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All Journal VALENSI JURNAL KIMIA SAINS DAN APLIKASI Jurnal Natur Indonesia AL KAUNIYAH Jurnal Penelitian Farmasi Indonesia Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Jurnal Edu Research Jurnal Kimia Riset Indonesian Journal of Chemistry Jurnal Penelitian Farmasi Indonesia Biosaintifika: Journal of Biology & Biology Education Jurnal Sinergitas PkM & CSR JOPS (Journal Of Pharmacy and Science) JURNAL PHOTON Eksakta : Berkala Ilmiah Bidang MIPA Molekul: Jurnal Ilmiah Kimia Majalah Farmasetika Dinamika Lingkungan Indonesia Jurnal Farmasi Indonesia
Hilwan Yuda Teruna
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Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Analisis komponen minyak atsiri daun nilam (Pogostemon cablin) lokal Pekanbaru menggunakan GC-MS Teruna, Hilwan Yuda; Rahayu, Wiwit Nur
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (419.986 KB) | DOI: 10.35617/jfionline.v13i1.69

Abstract

Pogostemon cablin or nilam Aceh is a patchouli oil producer plant that is widely cultivated in Indonesia because the quality of the essential oil produced is better than other types of Pogostemon. The purpose of this study was to extract the local patchouli oil of Pekanbaru and compare its chemical components with standard patchouli oil. The quality of the patchouli essential oil of local Pekanbaru was also analyzed based on the chemical components. The extraction method used in this research was hydrodistillation using Clevenger apparatus. Volatile oil vapor evaporated together with water vapor and passed through the condenser. The oil was characterized by its components by GC-MS. The results found that the concentration of patchouli alcohol was 31.13%, along with other compounds such as α-patchoulene, β-patchoulene, seychellene, α-bulnensene, and cyclosativene. The difference of patchouli oil of P. cablin grown in Pekanbaru with the standard patchouli oil was that the concentration of patchouli alcohol in the local patchouli oil of Pekanbaru was high with no α-guaiene, there was a cyclosativene instead. Based on this, the local patchouli oil of Pekanbaru has a fairly good quality and has the potential to be developed further.
Isolation and Characterization of Flavonoid from Mimosa pudica Muhamad Afham; Hendra, Rudi; Teruna, Hilwan Yuda
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 03 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss03/608

Abstract

Indonesia has a rich biodiversity, including the putri malu plant (Mimosa pudica L.) which is known to have secondary metabolites with medicinal potential but has not been fully utilized. The purpose of this work is to isolate and analyze secondary metabolites from M. pudica. The aerial portions were dried and macerated in methanol before being partitioned using n-hexane, dichloromethane, and ethyl acetate solvents. The ethyl acetate extract was separated using liquid vacuum chromatography, then recrystallized and purity tested (KLT, melting point, and HPLC). The chemical structure was characterized using UV-Vis, FTIR, and NMR (1H and 13C) spectroscopy. One of the 17 fractions generated pure yellow crystals with a melting point of 242-244°C and single prominent peak on HPLC. The study revealed that the chemical was quercetin, a flavonoid with a variety of biological functions. This study demonstrates that M. pudica include active flavonoid compounds that can supportaid in the development of herbal medications based on natural ingredients. These findings lay the groundwork for additional research into its bioactivity and pharmacological potential, particularly as an antidiabetic drug and antioxidant.
Design, Synthesis, and Antifungal Analysis of Pyrazoline Derivatives Against Candida Species: A Comprehensive In Vitro and In Silico Approach Rohim, Muhammad; Haryani, Yuli; Frimayanti, Neni; Muttaqin, Fauzan Zein; Teruna, Hilwan Yuda; Hendra, Rudi
Indonesian Journal of Chemistry Vol 25, No 4 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.105255

