Article Per Year (5 Year)
p-Index From 2020 - 2025
3.137
P-Index
This Author published in this journals
All Journal e-NERS e-GIGI e-CliniC Jurnal e-Biomedik JURNAL PESISIR DAN LAUT TROPIS PHARMACON Jurnal Bios Logos JURNAL BIOMEDIK KESMAS Jurnal Keperawatan Medical Journal of Indonesia JURNAL LPPM BIDANG SAINS DAN TEKNOLOGI Animal Production : Indonesian Journal of Animal Production Jurnal Kedokteran Klinik PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Promotif Preventif Jurnal Kesehatan Tambusai Medical Scope Journal (MSJ) eJournal Kedokteran Indonesia International Journal of Health and Pharmaceutical (IJHP)
Jimmy Posangi
Bagian Farmakologi Fakultas Kedokteran Universitas Sam Ratulangi Manado
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

Published : 69 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 9 Documents
Search
Journal : JURNAL BIOMEDIK

 1 
DAYA HAMBAT OBAT KUMUR CETYLPYRIDINIUM CHLORIDE DAN OBAT KUMUR DAUN SIRIH TERHADAP PERTUMBUHAN STREPTOCOCCUS MUTANS Toar, Amelia I.; Posangi, Jimmy; Wowor, Vonny
Jurnal Biomedik : JBM Vol 5, No 1 (2013): JURNAL BIOMEDIK : JBM Suplemen
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.5.1.2013.2639

Abstract

Abstract: Dental caries and periodontal diseases are still the major problems of oral health among the community. The microbes Streptococcus mutans that accumulate in plaques have an important role in the occurences of these two diseases. The control of plaque forming can be done chemically by using mouthwash. Cetylpyridinium chloride (CPC) and betle leaf (Piper betle Linn.), among others, are active ingredients that are added in the preparation of alcohol-free mouthwash. This study aimed to determine whether there was a difference between the inhibition of alcohol-free mouthwash containing CPC, and betle-leaf mouthwash to the growth of S. mutans. This was an experimental study with a post-test-only control-group design. The technique for testing inhibition used the Kirby Baurer disc diffusion method with samples of cultures of S. mutans The trial materials were commercial alcohol-free mouthwash and betle-leaf mouthwash; and aquadest as the negative control.  There were nine repetitions for each trial material group. The results of the Kruskal Wallis test showed significant differences (P <0.05) between alcohol-free mouthwash containing CPC, alcohol-free mouthwash containing piper betle Linn extract, and aquadest. The result of the Mann Withney test showed that there was a significant difference (P <0.05) between alcohol-free mouthwash containing CPC and alcohol-free mouthwash containing piper betle Linn extract. Alcohol-free mouthwash containing CPC had a wider zone of inhibition than the alcohol-free mouthwash containing betle leaf extract. Conclusion: Inhibition of the alcohol-free mouthwash containing cetylpyridinium chloride on the growth of S.mutans was significantly better than the alcohol-free mouthwash containing piper betle Linn extract. Keywords: cetylpyridinium chloride, betle leaf, mouthwash, Streptococcus mutans.   Abstract: Karies gigi dan penyakit periodontal  merupakan masalah bagi kesehatan gigi dan mulut di masyarakat. Streptococcus mutans dalam plak berperan dalam terjadinya kedua penyakit ini. Pengontrolan plak dapat dilakukan secara kimiawi dengan menggunakan obat kumur. Cetylpyridinium chloride (CPC) dan daun sirih merupakan bahan aktif yang ditambahkan dalam  sediaan obat kumur bebas alkohol. Penelitian ini bertujuan untuk melihat apakah terdapat perbedaan daya hambat antara obat kumur bebas alkohol yang mengandung CPC dengan obat kumur daun sirih terhadap pertumbuhan S. mutans. Penelitian ini bersifat eksperimental dengan post-test only control group design. Teknik pengujian daya hambat menggunakan metode difusi cakram Kirby Baurer dengan sampel S. mutans. Bahan coba yang digunakan yaitu obat kumur bebas alkohol, dan akuades sebagai kontrol negatif. Jumlah pengulangan pada masing-masing kelompok bahan coba sebanyak 9 kali.  Uji Kruskal Wallis menunjukkan perbedaan bermakna (P <0,05) antara obat kumur CPC, obat kumur daun sirih, dan akuades terhadap pertumbuhan S. mutans. Uji Mann-Whitney menunjukkan perbedaan bermakna (P <0,05) antara obat kumur CPC dan obat kumur daun sirih terhadap pertumbuhan S. mutans. Obat kumur CPC memiliki zona hambat lebih besar dibandingkan obat kumur daun sirih. Simpulan: Sediaan obat kumur bebas alkohol yang mengandung cetylpyridinium chloride memilliki daya hambat terhadap pertumbuhan Streptococcus mutans yang lebih tinggi secara bermakna dibandingkan sediaan obat kumur bebas alkohol yang mengandung ekstrak daun sirih.
NON-CALLIPHORIDAE-NECROPHAGOUS-DIPTERA SUCCESSION ON PIG CARCASSES IN MANADO, INDONESIA Wangko, Sunny; Sembel, Dantje T; Pinontoan, Oddi R; Posangi, Jimmy; Huijbregts, Hans
JURNAL BIOMEDIK : JBM Vol 4, No 1 (2012): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.4.1.2012.749

