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Phytochemical Composition And In Vitro Antifungal Limitations Of Salacca Zalacca Peel Extract Against Candida Albicans Aryasa, Mahesa Ajisaka; Mahendra, Agung Nova; Ernawati, Desak Ketut; Satriyasa, Bagus Komang
Jurnal Locus Penelitian dan Pengabdian Vol. 5 No. 2 (2026): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v5i2.5531

Abstract

Candidiasis, primarily caused by Candida albicans, continues to pose clinical challenges due to antifungal resistance and the adverse effects of synthetic agents. This study aimed to evaluate the phytochemical profile and antifungal efficacy of Salacca zalacca (Bali snakefruit) peel extract as a potential natural alternative. The extract was obtained using ethanol-based maceration and analyzed through UV-Vis spectrophotometry. The results revealed high concentrations of flavonoids (857.59 mg/100 g), phenolics (860.54 mg/100 g), vitamin C (8391.10 mg/100 g), and tannins, along with the qualitative presence of saponins. Antioxidant analysis indicated weak radical scavenging activity (IC?? = 546.19 ppm) but a high total antioxidant content (2532.17 mg GAE/L). Antifungal testing using the disk diffusion method against C. albicans showed no inhibition zones at extract concentrations of 2.5%, 5%, and 10%, whereas the ketoconazole control produced a strong inhibition zone (mean 20.33 mm). The lack of activity may be attributed to diffusion limitations or solubility issues rather than the absence of bioactive compounds. Despite the negative antifungal results, the high phytochemical content suggests potential for alternative therapeutic applications. Further studies employing alternative solvents, higher extract concentrations, and more sensitive antifungal assays are recommended.
The Potential of Binahong Leaf (Anredera cordifolia) Ethanol Extract on Male Fertility in Mice Exposed to E-Cigarette Smoke Widianti, I Gusti Ayu; Wardana, Nyoman Gede; Widhiartini, Ida Ayu Alit; Satriyasa, Bagus Komang; Antari, Ni Wayan Sukma; Pratiwi, Made Sindy Astri
Journal of Health and Nutrition Research Vol. 5 No. 1 (2026)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v5i1.1055