Abstract

This study utilized in vitro and in silico methods to assess the antifungal efficacy of synthesized pyrazoline derivatives (4a–e) against Candida species. The compounds were produced by a one-pot process and structurally analyzed using spectroscopic methods. The antifungal efficacy was evaluated against C. albicans, C. glabrata, and C. krusei using minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) assays. Among the derivatives, compound 4e exhibited potent antifungal action, displaying MIC values similar to ketoconazole. Molecular docking and pharmacophore modeling have shown that 4e interacts efficiently with critical residues of lanosterol 14α-demethylase (CYP51). The density functional theory (DFT) study indicated advantageous electrical characteristics, while molecular dynamics simulations validated the structural stability of the 4e–CYP51 complex, evidenced by low RMSD and RMSF values, along with an MM/GBSA binding energy comparable to that of ketoconazole. A robust association between binding energy and MIC substantiates the predictive use of computational data. The results suggest that compound 4e replicates the binding characteristics of ketoconazole and may be a viable candidate for antifungal medication development. This integrative strategy reinforces the justification for additional optimization and preclinical assessment of pyrazoline-based antifungal drugs aimed at CYP51.
A Novel Benzenesulfonylurea-Substituted Pyridazinone Derivative with Antidiabetic Effect as the Peroxisome Proliferator-activated Receptor (PPAR-γ) Agonist Fatisa, Yuni; Yasthophi, Arif; Elviyenti, Elviyenti; Ikhtiaruddin, Ihsan; Frimayanti, Neni; Teruna, Hilwan Yuda; Jasril, Jasril
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 1, May 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i1.42187

Abstract

Peroxisome Proliferator-activated Receptor (PPAR-γ) protein is one of the target proteins for insulin sensitivity therapy in Type 2 DM. PPAR-γ has a key role as a nuclear receptor that regulates the expression of several metabolism-related genes. This research aims to   synthesize a novel   benzenesulfonylurea-substituted   pyridazinone     derivative, namely (E)-N'-(1-(4-(3-(4-methoxyphenyl)-6-oxopyridazin-1(6H)- yl)phenyl)ethylidene)-4-methylbenzenesulfonohydrazide (8) and predicted it activity as the PPAR-γ agonist using a molecular docking approach and ADMET profiles. The compound 8 was obtained through a Schiff base condensation reaction between compound 6, p-tosyl hydrazine, and a glacial acetic acid catalyst using monowave. The purity of the compound was determined by TLC test, and melting point measurement. The structure was confirmed through FTIR, 1H-NMR, C-NMR and HRMS analysis. Molecular docking studies were carried out on the crystal structure of the human PPAR-γ Ligand Binding Domain target protein in complex with the α-aryloxyphenyl acetic acid agonist (PDB ID 1ZEO). The results of the docking show that compound 8 has a lower binding free energy than rosiglitazone (positive control) with a free energy value (S score) = -13.513 kcal/mol and -8.3089 kcal/mol, respectively. Compound 8 can form two hydrogen bonds with residues His323 and Ser289, π-π interactions with Phe363 and π-H interactions with Cys285.  The interactions are similar to the interaction between the native ligand agonists α-aryloxyphenyl acetic acid and rosiglitazone with the target protein. Furthermore, compound 8 is predicted to have a moderate ADME profile. The results support that compound 8 can be developed as a PPAR-γ agonist candidate for the antidiabetic therapeutic agent.
Sintesis dan Kajian Docking Molekular Senyawa 2’-Hidroksicalkon dan Flavonol Tersubstitusi Dimetoksi sebagai Inhibitor Kompleks NS2B-NS3 Serine Protease pada Virus Dengue-2 (DENV-2) Ikhtiarudin, Ihsan; Frimayanti, Neni; Hendra, Rudi; Teruna, Hilwan Yuda; Rahim, Fatma; Mora, Enda; Septama, Abdi Wira
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.347

Abstract

Exploration of the potential compounds as dengue antivirals is one of the efforts that must be considered, because no specific therapy has been found with antiviral drugs that is effective in treating dengue hemorrhagic fever (DHF) patients. The aim of this study is to synthesize and explore the potential of the (E)-3-(2,5-dimethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (compound 1) and 2-(2,5-dimethoxyphenyl)-3-hydroxy-4H-chromen-4-one (compound 2) as inhibitors of NS2B-NS3 serine protease complex of DENV-2. Synthesis of compounds 1 and 2 was carried out by stirring using a magnetic stirrer. The structures of the two synthesized compounds have been confirmed through UV-Vis, FT-IR and 1H NMR spectroscopic analyses. Molecular docking was performed using NS2B-NS3 complex (PDB ID: 2FOM) as a receptor. Compounds 1 and 2 were obtained in 21.11% and 66.84% yield, respectively. Based on the molecular docking studies, compounds 2 exhibited more negative binding free energy than compound 1 and panduratin A as a reference inhibitor. Compound 2 was observed to bind to the catalytic triad of NS2B-NS3 complex (His51, Asp75, Ser135) and form hydrogen bond with Gly153. Based on the results, it can be concluded that compounds 1 and 2 can be synthesized by stirring method and the compound 2 showed good potency to be developed as inhibitors of the NS2B-NS3 serine protease complex of DENV-2.
Potensi Pengembangan Antioksidan/Antidiabetes Turunan Piridazinon sebagai Agen yang Menjanjikan untuk Terapi Penyakit Diabetes: Review Fatisa, Yuni; Frimayanti, Neni; Teruna, Hilwan Yuda; Jasril , Jasril
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.390