Abstract

Abstrak. Penelitian mengenai suksesi Diptera nekrofagus non-Calliphoridae dilakukan di Manado, Indonesia pada tahun 2012. Tiga ekor bangkai babi domestik (berat badan 21-23 kg) dimatikan dengan tiga cara yang berbeda (dosis letal potasium sianida per oral, pukulan benda tumpul pada area osipital, dan tikaman benda tajam). Penelitian dilakukan selama 15 hari. Suhu udara ambien dan kelembaban, serta data suhu dari Badan Meteorologi Klimatologi dan Geofisika (BMKG) Stasiun Klimatologi Kayuwatu. Babi yang dimatikan dengan potasium sianida memperlihatkan perlangsungan dekomposisi yang lebih panjang (10 hari) dibandingkan dengan lainnya (delapan hari). Simpulan: Terdapat empat famili dan dua spesies Diptera nekrofagus non-Calliphoridae yang mengunjungi bangkai hewan coba: Sarcophagidae, Piophilidae, Ophyra, Phoridae, Musca domestica, dan Hermetia illucens. Sarcophagidae dan Ophyra telah ditemukan sejak hari ke-1. Dari keenam jenis serangga non-Calliphoridae yang berkunjung, hanya empat jenis yang berkolonisasi pada bangkai hewan coba, yaitu: Ophyra, Phoridae, Musca domestica, and Hermetia illucens. Kata kunci: nekrofagus non-Calliphoridae, babi domestik, suksesi, kolonisasi Abstract. A study was conducted on Non-Calliphoridae-Necrophagous-Diptera succession on pig carcasses in Manado, Indonesia, in the year 2012. Three domestic pig carcasses (weighing 21-23 kg) were killed by using three different manners (a lethal oral dose of potassium cyanide, a blow with a blunt material, and a stabbing with a sharp material). This study was conducted for 15 days. Ambient air temperatures and humidity, and temperature data of the Climatology Station, Kayuwatu were recorded. The pig killed with potassium cyanide showed a longer decomposition duration (10 days) than the others (eight days). Conclusion: there were four families and two species of Non-Calliphoridae-Necrophagous Diptera visited the carcasses: Sarcophagidae, Piophilidae, Ophyra, Phoridae, Musca domestica, and Hermetia illucens. The first visitors (day 1) were Sarcophagidae and Ophyra. From the six visitors, there were only four that colonized on the carcasses: Ophyra, Phoridae, Musca domestica, and Hermetia illucens.Key words: Non-Calliphoridae-Necrophagous-Diptera, domestic pigs, succession, colo-nization
EFEK EKSTRAK DAUN SIRSAK (ANNONA MURICATA L.) PADA KADAR KOLESTEROL TOTAL TIKUS WISTAR Posangi, Ira; Posangi, Jimmy; Wuisan, Jane
Jurnal Biomedik : JBM Vol 4, No 1 (2012): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.4.1.2012.750

