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All Journal Pharmasipha Jurnal Delima Harapan Jurnal Farmasi Indonesia PUBLIKASI PENELITIAN TERAPAN DAN KEBIJAKAN Jurnal Peduli Masyarakat Indonesian Journal of Global Health research Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan Medfarm: Jurnal Farmasi dan Kesehatan JOURNAL SCIENTIFIC OF MANDALIKA (JSM) Jurnal Kesehatan Tambusai Jurnal Ilmiah Wahana Pendidikan Jurnal Buana Farma Proceedings of the International Conference on Nursing and Health Sciences JIFI (Jurnal Ilmiah Farmasi Imelda) Sehat Rakyat: Jurnal Kesehatan Masyarakat JURNAL JAMU KUSUMA Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Jurnal Ilmiah Kesehatan Jurnal Medika Nusantara Parapemikir Jurnal Ilmiah Farmasi Jurnal Pengabdian Masyarakat dan Riset Pendidikan Jurnal Sains dan Kesehatan Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Science and Community Pharmacy Journal Jurnal Ilmiah Farmasi Indonesia (JIFIN)
Listyani, Tiara Ajeng
Universitas Duta Bangsa Surakarta
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Jurnal Delima Harapan

 1 
DESIGN AND MOLECULAR DOCKING STUDY ADME/TOX COMPOSITION COMPOUND OF EUCALYPTUS ESSENTIAL OIL (Eucalyptus Camaldulensis DEHNH.) AS AN INHIBITOR OF α-AMYLASE AND α-GLUCOSIDASE ENZYMES Listyani, Tiara Ajeng; Artini, Kusumaningtyas Siwi; Sejati, Siti Laila Utari
Jurnal Delima Harapan Vol 12 No 1 (2025): Maret
Publisher : AKADEMI KEBIDANAN HARAPAN MULYA PONOROGO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31935/delima.v12i1.279

Abstract

Background: Composition compound of Eucalyptus Essential Oil (Eucalyptus Camaldulensis DEHNH.) have been reported as inhibitors of α-amylase and α-glucosidase in vitro for antidiabetics. Objective: This study aims to determine the interaction patterns and ΔGbind between Composition compound of Eucalyptus Essential Oil on α-amylase and α-glucosidase with prediction ADME and toxicity. Method: Composition compound of Eucalyptus Essential Oil was optimized for geometry using VegaZZ and prepared as a ligand. Next, preparations for target receptors, α-amylase and α-glucosidase. Validation of docking method and molecular docking analysis using PyRx-Python-AutoDock Vina. Prediction of ADME values used SwissADME, while Toxicity Prediction used Toxtree. Results: There are hydrogen bond interactions between the amino acids GluA:233 and AspA:300, and AspA:197 in the compound 5-Amino-4-cyano-3-(4-ethyllaminobutyl) pyrazole from the α-amylase and AsnA:797 and AsnA:496 from the α-glucosidase. There is no relationship between ΔGbind and the Composition compound of Eucalyptus Essential Oil with the enzyme binding site. The compound 5-Amino-4-cyano-3-(4-ethyllaminobutyl) pyrazole has the lowest ΔGbind value and the RMSD on α-amylase and α-glucosidase is -3.7 kcal/mol; 1.85Å, -4.1 kcal/mol; 1.565Å. The results of the ADME test were found meet the Lipinski Five Rule. The toxicity test results are not carcinogenic or mutagenic, except 5-Amino-4-cyan0-3-(4-ethyllaminobutyl) pyrazole. The new compound design of 3-(4-(ethylamino)butyl)-5-hydroxy-1H-pyrazole-4-carbonitrile showed a decrease in ΔGbind of α-amylase with fixed ADME profile and safer toxicity parameters. Conclusion: Composition compound of Eucalyptus Essential Oil (Eucalyptus Camaldulensis DEHNH.) has the potential to be an oral medicine candidate inhibitors of α-amylase and α-glucosidase for antidiabetes.
FORMULASI DAN UJI STABILITAS SEDIAAN EYESHADOW CREAM EKSTRAK KELOPAK BUNGA ROSELLA (HIBISCUS SABDARIFFA L). Ekarani, Meisyah Litang; Listyani, Tiara Ajeng; Apriliawan, Hidayah
Jurnal Delima Harapan Vol 12 No 2 (2025): September
Publisher : AKADEMI KEBIDANAN HARAPAN MULYA PONOROGO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31935/delima.v12i2.324

