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Journal : Ovozoa: Journal of Animal Reproduction

Pengaruh ekstrak daun binahong (Anredera cordifolia ) terhadap pemulihan siklus estrus mencit (Mus musculus) Sari, Diana Novita; sumarmin, Ramadhan; Arsih, Fitri; Dwi Nugraha, Fitra Arya
Ovozoa: Journal of Animal Reproduction Vol. 10 No. 2 (2021): Ovozoa: Journal of Animal Reproduction
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ovz.v10i2.2021.32-38

Abstract

This study aimed to determine the effect of binahong (Anredera cordifolia) leaf extract on the recovery of the estrous cycle of mice (Mus musculus) which has been induced for the extension of the estrous cycle using angsana (Pterocarpus indicus) bark extract. In this study vaginal smear was performed daily at 10.00 WIB to determine the phase of the estrous cycle for 26 days. Mice were divided into 5 groups, each with 6 replicates. The treatments were T1 (positive control), T2 (negative control), T3 (0.8 mg/head/day), T4 (2.4 mg/head/day) and T5 (4 mg/head/day). The data obtained were processed using Analysis of Variance (ANOVA) and followed by the Duncan's New Multiple Range Test (DNMRT) at a 95% level of significance.  The results showed that the angsana (Pterocarpus indicus) bark extract adminsitration (T2) lengthen (p <0.05) the estrous cycle of mice compared to those of normal mice (T1). The administration of binahong (Anredera cordifolia) leaf extract on T3 and T4 groups mice were followed by shorter (p <0.05) estrous cycle than those of T2, and it were not significantly different (p >0.05) compared to T1 group. However, the higher dose of binahong (Anredera cordifolia) leaf extract (T5) revealed the length of estrous cycle was not significantly different (p >0.05) compared to T2 group. It can be concluded that the administration of binahong leaf extract was able to recover the normal estrous cycle of mice.
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Rajak Abdul Razak Abdul Razak Adi Winarto Afriani Afriani Ahyar, Rania Annika Maizeli Arafah, Auliani Ardi Ardi Arianti, Febri Arief Boediono Armein Lusi Ze swita Armein Lusi Zeswita Armen Lusi Asrizal Azwar Ananda Azwir Anhar Damaiyanti, Riska Defrian Melta Delni Oktavia Deni eliza Desi Anggriani Dewinda Yanua Putri Diana Novita Sari, Diana Novita Diana Susanti Diana Susanti, Febriyanti, Ruth Rize Paas Megahati S, Diana Susanti, Dra. NURSYAHRA M.Si Dra. NURSYAHRA M.Si Dwi Hilda Putri Dwi Nugraha, Fitra Arya Effendi, Jon Elda Riza Elsa Yuniarti Ennike Gusti Rahmi Ernie Novriyanti F, Farida Festiyed Fetro Dola Samsu Fingki Alvia Candra Fitri Arsih Fitri Malinda Sari Fitri, Ryantika Fitria Dona gusril gusril Gustina Indriati Hayuni Octavia Heffi Alberida Helendra Helendra Huryah, Fadhilatul Indra Madani Irawati, Wike Julia Maria Gorette Juni Asmi Lumban Toruan Kurniasih, Yulvina Lauren Lauren Linda Advinda Liza Yulia Sari Lufri Lufri M. Haviz Mailastri Suarna Margaretta Margaretta Maria Fransiska Mawarni Mawarni Meliya Wati Miswati Miswati Muhyiatul Fadilah Muthia Oktavia Natalia, Desfaur Nia Anggraini Nila Kusuma Wati Nindi Maiyora Nofri Zayani Nurul Fauziah Pardismi Pardismi Penatriwati Penatriwati Putra, Erik Nanda Putri, Rani Dwi Suci Rahma Wati Rahmadhani Fitri Rahmah Maulidiyah Rahmapela Zaima Rahmawati D Rahmi, Dini Relsas Yogica, Relsas Renidawati Hutapea Restia Nika Ria Kasmeri RINA M.Si WIDIANA S.Si Rini Silvina Roza, Rizka Khairia Rusdinal, Rusdinal Santosa, Tomi Apra Sarah Sarah, Sarah Selaras, Ganda Hijrah Sherly Serfitria Silvi Susanti Silvina Arifa Siska Adelya Ramadhani Susanti, Silvi Susanti, Wahyu Indah Syari, Elsy Melia Tomi Apra Santosa Tutty Laswardi Yusuf Tutty Laswardi Yusuf Ulfa Syukur Winda A. Fietri Winda Ayu Fietri Wismi Lenggo Geni Witma Novita Atnur Yulia Ratna Sari Yuni Ahda Zikra Zikra Zulyusri Zulyusri