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All Journal Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Respirologi Indonesia Jurnal Respirasi (JR) AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Respiratory Science Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED)
Noni Novisari Soeroso
Department Of Pulmonolgy And Respiratory Medicine, Faculty Of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Anaplastic Lymphoma Kinase (ALK) Rearrangement of Lung Adenocarcinoma among North Sumatera Population Putra, Muhammad Yusuf Adira; Soeroso, Noni Novisari; Syahruddin, Elisna; Suzanna, Evlina; Afiani, Dina; Ashar, Taufik; Lim, Darren Wan-Teck
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.47-53

Abstract

Introduction: Lung cancer is a malignancy of the lung parenchyma or bronchi. Molecular targeted therapy directed at oncogene driver mutations, such as anaplastic lymphoma kinase (ALK), improves the prognosis of patients with non-small cell lung carcinoma (NSCLC). This study aimed to determine the characteristics of lung adenocarcinoma patients and the prevalence of ALK rearrangement among the North Sumatra population. Methods: This descriptive study used data from patients' formalin-fixed paraffin-embedded (FFPE) ALK examination results and medical records. The laboratory analyzed the patient’s FFPE for ALK fusion protein expression using the VENTANA anti-ALK (D5F3) procedure to determine the prevalence of ALK rearrangement. Results: Of the 34 subjects, it was revealed that the characteristics of lung adenocarcinoma patients were 18 patients aged >60 years old (52.9%), 26 male patients (76.4%), and 24 heavy smoker patients (70.6%). Based on the pathological tumor-node-metastasis (pTNM) stage, most samples were classified as stage IVA, with 24 cases (70.6%) showing the highest metastases to the pleura. There were 2 cases of ALK mutations obtained through immunohistochemical examination with a percentage of 5.8%. Conclusion: There are relatively few ALK rearrangement mutations in lung adenocarcinoma patients without screening. Additional research is needed to ascertain the distribution of lung adenocarcinoma patient characteristics associated with a higher prevalence of ALK rearrangement mutations.
Indonesian Society of Respirology Position Paper on Lung Cancer Control in Indonesia Andarini, Sita; Santoso, Andintia Aisyah; Arfiansyah, Mochammad Aris; Syahruddin, Elisna; Zaini, Jamal; Putra, Andika Chandra; Kurniawan, Ferry Dwi; Ermayanti, Sabrina; Soeroso, Noni Novisari; Munir, Sri Melati; Infianto, Andreas; Setijadi, Ana Rima; Setyawan, Ungky Agus; Wulandari, Laksmi; Haryati, Haryati; Jasminarti, Ida Ayu; Hidayat, Moulid; Santoso, Arif
Jurnal Respirologi Indonesia Vol 44 No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.884

Abstract

Lung cancer is a major health concern in Indonesia due to its increasing prevalence, late-stage diagnosis, younger population, and high mortality. Addressing this issue requires nationwide implementation of comprehensive lung cancer control, which includes risk reduction and prevention strategies, focusing on tobacco control and air pollution mitigation. Screening with low-dose computed tomography (LDCT) and early detection in symptomatic patients, along with TB screening programs and all non-communicable diseases, is strongly recommended to enhance early case findings, treatment effectiveness, and overall patient outcomes. A multidisciplinary team (MDT) approach is important to ensure accurate diagnosis and comprehensive care. Moreover, the integration of palliative care at the early stages of advanced lung cancer is vital, focusing on symptom management and enhancing the quality of life for patients. While national guidelines are available for the diagnosis and treatment of lung cancer, significant disparities in healthcare access remain across Indonesia. Thus, it is essential to improve universal health coverage and referral systems to guarantee equal access to lung cancer care for patients at all levels through advocacy and ease of access.
Assessment of Heavy Risk Factor Association with Lung Cancer Risk Using Questionnaire-Based Screening: A Cross-Sectional Study at Medan Johor Public Health Center, Medan, Indonesia Auliya, Muhammad Azka; Soeroso, Noni Novisari; Amelia, Rina; Dalimunthe, Dina Arwina; Lim, Darren Wan-Teck
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.6-12

