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Stunting Management Education with the Application of Yodiwa Innovation Products in Padang Panjang City, West Sumatra, Indonesia Amelia, Rinita; Suryanis, Ira; Siana, Yusti; Ruhsyahadati, Ruhsyahadati; Harun, Harnavi; Pratama, Yudha Endra
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 7, No 6 (2024): Volume 7 No 6 2024
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v7i6.14974

Abstract

ABSTRAK Pemerintah telah meluncurkan program Rencana Aksi Nasional Penanganan stunting pada tingkat nasional, daerah terutama desa. Salah satu bagian dari program tersebut adalah pencegahan stunting yang terjadi di masyarakat. Karena sebagian besar masyarakat belum paham dengan benar menganai stunting, dan beranggapan bahwa stunting atau kerdil sebutan yang biasa digunakan di masyarakat adalah faktor keturunan. Penanganan bagi pasien stunting dilakukan dengan memberikan makanan yang bergizi tinggi, salah satu dengan pemanfaatan susu kambing sebagai sumber pretein hewani. Penerapan produk inovasi YODIWA (Yogurt dadiah Etawa) sebagai salah satu olahan susu kambing menjadi yogur dengan menggunakan starter dari dadiah. Metode yang dilakukan dalam pengabdian ini yaitu edukasi tentang manfaat dari susu kambing, dadiah dan probiotik; pelatihan pembuatan Yodiwa serta launching Pojok Yodiwa. Peserta pelatihan terdiri dari anggota TP-PKK Kota Padang Panjang yang berasal dari perakilan tiap kelurahan. Dengan diadakan pelatihan tentang pengolahan makanan tinggi protein berbahan dasar susu kambing in diharapkan mampu mengurangi prevalensi stunting di Kota Padang Panjang serta launching pojok Yodiwa ini sebagai centre pengolahan Yodiwa di Kota Padang Panjang yang berpusat di Kelurahan ganting. Kata Kunci: Dadiah, Stunting, Susu Kambing, Yodiwa, Padang Panjang  ABSTRACT The government has launched the National Action Plan program for handling stunting at the national, regional, and village levels. One part of the program is preventing stunting that occurs in the community. Most people do not understand properly about stunting and think that stunting or dwarfism, the term commonly used in society, is a hereditary factor. Treatment for stunting patients is carried out by providing highly nutritious food, one of which is using goat's milk as a source of animal protein. Application of the innovative YODIWA (Etawa dadiah yoghurt) as a form of processing goat's milk into yoghurt using a starter from dadiah. The method used in this service is education about the benefits of goat's milk, dadiah, and probiotics, as well as training on making Yodiwa and launching Pojok Yodiwa. The training participants comprised the Padang Panjang City TP-PKK members who came from each sub-district. By holding training on processing high protein foods made from goat's milk, it is hoped that it will be able to reduce the prevalence of stunting in Padang Panjang City and launch this Yodiwa corner as a Yodiwa processing centre in Padang Panjang City, which is based in Ganting Village. Keywords: Dadiah, Stunting, Goat's Milk, Yodiwa, Padang Panjang
The correlation between pentraxin-3, matrix metalloproteinase-9, and estimated glomerular filtration rate in patients with chronic kidney disease Harun, Harnavi; Dewi, Amelia Fitria; Amelia, Rinita
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art8

Abstract

Background: Chronic kidney disease (CKD) is diagnosed when there is a sustained decrease in the estimated glomerular filtration rate (EGFR) over a period of more than 3 months. While Pentraxin-3 (PTX-3) and Matrix Metalloproteinase-9 (MMP-9) levels increase during the acute phase of the kidney injury, chronic conditions often exhibit alteration in the epithelial mesenchymal transition (EMT).Objectives: This study aimed to elucidate the correlation between serum PTX-3, MMP-9, and eGFR in patients with CKD. Method: Thirty hypertensive patients with CKD stages 3, 4, and 5, aged between 16 and 65 years, were enrolled in the study (15 males and 15 females). Diagnosis of CKD was based on the 2012 Kidney Disease Improving Global Outcomes (KDIGO) criteria, utilizing serum creatinine, and CKD-epidemiology Collaboration (CKD-EPI) estimates. Subsequently, serum MMP-9 and PTX-3 levels were quantified. Result: Patients with CKD exhibited significantly higher serum levels of PTX3 and MMP9. Furthermore. a significant negative connection between PTX-3, MMP-9, and EGFR was observed. Additionally, CKD patients displayed a correlation between PTX-3 and MMP-9 concentrations.Conclusion: Plasma levels of PTX-3 and MMP-9 serve as unique, promising, and important markers that contribute to the pathogenesis of CKD.
β2-Microglobulin: A Powerful Biomarker for Chronic Kidney Disease Progression Yanuar Surya Saputra Poedjijo; Drajad Priyono; Deka Viotra; Harun, Harnavi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1219

