella; Harnavi Harun; Drajad Priyono; Deka Viotra
Indonesian Journal of Multidisciplinary Science Vol. 2 No. 5 (2023): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Assessment of renal function is based on determination of serum creatinine and creatinine-based equations to assess GFR. However, this marker is not perfect or accurate, especially for longitudinal monitoring of kidney function in Chronic Kidney Disease (CKD patients). Decreased kidney function can be slowed or even anticipated with early detection, so as to avoid secondary complications. So it is important to find new biomarkers that can identify individuals at risk as early as possible. Plasma galectin-3 is a ?-galactoside-binding lectin expressed in monocytes, which plays an important role in inflammation, immunity, cancer, and is involved in the pathogenesis of atherosclerosis, diabetes, renal fibrosis and asthma. Higher galectin-3 levels were associated with reduced eGFR in a cross-sectional study. Galectin-3 is essential in various biological activities including cell growth, cell proliferation, differentiation, apoptosis, pre-mRNA splicing, transformation, angiogenesis, inflammation, fibrosis, fibrogenesis and host defense. Galectin-3 is a stable biomarker and is not associated with age, body mass index or sex. Galectin-3 is also useful for detecting the early stages of some diseases. Galectin-3 shows no circadian variation and increases slightly after exercise, returning to normal levels after 1-3 hours. Higher concentrations of galectin-3 may be associated with CKD development, indicating the potential for new mechanisms related to galectin-3 expression that may contribute to CKD development. Galectin-3 has also been reported to play an important role in renal interstitial fibrosis. Thus, galectin-3 inhibition may be a promising therapeutic strategy to prevent kidney disease progression.

The Relationship between Nutritional Status and the Incidence of Hypertension in the Elderly at the Working Area of the Lubuk Pinang Health Center, North Bengkulu Amelia Rinita; Diana Melida; Sjaaf Fidiariani; Harun Harnavi
Jurnal Penelitian Pendidikan IPA Vol 9 No 3 (2023): March
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i3.3407

Hypertension may occur primarily or is idiopathic. Where the causative factor cannot be identified or can occur secondarily as a result of a particular disease. This study aims to determine the relationship between nutritional status and the incidence of hypertension in the Elderly Work Area of the Lubuk Pinang Health Center, Muko-Muko Regency, North Bengkulu. The type of research used is analytical observational research with a cross-sectional approach. The affordable population in this study was the elderly who were registered for treatment at the Lubuk Pinang Health Center, Muko-Muko Regency, North Bengkulu, with 36 samples using the total sampling technique. Univariate data analysis is presented in frequency and percentage distribution and bivariate analysis using the spearman correlation test and data processing using the computerized IBM SPSS program version 24.0. The results of this study show that the highest age was 60-70 years, namely 28 people (77.8%), and the most gender was female, namely 31 people (86.1%). The most nutritional status was overweight, 15 people each (41.7%), the most hypertension was stage II, namely 25 people (69.4%), and there was a relationship between nutritional status and the incidence of hypertension in the Elderly Work Area of the Lubuk Pinang Health Center, Muko-Muko Regency, North Bengkulu (p=0.031). This research concludes that the highest age is 60-70 years. The most gender is female, the most nutritional status is overweight, the most hypertension is stage II, and there is a relationship between nutritional status and the incidence of hypertension in the Elderly Work Area of the Lubuk Pinang Health Center, Muko-Muko Regency, North Bengkulu

The Role of Nutritional Therapy in Inhibiting the Progression of Chronic Kidney Disease: A Narrative Literature Review Harnavi Harun; Genta Pradana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 3 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i3.789

The need for proper nutrition and diet is fundamental in every stage of chronic kidney disease. The principle of nutritional therapy is slowing the progression of chronic kidney disease, delaying patients with CKD (chronic kidney disease) from getting kidney replacement therapy. In CKD patients, there is a disturbance of protein homeostasis, disturbance in metabolism protein, acid-base disorders, and hormonal dysfunctions. As the progression of CKD increases, nitrogen-containing products accumulate, causing a decrease in appetite. In CKD patients, intestinal absorption is also impaired because uremia causes microbiota disturbance and damage to the intestinal epithelium. These various things cause nutritional status to become often irregular, and protein energy wasting frequently occurs, thus requiring dietary adjustments in patients with CKD. In conclusion, each individual with CKD has a different nutritional therapy approach depending on the disease conditions and nutritional status of the individual. Appropriate nutritional therapy in CKD patients can reduce disease progression.

The Role of Nutritional Therapy in Inhibiting the Progression of Chronic Kidney Disease: A Narrative Literature Review Harnavi Harun; Genta Pradana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 3 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i3.789

The need for proper nutrition and diet is fundamental in every stage of chronic kidney disease. The principle of nutritional therapy is slowing the progression of chronic kidney disease, delaying patients with CKD (chronic kidney disease) from getting kidney replacement therapy. In CKD patients, there is a disturbance of protein homeostasis, disturbance in metabolism protein, acid-base disorders, and hormonal dysfunctions. As the progression of CKD increases, nitrogen-containing products accumulate, causing a decrease in appetite. In CKD patients, intestinal absorption is also impaired because uremia causes microbiota disturbance and damage to the intestinal epithelium. These various things cause nutritional status to become often irregular, and protein energy wasting frequently occurs, thus requiring dietary adjustments in patients with CKD. In conclusion, each individual with CKD has a different nutritional therapy approach depending on the disease conditions and nutritional status of the individual. Appropriate nutritional therapy in CKD patients can reduce disease progression.

Effect of Ramadan Fasting on DNA Repair, Immune System, Inflammation and Cognitive Function in Chronic Kidney Disease Patients: A Systematic Literature Review Drajad Priyono; Harnavi Harun; Deka Viotra; Zaki Mahmudi Dasril
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 4 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i4.809

Background: There have been many studies that say Ramadan fasting has a positive effect on reducing BMI, blood sugar, inflammatory factors, and DNA Repair. However, there are still no guidelines for fasting in patients with chronic kidney disease (CKD) both nationally and internationally. This study aimed to conduct a review to explore the effects of Ramadan fasting against chronic kidney disease, specifically on DNA repair, Immune System, Inflammation, and Cognitive Function in patients with chronic kidney disease. Methods: This study is a systematic literature review (SLR) with sources obtained from various reputable journal databases such as PubMed, Cochrane Library, EBSCO, and Elsevier using relevant keywords. The selected articles have passed the inclusion and exclusion criteria. A total of 39 articles that discuss fasting were obtained from Ramadan in chronic kidney disease patients on metabolic response and inflammatory markers in the body. Results: Ramadan fasting has a positive effect on the response to anti-inflammatory, expression of protective genes, markers of kidney and liver function, protective proteome, and oxidative stress. Conclusion: Ramadan fasting may provide a short-term protective effect against levels of systemic inflammation.

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