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Effect of Ramadan Fasting on DNA Repair, Immune System, Inflammation and Cognitive Function in Chronic Kidney Disease Patients: A Systematic Literature Review Drajad Priyono; Harnavi Harun; Deka Viotra; Zaki Mahmudi Dasril
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 4 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i4.809

Background: There have been many studies that say Ramadan fasting has a positive effect on reducing BMI, blood sugar, inflammatory factors, and DNA Repair. However, there are still no guidelines for fasting in patients with chronic kidney disease (CKD) both nationally and internationally. This study aimed to conduct a review to explore the effects of Ramadan fasting against chronic kidney disease, specifically on DNA repair, Immune System, Inflammation, and Cognitive Function in patients with chronic kidney disease. Methods: This study is a systematic literature review (SLR) with sources obtained from various reputable journal databases such as PubMed, Cochrane Library, EBSCO, and Elsevier using relevant keywords. The selected articles have passed the inclusion and exclusion criteria. A total of 39 articles that discuss fasting were obtained from Ramadan in chronic kidney disease patients on metabolic response and inflammatory markers in the body. Results: Ramadan fasting has a positive effect on the response to anti-inflammatory, expression of protective genes, markers of kidney and liver function, protective proteome, and oxidative stress. Conclusion: Ramadan fasting may provide a short-term protective effect against levels of systemic inflammation.

The Role of Monocyte Chemoattractant Protein-1 (MCP-1) in Diabetic Kidney Disease Deddy Canceria Suka Rahmatsyah; Harnavi Harun; Deka Viotra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 9 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i9.861

Monocyte chemoattractant protein-1 plays an important role in kidney disease. In several studies, the role of MCP-1 as a urine biomarker has been extensively studied. In many kidney diseases, there are elevated levels of MCP-1 in the kidney tissue and this is an important cause of monocyte infiltration in the pathogenesis of kidney damage. Elevated urinary MCP-1 levels have been able to predict outcome in proliferative kidney diseases such as lupus nephritis. However, in several studies it was also found that there was an increase in MCP-1 in diabetic kidney disease. Macrophages have even appeared early in diabetic kidney disease and are associated with the progression of kidney disease. Urinary MCP-1 levels are related to the degree of leukocyte infiltration in the tubulointerstitial. This supports inflammatory factors as part of the pathogenesis of diabetic kidney disease.

Symmetric Dimethylarginine as a Biomarker for Chronic Kidney Disease Khairat AS; Harnavi Harun; Deka Viotra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 9 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i9.866

Symmetric dimethylarginine (SDMA), is a post-translationally stable catabolic product of arginine-methylated proteins that plays an important role in basic cellular metabolism. SDMA is an endogenous biomarker of kidney function that has been widely used in veterinary medicine. Symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA) are 2 constant products of L-arginine proteolysis that undergo methylation. SDMA is almost completely excreted by the kidneys after filtration making SDMA an ideal GFR biomarker candidate. Apart from that, SDMA has several advantages as a biomarker of kidney function, namely that it is not affected by non-renal factors that influence creatinine and cystatin C. Apart from that, SDMA also increases earlier than other biomarkers.

The Difference of Survival Rate COVID-19 in Patients with Initiated Hemodialysis and Regularly Hemodialysis Deka Viotra; Harnavi Harun; Drajad Priyono; Fauzar; Roza Kurniati; Alexander Kam; Abdul Alim Rahimi; Jersivindo Ranazeri; Zaki Mahmudi Dasril
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 10 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i10.877