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Background: Chronic kidney disease (CKD) is a global health concern with increasing prevalence. Early detection and accurate prognosis are crucial for effective management. β2-microglobulin (β2M) has emerged as a promising biomarker in CKD, but its prognostic value requires further evaluation. This meta-analysis aimed to comprehensively assess the association between β2M and CKD progression. Methods: A systematic search of PubMed, Embase, and Cochrane Library was conducted for studies published between 2013 and 2024 investigating the relationship between β2M and CKD progression. Studies were included if they reported hazard ratios (HRs) with 95% confidence intervals (CIs) for the association between β2M levels and renal endpoints (e.g., end-stage renal disease [ESRD], doubling of serum creatinine, or a decline in estimated glomerular filtration rate [eGFR]). A random-effects model was used to pool the HRs. Results: Six eligible studies involving 5,420 participants were included. The pooled analysis demonstrated a significant association between elevated β2M levels and increased risk of CKD progression (HR = 2.15; 95% CI: 1.78-2.59; p < 0.001). Subgroup analyses revealed that this association remained consistent across different CKD stages and underlying etiologies. Conclusion: Elevated β2M is a strong and independent predictor of CKD progression. Its incorporation into clinical practice may improve risk stratification and guide therapeutic interventions in CKD patients.
The Role of Superoxide Dismutase in Kidney Aging: A Meta-Analysis of Oxidative Stress, Inflammation, and Renal Function Hannie Qalbina Syaiful; Harnavi Harun
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1234

Abstract

Background: Kidney aging is an inevitable physiological process characterized by a progressive decline in renal function, increased oxidative stress, and chronic low-grade inflammation. Superoxide dismutase (SOD), a key antioxidant enzyme, plays a crucial role in mitigating oxidative damage. This meta-analysis aimed to comprehensively evaluate the association between SOD levels/activity and markers of oxidative stress, inflammation, and renal function in the context of kidney aging. Methods: A systematic search of PubMed, Scopus, and Web of Science databases was conducted for relevant studies published between 2013 and 2024. Studies investigating the relationship between SOD (SOD1, SOD2, SOD3) and kidney aging in humans were included. Data on SOD levels/activity, oxidative stress markers, inflammatory markers, and renal function parameters were extracted. Random-effects models were used to pool the standardized mean differences (SMD) and 95% confidence intervals (CI). Results: Nine studies with a total of 1,245 participants were included in the meta-analysis. Pooled analysis revealed a significant negative association between SOD activity and markers of oxidative stress (SMD = -0.85, 95% CI: -1.20 to -0.50, p < 0.001). Similarly, SOD activity was inversely associated with inflammatory markers (SMD = -0.62, 95% CI: -0.95 to -0.29, p < 0.001). Furthermore, a significant positive association was observed between SOD activity and eGFR (SMD = 0.78, 95% CI: 0.41 to 1.15, p < 0.001). Conclusion: This meta-analysis provides compelling evidence that SOD plays a critical role in mitigating oxidative stress and inflammation in kidney aging, contributing to the preservation of renal function. These findings highlight the potential of SOD as a therapeutic target for age-related kidney diseases.
Clinical and Demographic Profile of Chronic Kidney Disease Patients Undergoing Kidney Transplantation at a Tertiary Hospital in Indonesia Khairil Faiz Amir; Ade Asyari; Harun, Harnavi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1243

Abstract

Background: Chronic kidney disease (CKD) is a global health problem, and kidney transplantation is the treatment of choice for end-stage renal disease (ESRD). This study aimed to describe the clinical and demographic profile of CKD patients undergoing kidney transplantation at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: A descriptive retrospective study was conducted using medical records of CKD patients who underwent kidney transplantation between 2015 and 2023. Data on age, gender, duration of hemodialysis, donor-recipient relationship, blood pressure, blood type, crossmatch results, serum urea and creatinine levels, and etiology of CKD were collected and analyzed. Results: The study included 18 patients, all aged 19 to 59 years. The majority of patients were male (55.6%) and had undergone hemodialysis for less than 3 years (55.6%). Prehypertension and hypertension were the most prevalent blood pressure categories (44.4% each). Blood types A and O were most common (27.8% each), with consistent crossmatch results across groups. High levels of serum urea and creatinine were predominant, and hypertension was the most frequent etiology of CKD (66.7%). Conclusion: This study provides valuable insights into the characteristics of CKD patients undergoing kidney transplantation in Indonesia. The findings highlight the importance of early detection and management of CKD, particularly hypertension, to reduce the burden of ESRD and the need for transplantation.
Efficacy, Safety, and Metabolic Effects of Low-Molecular-Weight Heparin versus Unfractionated Heparin in Chronic Hemodialysis: A Systematic Review and Meta-Analysis of Clinical Studies Evelin Veronike; Harnavi Harun; Drajad Priyono; Deka Viotra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 1 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i1.1494