Abstract

Hiperglikemia dapat menginduksi stress oksidatif yang dapat berkembang kearah patogenesis komplikasi diabetes. Strategi pengobatan biasanya menggunakan obat antidiabetes dan antioksidan untuk membantu mengelola diabetes pada pasien. Penemuan obat dengan sifat dual aktivitas akan bekerja pada dua target sekaligus dan dapat meminimalkan efek samping. Review ini bertujuan untuk menganalisis potensi pengembangan agen baru antidiabetes dan antioksidan dari senyawa turunan piridazinon. Metodologi studi literatur review menggunakan teknik Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Pencarian database elektronik dilakukan melalui Google Scholar, PubMed, dan Science Direct untuk mendapatkan literatur-literatur yang relevan sampai tahun 2024. Kriteria inklusi adalah turunan piridazinon sebagai antidiabetes dan antioksidan menggunakan uji in silico, in vitro, dan in vivo. Sebanyak 24 jurnal original research telah dianalisis untuk pembahasan review ini. Hasil review menemukan bahwa senyawa turunan piridazinon berpotensi sebagai inhibitor α-Glukosidase, antihiperglikemik, dan inhibitor aldosa reduktase dengan tingkat aktivitas sedang-kuat. Beberapa studi juga menemukan bahwa turunan piridazinon bersifat antioksidan. Hasil ini didukung oleh hasil prediksi melalui studi pendekatan molecular docking. Terdapat hubungan yang erat antara gugus-gugus aktif terikat cincin piridazinon dengan kekuatan efek farmakologisnya. Namun, hanya ada dua studi yang melaporkan turunan piridazinon yang memiliki sifat antidiabetes dan antioksidan sekaligus. Review ini membuka peluang untuk potensi pengembangan turunan piridazinon dengan dual bioaktivitas. Selain itu, penelitian lebih luas dan dalam dengan modifikasi struktur turunan piridazinon sebagai kandidat agen terapi bagi pasien diabetes perlu dilanjutkan.
Histopathological Overview of Kidney and Liver Female White Rat Administered (Ananas comosus var. microstachys L.) Extract as Herbal Plant for Dysmenorrhea Fitmawati, Fitmawati; Saputra, Agus; Teruna, Hilwan Yuda; Juliantari, Erwina
Al-Kauniyah: Jurnal Biologi Vol. 17 No. 2 (2024): AL-KAUNIYAH JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v17i2.31421

