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All Journal International Journal of Integrated Health Sciences The Indonesian Journal of Infectious Diseases Jurnal Respirologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Respiratory Science Narra J Malang Respiratory Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Ophthalmologica Indonesiana Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal) Jurnal Ilmu Kesehatan Masyarakat
Erlina Burhan
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Universitas Indonesia, Persahabatan General Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : respiratory science

 1 
Myocard Injury in COVID-19 Patients After Application Of Umbilical Cord Mesenchymal Stem Cell (UC-MSC) as Adjuvant Therapy in Persahabatan Hospital Mega Juliana; Triya Damayanti; Yasmina Hanifah; Erlina Burhan
Respiratory Science Vol. 3 No. 3 (2023): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i3.89

Abstract

Background: Myocardial injury was a frequent cardiovascular manifestation of COVID-19 and associated with high mortality.  Cell-based approaches, primarily using mesenchymal stem cell (MSC) has demonstrated safety and possible efficacy as adjuvant therapy in COVID-19 patients. This study aims to evaluate myocardial injury in patients with moderate-severe and critically ill COVID-19 after the application of umbilical cord mesenchymal stem cell (UC-MSC) as adjuvant therapy in Persahabatan hospital. Method: This is a retrospective and prospective cohort study. A total of 28 subjects were allocated to 13 subjects in the control and 15 subjects in the experimental group. Subjects were given the standard treatment and UC-MSC or placebo. Myocardial injury is defined by an increase of troponin I >26 pg/ml. The biomarkers of troponin I, NT-proBNP and CRP was examined periodically. Cardiac pump evaluated by EF and TAPSE from echocardiography examination before and after UC-MSC application. The evaluation of myocardial injury, biomarkers, cardiac pump and 15-day mortality were observed between the two groups. Results: The incidence of myocardial injury was 28,6% of total subjects. Subjects with worsening myocardial injury were higher in the control group (6 subjects) than the experimental group (4 subjects) although not statistically significant. The difference in biomarkers (troponin I, NT- pro-BNP and CRP), cardiac pump function (EF and TAPSE) and 15-day mortality between two groups were not statistically significant. There was a trend of decreasing troponin I, NT-proBNP and CRP in the experimental group. Conclusion: UC-MSC application can be an option as adjuvant therapy in improving myocardial injury of moderate-severe and critically ill COVID-19 patients.
Diagnosis and Management for Pulmonary Tuberculoma Syahruddin, Elisna; Burhan, Erlina; Saputra, Tetra Arya
Respiratory Science Vol. 4 No. 2 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i2.107

Abstract

Pulmonary tuberculoma, prevalent particularly in tuberculosis (TB)-endemic regions, often appears as a solitary nodule of less than 30 mm, or a tumor of more than 30 mm on radiological examinations. It may also present with a combination of abnormalities, such as multiple nodules with infiltration or pleuritis. Benign solitary pulmonary nodules represent up to 25% of all resected solitary pulmonary nodules, with approximately 5-24% of these identified as pulmonary tuberculoma post-surgery. This condition is prevalent particularly in TB-endemic regions, and must be considered while determining the diagnosis, especially for patients at high risk for lung cancer. Modalities for diagnosing pulmonary tuberculoma include chest radiography, USG, CT scan, PET scan and bronchoscopy with transbronchial biopsy. The treatments for pulmonary tuberculoma are anti-TB drugs and surgery. Pulmonary tuberculoma responds poorly to anti-TB drugs and requires long-term treatment. Surgery is performed when the diameter of tuberculoma still increases after adequate anti-TB treatment.
Evaluation of Mortality Risk Factors of COVID-19 in Jakarta Tertiary Hospital During Peak of Second Wave and Predictive Utility of Community RT-PCR Low CT Values Putra, Andika Chandra; Burhan, Erlina; Aufa, Akhdan; Bur, Rika; Pangestu, Hendri; Bahri, Syukrini; Souvriyanti, Elsye; Muchtiar, Mulyadi; Erlina, Andi; Aditama, Tjandra Yoga; Yuliwulandari, Rika; Kusuma, Indra; Suciati, Yulia; Rifqatussaadah, Rifqatussaadah; Jalal, Fasli; Gusnanto, Arief; Utomo, Ahmad Rusdan H
Respiratory Science Vol. 4 No. 2 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i2.133

Abstract

Background: The Delta variant of SARS-CoV-2 led to a surge in COVID-19 cases in Indonesia. This study aimed to assess the demographic profile and mortality rates of hospitalized COVID-19 patients in YARSI referral hospital, Jakarta, comparing pre-Delta and Delta wave periods. The study also investigated whether low CT values in RT-PCR tests indicated heightened viral transmission before the Delta wave surge. Method: A retrospective analysis was conducted on 1,457 COVID-19 patients hospitalized at YARSI (January-August 2021) and 25,279 RT-PCR test results from walk-in patients (April-August 17, 2021). Differences were evaluated using Chi-square or Fisher’s Exact Tests while binary logistic regression was used to assess mortality risk factors. Results: There were increased proportions of pregnant women, patients aged 20-29 and those with coronary artery disease during the Delta wave. This period also showed a significant increase in mortality rates, with the highest seen in patients >60 years old or those with multiple comorbidities. Notably, most of the deceased patients (131 of 139) were unvaccinated. Analysis of RT-PCR data showed rising percentages of positive results with low CT values (below 21 or 15) from April to June. Conclusion: The Delta wave saw a higher risk of hospitalization among young individuals and pregnant women, despite their low mortality risk. The unvaccinated and those with multiple comorbidities faced higher mortality risks. Increases in RT-PCR positivity with low CT values preceded the July COVID-19 case surge.
Levofloxacin as Tuberculosis Preventive Therapy for Household Contacts of Drug-Resistant Tuberculosis: Global Evidence and Implementation in Indonesia Kemas Rakhmat Notariza; Erlina Burhan
Respiratory Science Vol. 6 No. 3 (2026): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i3.235

