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All Journal Althea Medical Journal Global Medical and Health Communication Majalah Kedokteran Majalah Obstetri dan Ginekologi Journal of Medicine and Health Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Teknologi Sistem Informasi dan Aplikasi Jurnal Teknologi Informatika dan Komputer Jurnal Mekanik Terapan MEDICINUS Journal of Medicine and Health
Adhi Pribadi
Department Of Obstetric And Gynecology, Faculty Of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung
Automotive Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Electrical & Electronics Engineering Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Althea Medical Journal

 1 
The Teratogenic Effect of The Mindi (Melia azedarach L) Leaves Ethanol Extract on Mice (Mus musculus) Fetus Sutomo, Adisti Erlina; Sitorus, Trully D.; Pribadi, Adhi
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (571.353 KB)

Abstract

Background: Mindi leaves (Melia azeradach L.) were used by Indonesians as a traditional medicine for pregnant women because it was considered to be safe. Mindi leaves contain several active compounds and one of them is suspected as a teratogen and can disrupt fetus growth in gestation. This research aims to know about the teratogenic effect of ethanol extract of Mindi leaves by using mice.Methods: This was a laboratory experimental study using 27 pregnant female mice (Mus musculus) of Swiss Webster strain which were randomly assigned to 3 groups (n=9) controlled (Carboxymethyl cellulose 1% for day 1–18 of pregnancy), group I (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 1–5 of pregnancy), and group II (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 6–18 of pregnancy). Observation was done to see total amount of fetus, live normal fetus count, length and weight of fetus, abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorbed fetus count. This research was done from October to November 2012 in Pharmacological laboratory of Faculty of Medicine Universitas Padjajdjaran. Data analysis utilized unpaired t-test.Results: The result showed a significant difference (p<0.05), seen from live normal fetus count and abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorpted fetus count. Conclusions: Administration of Mindi leaves extract during pregnancy of mices can cause teratogenic effect.[AMJ.2015;2(1):221–25]
The Teratogenic Effect of The Mindi (Melia azedarach L) Leaves Ethanol Extract on Mice (Mus musculus) Fetus Adisti Erlina Sutomo; Trully D. Sitorus; Adhi Pribadi
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (571.353 KB)

Abstract

Background: Mindi leaves (Melia azeradach L.) were used by Indonesians as a traditional medicine for pregnant women because it was considered to be safe. Mindi leaves contain several active compounds and one of them is suspected as a teratogen and can disrupt fetus growth in gestation. This research aims to know about the teratogenic effect of ethanol extract of Mindi leaves by using mice.Methods: This was a laboratory experimental study using 27 pregnant female mice (Mus musculus) of Swiss Webster strain which were randomly assigned to 3 groups (n=9) controlled (Carboxymethyl cellulose 1% for day 1–18 of pregnancy), group I (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 1–5 of pregnancy), and group II (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 6–18 of pregnancy). Observation was done to see total amount of fetus, live normal fetus count, length and weight of fetus, abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorbed fetus count. This research was done from October to November 2012 in Pharmacological laboratory of Faculty of Medicine Universitas Padjajdjaran. Data analysis utilized unpaired t-test.Results: The result showed a significant difference (p<0.05), seen from live normal fetus count and abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorpted fetus count. Conclusions: Administration of Mindi leaves extract during pregnancy of mices can cause teratogenic effect.[AMJ.2015;2(1):221–25]
Co-Authors AA Sudharmawan, AA Achmad Fauzan, Achmad Adisti Erlina Sutomo Adisti Erlina Sutomo, Adisti Erlina Akhmad Yogi Pramatirta, Akhmad Yogi Aldiansyah, Dudy Aldika Akbar, Muhammad Ilham Alifa, Dhara Amillia Siddiq Andi Kurniadi, Andi Andi Rinaldi Andonotopo, Wiku Andri Reza Rahmadi Aqilah, Nurjihan Syarifah Arnova Reswari ASTRI ASTUTI Aziz, Muhammad Alamsyah Bachnas, Muhammad Adrianes Budi Handono Cool, Charlotte Johanna Cut Meurah Yeni Dany Hilmanto Dewi, Sawitri Dida Akhmad Gurnida Dodi Suardi Elsa Pudji Setiawati Eppy Darmadi Achmad Evert Solomon Pangkahila Evicenna Naftuchah Riani Firmansyah, Silva Elifa Hadyana Sukandar Hanom Husni Syam Herry Herman Hidayat, Dini I Nyoman Hariyasa Sanjaya Ismayadi, Tedi Jeffry Iman Gurnadi, Jeffry Iman Johanes C. Mose Julian Dewantiningrum Kurjak, Asim Laniyati Hamijoyo, Laniyati Luthfi Rahman, Luthfi Megantoro, Izzati Faustina Melsa Sagita Imaniar Muhammad Alif Nugrahani, Annisa Dewi Nuswil Bernolian Pramono, Mochammad Besari Adi Pramudyo, Miftah Pratiwi, Erlina Lutfiayu Putra, Ridwan Abdullah Rachmawati, Anita Ritonga, Mulyanusa Ritonga, Mulyanusa Amarullah Riva, Salma Nisrina Ruswana Anwar Ryan Saktika Mulyana Setyorini Irianti Solly Aryza Sri Sulistyowati Stanojevic, Milan Sulaiman, Aina Zakia Suri, Mulhamatus Latifatus Susiarno, Hadi Syahdony, Farrel Nolan Syahputra, Farsyah Septrial Hendra Trully D. Sitorus Trully D. Sitorus Utami, Hasri Larasati Wilis Dwi Pangesti Windi Nurdiawan Wiradnyana, Anak Agung Gede Putra Yordian, Kendry Savira