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All Journal Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Respirologi Indonesia Jurnal Respirasi (JR) AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Respiratory Science Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED)

Noni Novisari Soeroso

Department Of Pulmonolgy And Respiratory Medicine, Faculty Of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia

Author-ID : 3394663

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Correlation Between Carbon Monoxide Level In Exhaled Air and Pulmonary Function On Grill Street-Vendors In Medan City Chen, Jery; Noni Novisari Soeroso; Syamsul Bihar; Lambok Siahaan
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 3 No. 3 (2021): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Background. Air pollution is the result of household waste responsible for 3.8 million death and 7.7% of all mortality over the world. One air pollutant which tends to increase year by year is carbon monoxide (CO). CO is produced as the result of the imperfect combustion of machines and the combustion of charcoal. The purpose of this study is to assess the correlation between CO level in exhaled air and pulmonary function on grill street-vendors in Medan city. Method: This study is an observational analytic with a cross-sectional approach. The subjects were grill in Medan city who fulfilled certain inclusion and exclusion criteria with the consecutive sampling method. This study data is primary data which is collected using a questionnaire, smokerlyzer, and spirometry. Result: The subjects of this study are 25 grill street-vendors. Most subjects in this study have red (40%) and green (32%) zone in CO exhaled test and as in pulmonary function test, restrictive (56%) and mixed-type (40%) are the most. The Spearman correlation result between CO level in exhaled air and pulmonary functionÂ FEV1 and FVC are not significant (p=0.068 and p=0.251). Conclusion: There is no significant correlation between CO levels in exhaled air and pulmonary function

Assessment of Quality of Life in Advanced-Stage Lung Cancer Patients Using EORTC QLQ-C30 Questionnaire Ariantika, Ariantika; Lubis, Rahayu; Asfriyati, Asfriyati; Ashar, Taufik; Nurmaini, Nurmaini; Soeroso, Noni Novisari; Siregar, Kamal Basri; Lim, Darren Wan-Teck
Jurnal Respirasi Vol. 10 No. 3 (2024): September 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.3.2024.228-235

Introduction: Quality of life (QoL) is a multidomain concept that assesses a person through health status, functional status, and symptoms. The patient's QoL is greatly reduced due to the course of disease, severity of symptoms, and side effects of chemotherapy treatment. This study aimed to assess the QoL in advanced lung cancer patients using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30). Methods: This descriptive and observational study was conducted at the Pulmonary Polyclinic, Prof. Dr. Chairuddin Panusunan Lubis Universitas Sumatera Utara (USU) Hospital from February to July 2024, with a cross-sectional design using patient medical records and EORTC QLQ-C30 questionnaire. The EORTC QLQ-C30 questionnaire was analyzed with a score formula and categorized as good, moderate, and bad. The sample was 100 lung cancer patients using a purposive sampling technique according to the criteria. Results: The results showed that almost all QoL was in the moderate category (80%). The general health status was mostly in the moderate category (61.66%), the functional status was mostly in the good category (75.35%), and the symptoms were in the moderate category (35.65%). In the functional scale, the role domain had the lowest mean, 69.99 ± 29.43. In the symptoms scale, the pain domain had the highest mean, 52.66 ± 29.43. Conclusion: The overall QoL of lung cancer patients was in the moderate category, lower than the healthy population. It needs to be improved, especially in the role domain, by providing supportive-expressive group therapy.