Abstract

Latar Belakang: Kelopak bunga rosella (Hibiscus Sabdariffa L.) mengandung senyawa antosianin yang berpotensi sebagai pewarna alami dalam formulasi sediaan kosmetik. Tujuan: Pada penelitian ekstrak kelopak bunga rosella (Hibiscus sabdariffa L.) digunakan sebagai pewarna alami dalam formulasi eyeshadow cream yang memenuhi standar mutu fisik, mengetahui pengaruh konsentrasi terhadap stabilitas fisik sediaan, serta menentukan konsentrasi terbaik. Metode: Ekstrak kelopak bunga rosella diperoleh melalui metode maserasi menggunakan etanol 70%, kemudian diformulasikan menjadi sediaan eyeshadow cream dalam tiga konsentrasi, yaitu 1% (F1), 2% (F2), dan 3% (F3). Uji mutu fisik sediaan dilakukan melalui uji organoleptik, homogenitas, pH, viskositas, daya sebar, dan daya lekat. Stabilitas fisik diuji menggunakan metode cycling test selama 12 hari. Analisis data dilakukan dengan uji One Way ANOVA untuk mengetahui pengaruh variasi konsentrasi ekstrak terhadap parameter fisik. Hasil: Hasil menunjukkan bahwa seluruh formula memenuhi standar mutu fisik dan stabil selama penyimpanan. Variasi konsentrasi ekstrak memberikan pengaruh signifikan (p < 0,05) terhadap beberapa parameter fisik. Formula F3 (3%) dinilai sebagai formula terbaik karena memiliki pH sesuai kulit (4,56–4,94), viskositas ideal (3.170 mPa·s), daya sebar luas (57,6 mm), dan warna yang paling intens Simpulan: Kesimpulan dari penelitian ini adalah ekstrak kelopak bunga rosella dapat diformulasikan sebagai sediaan eyeshadow cream yang stabil pada uji stabilitas.
Co-Authors Achsantya, Raden Roro Karyna Cindy Addawiyyah, Muniroh Agung Eru Wibowo Aini, Riszki Nur Aisyah Rabitha Alisi Akhmad, Khabib Alia Anna Fitriawati Aprilia Rika Alvita Apriliawan, Hidayah Ariyanti Ariyanti Artini, Kusumaningtyas Siwi Azizah, Dinar Bagas Ardiyantoro Chyang, Pang Jyh Danang Raharjo Desy Ayu Irma Permatasari Dwi Bagus Pambudi Ekarani, Meisyah Litang Endang Suciati Fadila, Vera Nurhidayatul Fazlin Fauzi Galuh Puspitasari Guterres, Agostinha Hafalika, Aviv Ifalahma, Darah Kharisma, Putri Nur Khilda Hilyatul 'Ulya Krisnantari, Ni Luh Novelia Kusumaningtyas Siwi Artini Kusumasedya, Willyana Pratiwi Lende, Yulianus Erman Lisa Amalia Luthfiyanti, Niken Masruroh, Sururul Kamalin Nabillah Sirli Okta Maharani Niken Luthfiyanti ningsih, endang wahyu Nugraha, Novanda Satria Nur Azmi, Tasya Nabila Oktaviana, Aptika Pratama, Kharisma Jayak Puguh Ika Listyorini Puspitasari, Rara Ayu Rafidah Hanifah Rahmasari, Ikrima Rahmat Hidayat Ramadhani, Diza Aulia Ratna Safitri Rohmana, Vivin Marwiyati Sari, Cantyka Eka Viemala Sejati, Siti Laila Utari Septian Maulid Wicahyo Septiarini, Anita Dwi Silvia Devi Silvia Mawardani Siwi Artini, Kusumaningtyas Suwardi, Nisa Aura Rizky Tanoyo, William Tatiana Siska Wardani Tatiana, Siska Wardani Urip, Sri Khanti Veranita, Weri Wahyu Budi Utomo Wardani, Tatiana Siska Wargani, Rizki Nugraha Yoga Pratama Yuliana, Ana Yuliana, Silvia Zanjabila, Chanida Zavitra, Mei Nanda