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All Journal Jurnal Keperawatan Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Prosiding Seminas Competitive Advantage Wacana, Jurnal Sosial dan Humaniora Indonesian Journal of Disability Studies Research Journal of Life Science MNJ (Malang Neurology Journal) Universa Medicina Majalah Kesehatan FKUB BIMIKI (Berkala Ilmiah Mahasiswa Ilmu Keperawatan Indonesia) JSMARTech : Journal of Smart Bioprospecting and Technology Az-Zahra: Journal of Gender and Family Studies Pharmaceutical Sciences and Research (PSR) Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery)
Retty Ratnawati
Faculty of Medicine, Brawijaya University, Jl. Veteran, Malang
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Alterations in Blaood Profiles and Spleen Tissue Following Purple Sweet Pota-to Anthocyanin Extract Treatment in Restraint-Stressed Mice: Blood Profiles and Spleen Tissue Following Purple Sweet Potato Anthocyanin Extract Treatment Kurnianingsih, Nia; Artamevia, Dian; Hasanah, Dian; Harbiyanti, Novita Titis; Ratnawati, Retty
Journal of Tropical Life Science Vol. 14 No. 1 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.01.19

Abstract

Stress is associated with broad changes in blood and immune cell dysfunction, which are correlated with the spleen as a secondary lymphoid organ. Anthocyanin, a plant bioactive compound from purple sweet potatoes, has previously been reported to have a beneficial effect on stress response behavior. However, the limited studies evaluated anthocyanin's effect on blood profiles and spleen tissue under stress. Therefore, this study aimed to explore the effect of total anthocyanin extract (ANC) from purple sweet potatoes (PSP) on the blood profiles and spleen tissue of restraint stressed mice. A total of 20 male adult BALB/c mice were divided into control (CTRL), stress (STR), stress + ANC 10 mg/kgBW (STR+ANC10), stress + ANC 20 mg/kgBW (STR+ANC20), and stress + ANC 40 mg/kgBW (STR+ANC10). Restraint stress was applied two hours/day for 14 days. An automatic blood analyzer was used for blood profiling. Immunoblotting of caspase-3 and hematoxylin-eosin-stained histological slides were observed for spleen tissue analysis. Combination of STR and ANC treatment reduced the erythrocyte count, hemoglobin level, and leucocyte count. The ANC-treated groups had a higher percentage of lymphocytes and a lower percentage of granulocytes. The expression of caspase-3 declined among ANC-treated groups. Spleen extramedullary erythropoiesis, vacuolization, and white pulp involution were demonstrated in stress and ANC-treated animals. In summary, restraint stress modified the blood cell profiles and spleen tissue in the mice model. Further research is necessary to evaluate the mechanism of ANC during stress on blood cells and splenic tissue repair enhancement.
The Meaning of Menstruation in Women with Mild Disabilities Rahmah, Siti; Wike; Ratnawati, Retty
Indonesian Journal of Disability Studies Vol. 9 No. 1 (2022)
Publisher : The Center for Disability Studies and Services Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.282 KB) | DOI: 10.21776/ub.ijds.2022.009.01.04

Abstract

Women with Disabilities have a greater social vulnerability both as Women and Persons with Disabilities. The stigma formed by the community greatly influences them in interpreting their menstruation. This study aims to explore the meaning of menstruation for women with mild disabilities. This research was conducted qualitatively using Alfred Schutz's Phenomenological Approach and supported by Symbolic Interactionism Theory and Radical Feminist Theory. The results of the study found the concept of menstruation, the concept of personal hygiene during menstruation, and gender relations in menstruation. The implications of this research are 1) Implementation of health policies related to reproductive health services for women with disabilities; 2) Menstruation socialization and counseling for Women with Disabilities and their families; 3) Capacity building of Social Welfare Institutions related to Gender and Reproductive Health; 4) Development of skills training for making cloth pads for women with disabilities and their families.
Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Urine as a Potential Non-Invasive Method for Determine Kidney Damage in Predialysis Patients Titisari, Nurina; Hernowati, Tinny Endang; Ratnawati, Retty; Fauzi, Ahmad; Gunawan, Atma; Jaya, Wiwi
Research Journal of Life Science Vol 8, No 3 (2021)
Publisher : Direktorat Riset dan Pengabdian Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.rjls.2021.008.03.1

