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All Journal Jurnal Ilmiah Farmasi Jurnal Kesehatan Reproduksi AL KAUNIYAH Jurnal Kesehatan Andalas BIO-SITE |BIOLOGI Sains Terapan Majalah Kedokteran Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Pengabdian Pada Masyarakat SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Riau Journal of Empowerment Jurnal Ilmiah Kesehatan Amerta Nutrition PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Ners Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Kedokteran Universitas Palangka Raya Epidemiology and Society Health Review (ESHR) Respiratory Science Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmacy Reports Jurnal Pengabdian Mandiri Dharma Pengabdian Perguruan Tinggi (DEPATI) Madani : Jurnal Pengabdian Kepada Masyarakat Journal of Research in Pharmacy and Pharmaceutical Sciences Pharmacon: Jurnal Farmasi Indonesia Folia Medica Indonesiana
Erna Harfiani
Universitas Pembangunan Nasional Veteran Jakarta
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Journal : Amerta Nutrition

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Potensi Kefir Susu Kambing dengan Penambahan Madu Randu dalam Mencegah Stress Oksidatif pada Tikus Diabetes : Potential of Randu Honey Kefir to Prevent Oxidative Stress in Diabetic Rats Ilmi, Ibnu Malkan Bakhrul; Marjan, Avliya Quratul; Harfiani, Erna; Kusuma, Indra; Wahyuningsih, Utami; Fikriana, Chika Nur; Mulyadewi, Amelia Luthfiyah
Amerta Nutrition Vol. 9 No. 1SP (2025): AMERTA NUTRITION SUPPLEMENTARY EDITION Special 5th Amerta Nutrition Conferenc
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i1SP.2025.31-40

Abstract

Background: More than 90% of adults with type 2 diabetes are overweight or obese. This condition is known to increase oxidative stress, which contributes to cellular damage and disease complications. As a functional food, kefir has long been recognized for its various health benefits, including anti-inflammatory, antioxidant, and antidiabetic properties. Objectives: This study aimed to analyze the potential of randu honey kefir in preventing oxidative stress in diabetic rats. Methods: This study employed a randomized block design with a 21-day intervention period. A total of 42 male Sprague Dawley rats aged 6–8 weeks were divided into six groups: KS (standard), KN (negative control), K1 (quercetin), K2 (metformin), P1 (randu honey kefir 1.8 mL/200g BW), and P2 (preventive group). Diabetes was induced using streptozotocin at 40 mg/kgBW combined with a high-fat diet. Malondialdehyde (MDA) levels were analyzed using spectrophotometry, while interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) levels were measured using ELISA kits. Results: Significant differences (p-value<0.05) were observed in MDA, TNF-α, and IL-6 levels between the P1 and P2 groups compared with the KN group. Randu honey kefir groups showed mean oxidative stress marker levels comparable to those of quercetin and metformin treatments, including MDA (P1: 32.9 ± 29.35 nmol/mL; P2: 23.77 ± 11.63 nmol/mL), TNF-α (P1: 45.37 ± 31.25 pg/mL; P2: 37.81 ± 27.00 pg/mL), and IL-6 (P1: 64.81 ± 21.35 pg/mL; P2: 59.23 ± 14.95 pg/mL). Conclusions: Randu honey kefir intervention demonstrates potential in suppressing oxidative stress in diabetic rats.
Co-Authors ., Mashoedojo Abd. Rasyid Syamsuri Abdi Wira Septama Abdul Kolib Adi Sukrisno Agneta Irmarahayu Agus Aulung Aisyah, Ammara Almerveldy Azaria Dohongi Almerveldy Azaria Dohongi Angga Hardiansyah Anisah Anisah Anisah Anisah Aprilia, Citra Ayu Ashfia Desi Rahmalina Aulia Chaerani Aulia Chairani Avliya Quratul Marjan Az Zahra, Fatima Boenga Nurcita Budiman, Dicky Citra Ayu Aprilia Dicky Budiman Dinda Nuraini Hanifah Wahab Dwi Arwandi Yogi Saputra Fachri Razi Fajriati Zulfa Fikriana, Chika Nur Hany Yusmaini Ilmi, Ibnu Malkan Bakhrul Ima Maria Indra Kusuma Kartika Putri Amalia Makkiyah, Feda Anisah Manpan Drajat Maria Selvester Thadeus Md Ikhsan Mokoagow Meiskha Bahar Mila Citrawati Mokoagow, Md Ikhsan Muhammad Reiza Mulyadewi, Amelia Luthfiyah Muttia Amalia Nabilah, Ayi Nely Jumaliah Nugraha, Yudhi Nugrahayu Widyawardani Nurfitri Bustamam Nurhakim, Althaf Dhaifullah Pasaribu, Rini Sarah Pasiak, Taufiq Fredrik Primayanti Nurul Ilmi Pritasari, Ilham Arzy Diana Pritha Maya Savitri Putra Sang Fajar El Harry Putra Sang Fajar El Harry Rahmi, Eldiza Puji Ratna Puspita Ratna Puspita Reiza, Muhammad Retno Yulianti Revina, Rika Ria Maria Theresa Ria Maria Theresa Ryan Herardi Sarmoko Sarmoko Serli Marlina Siska Maydianah Sitinjak, Sahat Anugerah Immanuel Sri Rahayu Sri Wahyuningsih Susanti, Febriyolla Sutarto, Riyadi Taufiq Fredrik Pasiak Taufiq Fredrik Pasiak Taufiq Fredrik Pasiak Taufiq Fredrik Pasiak Taufiq Pasiak Taupan Ichsan Tuarita Theodora Putri Simanjaya Tresnawati, Nden Ajeng Ufi Dewintera Uswatun Hasanah Uswatun Hasanah Uswatun Hasanah Utami Wahyuningsih Wahab, Dinda Nuraini Hanifah Wibowo, Muhammad Rizky Wibowo, Putri Larasati Widianingsih Widianingsih Yanti Harjono Hadiwiardjo Yanto Sandy Tjang Yudivaniel Zihono Zihono, Yudivaniel