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Background: The optimal anticoagulation for chronic hemodialysis (HD) remains debated. Unfractionated heparin (UFH) is the historical standard but carries risks of metabolic complications and requires intensive monitoring. Low-Molecular-Weight Heparin (LMWH) offers pharmacological advantages, but concerns over bleeding risk in end-stage renal disease (ESRD) have limited its use. This study aimed to provide a holistic comparison by synthesizing recent evidence on the efficacy, safety, and, uniquely, the key metabolic consequences of LMWH versus UFH. Methods: This systematic review followed PRISMA 2020 guidelines. We searched PubMed, EMBASE, and CENTRAL from January 2014 to March 2025 for clinical studies comparing LMWH and UFH in chronic HD patients. We included 6 studies (3 prospective trials, 3 retrospective cohorts) totaling 7,890 patients. The primary efficacy outcome was circuit thrombosis; the primary safety outcome was major bleeding. Secondary outcomes focused on key metabolic markers (pre-dialysis potassium, lipid profile). Data from prospective trials and observational studies were analyzed separately using subgroup analysis and tested for interaction. Metabolic data were pooled using a random-effects model. Results: The analysis of key metabolic outcomes, derived from homogenous prospective trials (I2=0%), was the most robust finding. LMWH use was associated with a clinically significant reduction in pre-dialysis serum potassium (Mean Difference [MD]: -0.30 mEq/L; 95% CI: -0.50 to -0.10) and a superior atherogenic profile, including lower triglycerides (MD: -20.10 mg/dL) and higher HDL (MD: +4.50 mg/dL). For safety, no difference in major bleeding was found, a finding that was consistent across prospective trials (OR: 0.78; 95% CI: 0.33-1.85) and large retrospective cohorts (OR: 0.87; 95% CI: 0.69-1.09), with no subgroup interaction (p=0.75). Efficacy for preventing circuit thrombosis was also similar. Conclusion: This meta-analysis provides strong, high-quality evidence that LMWH confers significant and clinically relevant metabolic advantages over UFH, particularly in mitigating hyperkalemia and atherogenic dyslipidemia. Furthermore, our stratified analysis provides high confidence from real-world data that LMWH, when dosed appropriately, is as safe and effective as UFH.
THE DIFFERENCE IN TOTAL IMMUNOGLOBULIN E LEVELS AND EOSINOPHIL COUNTS AMONG ELDERLY INDIVIDUALS WITH AND WITHOUT ALLERGIC DISEASES Mulyana, Roza; Rio, Yugo Berri Putra; Raveinal, Raveinal; Martini, Rose Dinda; Harun, Harnavi; Asir, Taufik Rizkian; Fadrian, Fadrian; Murni, Arina Widya
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 4 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i4.3114

