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All Journal Jurnal Ilmiah Farmasi Jurnal Kesehatan Reproduksi AL KAUNIYAH Jurnal Kesehatan Andalas BIO-SITE |BIOLOGI Sains Terapan Majalah Kedokteran Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Pengabdian Pada Masyarakat SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Riau Journal of Empowerment Jurnal Ilmiah Kesehatan Amerta Nutrition PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kreativitas PKM Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Ners Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Kedokteran Universitas Palangka Raya Epidemiology and Society Health Review (ESHR) Respiratory Science Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmacy Reports Jurnal Pengabdian Mandiri Dharma Pengabdian Perguruan Tinggi (DEPATI) Madani : Jurnal Pengabdian Kepada Masyarakat Journal of Research in Pharmacy and Pharmaceutical Sciences Pharmacon: Jurnal Farmasi Indonesia Folia Medica Indonesiana
Erna Harfiani
Universitas Pembangunan Nasional Veteran Jakarta
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Metformin Effectiveness in Reducing Mortality among Covid-19 Patients with Type 2 Diabetes Mellitus at a Tertiary Hospital in Indonesia Zihono, Yudivaniel; Yusmaini, Hany; Hasanah, Uswatun; Harfiani, Erna; Mokoagow, Md Ikhsan; Budiman, Dicky
Folia Medica Indonesiana Vol. 59, No. 3
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights: 1. As there is a scarcity of publications on the use of metformin for COVID-19 in Indonesia, the findings of this present study may contribute more insight to the existing body of research and provide data specific to the Southeast Asian population. 2. This study revealed a decreased mortality rate associated with metformin use in diabetic patients with mild to moderate COVID-19 infection. 3. This study suggests that diabetic patients may continue metformin treatment during a COVID-19 infection as the medication has sustained therapeutic effects. Abstract COVID-19 patients with comorbidities, such as type 2 diabetes (T2DM), have a higher mortality rate compared to those without any comorbidities. T2DM patients usually receive metformin as their first-line treatment. However, the effectiveness of metformin in reducing mortality rates still requires further analysis. The objective of this study was to analyze the effectiveness of metformin in reducing mortality rates among COVID-19 patients with T2DM. An analytic observational design with a retrospective cohort approach was used in this study. Samples were acquired from hospitalized COVID-19 patients with T2DM medical records at Fatmawati Central General Hospital, Jakarta, Indonesia, throughout 2020–2021. The samples were collected using a purposive sampling technique and analyzed using Chi-square test (p<0.05; RR<1). This study comprised 137 samples, with 56 samples receiving metformin and 81 not receiving metformin. The mortality rate in the sample group that received metformin was lower (19.6%) compared to the group that was not given the medication (38.3%). The Chi-square test results indicated a statistically significant relationship between metformin treatment and a lower mortality rate among COVID-19-contracted individuals with T2DM (p=0.020; RR=0.513). Therefore, this study concludes that the administration of metformin treatment reduces mortality among COVID-19 patients with T2DM.
Optimization of Ultrasonic-Assisted Extraction Parameters and Antibacterial Activity of Zanthoxylum acanthopodium D.C against Cutibacterium acnes Rahmi, Eldiza Puji; Pasaribu, Rini Sarah; Harfiani, Erna; Revina, Rika; Septama, Abdi Wira
Pharmacon: Jurnal Farmasi Indonesia Vol. 22 No. 2 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i2.5932

