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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Penelitian Kesehatan Suara Forikes As-syifaa Jurnal Farmasi JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Media Ilmu Kesehatan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia JFIOnline Jurnal Mandala Pharmacon Indonesia Jurnal Biomedika Health Information : Jurnal Penelitian Science Midwifery International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Indonesian Journal of Global Health research Jurnal Health Sains Open Access Indonesian Journal of Medical Reviews Archives of The Medicine and Case Reports Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Jurnal Multidisiplin Madani (MUDIMA) East Asian Journal of Multidisciplinary Research (EAJMR) Formosa Journal of Multidisciplinary Research (FJMR) Formosa Journal of Science and Technology (FJST) Indonesian Journal of Pharmacy and Natural Product Jurnal Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian Kunir: Jurnal Farmasi Indonesia (KJFI) Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Wiwin Herdwiani
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Literature review of the cytotoxic activity of faloak (sterculia quaddrifida r.br) against t47d and mcf-7 breast cancer cells and its active compounds Rumaldus Seran; Wiwin Herdwiani; Titik Sunarni
Science Midwifery Vol 13 No 6 (2026): February: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i6.2246

Abstract

Faloak (Sterculia quadrifida R.Br) is one of the plants used by the community as a multipurpose drug. Faloak bark herb has long been used by the people of East Nusa Tenggara as a medicinal plant. Empirically, boiled water from the bark of the faloak plant is used by the people of East Nusa Tenggara as a cure for hepatitis, typhus, ulcers, and stamina recovery. The data extraction method used is narrative by grouping similar data from the literature review results according to the size of the results to be presented. The flow of the journal search is about testing the cytotoxic activity of faloak (Sterculia quadrifida R.Br) against T47D and MCF-7 breast cancer cells and the content of their active compounds. From these data, screening, journal eligibility, and monitoring of conformity with inclusion and exclusion criteria were carried out to obtain appropriate journals to conclude the cytotoxic activity of faloak. The results of a literature review showed that faloak (Sterculia quadrifida R.Br) had cytotoxic activity against T47D and MCF-7 breast cancer cells. Chemical compounds that have cytotoxic activity are alkaloids, flavonoids, terpenoids, tannins, naphthoquinone, apigenin, and puerarin. Naptaquinone derivatives 2,3-dihydro-6hydroxy-2-methylenenaphtho [1,2-b] furan-4,5-dione and 2-iminoethyl 2-(2-(1-hydroxypentan-2-yl) phenyl) acetate obtained from the extract or active fraction of faloak bark (Sterculia quadrifida R.Br) showed cytotoxic activity against T47D breast cancer cells. Apigenin compounds were found to be the most effective phytoestrogens in inhibiting the growth of breast cancer cells. Apigenin also has apoptotic effects and induces autophagy in breast cancer cells. an effective proteasome inhibitor in breast cancer cell culture and breast cancer xenografts, and puerarin can increase DUSP1 expression by increasing the expression level of miR-133a-3p in breast cancer cells.
SWOT Analysis with ServQual Model of Pharmaceutical Services at RSUD Ibu Fatmawati Soekarno Surakarta in 2024 Ayub Adhi Cahyana; Samuel Budi Harsono; Wiwin Herdwiani
Formosa Journal of Multidisciplinary Research Vol. 4 No. 4 (2025): April 2025
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjmr.v4i4.151

Abstract

The purpose of this study was to determine the level of patient satisfaction with pharmaceutical services partially from five-dimensional parameters, namely physical evidence (tangible), reliability, responsiveness, assurance, empathy and to determine the SWOT improvement strategy in increasing patient satisfaction with pharmaceutical services at RSUD Ibu Fatmawati Soekarno. This study uses a quantitative descriptive method that is prospective with a research instrument in the form of a validated questionnaire. The population of the study was outpatient BPJS patients in all polyclinics with a sample size of 380 respondents. The sampling technique used Purposive Sampling, using the service quality method. Data analysis was carried out by finding the correlation value, namely by comparing the reality and expectations of patients and validity and reliability tests, then an analysis of improvements to pharmaceutical services was carried out using a SWOT analysis. Based on the research conducted, the results of dissatisfaction with the service (negative) on the reliability dimension with a value of (0.17) and responsiveness with a value of (0.17). Then the results of satisfaction with the service (positive) on the tangible dimension with a value of (0.01), assurance with a value of (0.08) and empathy with a value of (0.04) were obtained.
Aktivitas Sitotoksik dan Ekspresi Protein p53 Bcl-2 Ekstrak dan Fraksi Daun Kersen (Muntingia calabura L.) terhadap Sel Kanker Payudara T47D Maulita Saraswati; Nuraini Harmastuti; Wiwin Herdwiani
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), Vol. 17 No. 02 Desember 20
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.7280