Abstract

NGAL expression in acute kidney failure is well known. It is approved that NGAL expression occurs earlier than the level of BUN and creatinine in acute kidney failure. NGAL is not only expressed in the blood but also in the urine, where urine collection has many advantages over blood collection. This study aims to observed the expression of NGAL in predialysis patients and to determine the correlation between NGAL serum and NGAL urine of patients. The sample was taken from healthy persons as control and predialysis patients. The examination of BUN, creatinine, and urinalysis were done to approve the diagnose in predialysis patients. While NGAL in serum and urine were analyzed using the Enzyme-Linked Immunoabsorbent Assay (ELISA). The results showed that the concentration of NGAL in serum was higher in the predialysis patients compared to the healthy subjects (p<0.05). There was a strong positive correlation between the NGAL in the serum and the NGAL in the urine (r= 0.98 and p<0.000). It is concluded that the non-invasive examination of NGAL in urine can be choose rather than using serum NGAL. However, it must be noted that NGAL could be used for chronic renal failure in predialysis patients as long as other biomarkers have been proven.
Dampak Penanganan Kekerasan Seksual dalam Rumah Tangga melalui Hukum Adat Merangin Aulia, Lisa; Wike, Wike; Ratnawati, Retty
Az-Zahra: Journal of Gender and Family Studies Vol 5, No 1 (2024)
Publisher : UIN Sunan Gunung Dajti Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/azzahra.v5i1.33986

Abstract

Penelitian ini bertujuan mengetahui dampak penerapan hukum adat terhadap implementasi UU PKDRT 23/2004 yaitu penanganan KDRT di Kabupaten Merangin. Penelitian ini merupakan penelitian kualitatif dengan menggunakan studi kepustakaan dan lapangan. Teori kebijakan publik oleh Thomas Dye digunakan untuk menganalisis keterkaitan antara kebijakan publik dengan institusi pemerintah dan masyarakat Merangin yang mengakui hukum adat. Hasil penelitian ini menemukan penanganan KDRT melalui hukum adat cenderung merugikan korban karena ketiadaan perspektif perlindungan perempuan, sanksi adat berupa utang adat yang dibebankan kepada pelaku minim efek jera dan mempersulit pemulihan psikis korban. Penanganan KDRT oleh lembaga adat melalui pemberlakuan hukum adat juga berdampak pada semakin meningkatnya potensi rendah pelaporan dan kemunduran kinerja implementasi UU PKDRT 23/2004 seperti ketiadaan fasilitas kesehatan yang memadai dan terjangkau untuk mempermudah korban mendapatkan bukti tindakan kekerasan seksual. Berdasarkan hasil penelitian ini, penerapan hukum adat berdampak negatif terhadap korban kekerasan seksual dalam rumah tangga, penanganan KDRT yang berkeadilan gender dan kinerja implementasi UU PKDRT 23/2004.
Anticancer Potential of Cyanidin and Cyanidin-3-Glucoside Through TrkB Receptor Inhibition: Evidence From Molecular Interaction Docking Kurnianingsih, Nia; Suprapto, Ratih Paramita; Ratnawati, Retty
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 5 No. 2 (2024): JSMARTech Volume 5, No. 2, 2024
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2024.005.02.41