The Characteristics of The General Population in Medan Undergoing Lung Cancer Screening with NARU Febiyanti, Mica; Tarigan, Setia Putra; Soeroso, Noni Novisari; Eyanoer, Putri Chairani
Journal of Society Medicine Vol. 3 No. 10 (2024): Oktober
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i10.165

Introduction: Indonesia introduced the NARU lung cancer screening form to assess individual risk levels for lung cancer, classifying them as low, medium, or high risk. This study aimed to analyze the characteristics of low, medium and high risk groups in Medan city. Methods: A quantitative, descriptive cross-sectional design was used, involving 100 individuals from primary health care facilities across 11 areas, who were evaluated using the 9-question NARU form. Evaluation concluded the individuals into low, medium, and high risk of lung cancer. Results: The majority of the responded high-risk group for lung cancer, the majority were males aged 45-65 years. They had no personal or family history of cancer but were active smokers, worked in carcinogenic environments, and did not live in homes or environments with carcinogenic risks. Additionally, they had a history of COPD and/or TB. In the moderate-risk group, both males and females aged 45-65 years were included, with no personal or family cancer history. They were passive smokers, did not work in carcinogenic environments, and did not live in homes or environments with carcinogenic risks. None had a history of COPD or TB. In the low-risk group, the majority were females under 45 years. They had no personal or family cancer history, were non-smokers, did not work in carcinogenic environments, and did not live in homes or environments with carcinogenic risks. They also had no history of COPD or TB. Conclusion: The study concluded that in Medan, 48% of the population fell into the moderate-risk group for lung cancer, while 31% were in the low-risk group, and 21% were classified as high risk.

Indonesian Society of Respirology Position Paper on Lung Cancer Control in Indonesia Andarini, Sita; Santoso, Andintia Aisyah; Arfiansyah, Mochammad Aris; Syahruddin, Elisna; Zaini, Jamal; Putra, Andika Chandra; Kurniawan, Ferry Dwi; Ermayanti, Sabrina; Soeroso, Noni Novisari; Munir, Sri Melati; Infianto, Andreas; Setijadi, Ana Rima; Setyawan, Ungky Agus; Wulandari, Laksmi; Haryati, Haryati; Jasminarti, Ida Ayu; Hidayat, Moulid; Santoso, Arif
Jurnal Respirologi Indonesia Vol 44, No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.884

Lung cancer is a major health concern in Indonesia due to its increasing prevalence, late-stage diagnosis, younger population, and high mortality. Addressing this issue requires nationwide implementation of comprehensive lung cancer control, which includes risk reduction and prevention strategies, focusing on tobacco control and air pollution mitigation. Screening with low-dose computed tomography (LDCT) and early detection in symptomatic patients, along with TB screening programs and all non-communicable diseases, is strongly recommended to enhance early case findings, treatment effectiveness, and overall patient outcomes. A multidisciplinary team (MDT) approach is important to ensure accurate diagnosis and comprehensive care. Moreover, the integration of palliative care at the early stages of advanced lung cancer is vital, focusing on symptom management and enhancing the quality of life for patients. While national guidelines are available for the diagnosis and treatment of lung cancer, significant disparities in healthcare access remain across Indonesia. Thus, it is essential to improve universal health coverage and referral systems to guarantee equal access to lung cancer care for patients at all levels through advocacy and ease of access.

Effectiveness of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) on Life Expectancy in Non-Small Cell Lung Cancer Patients in Medan City Harahap, Putri Wulandari; Tarigan, Setia Putra; Soeroso, Noni Novisari; Ashar, Taufik
Journal of Society Medicine Vol. 4 No. 2 (2025): February
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i2.193

Introduction: Non-small cell lung cancer (NSCLC) is strongly linked to epidermal growth factor receptor (EGFR) mutations, with tyrosine kinase inhibitors (TKIs) serving as a primary treatment. While TKIs demonstrate substantial antitumor effects, resistance differs across generations. This study evaluates the impact of first- and second-generation EGFR TKIs on the survival outcomes of NSCLC patients in Medan. Method: A retrospective cross-sectional study was conducted on 67 EGFR-positive NSCLC patients treated with TKIs between 2017 and 2022. Medical records from four hospitals-Haji Adam Malik Hospital, Elisabeth Hospital, Prof. Dr. Chairuddin Panusunan Lubis USU Hospital, and Pirngadi Hospital-were analyzed. Patients aged >18 years with EGFR mutations (exon 18, 19, or 21) and complete records were included. Survival outcomes, including Progression-Free Survival (PFS), Median Survival Time (MST), and Overall Survival (OS), were compared using the Mann-Whitney test. Results: All 67 patients received either first- or second-generation TKIs. Statistical analysis revealed that patients treated with second-generation TKIs had significantly better PFS, MST, and OS than those receiving first-generation TKIs (p < 0.05). Conclusion: This retrospective study faced limitations due to incomplete data and did not assess adverse effects. However, findings indicate that second-generation EGFR TKIs provide superior survival benefits for NSCLC patients compared to first-generation TKIs. Further prospective studies are needed to validate these results and explore the impact of treatment-related toxicity.