Background: Since December 2019, a novel coronavirus called SARSCoV-2 (severe acute respiratory syndrome coronavirus) has caused an international outbreak of respiratory illness described as COVID-19. This study aimed to describe the difference in the survival rate of COVID-19 induced AKI with hemodialysis and COVID-19 in patients with CKD on hemodialysis in Dr. M Djamil General Hospitals. Also, in this review, we provide a comprehensive overview of data on the factors that may be affected by COVID-19 survival rates in patients with COVID-19 induced AKI with hemodialysis and COVID-19 in patients with CKD on hemodialysis. This study was conducted to analyze the survival of COVID-19 with initiated or regular HD patients in Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This study was conducted from January 2021 to July 2021 in Dr. M. Djamil General Hospital, Padang, West Sumatera, Indonesia. Data for this study was collected through medical records of patients admitted for COVID-19 with CKD in hemodialysis and acute renal failure induced by COVID-19 to show the demographics, comorbidities, and survival rates of the patients who underwent hemodialysis. Results: Factors associated with survival in COVID-19 with hemodialysis were COVID-19 severity and abnormal potassium serum level (Table 3). Moderate COVID-19 patients tend to survive than severe COVID-19 patients (OR 60; 95% CI 16.034 – 224.525). There was no significant difference in survival between initiated and regular HD (p = 0.829). Conclusion: There is no difference in clinical outcome from patients with COVID-19 who initiated hemodialysis or regularly HD to the survival rates.

Edukasi Manfaat Probiotik Susu Kambing Etawa dalam Percepatan Penurunan Prevalensi Stunting di Kota Padang Panjang Rinita Amelia; Yusti Siana; Ruhsyahadati Ruhsyahadati; Dian Puspita; Ira Suryanis; Harnavi Harun; Yudha E. Pratama
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 6, No 11 (2023): Volume 6 No 11 2023
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v6i11.12376

ABSTRAK Stunting adalah suatu kondisi dimana anak mengalami gangguan pertumbuhan, sehingga tinggi badan anak tidak sesuai dengan usia nya (stunted), sebagai akibat dari masalah gizi kronis yaitu, kekurangan asupan gizi dalam waktu yang lama. Data Riset Kesehatan Dasar (Riskesdas) tahun 2018 menunjukkan prevalensi stunted di Indonesia sebesar 30,8%. Prevalensi stunted balita untuk tahun 2022 adalah 24,1% di Indonesia, 23,3% di Sumatera Barat, dan 20% di Kota Padang Panjang (Kemenkes 2022). Stunting melibatkan multifaktorial seperti ekonomi, nutrisi, pola asuh yang salah, pendidikan, pengetahuan dan lain- lain. Stunting dapat memperlambat perkembangan motorik dan mental serta akan meningkatkan resiko terhadap penyakit degeneratif dan Infeksi. Metode yang dipakai pada pengabdian kepada masyarakat ini adalah memberikan edukasi dan pelatihan kepada 15 kader TP-PKK Padang Panjang dari 15 Kelurahan tentang pembuatan minuman sehat “yodiwa (yogurt dadiah Etawa) sebagai makanan high protein untuk anak stunting dengan penggunaan starter bakteri halal yang berasal dari dadiah. Selain itu juga diberikan edukasi pentingnya pemberian menu seimbang dan bahaya Stunting. Hasil yang didapatkan adalah peserta edukasi yang terbanyak pada usia 30-50 tahun (60%) dengan tingkat pendidikan terakhir Sekolah Menengah Atas/SMA sebanyak 73%. Terjadi peningkatan penegetahuan kader dengan score Baik dari 7% menjadi 33%. Pada kegiatan pelatihan pembuatan produk Inovasi yogurt yang berasal dari susu kambing dengan penambahan starter makanan lokal dadiah menghasilkan kader yang dapat mandiri membuat minuman yodiwa dan memiliki rencana dalam usaha untuk membantu meningkatkan perekonomian keluarga khususnya dan perekonomian daerah umumnya. Kata Kunci: Yogurt, Susu Kambing Etawa, Dadiah, Probiotik, Stunting ABSTRACT Stunting is a condition where a child experiences growth disorders, so that the child's height does not correspond to his age (stunting), as a result of chronic nutritional problems, namely, lack of nutritional intake for a long time. Basic Health Research (Riskesdas) data for 2018 shows that the prevalence of stunting in Indonesia is 30.8%. The prevalence of stunting under five in 2022 is 24.1% in Indonesia, 23.3% in West Sumatra, and 20% in Padang Panjang City (Ministry of Health 2022). Stunting involves multifactorial factors such as economics, nutrition, wrong parenting patterns, education, knowledge and others. Stunting can slow down motor and mental development and increase the risk of degenerative diseases and infections. The method used in this community service is providing education and training to 15 TP-PKK Padang Panjang cadres from 15 sub-districts on making the healthy drink "yodiwa (dadiah etawa yoghurt) as a high-protein food for stunted children using halal bacterial starter originating from Dadiah. Apart from that, education was also provided on the importance of providing a balanced menu and the dangers of stunting. The results obtained were that the majority of educational participants were aged 30-50 years (60%) with the highest level of education being high school/high school at 73%. There was an increase in knowledge of cadres with a Good score from 7% to 33%. In the training activity for making innovative yogurt products made from goat's milk with the addition of the local food starter dadiah, it produces cadres who can independently make yodiwa drinks and have business plans to help improve the family economy in particular and the regional economy in general. Keywords: Yogurt, Etawa Goat Milk, Dadiah, Probiotics, Stunting