Abstract

Binahong leaf is known for its strong ability to prevent oxidation due to its active flavonoid compounds. Exposure to electronic cigarette smoke can increase reactive oxygen species (ROS), as a contributing factor to infertility. This study aims to identify the potential of Binahong leaf (Anredera cordifolia) ethanol extract on testosterone levels and spermatogenic cells in adult mice (Mus musculus) exposed to electronic cigarette smoke. A post-test control group design was used, with 28 male Balb/c mice allocated to four groups. The control group received 0.3% CMC, while the three treatment groups were administered Binahong leaf ethanol at doses of 50, 100, and 200 mg/kg body weight, in a volume of 0.1 ml orally each evening for 35 days. All mice were exposed to an electronic cigarette containing 6 mg of nicotine for 20 minutes. On day 36, blood samples were obtained to measure testosterone levels via ELISA. Testicular tissue was observed using Hematoxylin-Eosin staining. A marked elevation in testosterone concentrations and spermatogenic cell count was observed in the group treated with 50 mg/kg BW of Binahong leaf ethanol extract in contrast to the control group (p = 0.014 and 0.008, respectively). Higher doses reduced testosterone/spermatogenesis compared to the optimal dose, potentially implying a toxic or inhibitory effect. Binahong leaf ethanol extract administered at 50 mg/kg BW is effective in increasing testosterone levels and spermatogenic cells in adult mice (Mus musculus) exposed to electronic cigarette smoke.
Co-Authors A.N. Mahendra A.W. Indrayani Adiputra, LMIS. Handari Agung Bagus S. Satyarsa Agung Nova Mahendra Agung Wiwiek Indrayani Ali Imron Amaral, Meriana Barreto Anak Agung Gede Eka Septian Utama Anak Agung Gede Fandhiananta Widyanjaya Artini , I Gusti Ayu Aryasa, Mahesa Ajisaka Ayu Diandra Sari Bastianus Alfian Juatmadja Desak Ketut Ernawati Desak Made Wihandani Dewa Ayu Putu Rasmika Dewi Dewa Putu Gede Purwa Samatra Dita Permatasari Edelweishia, Melissa Efraldo Yudistira Fendy Nugroho I Dewa Ayu Inten Dwi Primayanti I Dewa Made Sukrama I Dewa Putu Sutjana I Gde Haryo Ganesha I Gede Krisna Putra Yasa I Gede Restu Mahendra Sugiarta I Gede Widhiantara I Gusti Ayu Widianti I Gusti Made Aman I Kadek Arya Gangga Permana I Made Ady Wirawan I Made Jawi I Made Krisna Dinata I MADE MULIARTA . I Made Sudarmaja I Nengah Sandi I Nyoman Adi Putra I Nyoman Mangku Karmaya I P G. Adiatmika I Pande Putu Deny Heriwijaya I Putu Adiartha Griadhi I Putu Agus Budi Sudarsana I Putu Eka Kusuma Yasa I Putu Riska Ardinata I Wayan Putu Sutirta Yasa I Wayan Rosiana I Wayan Sumardika I Wayan Sumardika I Wayan Weta I.A.A. Widhiartini I.G. Wiranatha I.G.A. Artini I.G.M. Aman I.G.M.G.S.C. Trapika IB Putra Manuaba, IB Putra Ida Ayu Mas Suryani Ida Bagus Budha Dharma Kusuma Ida Bagus Ngurah Ida Bagus Putra Manuaba IKW. Suryawan Imakulata Magi Loda Iman Santoso Irawan, Angeline Aprilia Ivana, Jocelyn J. A. Pangkahila Joppi Huwae Karta Sawenda Ketut Agus Adrianta Ketut Tirtayasa Klaudius H. M. Meti Kristanto, Andre Kurniawan, Yukhi Listya Triandari LMIS. Handari Adiputra Lorena Samanta Adelina Luh Made Indah Sri Handari Adiputra Luh Sonya Astana Putri M Widnyana M. Ali Imron Made Indra Prasetya Permana Maura Marda Mayang Sari Muh. Ali Imron Muh. Ali Imron Muh. Irfan Muhammad Irfan Muthiah Munawaroh N. Adiputra N. Adiputra N.W. Tianing N.W.S. Dewi Nabasa, Gayus Erino Ni Luh Gede Ayu Candranita Dharmadi Ni Luh Suriani Ni Made Intansari Tri Buana Ni Made Linawati Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Budiani, Ni Nyoman Ni Putu Oka Mahayani* Ni Putu Widya Astuti Ni Putu Wirantari Ni Wayan Arni Sardi Ni Wayan Saka Rahayu Ni Wayan Sinta Devi Arini Ni Wayan Sucindra Dewi Ni Wayan Sucindra Dewi Ni Wayan Sukma Antari Nyoman Ratep Nyoman Suarjana Ocktaviana Saputri, Legis Ode Mahesa Putra Oktovianus Fufu Oktovianus Fufu Oktovianus Fufu Permatasari, Anak Agung Ayu Putri Pratiwi, Made Sindy Astri Putri Uli Saktina Putu Ananda Sutiksna Mulya Putu Angga Wiradana Putu Astawa Putu Susilawati Putu Wandari Pranitha S.Indra Lesmana Selviani, Iit Sugijanto - Sugijanto - Sugijanto - Sugijanto - Suryawan, IKW. Susy Purnawati Syahmirza Indra Lesmana Tharsani Devi Srinivasagam Tjokorda Gde Bagus Mahadewa Tri Wahyu Wulandari Wahyuddin, Wahyuddin Wardana, Nyoman Gede Widianti, I Gusti Ayu Widiyanti, I Gusti Ayu Wijaya Surya, I Gede Ngurah Harry Wimpie I Pangkahila Wirawan, IMA. Xena Laveda Yogie Wiswadewa Yuniarti N