Abstract

Penyakit alergi dapat terjadi pada lansia dengan gejala yang dapat memburuk akibat adanya proses imunosenesens. Kadar IgE total dan jumlah eosinofil dapat digunakan sebagai pemeriksaan tambahan untuk penyakit alergi. Penelitian ini bertujuan untuk mengetahui perbedaan kadar IgE total dan jumlah eosinofil pada lansia dengan dan tanpa penyakit alergi. Penelitian observational analitik ini dilakukan pada lansia usia 60-80 tahun di RSUP DR. M. Djamil Padang selama Januari–Juni 2024. Sampel dikelompokkan menjadi kelompok lansia dengan penyakit alergi dan kelompok lansia tanpa penyakit alergi. Pengambilan sampel dilakukan secara consecutive sampling, melibatkan 52 partisipan (masing-masing 26 dengan dan tanpa penyakit alergi).  Kadar IgE total dan jumlah eosinofil diperiksa dengan menggunakan sampel darah vena. Analisis data menggunakan uji Mann-Whitney. Hasil penelitian menunjukkan median kadar IgE total pada kelompok alergi sebesar 1.741,1 kIU/L (minimum 517,7 kIU/L; maksimum 4843 kIU/L), sedangkan kelompok non-alergi 177,1 kIU/L (minimum 14 kIU/L; maksimum 800 kIU/L). Median jumlah eosinofil pada kelompok alergi sebesar 378 sel/µL (min: 100; maks: 950), sedangkan kelompok non-alergi 61,5 sel/µL (min: 17; maks: 189). Terdapat perbedaan signifikan kadar IgE total dan jumlah eosinofil antara lansia dengan dan tanpa penyakit alergi (p<0,001). Lansia yang mengalami Alergi menunjukkan kadar IgE  dan jumlah eosinofil lebih tinggi dibandingkan lansia yang tidak  alergi.  
The Role of Vitamin C in Management of Hypertension: A systematic review Rivani Sintia Suratman; Harnavi Harun; Drajad Priyono; Deka Viotra
Indonesian Journal of Kidney and Hypertension Vol 2 No 1 (2025): Volume 2 No. 1, April 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i1.184

Abstract

Background: Vitamin C is an antioxidant that can reduce oxidative stress. Oxidative stress has been thought to play an important role in the pathophysiology of hypertension. Studies have looked at Vitamin C as a supplement to treat hypertension. Vitamin C’s use as a complementary treatment for hypertension remains controversial, nevertheless. This study aims to evaluate vitamin C’s contribution to the treatment of hypertension. Objective: To conduct a literature review that examines how vitamin C (VC) supplements affect hypertension. Methods: This research uses a systematic literature review (SLR) approach with sources obtained from various online databases, including PubMed, Cochrane Library, EBSCO, and Elsevier, using the keywords "vitamin C" and "Hypertension". The selected articles were in accordance with the inclusion and exclusion criteria and discussed the role of vitamin C in lowering blood pressure in hypertension. Results: All the articles displayed fair methodological quality and reported significant positive effects of vitamin C for lowering blood pressure. Conclusions: Vitamin C can help decrease blood pressure as a complementary treatment.
Management of Iodine Contrast Media Related Anaphylactic Shock following Renal Arteriography: A Rare Case Report Kino, Kino; Karmia, Rofila Dita; Harun, Harnavi
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501429

Abstract

Background, anaphylactic shock (AS) caused by iodinated contrast media (ICM) is a rare but potentially life-threatening immediate hypersensitivity reaction. Despite widespread use of ICM in diagnostic imaging, data on ICM-related AS are limited, particularly in Indonesia. Early recognition and timely intervention are crucial to reduce morbidity and mortality. Case presentation, a 28-year-old female underwent renal arteriography with iodixanol. Within 5 minutes of contrast administration, she developed a generalized pruritic rash, dyspnea, vomiting, hypotension, and unstable cardiac parameters. Clinical presentation confirmed iodixanol-induced anaphylactic shock. Management, initial management included intramuscular epinephrine, rapid intravenous fluids, intravenous antihistamines and corticosteroids, and norepinephrine infusion. The patient’s hemodynamic status stabilized, and she was monitored in the CVCU for 48 hours. Outcome and conclusion, the patient recovered fully without complications. This case emphasizes the importance of rapid recognition and prompt pharmacologic intervention in ICM-induced anaphylaxis, while highlighting the value of thorough allergy documentation and preventive counseling.
OPTIMALISASI LAYANAN KESEHATAN IBU DAN ANAK MELALUI PROGRAM TANGGAP BENCANA HIDROMETEOROLOGI PADA MASYARAKAT TERDAMPAK BANJIR BANDANG DI KABUPATEN AGAM Rinita Amelia; Ira Suryanis; Dessy Abdullah; Yudha Endra Pratama; Harnavi Harun; Sari Setiarini; Afrah Diba Faisal
Nusantara Hasana Journal Vol. 5 No. 7 (2025): Nusantara Hasana Journal, December 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i7.1807

