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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Medula Jurnal Dunia Kesmas Journal of Language and Health Jurnal Farmasetis Sains Medisina JOURNAL OF Qualitative Health Research & Case Studies Reports Journal of Health Science and Medical Therapy JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Tri Umiana Soleha
Bagian Mikrobiologi, Fakultas Kedokteran, Universitas Lampung
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Pendekatan Diagnostik Berbasis Manifestasi, Pemeriksaan Klinis dan Tatalaksana Pada Tuberkulosis Paru Juliana, Risna; Soleha, Tri Umiana; Yunianto, Andi Eka; Ismunandar, Helmi Ismunandar
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1347

Abstract

TB is a disease caused by MTB bacteria where this bacteria is able to attack the lung organs or extrapulmonary organs. The etiology of TB is caused through spit or phlegm from patients whose phlegm contains MTB bacteria. MTB bacteria have a rod shape and are acid-resistant, so they are known as acid-resistant bacteria (AFB). These bacteria do not have spores, so they will easily die if exposed to sunlight. However, this type of bacteria will be difficult to dye because it is acid-resistant, so a special staining method is needed, namely Ziehl Neelsen  staining. When a person coughs, water splashes will spread into the air and will then be inhaled by a healthy person, so the bacteria will enter the lungs and carry out the infection process. Usually, TB disease attacks at a productive age because at that age many people interact socially, making it easier for infectious infections to occur. . In general, the main symptoms are coughing up phlegm, which in some cases can mix with blood, chest pain, and shortness of breath . Confirmation of TB diagnosis can be done by conducting an anamnesis, physical examination, and supporting examination. TB treatment takes 6-12 months for patients who do not experience drug resistance. TB treatment consists of two stages, namely the initial stage and the advanced stage. The initial stage will last for two months, with the type of drug given is a combination of 2 HRZEs (Isoniazid, Rifampicin, Pirazinamid, and Etambutol). The advanced stage of treatment lasted for 4 months, with the drug given in the form of a combination of 4HR (isoniazid and rifampicin).
Peran Flavonoid Sebagai Antiulser dan Antioksidan pada Ulkus Duodenum Zahra, Aulia Jannatuz; Susianti, Susianti; Happy, Terza Aflika; Soleha, Tri Umiana
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1415

Abstract

Duodenal ulcer is a pathological condition characterized by damage to the duodenal mucosa due to an imbalance between protective and aggressive factors, such as gastric acid and pepsin. The primary factors contributing to the development of this ulcer include Helicobacter pylori infection. Additionally, prolonged use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) is also a significant factor in the occurrence of duodenal ulcers, as these drugs inhibit prostaglandin synthesis, which plays a crucial role in mucosal protection. In Indonesia, the prevalence of duodenal ulcers is estimated to be around 11–14%. Flavonoids, as bioactive compounds with antioxidant, anti-inflammatory, and anti-ulcer properties, have been widely studied for their potential in the management of peptic ulcers, including duodenal ulcers. Flavonoids have been shown to inhibit gastric acid secretion, stimulate mucus production, and protect the gastrointestinal mucosa through cytoprotective and antioxidative mechanisms, specifically by inhibiting reactive oxygen species (ROS). Furthermore, flavonoids have the ability to suppress H. pylori growth, thereby contributing to the prevention of ulcer pathogenesis caused by this bacterium. Flavonoids also enhance blood flow to the gastric mucosa and modulate enzymes involved in epithelial defense. Despite these benefits, the main challenges in utilizing flavonoids are their low bioavailability and potential toxicity at high doses. Therefore, further studies are essential to evaluate the efficacy, safety, and formulation optimization of flavonoids to enhance their availability as a natural therapeutic alternative and their application in the clinical treatment of peptic ulcers.
Krisis Hiperglikemik: Diabetic Ketoacidosis (DKA) dan Hyperglycemic Hyperosmolar State (HHS) Wibowo, Muhammad Rafi; Rudiyanto, Waluyo; Yunianto, Andi Eka; Soleha, Tri Umiana
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1435

Abstract

Hyperglycemic crisis is an acute metabolic complication of diabetes mellitus that can be life threatening if not treated appropriately. This research aims to examine in more depth the hyperglycemia crisis. This research is a literature study using relevant literature such as articles and journals from various national and international databases such as Google Scholar, NCBI, and PubMed. Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar State (HHS) are serious and emergency forms of hyperglycemic crisis. DKA is often found in people with type 1 diabetes due to severe insulin deficiency, which is characterized by the triad of hyperglycemia, acidosis, and ketosis. In contrast, HHS occurs more frequently in type 2 diabetes, with features of hyperglycemia, hyperosmolarity, and dehydration, but without significant ketosis and acidosis. Both of these conditions have a high risk of death if left untreated, with the death rate for DKA around <1% and HHS around 15%. The goal of treatment for both is to improve circulation and tissue perfusion, correct hyperglycemia, ketogenesis, and electrolyte imbalances, and identify precipitating factors. Treatment begins with correcting dehydration and electrolyte imbalances through rehydration with crystalloid fluids, as well as treating hyperglycemia by administering insulin boluses or infusions. Prevention of DKA and HHS is to ensure that patients do not stop insulin or oral hyperglycemic drugs, monitor blood sugar levels regularly and immediately seek professional medical help if something undesirable happens.
Hubungan Jenis Kelamin, Usia, dan Pekerjaan dengan Kejadian Anemia pada Pasien Tuberkulosis Paru di Rumah Sakit Umum Daerah Abdul Moeloek Bandar Lampung pada Bulan Januari - Agustus 2022 Fathunnisa, Ridha Riano; Sangging, Putu Ristyaning Ayu; Utami, Winda Trijayanthi; Soleha, Tri Umiana
Medula Vol 16 No 1 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i1.1754