Abstract

Abstract: Treatment using medicinal plants has already been applied before modern medicine. Soursop (Annona muricata L.) leaves have been used for the treatment of various diseases. The purpose of this study was to test whether the soursop leaf extract could lower the total cholesterol levels of wistar rats used as test animals. Prior to lowering the cholesterol levels, they first had to be raised, and to raise the level of total cholesterol, all test animals were induced by propyl thiouracyl (PTU). Rosuvastatin was used for positive control group F. Wistar rats were divided into six groups. Group A was the normal control group. Group B was given just PTU. Groups C, D, and E, after having been given PTU, were given respective doses of 50mg, 100mg, and 200mg/day of soursop leaf extract. Group F was given PTU and then rosuvastatin. The results showed that the total cholesterol levels in rats given soursop leaf extract or rosuvastatin were lower than rats that were not given soursop leaf extract or rosuvastatin. Conclusion: soursop leaf extract could lower the total cholesterol levels of wistar rats. Key words: soursop leaves, cholesterol Abstrak: Pengobatan menggunakan tanaman berkhasiat obat sudah lebih dulu diterapkan dari obat-obat modern. Daun sirsak telah digunakan untuk pengobatan bermacam penyakit. Tujuan penelitian ini untuk menguji apakah ekstrak daun sirsak dapat menurunkan kadar total kolesterol tikus wistar yang digunakan sebagai hewan uji. Untuk menaikkan kadar total kolesterol hewan uji diinduksi dengan PTU. Untuk kontrol positif digunakan rosuvastatin. Tikus wistar dibagi dalam 6 kelompok yang terdiri Kelompok A sebagai kontrol normal, Kelompok B diberikan PTU, Kelompok C, D, dan E diberikan PTU kemudian diberikan berturut-turut ekstrak daun sirsak dosis 50mg, 100mg, dan 200mg/hari, Kelompok F diberikan PTU kemudian rosuvastatin. Hasil penelitian menunjukkan kadar kolesterol total pada tikus yang diberikan ekstrak daun sirsak atau rosuvastatin lebih rendah daripada tikus yang tidak diberikan ekstrak daun sirsak atau rosuvastatin. Simpulan: ekstrak daun sirsak dapat menurunkan kadar total kolesterol tikus wistar.Kata kunci: daun sirsak, kolesterol
PREFERENSI NYAMUK AEDES AEGYPTI PADA BEBERAPA MEDIA AIR Wuwungan, Antje A; Lumanauw, Saartje J; Posangi, Jimmy; Pinontoan, Odi R
Jurnal Biomedik : JBM Vol 5, No 1 (2013): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.5.1.2013.2043

Abstract

Abstract: The Aedes aegypti mosquitoes are the main vectors of Dengue virus which causes Dengue Fever and Dengue Haemorrhagic Fever. Their blood sucking activity occurs during the day and they rest inside houses (endophagic and anthropophilic). Ae. aegypti females prefer to lay eggs in man-made containers. The purpose of this study was to determine the habitat and development of Ae. aegypti in four types of water (rain water, well water, tap water, and soap water). The method of this study was random group design. The results showed that Ae. aegypti prefered black containers to white containers. Conclusion: The preference of the Ae. aegypti mosquitos in choosing the water media for laying eggs and their development whether in rain water, well water, tap water, or soap water were not significantly different. Keywords: Aedes aegypti, Dengue, types of water.     Abstrak: Nyamuk Aedes aegypti merupakan vektor Dengue utama yang mejadi penyebab Demam Dengue dan DBD. Aktivitas mengisap darah terjadi pada siang hari dan nyamuk dewasa cenderung beristirahat di dalam rumah (endofagik dan antropofilik).  Ae. aegypti lebih menyukai wadah buatan manusia untuk tempat berkembang biak. Tujuan penelitian ini untuk mengetahui habitat nyamuk Ae. aegypti pada empat jenis air. Metode penelitian yang digunakan yaitu metode rancangan acak kelompok. Hasil  penelitian  menunjukkan bahwa Ae. aegypti lebih memilih  wadah  berwarna  hitam  dari pada  wadah  berwarna  putih. Simpulan: Preferensi  nyamuk  Ae. aegypti untuk meletakkan telur  pada  media air hujan, air sumur, air PAM, dan air sabun tidak memperlihatkan perbedaan bermakna. Kata kunci: Aedes aegypti, Dengue, jenis air.
Uji Efek Daya Hambat Jamur Endofit Rimpang Jahe (Zingiber officinale Rosc) terhadap Bakteri Staphylococcus aureus dan Escherichia coli Abdul, Jihan A.; Posangi, Jimmy; Wowor, Pemsi M.; Bara, Robert A.
Jurnal Biomedik : JBM Vol 12, No 2 (2020): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.12.2.2020.29163