Characteristic of Adenocarcinoma Lung Patients With Ros-1 Mutation Among North Sumatra Population Ritonga, Adewita; Soeroso, Noni Novisari; Tarigan, Setia Putra
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar

Lung cancer is expected to be the most frequent cancer by 2020, accounting for over 2 million diagnoses and approximately 1.8 million deaths globally. Lung cancer, the most prevalent cancer, is identified by histopathological characteristics such as ROS-1 mutations, which impact 0.9% to 2.6% of adenocarcinomas worldwide with no data from Indonesia. The aim of this study is to examine the clinical characteristics of patients with ROS-1-mutant adenocarcinomas. A study with a cross-sectional design. Clinical characteristics of patients include their gender, history of smoking, family history of cancer, clinical stage, and the histological grading of their adenocarcinoma in hospitals. ROS-1 using RT-PCR in conjunction with paraffin blocks. A total of 90 adenocarcinoma patients were included in the study. The majority of patients were male (66.7%), aged 41–60 years (55.6%), former smokers (67.8%), and had no family history of cancer (97.8%). The highest malignancy level was at stage IVA (82.2%), with poorly differentiated histopathological grading being the most common (53.3%). The detection of ROS-1 fusion in 2% of patients emphasizes the need for molecular analysis in assessing individual genetic risk. ROS-1 fusion detection was obtained in 2% of female patients who were younger (average age 50 years) and never smoked. Only 2% of patients in the North Sumatra region met the criteria for ROS-1 fusion, including being female, being younger than the average patient age of 50, and not smoking.

Risk Factors of Type 2 Diabetes Mellitus in Pulmonary Tuberculosis Patients at Prof. Dr. Chairuddin P. Lubis Hospital USU Neny Pristiwati Harahap; R Lia Kusumawati; Noni Novisari Soeroso; Santi Syafril; Gema Nazri Yanni
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 3 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i3.20809

Background: Diabetes mellitus (DM) and tuberculosis (TB) are major global health concerns with a bidirectional relationship that exacerbates clinical outcomes. Indonesia faces a high prevalence of both diseases; however, specific risk factors contributing to the incidence of Type 2 DM (T2DM) among pulmonary TB patients remain underexplored, particularly in North Sumatra. This study aims to identify risk factors associated with T2DMin patients with pulmonary TB. Method: A retrospective case-control study was conducted involving 80 participants, comprising 40 pulmonary TB patients with T2DM and 40 without DM. Data were obtained from electronic medical records and analyzed using Chi-square tests, Fisher’s Exact Test, and multivariate logistic regression. Result Educational level (OR = 5.001; p = 0.027), occupational status (OR = 3.500; p = 0.038), and nutritional status based on body mass index (OR = 3.498; p = 0.017) were significantly associated with the incidence of T2DM in pulmonary TB patients. Result: No significant associations were found for age, gender, radiographic findings, or smoking habits. Higher educational level, employment in the private sector, and having a normal to overweight BMI are key risk factors for T2DM among pulmonary TB patients.