Abstract

Daun kersen (Muntingia calabura L.) merupakan tanaman yang dapat digunakan sebagai alternative pengobatan kanker. Penelitian ini bertujuan mengetahui aktivitas sitotoksik ekstrak etanol daun kersen, fraksi n-heksan, fraksi etil asetat dan fraksi air ekstrak daun kersen terhadap sel T47D dan mengetahui pengaruh ekspresi protein p53 dan Bcl-2 pada pemberian fraksi aktif daun kersen. Daun kersen diekstrak dengan metode maserasi menggunakan pelarut etanol 70%. Ekstrak etanol kemudian difraksinasi dengan partisi cair-cair. Uji sitotoksik dilakukan pada sel kanker payudara T47D dan sel vero dengan metode MTT assay dan dibaca absorbansinya menggunakan ELISA reader. Untuk mengetahui pengaruh ekspresi protein p53 dan Bcl-2 dilakukan uji imunositokimia. Hasil penelitian ini menunjukkan bahwa fraksi n-heksan daun kersen memiliki aktivitas sitotoksik potensial terhadap sel kanker payudara T47D, sedangkan pada ekstrak, fraksi etil asetat, dan fraksi air memiliki aktivitas sitotoksik moderat. Fraksi n-heksan daun kersen mampu meningkatkan ekspresi protein p53 dan Bcl-2 pada konsentrasi 6,79 - 27,16 µg/mL.
Aktivitas Antihiperglikemia Ekstrak Dan Fraksi-Fraksi Buah Merah (Pandanus Conoideus L) Terhadap Perbaikan Fungsi Ginjal Pada Tikus Diabetes Nefropati Sakinah Sarnia Iriani; Wiwin Herdwiani; Tri Wijayanti
Health Information : Jurnal Penelitian Vol 16 No 3 (2024): September-Desember
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36990/hijp.v16i3.1457

Abstract

Buah merah (Pandanus conoideus L) merupakan tumbuhan yang memiliki kandungan antioksidan yang tinggi yang dapat digunakan sebagai alternatif pengobatan penyakit diabetes mellitus. Tujuan dari penelitian ini untuk mengetahui aktivitas antihiperglikemia dari pemberian ekstrak dan fraksi-fraksi buah merah (Pandanus Conoideus L) terhadap perbaikan glukosa darah, mikroalbuminuria, kreatinin dan histopatologi ginjal pada tikus diabetes nefropati yang diinduksi STZ-NA. Penelitian ini merupakan penelitian eksperimental, menggunakan 30 ekor tikus dan dikelompokkan menjadi 6 kelompok yaitu kelompok I normal,kelompok II kontrol negatif STZ 65 mg/kg BB dan NA 230 mg/kg BB, kelompok III kontrol positif pioglitazone 15 mg/kg BB, kelompok IV ekstrak buah merah 250 gr/kg BB, kelompok V fraksi n-heksan buah merah 71,42 mg/kg BB, kelompok VI fraksi etil asetat buah merah 17,85 mg/kg BB, dan Kelompok VII fraksi air buah merah 128,57 mg/kg BB. Data dianalisis menggunakan ANOVA dan uji lanjutan Post Hoc Tukey. Hasil penelitian menunjukkan kelompok fraksi etil asetat buah merah 17,85 mg/kg BB yang paling efektif dalam menurunkan kadar glukosa darah, kreatinin, mikroalbuminuria serta memperbaiki kerusakan pada ginjal tikus. Fraksi etil asetat menunjukkan penurunan yang signifikan dibandingkan kelompok yang lain dengan per-sentase aktivitas fraksi etil asetat yaitu glukosa darah 98.41%, kreatinin 0.92, mikroalbuminuria 30.65%,  serta perbaikan kerusakan ginjal 6,67% dengan kerusakan ringan.
Co-Authors - SUHARTINAH Afrina Fajar Ekowati Aminudin AMINUDIN Ana Indrayati Andito, Didik Anita K Apriani, Dwi Wulan ARIKA WIDYARINI Armayanti Rindiarko Hasbrianti Astuty, Meilinda Windy Ayub Adhi Cahyana Dian Kresnadipayana Dina Maryati Doso, Tri Dyaricha Amanda Cahya K Elfahmi Elfahmi, Elfahmi Endang Sri Rejeki Fransiska Leviana Frihani, Assyifa Adelia Galih Kurniawan Ika Purwidyaningrum Ilham Kuncahyo, Ilham Imba, Farhan Jason Merari Peranginangin Johnes Kalfari Kristi Melsi Kurniasari, Fitri Lidia Kurniawati Imanuel Lola’ Tulak Rerung lrfan Zamzani Maryati, Dina Maulita Saraswati MELINDA WIDIANINGRUM Merari Peranginangin, Jason Mia Ariasti Muhammad Aisy Akbar Firdaus Mukhamad Afandi Nabila K Nisa, Sabila Alfa Nuraini Harmastuti Opstaria Opstaria saptarini Patricia Alfayu Velix Puspitasari, Ismi Putri Rinda Pratiwi RA. Oetari Rahayu Rahmawati, Ismi Rendati, Hema Novita Rica Rica Rica Rica, Rica Rina Herowati Rumaldus Seran Safitri, Devita Sakinah Sarnia Iriani Samuel Budi Harsono Sari R Sari R, Sari Sarimanah, Jamilah Sarimanah, Jamilah Setiaji Wisnu Wardana setyawan, Ferdinta D Soemardji AA Sofia, Anna Syamsul Ma'arif Tan MI Titik Sunarni Titik Sunarni Titik Sunarni Tri Wijayanti Tri Wijayanti Triana Hertiani Wijayanti, Ifa Rizki Yanti, Masyitah Novia Yolanda Yolanda Yolanda Yolanda, Yolanda Yul Mariyah Yunilah Sukmadryani Zahra Zahra Zahra Zahra Zakiyyah Qurrotul ‘Aini Zamzani, Irfan Zulfah, Khairina