Abstract

Cancer remains a global health problem with persisten demand on therapeutic development to inhibit cancer cells growth without harmful effects on healthy cells. Plant bioactive compounds are intensively studied as anticancer via several signalling pathway. Anticancer therapy via inhibition of tropomyosin kinase receptor-B (TrkB) signal was previously proposed as target therapy. The role of plant metabolites cyanidin and cyanidin-3-glucoside as TrkB inhibitor is has not been investigated. This study was aimed to identify physicochemical of cyanidin and cyanidin-3-glucoside as well as determine it’s role towards TrkB receptor signalling pathway through in silico approach. Molecular docking was performed using Hex 8.0.0 software and visualizes using Discovery Studio Visualizer. The energy binding of TrkB with cyanidin and cyanidin-3-glucoside was -263,21 kcal/mol and 281,65 kcal/mol respectively. Complex of cyanidin-3-glucoside had hydrogen and hydrophobic bond more than TrkB-cyanidin complex. The hydrogen bond formed at Lys637, Arg558 and Gly 561 amino residues. Physicochemical analysis demonstrated that both ligand are potential as kinase enzyme inhibitor. Cyanidin-3-glucoside was predicted more potential as anticancer than cyanidin via TrkB receptor inhibition. Future studies are required to confirm current finding both in-vitro and in-vivo models.
DEPRESSION AND INTERNET GAMING DISORDER AMONG MEDICAL STUDENT IN MALANG, INDONESIA Kurnianingsih, Nia; Cahayani, Wike Astrid; Yudhantara, Dearisa Surya; Ratnawati, Retty
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.08

Abstract

Background: Medical education is widely regarded as a highly demanding curriculum that causes significant stress among students. Chronis stress generates depression and increase of internet gaming activity. Previous research examined the relationship between the length of time spent for internet gaming activity as well as grade point average (GPA) towards internet gaming disorder (IGD) among medical student in Malang Indonesia. The limited data on the frequency of depression and the association between depression with IGD among medical students calls for more research. Objectives: This study was purposed to analyse the prevalence of depression as well as its association with IGD among medical students in Malang, Indonesia. Methods: This descriptive and cross-sectional study involved 437 medical students who completed a set of self-report questionnaires. The questionnaires included sociodemographic data, Beck Depression Inventory (BDI) scale and Personal Internet Gaming Disorder-9 (PIE-). Descriptive and bivariate analyses were employed for statistical analysis. Results: Depression was identified among 37.99% students, with female being more likely to suffer from it. There were 59.64%, 34.94% and 5.42% correspondingly of students with mild, moderate, and severe depression. The rate of depression was highest among 1st year students. Poor GPA achievement was observed in 50.98% of students with depression. Students without internal motivation were more likely to have depression (57.14%). Surprisingly, depression was not linked associated with IGD (p=0.06). Conclusion: This study concluded a high prevalence of depression among medical students with various sociodemographic characteristics. Despite depression had no association with IGD, future research is necessary for evaluate the potential risk factor of depression among medical students.
Dynamics Resilience of Female Influencer as NCII Victim on Social Media Almira, Nabila Sella; Wahyuni, Lilik; Ratnawati, Retty
Wacana Journal of Social and Humanity Studies Vol. 27 No. 2 (2024)
Publisher : Sekolah Pascasarjana Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.wacana.2024.027.02.06