CYP2A6 Genetic Polymorphism and Nicotine Metabolism of Male Smokers in Indonesia Soliha, Chaliza; Soeroso, Noni Novisari; Ananda, Fannie Rizki; Zain-Hamid, Rozaimah; Bihar, Syamsul; Lim, Darren Wan-Teck
Jurnal Respirasi Vol. 10 No. 2 (2024): May 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.2.2024.93-98

Introduction: One of the main ingredients in cigarettes is nicotine, which has a significant impact on a person's dependence on cigarettes. Nicotine can be detected in a smoker's urine as a sign that his body is processing nicotine. The important enzyme CYP2A6 is involved in nicotine metabolism. This study aimed to determine the relationship between CYP2A6 genetic polymorphisms and nicotine metabolism among male smokers in Indonesia. Methods: This study included 100 male smokers who met the inclusion criteria in a cross-sectional design using a consecutive sampling between the ages of 20 and 65 years old. Restrictions fragment length polymorphism (RFLP) of the polymerase chain reaction (PCR) was applied to examine the genetic polymorphism of CYP2A6, and nicotine metabolite levels in urine were examined by high-performance liquid chromatography (HPLC) examination. Results: This study involved one hundred smokers, and 78 tested positive for the CYP2A6 polymorphism. The CYP2A6 genetic polymorphism and nicotine metabolism were not significantly correlated (p-value > 0.05). Allele *1A and genotype 1B/1B were more common in this study population. The majority of study participants had fast metabolic rates. Conclusion: No correlation was seen between the genetic polymorphisms of CYP2A6 and nicotine metabolism in Indonesian male smokers. Consequently, it is crucial to conduct future research in diverse populations with larger samples.

Double-Lumen vs Small-Bore Pigtail Catheter for Pleural Effusion: Which is Superior? Siagian, Novi Andriani; Soeroso, Noni Novisari; Bihar, Syamsul; Ashar, Taufik
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.39-46

Introduction: Pleural effusion is associated with a high mortality rate. Tube thoracostomy remains the standard treatment. Despite this, double-lumen catheters, typically used for central venous access, are infrequently employed for pleural drainage. This study compared the characteristics of patients undergoing double-lumen catheter versus pigtail catheter placements for pleural effusion. Methods: A retrospective cross-sectional study was conducted on adult patients at Prof. Dr. Chairuddin Panusunan Lubis Universitas Sumatera Utara Hospital, Haji Adam Malik General Hospital, and St. Elisabeth Hospital, Medan, from September 2022 to April 2024. This study analyzed patient demographics and clinical presentations for those receiving either catheter type. Results: The mean age of patients with double-lumen catheters was 58.21 years old, while those with pigtail catheters averaged 54.9 years old. Patients with double-lumen catheters frequently presented with a combination of shortness of breath, cough, and chest pain, while those with pigtail catheters primarily reported shortness of breath. Both groups predominantly exhibited exudative pleural effusions. Radiological evaluations indicated moderate pleural effusion was most common in both groups, with thoracic ultrasound revealing fluid volumes between 500 and 2,000 cc. Conclusion: Double-lumen catheters are more frequently utilized for moderate to massive pleural effusion, whereas pigtail catheters are typically reserved for moderate cases. The choice of catheter depends on the patient's condition, the underlying cause of the effusion, and radiological findings.

The Time to Progression in Lung Adenocarcinoma Patients Receiving First- and Second-Generation EGFR-TKI in Indonesia Syahruddin, Elisna; Soeroso, Noni Novisari; Ananda, Fannie Rizki; Wulandari, Laksmi; Setijadi, Ana Rima; Ermayanti, Sabrina; Pratiwi, Suryanti Dwi; Infianto, Andreas; Andayani, Novita; Munir, Sri Melati; Pratama, Avissena Dutha; Kusumawardani, Ida Ayu Jasminarti Dwi; Haryati, Haryati; Duyen, Natalie; Hanif, Muhammad Alfin; Lim, Darren Wan-Teck
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.22-30

