Article Per Year (5 Year)
p-Index From 2021 - 2026
4.589
P-Index
This Author published in this journals
All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Juke Jurnal Pengabdian Kepada Masyarakat Sakai Sambayan The Journal of Pure and Applied Chemistry Research Transformasi: Jurnal Pengabdian Masyarakat MEDISAINS Biology, Medicine, & Natural Product Chemistry The Indonesian Biomedical Journal Wikrama Parahita : Jurnal Pengabdian Masyarakat JPM (Jurnal Pemberdayaan Masyarakat) Jurnal Pengabdian Pada Masyarakat Martabe : Jurnal Pengabdian Kepada Masyarakat CARADDE: Jurnal Pengabdian Kepada Masyarakat Acta Biochimica Indonesiana UMI Medical Journal Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat INTEGRITAS : Jurnal Pengabdian Jurnal Ners Journal of Borneo Holistic Health Jurnal Bakti Masyarakat Indonesia BERNAS: Jurnal Pengabdian Kepada Masyarakat JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Penyuuhan dan Pemberdayaan Masyarakat (JPPM) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Abdimas Indonesian Journal Madani : Jurnal Pengabdian Kepada Masyarakat SEGARA : Jurnal Pengabdian Kepada Masyarakat JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Tiwuk Susantiningsih
Universitas Pembangunan Nasional Veteran Jakarta
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

Published : 46 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : medisains

 1 
Anti-inflammatory and hepatoprotective effects of Moringa oleifera fruit in obesity-induced liver injury Susantiningsih, Tiwuk; Thadeus, Maria Selvester; Citrawati, Mila; Setyaningsih, Yuni
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.30081

Abstract

Background: Hepatic metabolic disorders are closely associated with obesity and are characterized by systemic inflammation and liver injury. Moringa oleifera fruit contains various bioactive compounds with potential anti-inflammatory and hepatoprotective properties. However, evidence regarding its effects on obesity-induced liver injury remains limited..   Objective: This study aimed to evaluate the anti-inflammatory and hepatoprotective effects of Moringa oleifera fruit extract in an obesity-induced rat model..   Methods: This experimental study used 30 male Sprague-Dawley rats divided into five groups: normal control (N), obese control (O), obese rats treated with Moringa oleifera fruit extract at 500 mg/kg body weight once daily (OEMO1), twice daily (OEMO2), and obese rats treated with vitamin C (OC). Systemic inflammation was assessed by measuring serum C-reactive protein (CRP) levels using ELISA, while hepatic changes were evaluated through biochemical markers and histopathological analysis. Data were analyzed using one-way ANOVA followed by post hoc testing.   Results: Obese rats exhibited significantly elevated serum CRP levels and marked hepatic alterations compared to normal controls (p < 0.05). Administration of Moringa oleifera fruit extract significantly reduced CRP levels and improved hepatic histoarchitecture in obese rats, with the greatest effect observed in the twice-daily treatment group (OEMO2) (p < 0.05). The effects were comparable to or greater than those observed with vitamin C. Conclusions: Moringa oleifera fruit extract demonstrates significant anti-inflammatory and hepatoprotective effects in an obesity-induced rat model, suggesting its potential as a natural therapeutic agent for obesity-related liver injury.
Co-Authors Abd. Rasyid Syamsuri Abdul Halim Arif Agneta Irmarahayu Amarisa Nur Affifah Andri Pramesyanti Pramono Ani R. Prijanti Ani Retno Prijanti Arfiyanti, Arfiyanti Asep Sukohar Audrey Alvura Digna Azzahra Cahya Maulida Baehaqi Basuki Supartono Bella Pricilya Nababan Boenga Nurcita Bulan Cahyani Wibowo Chantika Zahra Adisaputra Dara Juliana Desi Purwaningsih Dian Ayu Paramitha Dwi Arwandi Yogi Saputra Evi Kurniawaty Fachruddin Perdana Fadilah Fajriati Zulfa Fajriati Zulfa Fera Kurniadewi HANS-JOACHIM FREISLEBEN Hardyanti, Putri Heryani, Monalisa Hikmah Muktamiroh Hikmah Muktamiroh Huzaimah Huzaimah Ikhsandy Alfindo Irma Kartika Isniani Ramadhani Juliana, Dara Karimah Ihda Husnayain Karimatul Himmah Khairun Nisa Konita Adhani Kristina Simanjuntak Kristina Simanjuntak Kristina Simanjuntak Kristina Simanjuntak Kristina Simanjuntak, Kristina Simanjuntak Kurniawaty, Evi Lana Asfaradilla Makkiyah, Feda Anisah Maria Selvester Thadeus Melly Kristanti Mila Citrawati Mohamad Sadikin Monalisa Heryani Mufidatur Rosyidah, Mufidatur Muhammad Alif Farhan Muhammad Kevin Auliansyah Akbar Muktamiroh Hikmah Muktiningsih Nurjayadi Muttia Amalia Muttia Amalia Ni Luh Aurial Widjayanti Novi Silvia Hardiany Nunuk Nugrohowati Pritha Maya Savitri Putri Elok Septiana Dewi Rahajeng, Herera Rahmah, Nida Nabila Rahman, Ihsan Febrianto Rahmawati Ridwan Reinhart Fikram Imam Akbar Retno Yulianti Retno Yuliyanti Ria Maria Theresa Roro Rukmi Windi Perdani, Roro Rukmi Rukman Abdullah Setiya Purbasari Setyaningsih, Yuni Setyaprawira, Fallery Simanjuntak, Kristina Soraya Rahmanisa Soroy Lardo Sri Wahyuningsih Sri Wahyuningsih Sri Wahyuningsih Sukmara, Uta Provinsiana Syazili Mustofa Tasya Nooramadhani Thadeus, Maria Selevster Wandira Danil Ramadhan Wendi Corlia Cahyaninglatri Yanto Sandy Tjang Yuliyanti, Retno Yuni Setyaningsih Yuni Setyaningsih Zihono, Yudivaniel