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Purwitasari, Neny
Department Of Pharmacognosy And Phytochemistry, Faculty Of Pharmacy, Universitas Airlangga
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Journal : science and technology indonesia

 1 
Synthesis, In-Vitro Evaluation, and Computational Investigation of Salicylic Hydrazide Derivatives as Potential Tyrosine Kinase–Targeted Anticancer Agents Sulistyowaty, Melanny; Tri Widiandani; Albertus Aditya Setiawan; Seow Lay Jing; Neny Purwitasari; Ferlinahayati; Dwi Setyawan; Galih Satrio Putra; Anastasia Wheni Indrianingsih
Science and Technology Indonesia Vol. 11 No. 2 (2026): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.2.609-620

Abstract

A series of N2-acyl salicylic hydrazides (S2-S6) and N-(substituted benzylidene) salicylic hydrazides (S7-S9) were synthesized from 2-hydroxybenzohydrazide (S1), using both microwave irradiation and conventional methods, and tested for its in vitro anticancer activity against human lung cancer cell, A549. The salicylic hydrazides were successfully synthesized in good yields (79–98%) and the in-vitro study results indicated that 3,4-dichloro-N'-(2-hydroxybenzoyl)benzohydrazide (S5) was most active among the tested compounds (IC50 value of 68.75 µM). In this work, we applied an integrated approach combining network pharmacology and computational analysis to explore how salicylic hydrazide derivatives affect tyrosine kinase–related pathways. The in-silico findings were in agreement with the in vitro results, indicating that compound S5 produced a docking score of –6.53468 kcal/mol. The findings of this research are expected to support further development toward identifying promising anticancer drug candidates derived from salicylic hydrazide derivatives.
Co-Authors Abdul Rahem ACHMAD FUAD Achmad Fuad Hafid Afandi, Ryan AGUS HARIANTO Albertus Aditya Setiawan Ana Yuda Anastasia Wheni Indrianingsih Andang Miatmoko Andi Hermansyah Arie Sulistyarini Aty Widyawaruyanti Aty Widyawaruyanti Aura, Jihan Bambang Subakti Z Bambang Tri Purwanto Bermawi, Bastiana Burhan Ma'arif Dahri, Baso Devanus lahardo Dewi Isadiartuti Dewi Melani Hariyati Dini Retnowati Djoko Agus Purwanto Djoko Agus Purwanto Dwi Setyawan Esti Hendradi Etik Wahyuningsih Faisal Akhmal Muslikh Farida Ifadotunnikmah Fathia Faza Rahmadanita Fatin Fadhilah Hasib Febrianti, Winanda Rizki Ferlinahayati Ferlinahayati Firman Wicaksana Firman Wicaksana Galih Satrio Putra Gusti Noorrizka V Hadi Poerwono Hamizah Haula Hanifa Rahma Putri Hidayati, Agriana Rosmalina Hilkatul Ilmi Hilkatul Ilmi I NYOMAN WIJAYA Ichsanto, Farhan Hanang Idha Kusumawati Iis Wahyuningsih Isnalita Isnalita, Isnalita Juni Ekowati Kholis Amalia Nofianti Lidya Tumewu Ma'arif, Burhan Mangestuti Agil Marcellino Rudyanto Maulida Rizki Roswandi, Alyaa' Maylisa Natalia Corry Melanny Ika Sulistyowaty Mochammad Yuwono Mohammad Yusuf Alamudi Muhammad Amir Hasan Muhammad Faris Adrianto, Muhammad Faris Myrna Adianti Narendrani Sasmitaning Edhi Noorma Rosita Pratama, Adam Prayoga, Adistiar Qurnianingsih, Ema Retno Widyowati Retno Widyowati Retno Widyowati Rianti, Dian Ratna Rice Disi Oktarina Riesta Primaharinastiti Rini Hamsidi Rizki Rahmadi Pratama Rochmah Kurnijasanti Sahu, Ram Kumar Seow Lay Jing Setiawan, Albertus Aditya Suciati Suciati Suciati Suciati Sudjarwo Sudjarwo Sukardiman Sukardiman Sukardiman Sulistyowaty, Melanny Sumardiko, Dwi Setiani Suryadi, A. Mu’thi Andy SUZANA, SUZANA Tri Widiandani Tri Widiandani Tri Widiandani Tutiek Purwanti Tutik Sri Wahyuni Ulvan, Angkasa Megistra Umi Athiyah Wiwied Ekasari Wiwied Ekasari Yanu Andhiarto Yuni Priyandani Yunita Nita Yusniasari, Putri Antika Yusuf, Helmy