Introduction: Targeted therapy, particularly epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), is the first-line treatment for non-small cell lung cancer (NSCLC). However, drug resistance has grown in the last few decades. This study compared the progression time of lung cancer patients treated with first- and second-generation EGFR-TKI. Methods: Based on cytology and histological results, this cross-sectional study included 1,008 participants diagnosed with lung adenocarcinoma (LUAD) from 11 Indonesian Respiratory Centers. Every three months, the response to treatment was assessed using the Response Evaluation Criteria in Solid Tumours (RECIST) criteria in 1.1. Significant differences in the clinical features of the three TKI treatment groups were identified using logistic regression analysis, the median time to disease progression was estimated using the Kaplan-Meier technique, and independent prognostic factors related to the time to progression (TTP) were assessed using Cox proportional hazards regression. Results: This study examined 505 patients, the majority of whom were females (50.9%), never smoked (59.8%), diagnosed at an advanced stage (99.2%), and had an Eastern Cooperative Oncology Group (ECOG) scale of 0-1 (83.2%). Approximately 98.1% of patients were treated with afatinib (14.8%), erlotinib (18.6%), and gefitinib (66.1%) due to common mutations. The groups did not differ significantly (p>0.05). The median overall survival (OS) rate was 9 months. The time to LUAD progression in lung cancer was significantly impacted by poor performance (p=0.001). Conclusion: Epidermal growth factor receptor-tyrosine kinase inhibitor treatment can only prolong the TTP of LUAD by up to 9 months, and the performance scale when receiving the EGFR-TKI significantly affects the prognosis.

Co-Authors Afiani, Dina Ana Rima Ana Rima Setijadi Ananda, Fannie Rizki Andarini, Sita Andreas Infianto Arfiansyah, Mochammad Aris Ariantika, Ariantika Arif Santoso Arif Santoso Asfriyati ,MKes Auliya, Muhammad Azka Bihar, Syamsul Bintang Yinke Magdalena Sinaga Chen, Jery Dian Cahyadi Dina Arwina Dalimunthe, Dina Arwina Dumasari Siagian Duyen, Natalie Elisna Syahruddin Ermayanti, Sabrina Ermayanti, Sabrina Erna Mutiara Erna Mutiara EVLINA SUZANNA, EVLINA Febiyanti, Mica Ferry Dwi Kurniawan Fotarisman Zalukhu Gema Nazri Yanni Hanif, Muhammad Alfin Harahap, Putri Wulandari Haryati Haryati Haryati Haryati Hendra Taufik Hidayat Hidayat Hidayat, Moulid Ida Ayu Jasminarti Ida Ayu Jasminarti Dwi Kusumawardani Infianto, Andreas Jasminarti, Ida Ayu Kurniawan, Ferry Dwi Laksmi Wulandari Lambok Siahaan Lim, Darren Wan-Teck Lucia Aktalina Lucia Aktalina Muhammad Harbi Praditya Nathaniel Aditya Neny Pristiwati Harahap Novita Andayani, Novita Novita Margaretta Ambarita Nurmaini Nurmaini Nurul Ramadhani Ozar Sanuddin Pratama, Avissena Dutha Pratiwi, Suryanti Dwi Putra, Andika Chandra Putra, Muhammad Yusuf Adira Putri C Eyanoer Putri Chairani Eyanoer, Putri Chairani R Lia Kusumawati R.A Henny Anggriani Rahayu Lubis Rahmat Hidayat Rina Amelia Ritonga, Adewita Rosidah Hanum Hasibuan Santi Syafril Santoso, Andintia Aisyah Setiaputra Setiaputra Setyawan, Ungky Agus Siagian, Novi Andriani Siregar, Kamal Basri Sita Andarini Soliha, Chaliza Sri Melati Munir Sri Melati Munir Syamsul Bihar Tarigan, Amira Permatasari Tarigan, Setia Putra Taufik Ashar Yahwardiah Siregar Yahwardiah Siregar Zain-Hamid, Rozaimah Zaini, Jamal

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