Abstract

The widespread distribution of non-consensual intimate content carried out by the increasing development of technology cannot be stopped. Komnas Perempuan recorded 281 cases of cybercrime out of 1,277 cases of gender-based violence reported in 2021, which experienced an increase in CATAHU Komnas Perempuan 2023, where there were 869 cases of cyberviolence out of 1,276 cases of gender-based violence. Technological developments can make it easier for someone to commit cyber crimes. On the other hand, this technological development influences the rapid dissemination of information, especially with the mass presence of influencers. Influencers are social media users who generally come from ordinary people who have succeeded in gathering large numbers of followers so they can monetize their influence. However, influencers also have dangerous risks, in which one of them is vulnerable to becoming a victim of NCII with how often they use social media to show their face, body, and even voice. Non-consensual dissemination of intimate images (NCII) is a cybercrime where the use of intimate or sexual content for threats. This research aims to analyze the resilience of female influencers who have experienced NCII threats. This research used the qualitative method. The data used interviews with influencers who have experienced NCII but choose to continue their career. The results show that the subject’s resilience came from external support from family and peers, revenge for the perpetrator, and religiosity. Legal action and official protection against the threat of NCII are necessary to prevent the increase in victims.Keywords: dynamics of resilience, cybercrime, female influencer, NCII
Women and Climate Change: A Slow Violence Study by Batang Masumai River Aulia, Lisa; Wike, Wike; Ratnawati, Retty
Wacana Journal of Social and Humanity Studies Vol. 27 No. 2 (2024)
Publisher : Sekolah Pascasarjana Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.wacana.2024.027.02.05

Abstract

This research aims to explore the experience of women by Batang Masumai river to slow violence. Limited access to water services and infrastructure in rural area affect women who bear the responsibility to meet household water need because they depend on the river as water source and sanitation facilities. Climate change as a form of slow violence that occurred gradual and attritional becomes a major threat to household water security. The method of this qualitative research is interpretative phenomenological analysis. The data is collected through an in-depth interview with four women from low-income households by Batang Masumai river and observation. The result of this reseacrh shows that floods and droughts that become more severe contribute to water availability, accessabiliy, and quality so that women by Batang Masumai river have to walk longer distances to meet clean household water, carry heavy burden load while also exposed to water conflicts in water points. As slow violence becomes more destructive in a long period of time, there is a need for government to fully implement Law 17/2019 regarding Water Resources to help women with limted sources to adapt and build their resiliency. Keywords: slow violence, women’s experiences, household water, Batang Masumai river
Anthocyanin-Rich Extract from Purple Sweet Potatoes Modified Body Weight, Visceral Fat and Circulatory IL-10 in Stressed-Mice Kurnianingsih, Nia; Rahma, Oktivani Adelathifa; Prayogo, Nabila Putri; Rayhanna, Qanitha Ailsya; Fahanani, Agwin Fahmi; Suprapto, Ratih Paramita; Prakosa, Ardani Galih; Ratnawati, Retty
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Stress-induced inflammation and oxidative stress mechanisms thus plant bioactive compounds as anti-inflammation and antioxidants are placed as novel strategies to resist the adverse effects of stress. Purple sweet potatoes (PSP) as a rich source of macronutrients and anthocyanin showed health benefits as neuroprotective and metabolic diseases. However, limited research explored the effect of PSP extract on stressed animal models. This study aimed to evaluate the bioactive compound analysis of PSP and the effect on body weight gain (BW), visceral fat (VF), and interleukin-10 (IL-10) of stressed model mice. Adult male BALB/c mice (6-8 weeks) were divided into control (CTRL), and stress (STR), stress+anthocyanin-rich extract (ANC) of PSP dose 10, 20, and 40 mg/kgBW. Stress was exposed as restraint stress for 2 hours/day for 14 days. The ANC was administered once a day orally. The IL-10 was measured by enzyme-linked immunosorbent assay (ELISA). Qualitative plant compound analysis showed the presence of flavonoids, alkaloids, phenolics, glycosides, and tannins in PSP extract. The PSP extract also contains a high level of total anthocyanin, 2468.9 ± 159.38 mg/l, and high antioxidant activity. This study observed tendencies to decrease BW and VF following ANC dose of 10 mg/kgBW treatment. The administration of ANC significantly increased the level of circulatory IL-10 cytokine. In conclusion, an anthocyanin-rich extract of PSP modified BW, VF, and IL-10 levels of restraint-stressed model mice.
Pengaruh Antosianin terhadap Ketebalan Epitel, Indeks Apoptosis dan Ekspresi p53 Sel Epitel Vagina pada Tikus Putih (Rattus norvegicus) Ovariektomi Ferdina, Cucun Setya; Ratnawati, Retty; Andarini, Sri
Journal of Ners and Midwifery Vol 6 No 2 (2019)
Publisher : STIKes Patria Husada Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26699/jnk.v6i2.ART.p126-133