Abstract

Abstract: Ginger rhizome contains antimicrobial compounds of phenol group, flavonoids, terpenoids, and aetheric oil. Endophytic fungi are commonly found in ginger plant Zingiber officinale Rosc. which is widely available in Indonesia. There is a symbiosis between these endophytic fungi and its host plants in a form of genetic material transform, thus these fungi could produce the same active compounds as the host does, or at least involved in the host’s biosynthetic pathway. This study was aimed to determine the inhibitory effect of endophytic fungi isolated from ginger (Zingiber officinale Rosc) against clinical isolates Staphylococcus aureus and Escherichia coli. The endophytic fungi were isolated and their activities were screened. Initial screening of 6 isolates showed that only 3 isolates had relatively strong inhibitory effect against the bacteria. Therefore, they were cultured again, and their extracts were tested against the same types of bacteria. The mean diameters of the inhibition zones against S. aureus were, as follows: 18.7 mm (JJR extract), 11 mm (JJA 1.3 extract), and 17.3 mm (JJA 2.1 extract). Moreover, the mean diameters of the inhibition zone against E. coli were, as follows: 18 mm (JJR extract), 17.3 mm (JJA 1.3 extract), and 23.3 mm (JJA 2.1 extract). In conclusion, endophytic fungi isolated from Zingiber officinale Rosc. had inhibitory effect against S. aureus and E. coli. The inhibitory effect against E. coli was stronger than against S. aureus.Keywords: Zingiber officinale Rosc, endophytic fungi, E. coli, S. aureus Abstrak: Rimpang jahe mengandung senyawa antimikroba fenol, flavonoid, terpenoid, dan minyak atsiri. Jamur endofit sering ditemukan pada tumbuhan jahe Zingiber officinale Rosc, yang tersebar di Indonesia. Terdapat simbiosis antara jamur endofit dan tanaman inang dalam bentuk transformasi materi genetik sehingga jamur tersebut dapat menghasilkan senyawa aktif yang sama, atau setidaknya terlibat dalam jalur biosintesis inang. Penelitian ini bertujuan untuk mengetahui daya hambat jamur endofit yang terdapat pada jahe (Zingiber officinale Rosc) terhadap bakteri Staphylococcus aureus dan Escherichia coli. Jamur endofit diisolasi dan diskrining aktivitasnya. Hasil skrining awal dari 6 isolat yang diperoleh memperlihatkan hanya 3 isolat jamur endofit memiliki daya hambat yang relatif kuat terhadap bakteri uji. Ketiga isolat tersebut dikultur kembali dan ekstraknya diuji aktivitas dengan bakteri yang sama. Hasil pengukuran zona hambat 3 isolat jamur ialah sebagai berikut: pada bakteri Staphylococcus aureus didapatkan jamur JJR 18,7 mm, jamur JJA 1.3 11 mm, dan JJA 2.1 17,3 mm; pada bakteri Escherichia coli didapatkan jamur JJR 18 mm, JJA 1.3 17,3 mm, dan JJA 2.1 23,3 mm. Simpulan penelitian ini ialah jamur endofit isolat dari Zingiber officinale Rosc. memiliki aktivitas antibakteri terhadap S. aureus dan E. coli. Daya hambat jamur endofit lebih besar terhadap E. coli dibandingkan S. aureus.Kata kunci: Zingiber officinale Rosc, jamur endofitik, E. coli, S. aureus
Hubungan antara pengetahuan gizi, aktivitas fisik, dan intensitas olahraga dengan status gizi Roring, Natalia Megawati; Posangi, Jimmy; Manampiring, Aaltje Ellen
Jurnal Biomedik : JBM Vol 12, No 2 (2020): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.12.2.2020.29442