Abstract

Introduction: Lung cancer remains a major public health concern in Indonesia, characterized by high morbidity and mortality rates. Effective prevention and management strategies necessitate the accurate identification of lung cancer risk factors. The questionnaire was developed and validated as a screening tool to evaluate risk factors and generate lung cancer risk scores. This study aimed to assess the questionnaire’s utility for identifying lung cancer risk factors and categorizing risk levels among individuals at the Medan Johor Public Health Center, Medan, Indonesia. Methods: This study enrolled 180 subjects who met the inclusion criteria. These subjects were part of the population, specifically non-lung-cancer patients at the Medan Johor Public Health Center in Medan, Indonesia. A cross-sectional analytic design was used to examine the correlation between risk factors and risk levels. Results: Among 180 lung cancer patients screened, the tool classified most individuals into moderate- to high-risk strata and showed significant between-group differences for most risk factors (p<0.05). In addition, the Kenali Paru (NARU) screening tool is accessible, reproducible, and cost-effective, using a 14-item multiple-choice format (2-3 options per item) with weighted scoring that converts responses into a total risk score. Conclusion: The questionnaire demonstrates its effectiveness as a screening tool for identifying lung cancer risk factors and stratifying risk levels. Nevertheless, refinement is necessary to address its limitations, including the addition of tailored questions for sub-populations with specific comorbidities or health conditions.
Co-Authors Afiani, Dina Ana Rima Ana Rima Setijadi Ananda, Fannie Rizki Andarini, Sita Andreas Infianto Arfiansyah, Mochammad Aris Ariantika, Ariantika Arif Santoso Arif Santoso Asfriyati ,MKes Auliya, Muhammad Azka Bihar, Syamsul Bintang Yinke Magdalena Sinaga Chen, Jery Dian Cahyadi Dina Arwina Dalimunthe, Dina Arwina Dumasari Siagian Duyen, Natalie Elisna Syahruddin Ermayanti, Sabrina Ermayanti, Sabrina Erna Mutiara Erna Mutiara EVLINA SUZANNA, EVLINA Febiyanti, Mica Ferry Dwi Kurniawan Fotarisman Zalukhu Gema Nazri Yanni Hanif, Muhammad Alfin Harahap, Putri Wulandari Haryati Haryati Haryati Haryati Hendra Taufik Hidayat Hidayat Hidayat, Moulid Ida Ayu Jasminarti Ida Ayu Jasminarti Dwi Kusumawardani Infianto, Andreas Jasminarti, Ida Ayu Kurniawan, Ferry Dwi Laksmi Wulandari Lambok Siahaan Lim, Darren Wan-Teck Lucia Aktalina Lucia Aktalina Muhammad Harbi Praditya Nathaniel Aditya Neny Pristiwati Harahap Novita Andayani, Novita Novita Margaretta Ambarita Nurmaini Nurmaini Nurul Ramadhani Ozar Sanuddin Pratama, Avissena Dutha Pratiwi, Suryanti Dwi Putra, Andika Chandra Putra, Muhammad Yusuf Adira Putri C Eyanoer Putri Chairani Eyanoer, Putri Chairani R Lia Kusumawati R.A Henny Anggriani Rahayu Lubis Rahmat Hidayat Rina Amelia Ritonga, Adewita Rosidah Hanum Hasibuan Santi Syafril Santoso, Andintia Aisyah Setiaputra Setiaputra Setyawan, Ungky Agus Siagian, Novi Andriani Siregar, Kamal Basri Sita Andarini Soliha, Chaliza Sri Melati Munir Sri Melati Munir Syamsul Bihar Tarigan, Amira Permatasari Tarigan, Setia Putra Taufik Ashar Yahwardiah Siregar Yahwardiah Siregar Zain-Hamid, Rozaimah Zaini, Jamal