Abstract

Acne is a disease that has affected many populations globally. One of the causes of acne is the presence of acne-causing bacteria, namely Cutibacterium acnes, which is reportedly resistant to several antibiotics. Andaliman fruit (Zanthoxylum acanthopodium DC.) is traditionally used by Indonesian people as a spice which has antibacterial potential. This study aims to evaluate the antibacterial activity of the ethanolic extract of Andaliman fruit against C. acnes using the microdilution method. The extraction method for andaliman fruit was the Ultrasonic-Assisted Extraction with variations in frequency (30, 40, and 50 kHz) and duration (10, 15, and 20 minutes). Phytochemical screening showed the presence of flavonoids, alkaloids, tannins, steroids, and saponins in the extract. The results showed the antibacterial activity of Andaliman fruit extract against C. acnes, with the Minimum Inhibitory Concentration (MIC) observed in the extract with a frequency of 40 kHz and an extraction duration of 10 and 15 minutes at a concentration of 5000 ppm. However, the Minimum Bactericidal Concentration (MBC) test showed negative results, indicating that Andaliman extract did not have a bactericidal effect on these bacteria. Statistical analysis using the Kruskal–Wallis and Dunn tests revealed significant differences (p < 0.05) between extraction treatments and the positive control in MIC and MBC values. These findings indicate that the ethanolic extract of andaliman fruit possesses inhibitory but not bactericidal activity against C. acnes, suggesting its potential as a natural anti-acne agent for further formulation and mechanistic studies.
Uji Indeks Glikemik Pangan Fungsional Kefir Susu Kambing dengan Penambahan Madu Randu ( Ceiba Pentandra ) Serli Marlina; Ibnu Malkan Bakhrul Ilmi; Utami Wahyuningsih; Erna Harfiani; Angga Hardiansyah
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.43816

Abstract

Penelitian ini bertujuan untuk mengetahui nilai indeks glikemik dan beban glikemik dari produk kefir susu kambing dengan penambahan madu randu ( Ceiba Pentandra ). Desain penelitian yang digunakan adalah true experimental dengan desain crossover ( non-randomized ) dengan dua perlakuan. Perlakuan pertama yaitu pemberian makanan standar ( glukosa murni ) sementara untuk perlakuan kedua yaitu pemberian makanan uji ( kefir susu kambing dengan penambahan madu randu ( Ceiba Pentandra ) ) yang dilakukan pada waktu yang berbeda. Pengujian produk ini melibatkan 8 orang panelis tidak terlatih.  Hasil penelitian ini menunjukkan bahwa kefir madu randu  memiliki indeks glikemik kategori  rendah 53,98 ± 42,26   dengan beban glikemik kategori rendah pula ( 1,27 ) dalam sajian 100 ml. Terdapat perbedaan yang signifikan antara kefir madu dengan makanan standar ( p=0,018 ). Kefir madu randu ini cenderung dapat mengontrol kestabilan dan mengurangi lonjakan pada glukosa darah sehingga cukup aman dikonsumsi untuk penderita diabetes.
Potensi Kefir Susu Kambing dengan Penambahan Madu Randu dalam Mencegah Stress Oksidatif pada Tikus Diabetes : Potential of Randu Honey Kefir to Prevent Oxidative Stress in Diabetic Rats Ilmi, Ibnu Malkan Bakhrul; Marjan, Avliya Quratul; Harfiani, Erna; Kusuma, Indra; Wahyuningsih, Utami; Fikriana, Chika Nur; Mulyadewi, Amelia Luthfiyah
Amerta Nutrition Vol. 9 No. 1SP (2025): AMERTA NUTRITION SUPPLEMENTARY EDITION Special 5th Amerta Nutrition Conferenc
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i1SP.2025.31-40