Abstract

Abstract: The purpose of this research to determine the relationship between nutritional knowledge, physical activity with exercise intensity and nutritional status. The method used is quantitative research with the approach cross sectional study. Determination of sample was done by total sampling totaled 118 Church youth GMIM Kanaan Pinabetengan. Analysis of test data using spearman correlation coefficient. The results showed the nutritional status of the most many categories of normal 43.3%, fat 29.9%, skinny 26.9%. Knowledge of nutrition both categories 56.7%, less good 43.3%. Physical activity in the category of pretty 53.7%, less 46.3%. The intensity of the sport category better 55.2%, less good 44.8%. Spearman test between nutritional knowledge and nutritional status are known to have a relationship, be aware the value of significant (2tailed), namely 0.003. The strength of the relationship moderates the positive direction. Spearman test between physical activity and nutritional status are known to have a relationship, be aware the value of significant (2tailed), namely 0.003. The strength of the relationship moderates the positive direction. Spearman test between intensity of exercise and nutritional status are known to not have a relationship. The conclusion there is a relationship between knowledge of nutrition, physical activity and nutritional status. There is no relationship between exercise intensity and nutritional status on the youth of the Church GMIM Kanaan Pinabetengan.Keywords: knowledge, physical activity, exercise intensity, nutritional status  Abstrak: Penelitian ini bertujuan mengetahui hubungan antara pengetahuan gizi, aktivitas fisik dengan intensitas olahraga dan status gizi. Metode yang digunakan yaitu penelitian kuantitatif dengan pendekatan cross sectional study. Penentuan sampel dilakukan secara total sampling berjumlah 118 pemuda Jemaat GMIM Kanaan Pinabetengan. Analisis data menggunakan uji koefisien korelasi spearman. Hasil penelitian menunjukkan status gizi paling banyak kategori normal 43.3%, gemuk 29.9%, kurus 26.9%. Pengetahuan gizi kategori baik 56.7%, kurang baik 43.3%. Aktivitas fisik pada kategori cukup 53.7%, kurang 46.3%. Intensitas olahraga kategori baik 55.2%, kurang baik 44.8%. Uji spearman antara pengetahuan gizi dengan status gizi diketahui memiliki hubungan, diketahui nilai signifikan (2tailed) yaitu 0.003. Kekuatan hubungan moderat arah positif. Uji spearman antara aktivitas fisik dengan status gizi diketahui memiliki hubungan, diketahui nilai signifikan (2tailed) yaitu 0.003. Kekuatan hubungan moderat arah positif. Uji spearman antara intensitas olahraga dengan status gizi diketahui tidak memiliki hubungan. Simpulan ada hubungan antara pengetahuan gizi, aktivitas fisik dengan status gizi. Tidak ada hubungan antara intensitas olahraga dengan status gizi pada pemuda Jemaat GMIM Kanaan Pinabetengan.Kata kunci: pengetahuan, aktivitas fisik, intensitas olahraga, status gizi
Hubungan antara kelelahan, motivasi belajar, dan aktivitas fisik terhadap tingkat prestasi akademik Welong, Seftian Surya; Manampiring, Aaltje Ellen; Posangi, Jimmy
Jurnal Biomedik : JBM Vol 12, No 2 (2020): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.12.2.2020.29516