Abstract

Drug-resistant (DR) tuberculosis (TB), including multidrug-resistant (MDR) and rifampicin-resistant (RR) TB, remains a major global public health problem. This narrative review aims to summarize evidence regarding the effectiveness and safety of levofloxacin as tuberculosis preventive therapy (TPT) among household contacts of DR-TB patients and its implementation in Indonesia. The clinical spectrum of TB spans from infection to active disease, the progression of which can be prevented through TPT. Drug resistance in TB develops through genetic mutations. Levofloxacin (Lfx) exerts antimycobacterial activity by inhibiting the deoxyribonucleic acid (DNA) gyrase enzyme. The Vietnam Quinolones for MDR-TB Trial (VQUIN) demonstrated an incidence rate ratio of TB disease of 0.55 (95% confidence interval [CI]=0.19–1.62) in the Lfx group compared with the placebo group. In the Tuberculosis Child Multidrug-Resistant Preventive Therapy (TB-CHAMP) study, the hazard ratio for TB disease was 0.44 (95% CI=0.15–1.25) in the Lfx group compared with placebo. Although neither trial individually achieves statistical significance in reducing TB incidence, a meta-analysis of both studies revealed a significant relative reduction in cumulative TB incidence of 0.41 (95% CI=0.18–0.92) in the Lfx group compared with placebo. The administration of Lfx was associated with low-grade musculoskeletal adverse events (risk ratio=6.36; 95% CI=4.30–9.42). Overall, daily administration of Lfx for six months is recommended as the standard TPT regimen for DR-TB, particularly among household contacts of MDR/RR-TB cases.
Co-Authors A. M. Jayusman Adang Bachtiar Adang Bachtiar Adyasiwi, Galoeh Afladhia, Hanna L. Afrizal Afrizal Agus Dwi Susanto Agustin, Heidi Agustin, Heidy Akbar, Fadhian Andika Chandra Putra Andini, Salsabila R. Aniwidyaningsih, Wahju Anna Rozaliyani Anwar Jusuf Anwar Jusuf Arfan, Ahmad Aria Kekalih Arief Riadi Arifin Arifin Nawas Arifin Nawas Arifin, Arief Riadi Aristyo, Kevin Ary Indriana Savitri Asri C. Adisasmita Aufa, Akhdan Azzumar, Farchan Bahri, Syukrini Bahtiar Husain Bambang Dwi Hasto Baskoro, Hario Budhi Antariksa Budi Haryanto Budi Prasetyo Budi Prasetyo Budiman Bintang Prakoso Dahlan, Muhammad Sopiyudin Dewi Yennita Sari Diah Handayani Dwi Rendra Hadi Eddy Suratman Elisna Syahruddin Elsye Souvriyanti, Elsye Erlina, Andi Farchan Azzumar Fasli Jalal Felim, Ris Raihan Ferian, Muhammad Farel Firdawati Firdawati Gusnanto, Arief Gustya, Gita Fajri Hasto, Bambang Dwi Henie Widowati Hera Afidjati Husain, Bahtiar Ibrahim Nur Insan Putra Darmawan Ilham, Ahmad F. Ilham, Ahmad Fadhil Indra Kusuma Isbaniah, Fathiyah Jaka Pradipta Jendrius Jendrius Kemas Rakhmat Notariza Khansa Putriana Kurniawan, Gerry Mega Juliana Mega Juliana Mirza Purwitasari Mohamad Fahmi Alatas Muchtiar, Mulyadi Muhamad Sidik Muhammad Alkaff Muhammad Ikhsan Mokoagow Muhammad Ilham Dhiya Rakasiwi MUHAMMAD TAUFIK Noorwati Sutandyo Nugraha, Darrin Ananda Pandu Widiarto Pangestu, Hendri Priyanti Z. Soepandi Priyanti ZS Putri Suci Ramadhany Raden Rara Diah Handayani Rahmad Gurusinga Rahmad Gurusinga Rakasiwi, Muhammad ID. Rakasiwi, Muhammad Ilham Dhiya Rifqatussaadah, Rifqatussaadah Rika Bur Rika Yuliwulandari Rima Semiarty Ririen Razika Ramdhani Rita Rogayah Rizanda Machmud Samoedro, Erlang Saputra, Tetra Arya Sari, Adistya Sariasih Arumdati Satria Pratama Satria Pratama Satria Pratama Savitri, Ary Indriana Setianingrum, Findra Siti Chandra Widjanantie Soehardiman, Dicky Syntia Nusanti Taufik, Feni Fitriani Tika Dwi Tama Tjandra Yoga Aditama Triya Damayanti Triya Damayanti Tugas Ratmono Tugas Ratmono, Tugas Utomo, Ahmad Rusdan H Wandawa, Azlina D Wardoyo, Muhammad Prasetio Widhy Yudistira Nalapraya Yasmina Hanifah Yasmina Hanifah Yulia Suciati Zaini, Jamal