Breast cancer is one of the most common and deadly types of cancer among women, including in Indonesia, with an increasing incidence rate. This study aims to understand the coping mechanisms used by women with breast cancer in Kupang City in dealing with the disease. The method used in the research is qualitative with a phenomenological approach. Data collection techniques were carried out by in-depth interviews with five main informants who were women with breast cancer, as well as six supporting informants consisting of parents, husband, and psychologists. The results showed that the coping mechanisms applied by informants included problem-focused coping, emotion-focused coping, and meaning-focused coping. Informants make efforts to seek treatment both medical and traditional, and apply a healthy diet as part of the coping mechanism. In addition, social support from the family plays an important role in increasing the enthusiasm and motivation of informants to fight the disease. The Health Office is expected to integrate the results of this study in developing policies and support programs for breast cancer patients, as well as increasing public awareness about the importance of social support and healthy coping mechanisms for women with breast cancer.