Abstract

Abstract: This study aim to determine between fatigue, learning motivation, and physical activity on the level of academic achievement use quantitative study. The population is all students of the specialization Ocupational Health and Safety class of 2017 totaling 60 Students and the sample is the total population. Statistical analysis the chi square test. The results of the study level of academic achievement found category good 60%, very good 40%. Fatigue found category not found 58.3%, tired of 41.7%. Motivation to learn found low category 51.7%, high of 48.3%. Physical activity found categories quite 53.3%, less 46.7%. The results of the chi square test confirms there is a relationship between fatigue on the level of academic achievement. The results of the chi square test confirms there is a relationship between learning motivation on the level of academic achievement. The results of the chi square test confirms there is a relationship between physical activity on the level of academic achievement. There is a relationship between fatigue, motivation to learn, and physical activity on the level of academic achievement.Keywords:  achievement, fatigue, motivation, physical activity  Abstrak: Penelitian ini untuk mengetahui hubungan antara kelelahan, motivasi belajar, aktivitas fisik terhadap tingkat prestasi akademik. Jenis penelitian kuantitatif. Populasi ialah seluruh mahasiswa peminatan Kesehatan dan Keselamatan Kerja Angkatan 2017 berjumlah 60 Mahasiswa dan sampel adalah total populasi. Analisis statistik uji chi square. Hasil penelitian tingkat prestasi akademik ditemukan kategori baik 60%, sangat baik 40%. Kelelahan ditemukan kategori tidak lelah 58.3%, lelah 41.7%. Motivasi belajar ditemukan kategori rendah 51.7%, tinggi 48,3%. Aktivitas fisik ditemukan kategori cukup 53.3%, kurang 46.7%. Hasil uji chi square menegaskan ada hubungan antara kelelahan terhadap tingkat prestasi akademik. Hasil uji chi square menegaskan ada hubungan antara motivasi belajar terhadap tingkat prestasi akademik. Hasil uji chi square menegaskan ada hubungan antara aktivitas fisik terhadap tingkat prestasi akademik. Terdapat hubungan antara kelelahan, motivasi belajar, dan aktivitas fisik terhadap tingkat prestasi akademik.Kata kunci: prestasi, kelelahan, motivasi, aktivitas fisik
Diet Ketogenik untuk Penyakit Epilepsi Resisten Obat Kurnia, Bonar; Nangoy, Edward; Posangi, Jimmy
Jurnal Biomedik : JBM Vol 13, No 3 (2021): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.13.3.2021.31946

Abstract

Abstract: Epilepsy is estimated to affect 70 people worldwide. Anti-epileptic drugs (AED) as the main therapy for epilepsy can treat epilepsy in 70% of patients but 20-30% of patients experience Drug-Resistant Epilepsy (DRE). One therapy that can be given to patients who are not responsive to AED is ketogenic diet, a diet high in fat, low in carbohydrates and sufficient protein, which can help control seizures. The mechanism of action is still not known, but it may relate to AED. This study aims to determine the role or effect of ketogenic diet for DRE. This research is in the form of a literature review. In this study, the ketogenic diet was found to be effective in treating DRE especially in reducing seizure frequency. Ketogenic diet is particularly effective in treating focal seizures and West syndrome, and the correlation between ketogenic diet and AED can be found in a theory of the mechanism of action of the ketogenic diet with the mechanism of action of AED which is the actual therapy of this epilepsy. Ketogenic diet is effective as an alternative therapy for DRE in infants to adults. What needs to be considered is the type of ketogenic diet used must be suitable for the patient in order to achieve the best adherence, tolerability and effectiveness. Classification of the patient's epilepsy such as the type of seizure or the etiology of the epilepsy may also be a factor in starting a ketogenic diet therapy.Keywords: Epilepsy, Refractory Epilepsy, Drug Resistant Epilepsy, Ketogenic Diet  Abstrak: Epilepsi diperkirakan diderita oleh 70 orang di seluruh dunia. Obat anti epilepsi (OAE) sebagai terapi utama untuk epilepsi dapat menangani epilepsi pada 70% penderita namun 20-30% pasien mengalami Epilepsi Resisten Obat. Terapi yang dapat diberikan untuk pasien yang tidak responsif terhadap pemberian OAE adalah diet ketogenik, diet tinggi lemak, rendah karbohidrat dan cukup protein yang dapat membantu mengontrol bangkitan. Mekanisme kerja diet ketogenik masih belum diketahui namun kemungkinan ada kaitannya dengan OAE. Penelitian ini bertujuan untuk mengetahui peran atau efek diet ketogenik untuk penyakit epilepsi resisten obat. Penelitian ini berbentuk literature review. Dalam penelitian ini, diet ketogenik ditemukan efektif untuk menangani epilepsi resisten obat khususnya dalam menurunkan frekuensi bangkitan. Diet ketogenik secara khusus efektif dalam menangani bangkitan fokal dan sindrom west, dan korelasi antara diet ketogenik dengan OAE dapat ditemukan dalam teori mekanisme kerja diet ketogenik dengan mekanisme kerja OAE yang merupakan terapi sebenarnya epilepsi ini. Diet ketogenik efektif sebagai terapi alternatif untuk epilepsi resisten obat baik untuk pasien bayi hingga dewasa. Adapun yang perlu diperhatikan adalah jenis diet ketogenik yang digunakan harus sesuai dengan pasien guna mencapai ketaatan, tolerabilitas dan efektivitas yang terbaik. Klasifikasi epilepsi pasien seperti tipe bangkitan atau etiologi penyebab epilepsi dapat juga menjadi faktor pertimbangan untuk memulai terapi diet ketogenik.Kata Kunci: Epilepsi, Epilepsi Refrakter, Epilepsi Resisten Obat, Diet Ketogenik
Perbandingan Efektivitas Penggunaan Donepezil dan Memantine Terhadap Perbaikan Fungsi Kognitif pada Penyakit Alzheimer Alamri, Khairun N. H.; Posangi, Jimmy; Nangoy, Edward
Jurnal Biomedik : JBM Vol 13, No 2 (2021): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.13.2.2021.31950