Abstract

Background: More than 90% of adults with type 2 diabetes are overweight or obese. This condition is known to increase oxidative stress, which contributes to cellular damage and disease complications. As a functional food, kefir has long been recognized for its various health benefits, including anti-inflammatory, antioxidant, and antidiabetic properties. Objectives: This study aimed to analyze the potential of randu honey kefir in preventing oxidative stress in diabetic rats. Methods: This study employed a randomized block design with a 21-day intervention period. A total of 42 male Sprague Dawley rats aged 6–8 weeks were divided into six groups: KS (standard), KN (negative control), K1 (quercetin), K2 (metformin), P1 (randu honey kefir 1.8 mL/200g BW), and P2 (preventive group). Diabetes was induced using streptozotocin at 40 mg/kgBW combined with a high-fat diet. Malondialdehyde (MDA) levels were analyzed using spectrophotometry, while interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) levels were measured using ELISA kits. Results: Significant differences (p-value<0.05) were observed in MDA, TNF-α, and IL-6 levels between the P1 and P2 groups compared with the KN group. Randu honey kefir groups showed mean oxidative stress marker levels comparable to those of quercetin and metformin treatments, including MDA (P1: 32.9 ± 29.35 nmol/mL; P2: 23.77 ± 11.63 nmol/mL), TNF-α (P1: 45.37 ± 31.25 pg/mL; P2: 37.81 ± 27.00 pg/mL), and IL-6 (P1: 64.81 ± 21.35 pg/mL; P2: 59.23 ± 14.95 pg/mL). Conclusions: Randu honey kefir intervention demonstrates potential in suppressing oxidative stress in diabetic rats.
Pendampingan Atlet Sepak Bola Profesional untuk Membentuk Smart Healthcare Ecosystem and Community sebagai Upaya Mewujudkan Indonesia Lolos Piala Dunia Agustiyawan, Agustiyawan; Praptiningsi, Praptiningsi; Harfiani, Erna; Alamsyah, Nanang
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 9, No 4 (2026): Volume 9 Nomor 4 (2026)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v9i4.23751