Abstract

Hydrometeorological disasters such as flash floods significantly impact access to and quality of health services, particularly for vulnerable groups such as pregnant women, postpartum mothers, breastfeeding mothers, infants and toddlers. Agam Regency, West Sumatra, is one of the areas affected by flash floods, with the risk of disruption to maternal and child health services. This Community Service (PKM) activity aims to optimize maternal and child health services through a hydrometeorological disaster response program for communities affected by flash floods in Agam Regency. The activity uses a descriptive-participatory approach, implemented through preparation, implementation, monitoring, and evaluation. The activities include comprehensive midwifery services, health services, maternal and child health education, and basic psychosocial support. The results of the activity indicate that the PKM program can improve access to maternal and child health services and achieve a high level of participant satisfaction. This activity is considered beneficial and appropriate to the needs of disaster-affected communities. This program is expected to become a model of applicable and sustainable community service in supporting maternal and child health services in hydrometeorological disaster situations.
Co-Authors -, Sari Setiarini Abdul Alim Rahimi Abdul Alim Rahimi Adang Bachtiar Adang Bachtiar Ade Asyari Ade Sukma Ade Teti Vani Afdhol Falah Afrah Diba Faisal Ajat Sudrajat Akmal M Hanif Alexander Kam Alexander Kam Alexander Kam Alvarino Alvarino Amelia, Rinita Anandia Putriyuni Andikha Putra Annesa Fadella Arief Rinaldy Arina Widya Murni Arina Widya Murni Arnelis Arnelis Asir, Taufik Rizkian Athasya Aulia Mufidah Athif Abyaz Khalil Putra ayu pathya Bayu Arief Hartanto Dasman, Hardisman Deddy Canceria Suka Rahmatsyah Deka Viotra Deka Viotra Deka Viotra Deka Viotra Deka Viotra Deka Viotra Deka Viotra Dela Hangri Jalmas Dessy Abdullah Dewi, Amelia Fitria Dian Puspita Diana Melida Dinda Aprilia Dional Setiawan Drajad Priyono Drajad Priyono Drajad Priyono Dwitya Elvira Efrida Efrida Eryati Darwin Ety Yerizel Evelin Veronike Evelin Veronike Evelin Veronike Evelin Veronike Fadrian, Fadrian Faheri, Eifel Fauzar Fauzar Fauzar Fauzar Fauzar Fauzar Fauzar, Fauzar Faza Yasira Rusdi Febrianti Ika Kurnia Festi Eliza Finny Fitry Yani Garri Prima Decroli Garri Prima Decroli Genta Pradana gina ariani Hanifa Alyu Hannie Qalbina Syaiful Hardisman Dasman Husna Yetti Ilmiawati Ilmiawati, Ilmiawati Indra, Syarif Indrapriyatna, Ahmad Syafruddin Ira Suryanis Irena Fathin Amelia Jalmas, Dela Hangri Jen Hendriman Jersivindo Ranazeri Jersivindo Ranazeri Kam Alexander Kam, Alexander Karmia, Rofila Dita Khairat AS Khairil Faiz Amir Kino Kino Ligat Pribadi Sembiring Meri Wulandari Miftah Irramah Muhammad Ridhwan Fatharanifurqan Murni, Arina W Nadia Purnama D Najirman Najirman Najirman, Najirman Naufal Fathi Ashari Nur Indrawaty Lipoeto Nursyirwan Effendi, Nursyirwan Pratama, Yudha Endra Priyono, Drajad Puti Anggun Sari Putra, Mindy Pasuma Putri Lisna Radias Zasra Radias Zasra Rangga Lunesia Rapida Saragih RAVEINAL RAVEINAL Restu Susanti Rezki Sadeli Rini Yulia Rinita Amelia Rinita Amelia Rivai, Muhammad Iqbal Rivani Sintia Suratman Rizkianto Imannual Rose Dinda Martini Roslaini Roslaini Roza Kurniati Roza Kurniati Roza Kurniati Roza Kurniati Roza Mulyana Ruhsyahadati Ruhsyahadati Ruhsyahadati, Ruhsyahadati Rusdi, Faza Yasira Russilawati Selfi Renita Rusjdi Siana, Yusti Simajuntak, Rohayat Bilmahdi Sjaaf Fidiariani SM Rezvi Sofiani, Dinda Putri Sri Puji Rahayuningsih Suchitra, Avit Syaiful Azmi Syaiful Azmi Syaiful Azmi Syaiful Azmi Syaiful, Hannie Q Vendry Rivaldy Veronike, Evelin Vesri Yoga Vidiansyah, Achmad Wahyudi, Adefri Yanuar Surya Saputra Poedjijo Yerizal Karani Yudha E. Pratama Yudha Endra Pratama Yugo Berri Putra Rio Yulia Devi Putri Yulia Devi Putri Yuliarni Syafrita Yulistia Asmi Yusti Siana Zaki Mahmudi Dasril Zaki Mahmudi Dasril Zaki Mahmudi Dasril