Abstract

Menopause merupakan suatu keadaan fisiologis yang pasti dialami oleh semua wanita, pada masa menopause terjadi peningkatan stres oksidatif karena penurunan hormon estrogen (hipoestrogen). Salah satu organ yang mengalami dampak akibat terjadinya hipoestrogen adalah vagina. Pada vagina terjadi atrofi dan penipisan epitel. Antosianin merupakan salah satu antioksidan yang dapat menyelamatkan sel – sel tubuh dari stres oksidatif. Penelitian ini dilakukan untuk membuktikan pengaruh antosianin terhadap ketebalan epitel, indeks apoptosis dan ekspresi p53 sel epitel vagina pada tikus putih (Rattus norvegicus) ovariektomi. Desain penelitian ini adalah True Experimental laboratory, dengan menggunakan pendekatan posttest only group control design. Penelitian ini dilakukan dengan memberikan perlakuan pada hewan coba, yaitu tikus putih (Rattus norvegicus) betina. Hasil penelitian menunjukkan pemberian antosianin terbukti berpengaruh secara signifikan (p-value = 0,000 < α=0,05) dalam menurunkan ekspresi p53 dan indeks apoptosis sel epitel vagina serta meningkatkan ketebalan epitel vagina pada tikus ovariektomi.
Co-Authors A.A. Ketut Agung Cahyawan W AA Sudharmawan, AA Almira, Nabila Sella Anak Agung Gede Sugianthara Analis W Wardhana Anastasia Novitasari, Anastasia Annisa Nurul Arofah Annisa' Wigati Rozifa Ardani Galih Prakosa, Ardani Galih Artamevia, Dian Arum Desi Pratiwi, Arum Desi Atma Gunawan Aulanni'am, Aulanni'am Cahayani, Wike Astrid Christian Julio Suhardi, Christian Julio Darwatik, Darwatik Dian Hasanah Dian Susmarini, Dian Diana Lyrawati Dina Dewi SLI Eviana Norahmawati Fahanani, Agwin Fahmi Faridha Khaira H Fauzi Ahmad Muda Ferdina, Cucun Setya Harbiyanti, Novita Titis HARI PURNOMO Heri Kristianto Herin Mawarti Hery Wibowo Hidayat Sujuti Ika Subekti Wulandari, Ika Subekti Ikhda Ulya, Ikhda Inggita Kusumastuty Intan Berlian, Intan Irawan, Dwi Dianita Kenty Wantri Anita, Kenty Wantri Kumboyono Kumboyono Kumboyono, K Kurnianingsih, Nia Lilik Supriyati, Lilik Lilik Wahyuni Lisa Aulia, Lisa Made Ayu Hariningsih, Made Ayu Masruroh Rahayu, Masruroh Mochammad Dalhar Noorma Lukitasari Nur Permatasari Nurdiana Nurdiana Pratista Adi Krisna, Pratista Adi Prayogo, Nabila Putri Purwitasari, Alief Ayu Rahma, Oktivani Adelathifa Rayhanna, Qanitha Ailsya Reza Fitra Kusuma, Reza Fitra Rinik Eko Kapti, Rinik Ririn Handayani Risma Karlina Prabawati Sartika Dewi Utami, Sartika Dewi Sarwono . Sawitri, Lia Siti Nurfitria, Siti Sri Andarini Sri Budhi Rianawati, Sri Budhi Sri Haryuni Sri Rianawati Suprapto, Ratih Paramita Tinny Endang Hernowati Titisari, Nurina Wike Wike, Wike Wiwi Jaya Yudhantara, Dearisa Surya