The Role of Monocyte Chemoattractant Protein-1 (MCP-1) in Diabetic Kidney Disease Deddy Canceria Suka Rahmatsyah; Harnavi Harun; Deka Viotra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 9 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i9.861

Monocyte chemoattractant protein-1 plays an important role in kidney disease. In several studies, the role of MCP-1 as a urine biomarker has been extensively studied. In many kidney diseases, there are elevated levels of MCP-1 in the kidney tissue and this is an important cause of monocyte infiltration in the pathogenesis of kidney damage. Elevated urinary MCP-1 levels have been able to predict outcome in proliferative kidney diseases such as lupus nephritis. However, in several studies it was also found that there was an increase in MCP-1 in diabetic kidney disease. Macrophages have even appeared early in diabetic kidney disease and are associated with the progression of kidney disease. Urinary MCP-1 levels are related to the degree of leukocyte infiltration in the tubulointerstitial. This supports inflammatory factors as part of the pathogenesis of diabetic kidney disease.

Symmetric Dimethylarginine as a Biomarker for Chronic Kidney Disease Khairat AS; Harnavi Harun; Deka Viotra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 9 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i9.866

Symmetric dimethylarginine (SDMA), is a post-translationally stable catabolic product of arginine-methylated proteins that plays an important role in basic cellular metabolism. SDMA is an endogenous biomarker of kidney function that has been widely used in veterinary medicine. Symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA) are 2 constant products of L-arginine proteolysis that undergo methylation. SDMA is almost completely excreted by the kidneys after filtration making SDMA an ideal GFR biomarker candidate. Apart from that, SDMA has several advantages as a biomarker of kidney function, namely that it is not affected by non-renal factors that influence creatinine and cystatin C. Apart from that, SDMA also increases earlier than other biomarkers.

The Difference of Survival Rate COVID-19 in Patients with Initiated Hemodialysis and Regularly Hemodialysis Viotra, Deka; Harnavi Harun; Drajad Priyono; Fauzar; Roza Kurniati; Alexander Kam; Abdul Alim Rahimi; Jersivindo Ranazeri; Zaki Mahmudi Dasril
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 10 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i10.877

Background: Since December 2019, a novel coronavirus called SARSCoV-2 (severe acute respiratory syndrome coronavirus) has caused an international outbreak of respiratory illness described as COVID-19. This study aimed to describe the difference in the survival rate of COVID-19 induced AKI with hemodialysis and COVID-19 in patients with CKD on hemodialysis in Dr. M Djamil General Hospitals. Also, in this review, we provide a comprehensive overview of data on the factors that may be affected by COVID-19 survival rates in patients with COVID-19 induced AKI with hemodialysis and COVID-19 in patients with CKD on hemodialysis. This study was conducted to analyze the survival of COVID-19 with initiated or regular HD patients in Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This study was conducted from January 2021 to July 2021 in Dr. M. Djamil General Hospital, Padang, West Sumatera, Indonesia. Data for this study was collected through medical records of patients admitted for COVID-19 with CKD in hemodialysis and acute renal failure induced by COVID-19 to show the demographics, comorbidities, and survival rates of the patients who underwent hemodialysis. Results: Factors associated with survival in COVID-19 with hemodialysis were COVID-19 severity and abnormal potassium serum level (Table 3). Moderate COVID-19 patients tend to survive than severe COVID-19 patients (OR 60; 95% CI 16.034 – 224.525). There was no significant difference in survival between initiated and regular HD (p = 0.829). Conclusion: There is no difference in clinical outcome from patients with COVID-19 who initiated hemodialysis or regularly HD to the survival rates.