Abstract

Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis and is classified as a chronic multisystem infection with diverse clinical manifestations. Hematological abnormalities are frequently observed in tuberculosis patients and are generally associated with non-immunological mechanisms. Anemia is one of the most common abnormalities. All chronic infections, including tuberculosis, can induce anemia through various pathogenic pathways. However, most studies indicate that suppression of erythropoiesis mediated by inflammatory factors plays a major role in the development of anemia in tuberculosis patients. This study aimed to describe the characteristics of anemia and identify factors associated with its occurrence in patients with pulmonary tuberculosis. An observational analytic study with a cross-sectional design was conducted. Data were obtained from the medical records of pulmonary tuberculosis patients with anemia at the Medical Records Unit of RSUD Dr. H. Abdul Moeloek Bandar Lampung from January to December 2022. A total of 85 patients who met the inclusion criteria were included and analyzed using univariate and bivariate analyses with the Chi-Square test. Univariate analysis showed that most patients had normocytic normochromic anemia, accounting for 66 patients or 77.6%, while microcytic hypochromic anemia was observed in 19 patients or 22.4%. Anemia was more common in male patients, with a proportion of 74.1%. Bivariate analysis demonstrated a significant association between age and anemia occurrence, with a p value of 0.024. No significant association was found between occupation and anemia or between sex and anemia. This study concludes that age is the only factor associated with anemia among pulmonary tuberculosis patients at RSUD Dr. H. Abdul Moeloek Bandar Lampung.
Efektivitas Amoxicillin dan Piperacillin Terhadap Klebsiella pneumoniae pada Kasus Infeksi Saluran Pernapasan Akut di RSUD Dr. H. Abdul Moeloek Periode 2019 – 2023 Azalia, Nadhira; Soleha, Tri Umiana; Larasati, Ratri Mauluti; Utama, Winda Trijayanthi
Medula Vol 16 No 4 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i4.1846

Abstract

Acute respiratory tract infection (ARI) is one of the leading causes of morbidity that often requires antibiotic therapy, with Klebsiella pneumoniae being one of the most commonly found bacterial pathogens and known to have a high level of antibiotic resistance. Irrational use of antibiotics can accelerate the development of resistance, so the effectiveness of antibiotics needs to be evaluated periodically. Amoxicillin and piperacillin are commonly used antibiotics in the management of ARTI. This study aimed to evaluate the effectiveness of amoxicillin and piperacillin against Klebsiella pneumoniae in cases of ARTI at Dr. H. Abdul Moeloek General Hospital from 2019 to 2023. This study is an observational analytical study with a cross-sectional design using secondary data in the form of culture results and antibiotic sensitivity tests from patient medical records. The sampling technique used total sampling with a total of 106 Klebsiella pneumoniae isolates. Data analysis was performed using the Chi-Square test. The results showed that the resistance rate of Klebsiella pneumoniae to amoxicillin was 92.5% with a sensitivity of 7.5%. In contrast, piperacillin showed a higher sensitivity of 58.5% although resistance was still found at 41.5%. Statistical tests showed a significant relationship between the type of antibiotic and the level of bacterial sensitivity (p-value < 0.001). The conclusion of this study indicates that piperacillin is more effective than amoxicillin in the management of ARI caused by Klebsiella pneumoniae and can be considered in the selection of empirical antibiotic therapy.
Co-Authors Anggraeni Janar Wulan, Anggraeni Janar Anggraini, Dian Isti Ari Irawan Artanti, Mariesela Ayu S, Putu Ristyaning Azalia, Nadhira Bajuri, Annisa Nur Oktavia Baradatu, Mirza Sultan Betta Kurniawan, Betta Caesarridha, Dhaifany Karissa Cyntithia, L. Gita Damayanti, Ervina Dewayanti, Wahyu Dyah Wulan Sumekar Rengganis Wardani Ermin Rachmawati Ety Apriliana Fathunnisa, Ridha Riano Frauprades, Kaltihennah Oktavia Gliselda, Vika Kyneissia Gozali, Achmad Hanna Mutiara, Hanna Happy, Terza Aflika Helmi Ismunandar Indri Windarti Ismunandar, Helmi Ismunandar Jausal, Anisa Nuraisa Jessy Dewi Awali Juliana, Risna Junando, Mirza Kurniawaty, Evi Larasati, Ratri Mauluti Liana Sidharti, Liana Lusina, Septia Eva Mallarangeng, Andi Nafisah Tendri Adjeng Morfi, Chicy Widya Muhammad Iqbal Muhammad Ricky Ramadhian Muhammad Yusran Nabila, Afia Farah Nasution, Artika Ananda Putri Nikita, Marshanda Oktafany, Oktafany Oktoba, Zulpakor Pardilawati, Citra Yuliyanda Poty, Pitha Maykania Purba, Gemi Sabrina Putri, Abrila Tamara Putri, Yessa Rahmadini Rahel, Clara Arta Uli Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Rika Lisiswanti Risal Wintoko Risti Graharti Rizki Hanriko Rudiyanto, Waluyo Sa'diyah, Isma Fadlilatus Sangging, Putu Ristyaning Ayu Septiani, Linda Shinta Dewi, Brigitta Shinta Nareswari, Shinta Sinulingga, Anselmus Libreya Situmorang, Ezra Winandi Susianti, Susianti Sutyarso Sutyarso Syazili Mustofa Triyandi, Ramadhan Utami, Winda Trijayanthi Wibowo, Muhammad Rafi Winda Trijayanthi Utama, Winda Trijayanthi Wulan, Anggraini Janar Yunianto, Andi Eka Zahra, Aulia Jannatuz