Abstract

Abstract: Pharmacological therapy for Alzheimer’s disease are cholinesterase inhibitors (donepezil) and N-methyl-D-aspartate (memantine) receptor antagonists. The use of donepezil and memantine in elderly patients must be considered because they can affect the pharmacokinetic process of drugs and the effect of drugs on the body.The aim of the study was knowing the difference in the effectiveness of using Donepezil and Memantine on the improvement of cognitive function in Alzheimer's patients. This study was in the form of a literature review with data searches using three databases, namely Pubmed, ClinicalKey, Science Direct.  Keywords used are Donepezil AND Cognitive .AND Alzheimer, Memantine AND Cognitive AND Alzheimer. After being selected, 12 literature was obtained based on inclusion and exclusion criteria. In this study, Donepezil and memantine are beneficial in improving cognitive function in moderate to severe Alzheimer's disease but side effects tend to be more frequent with the use of donepezil than memantine. donepezil and memantine can be combined for the treatment of Alzheimer's disease but must pay attention to the effectiveness in clinical evaluation of patients and the cost effectiveness of the combination. Conclusion: Memantine and donepezil are effective and safe to use as therapy for moderate to severe Alzheimer’s disease. Donepezil and memantine combination therapy is more effective than donepezil or memantine monotherapy.Keywords: Donepezil, Memantine, Cognitive, Alzheimer  Abstrak: Terapi farmakologi untuk penyakit alzheimer adalah inhibitor kolinesterase (donepezil) dan antagonis reseptor N-metil-D-aspartat (memantine). Penggunaan donepezil dan memantine pada pasien lanjut usia harus diperhatikan karena dapat mempengaruhi proses farmakokinetik obat dan efek obat terhadap tubuh. Penelitian ini bertujuan untuk mengetahui perbedaan efektivitas penggunaan Donepezil dan Memantine terhadap peningkatan fungsi kognitif pada pasien Alzheimer. Penelitian ini berbentuk Literature Review dengan pencarian data menggunakan tiga database yaitu Pubmed, ClinicalKey, Science Direct. Kata kunci yang digunakan adalah Donepezil AND Cognitive AND Alzheimer, Memantine AND Cognitive AND Alzheimer. Setelah dipilih, diperoleh 12 literatur berdasarkan kriteria inklusi dan eksklusi. Dalam penelitian ini, Donepezil dan memantine bermanfaat dalam meningkatkan fungsi kognitif pada penyakit Alzheimer sedang hingga berat tetapi efek sampingnya cenderung lebih sering dengan penggunaan donepezil daripada memantine. donepezil dan memantine dapat digabungkan untuk pengobatan penyakit Alzheimer tetapi harus memperhatikan keefektifan dalam evaluasi klinis pasien dan efektivitas biaya dari kombinasi tersebut. Kesimpulan: Memantine dan donepezil efektif dan aman digunakan sebagai terapi penyakit Alzheimer sedang hingga berat. Terapi kombinasi donepezil dan memantine lebih efektif dibandingkan dengan monoterapi donepezil atau memantine.Kata Kunci : Donepezil, Memantine, Cognitive, Alzheimer