Indoxyl Sulfate Levels and Its Relation with Executive Function in Routine Hemodialysis Patients Syafrita, Yuliarni; Susanti, Restu; Indra, Syarif; Harun, Harnavi
Global Medical & Health Communication (GMHC) Vol 11, No 2 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i2.10964

Executive function is a crucial cognitive domain that can be adversely affected by various toxic substances, including the uremic toxin indoxyl sulfate. Although it's known that indoxyl sulfate has harmful effects on intra or extra-kidney organs, its impact on executive function remains unclear. This study aimed to evaluate indoxyl sulfate levels in patients with chronic kidney disease (CKD) undergoing hemodialysis and to understand its correlation with executive function impairments. This observational cross-sectional study was conducted at the Dr. M. Djamil General Hospital Padang Hemodialysis Unit from March to July 2022; 60 patients undergoing hemodialysis and 20 healthy controls participated. Executive function was assessed using the Trail Making Test B (TMT-B). Indoxyl sulfate levels were quantified using an ELISA assay with the Assay Genie kit. The Mann-Whitney test set statistical significance at a p<0.05. The average age of the subjects was 51.4±11.4 years, with 53% being male. The mean indoxyl sulfate levels were considerably higher in the CKD group (118.79 ng/ml, range: 11–1,709 ng/ml) compared to the control group (6.028±1.829 ng/ml), with a significant difference (p<0.001). Impaired executive function was observed in 75% of the CKD patients. The average indoxyl sulfate level was 165.12 ng/ml (range: 29–1,709 ng/mL) in the impaired executive function group and 71.22 ng/ml (range: 11–333 ng/mL) in the group with normal executive function, indicating a significant difference (p=0.013). Patients with CKD undergoing hemodialysis exhibit elevated serum indoxyl sulfate levels compared to healthy individuals. Moreover, CKD patients with impaired executive function have notably higher indoxyl sulfate levels than those with normal executive function. Further research is needed to elucidate the mechanistic links between indoxyl sulfate and cognitive impairments.

EFEK PEMBERIAN DADIAH LINTAU SUMATERA BARAT TERHADAP PERUBAHAN STRUKTUR HISTOPATOLOGI PADA JARINGAN PANKREAS TIKUS MODEL DIABETES Rinita Amelia; Rini Yulia; Putri Lisna; Anandia Putriyuni; Nadia Purnama D; Dessy Abdullah; Ade Teti Vani; Harnavi Harun
Nusantara Hasana Journal Vol. 4 No. 3 (2024): Nusantara Hasana Journal, August 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i3.1212

Diabetes mellitus is a metabolic disorder characterized by the loss or progressive dysfunction of insulin-producing cells in the pancreas, leading to multiple long-term complications and organ damage. Dadiah is one of the traditional probiotic milk products in West Sumatra that is rich in lactic acid bacteria (BAL). Dadiah contains Lactobacillus fermentum which has characteristics as a probiotic and stimulates endogenous antioxidants. The study aimed to determine the difference in the effect of giving curd with dadiah probiotics (L. Fermentum) on changes in the structure of Langerhans pancreatic islets in streptozotocin-induced diabetes model rats. Methods This study was experimental with animals using 2 control groups and 3 intervention groups, namely the negative control was normal intervention mice, the positive control was diabetic mice without intervention. P1 in the 3g/300g BB intervention group, P2 in the low dose (L. Fermentum) probiotic intervention (7.1 × 1010 CFU/mL) and P3 in the high dose 2 probiotic intervention × 7.1 × 1010 CFU/mL)) each group consisted of 5 mice, the intervention lasted for 8 weeks, then organ sampling was carried out. The results of pancreatic histopathology and Langerhans islets showed that in the 3g/300g BB treatment of curd gave an overview of the best cell repair close to negative control (-)/normal Conclusion: Dadiah and probiotic have been pathologically proven to provide anatomical improvement to Langerhans islet cells that undergo degeneration and necrosis in diabetic model mice, due to the presence of antioxidant and probiotic activity. Therefore, dadiah and probiotic dadiah have proven to be useful as a supportive therapy for diabetics.

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