Abstract

ABSTRAK Pembinaan atlit usia muda merupakan fondasi penting dalam pengembangan sepak bola nasional untuk meningkatkan prestasi. Akan tetapi, pemain sepak bola muda Indonesia masih menghadapi sejumlah tantangan seperti kurangnya pemahaman tentang nutrisi atlet, kebugaran fisik, recovery, gaya hidup sehat, dan pencegahan cedera, yang berdampak pada performa, risiko cedera, serta durasi karier profesional. Pemanfaatan Internet of Things (IoT) dan pemberdayaan komunitas atlet muda dinilai mampu menjawab hambatan tersebut melalui pendekatan pemantauan dan edukasi yang lebih sistematis. Kegiatan ini bertujuan untuk meningkatkan pemahaman dan kapasitas pemain sepak bola profesional muda terkait kebugaran fisik, mental dan gaya hidup sehat melalui pendampingan berbasis IoT dan metode ABCD. Kegiatan dilaksanakan menggunakan pendekatan Asset-Based Community-driven Development(ABCD) melalui tahapan pemetaan aset, penyusunan program, penyuluhan, pendampingan atlet, pengembangan aplikasi IoT, dan evaluasi. Sebanyak 28 atlet muda mengikuti penyuluhan, demonstrasi, diskusi, dan pengisian pre-testserta post-test menggunakan skala Likert. Pre-test menunjukkan tingkat pemahaman berada pada kategori cukup (mean 2.68–3.10). Setelah penyuluhan dan pendampingan, hasil post-test menunjukkan peningkatan pada seluruh variabel dengan rerata pengetahuan menjadi: nutrisi atlet (3.38), pencegahan cedera (3.87), recovery (3.55), kebugaran fisik (3.77), dan gaya hidup (3.89). Peningkatan terbesar terjadi pada pencegahan cedera dan gaya hidup sehat. Pendampingan atlet muda berbasis komunitas dengan dukungan IoT terbukti efektif meningkatkan pengetahuan fundamental yang menunjang performa, kesehatan, dan karier profesional atlet. Model smart healthcare ecosystem and community ini dapat menjadi inovasi strategis dalam pembinaan atlet muda Indonesia untuk meningkatkan prestasi dan memperkuat pondasi pemain lokal masa depan. Kata Kunci: Atlet Muda, Iot, Kebugaran Fisik, Gaya Hidup, Pemberdayaan.  ABSTRACT Youth athlete development is a crucial foundation for national soccer development and enhanced performance. However, young Indonesian soccer players still face several challenges, such as a lack of understanding of athlete nutrition, physical fitness, recovery, healthy lifestyles, and injury prevention, which impact performance, injury risk, and the duration of their professional careers. The use of the Internet of Things (IoT) and the empowerment of young athlete communities are considered capable of addressing these challenges through a more systematic monitoring and education approach. This activity aims to improve the understanding and capacity of young professional soccer players regarding physical and mental fitness, and a healthy lifestyle through IoT-based mentoring and the ABCD method. The activity was implemented using an Asset-Based Community-Driven Development (ABCD) approach, including asset mapping, program development, outreach, athlete mentoring, IoT application development, and evaluation. A total of 28 young athletes participated in outreach, demonstrations, discussions, and completed pre- and post-tests using a Likert scale. The pre-test showed a level of understanding in the sufficient category (mean 2.68–3.10). After counseling and mentoring, post-test results showed improvements in all variables, with average knowledge scores of: athlete nutrition (3.38), injury prevention (3.87), recovery (3.55), physical fitness (3.77), and lifestyle (3.89). The greatest improvements occurred in injury prevention and healthy lifestyle. Community-based mentoring of young athletes supported by IoT has proven effective in increasing fundamental knowledge that supports athletes' performance, health, and professional careers. This smart healthcare ecosystem and community model can be a strategic innovation in the development of young Indonesian athletes to improve performance and strengthen the foundation of future local players. Keywords: Young Athletes, Iot, Physical Fitness, Lifestyle, Empowerment
Co-Authors ., Mashoedojo Abd. Rasyid Syamsuri Abdi Wira Septama Abdul Kolib Adi Sukrisno Agneta Irmarahayu Agus Aulung Aisyah, Ammara Alamsyah, Nanang Almerveldy Azaria Dohongi Almerveldy Azaria Dohongi Angga Hardiansyah Anisah Anisah Anisah Anisah Aprilia, Citra Ayu Ashfia Desi Rahmalina Aulia Chaerani Aulia Chairani Avliya Quratul Marjan Az Zahra, Fatima Boenga Nurcita Budiman, Dicky Citra Ayu Aprilia Dicky Budiman Dinda Nuraini Hanifah Wahab Dwi Arwandi Yogi Saputra Fachri Razi Fajriati Zulfa Fikriana, Chika Nur Hany Yusmaini Ilmi, Ibnu Malkan Bakhrul Ima Maria Indra Kusuma Kartika Putri Amalia Makkiyah, Feda Anisah Manpan Drajat Maria Selvester Thadeus Md Ikhsan Mokoagow Meiskha Bahar Mila Citrawati Mokoagow, Md Ikhsan Muhammad Reiza Mulyadewi, Amelia Luthfiyah Muttia Amalia Nabilah, Ayi Nely Jumaliah Nugraha, Yudhi Nugrahayu Widyawardani Nurfitri Bustamam Nurhakim, Althaf Dhaifullah Pasaribu, Rini Sarah Pasiak, Taufiq Fredrik Praptiningsi, Praptiningsi Primayanti Nurul Ilmi Pritasari, Ilham Arzy Diana Pritha Maya Savitri Putra Sang Fajar El Harry Putra Sang Fajar El Harry Rahmi, Eldiza Puji Ratna Puspita Ratna Puspita Reiza, Muhammad Retno Yulianti Revina, Rika Ria Maria Theresa Ria Maria Theresa Ryan Herardi Sarmoko Sarmoko Serli Marlina Siska Maydianah Sitinjak, Sahat Anugerah Immanuel Sri Rahayu Sri Wahyuningsih Susanti, Febriyolla Sutarto, Riyadi Taufiq Fredrik Pasiak Taufiq Fredrik Pasiak Taufiq Fredrik Pasiak Taufiq Fredrik Pasiak Taufiq Pasiak Taupan Ichsan Tuarita Theodora Putri Simanjaya Tresnawati, Nden Ajeng Ufi Dewintera Uswatun Hasanah Uswatun Hasanah Uswatun Hasanah Utami Wahyuningsih Wahab, Dinda Nuraini Hanifah Wibowo, Muhammad Rizky Wibowo, Putri Larasati Widianingsih Widianingsih Yanti Harjono Hadiwiardjo Yanto Sandy Tjang Yudivaniel Zihono Zihono, Yudivaniel