Co-Authors Abdul, Jihan A. Achmad, Mardhita Nilamsari Alamri, Khairun N. H. Amelia I. Toar Anak Agung Istri Sri Wiadnyani Angela Christin Tiwa Angelina Stevany Regina Masengi Antje A Wuwungan Antonius R.B. Ola Arthur Mongan Ayu S. Gugule B H. R. Kairupan Bagaray, Evangelin Fresianly Bernat S. P. Hutagalung Budhi Setianto Christy N. Mintjelungan Citra R. Irianty Clara, Santi Daniel Febrian Sengkey Dantje T Sembel Dimas Prakoso Dina Rombot Dwilestari . Edward Nangoy, Edward Edward S. Oroh, Edward S. Elisa Mangkey Esther Ariny Rumimper Eva A. Sijabat, Eva A. Faidiban, Aqueline N. Falugah, Fathia Fatimawali . Febriana ., Febriana Frengki P. Menggelea Grace D. Kandau, Grace D. Grace Debbie Kandou Gresty Masi Gustaaf A. E. Ratag Hans Huijbregts Harmani Kalim Hasanuddin, Israyati R. Hendra Sandag Henoch Awaloei Herman Warouw IC Manoppo, Jeanette IC Ira Posangi Jane Wuisan Judo Prihartono Juliatri . Julio Lopez Aban, Julio Lopez Katuuk, Mario Esau Kipimbob, Eflentina Kurnia, Bonar Kurniawan Kurniawan Laurentius Rumokoy, Laurentius Lendombela, Ditya P. J. Lengkong, Gledys Tirsa Lesar, Imelda Lidia Lidia Iswanto, Lidia Linnie Pondaag Mamahit, Juliet Merry Eva Mambo, Christi D. Mambo, Christi Diana Manampiring, Aaltje Ellen Manannohas, Mouren Mantjoro, Eva M. Marthen Theogives Lasut, Marthen Theogives Masi, Gresty N.M. Maya Memah Mewengkang, Mario L. Michael A. Leman Minarma Siagian Mona P. Wowor Murdani Abdullah Nas Lokbere Natalia Christine Mantiri Ni Luh G.L. Jayalandri, Ni Luh G.L. Ni Wayan Mariati Nina S Widiarto Ning Irianti, Ning O. Mona Wowor Oddi R Pinontoan Oroh, Wenda P. Djufri, Moh Akbar P. M. Wowor P. S. Anindita Paliling, Agrianto Pandegirot, Juliana Sisca Pangouw, Excel Paulina yamlean Pemsi M. Wowor, Pemsi M. Pertiwi, Junita Maja Polii, Erfand Putri, Vita A.D Ramadi, Reza Pahlevi Rampengan, Nancy Ratag, Gustaaf Ristanti Pratiwi Robert A. Bara Rondonuwu, Yohanes Amazia Zet Roring, Natalia Megawati Rudianto Tari S. Surya, Welong S. V. Sinolungan, Jehosua Saartje J Lumanauw Santi Turangan, Santi Sarwono Waspadji Sirowanto Inneke Sondakh, Refrando M. Starry H. Rampengan Sunny Wangko Surya, Welong S. Suzanna Immanuel T. Lasut, Markus Tangkuman, Victor Yohanes Tansil, Alberta Y.M. Tarigan, Paulus B. Titi L. Faraknimella, Titi L. V. Rombot, Dina Venesia Pengan Vivi P. Santoso Vonny N. S. Wowor Vonny Wowor Walewangko, Marfincy Walewangko, Marfincy S. Warouw, Finny Warouw, Inggrid Welong, Seftian Surya Widya Astuty Lolo, Widya Astuty Wisie Lusia Toar, Wisie Lusia Y. Tangkuman, Yundi Y. Yolanda A. Kasi Yolanda Bataha Yulianty Sanggelorang