Abstract

Abstract Dysmenorrhea is an important clinical as well as social problem affecting more than 50% of menstruating women. Nanas bongsai (Ananas comosus var. microstachys L.) is commonly used as a medical plant, which local people believe of Riau Province Indonesia, as medicine to reduce pain while the menstruation period (dysmenorrhea). This study was aim to find histopathologic changes in the kidney and liver after being treated with nanas bongsai extract in the female white rat.  Design experimental of this research is complete randomized design with 5 treatments. Each treatment was composed of two control (zero control given with water, positive control given with mefenamic acid) and nanas bongsai extract with 3 different dosage serials. Histology preparations were made by paraffin method and Hematoxylin-Eosin staining. The results showed that given nanas bongsai extract with three serial dosages towards the kidney show a picnosis in the nucleus. However, this damage did not affect the glomerulus structure. While observation towards the liver shows some injury, namely hydropic degeneration, lipid degeneration, and necrosis. Both of these damaged less than 25%. As a result, this percentage did not affect the structure of the kidney and liver. The results of this study indicate that there is no damage to the kidneys and liver due to the use of nanas bongsai so it is safe to use in herbal medicine and can be developed as a dysmenorrhea drug.AbstrakDismenore merupakan masalah klinis dan sosial yang penting yang memengaruhi lebih dari 50% wanita menstruasi. Nanas bongsai (Ananas comosus var. microstachys L.) dipercayai oleh masyarakat Desa Muara lembu, Kabupaten Kuantan Singingi, Provinsi Riau sebagai obat untuk mengurangi nyeri saat haid (dismenore). Penelitian ini bertujuan untuk mengetahui perubahan histopatologi pada ginjal dan hati setelah diberi perlakuan ekstrak nanas bongsai pada tikus putih betina. Rancangan percobaan yang digunakan adalah rancangan acak lengkap dengan 5 perlakuan. Masing-masing perlakuan terdiri dari dua kontrol dan ekstrak nanas bongsai dengan 3 seri dosis yang berbeda. Preparat histologi dibuat dengan metode parafin dan pewarnaan Hematoxylin-Eosin. Hasil penelitian menunjukkan bahwa pemberian ekstrak nanas bongsai dengan dosis tiga seri terhadap ginjal menunjukkan picnosis pada nukleus. Namun, kerusakan ini tidak memengaruhi struktur glomerulus. Sedangkan pengamatan terhadap hati menunjukkan beberapa cedera, yaitu degenerasi hidropik, degenerasi lipid, dan nekrosis. Keduanya rusak kurang dari 25%. Akibatnya, persentase ini tidak memengaruhi struktur ginjal dan hati. Hasil penelitian ini menunjukkan bahwa tidak ada kerusakan pada ginjal dan hati akibat penggunaan Nanas bongsai sehingga aman digunakan dalam pengobatan herbal dan dapat dikembangkan sebagai obat dismenore.
Co-Authors ', Yuharmen - Aisyah - Miranti - Nurlaili -, Lelani Abdi Wira Septama Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Agus Saputra Aini, Rhida - Aisyah Aisyah Aisyah, - Ardhi, Aulia Arjinal Arjinal Ary Puspita Christine Christine Jose Christine Jose Christine Jose Dahliarti ' Darian Alfatos Dede Indra Syari Destawira Hariani Desviana, Laila Desy Hariyanti Dimas Pramita Nugraha Diski Rahman Hakim Elfi Khairina, Elfi Elka Yuslinda Elsaria Karsana Elviyenti, Elviyenti Enda Mora ERWINA JULIANTARI, ERWINA Fajri Khatami Fifira Safitri Filza Yulina Ade Fitmawati Fitmawati Fitmawati Fitmawati Ganis Fia Kartika Hamidi, Yulis Harni Sepriani Hasmalina Nasution Hendra, Rudi Herix Sonata MS Ibnu Rush Ihsan Ikhtiarudin Ikhtiaruddin, Ihsan Islami, Deri Jasril ' Jasril , Jasril Jasril - Jasril Jasril Jismi Mubarrak Juwita Oktavani Kamal Rullah Kamal Rullah Karsana, Elsaria Laila Desviana Lelani - M Almurdani Marlinda, Sri Miranti Miranti Miranti, - Muhamad Afham Muhamad Rokhim Muttaqin, Fauzan Zein Nelma Yeni Neni Frimayanti Neri Sofiyanti Nova Rianti Putri NOVA WAHYU PRATIWI, NOVA WAHYU Nugraha, Dimas Pramita Nurlaili Nurlaili Nurlaili, - Pusaka, Semerdanta Putri Bela Utama Putri, Nova Rianti Putri, Rianti Rachel Fachira Rahayu, Wiwit Nur Rahim, Fatma Rahmiwati Hilma Retno Puji Lestari Rhida - Aini Rianti Putri Riki Setiawan Riki Setiawan Rissan Ramaesy Tobing Rohim, Muhammad Rohimatul Khodijah Rokim, Muhamad Rudi Hendra Rudi Hendra Rudi Hendra Rudi Hendra Sy Saputra, Agus Saputra, Agus Saryono Saryono Saryono Saryono Sepriani, Harni Shafira Melsonia Shinta, Dewi Yudiana shinta, dewi yudiana Siti Aisyah Siti Aisyah Sonata MS, Herix Syari, Dede Indra Syilfia Hasti Titania Tjandrawati Nugroho Tri Windarti Tri Windarti Veithzal Rivai Zainal Wahyuningsih Wahyuningsih Wina Noviana Widaningsih Yasthophi, Arif Yohanes Yohanes Yohanes Yohanes Yondra Arif D Yuana Nurulita Yuharmen ' Yuharmen - Yuli Haryani Yulis Hamidi Yum Eryanti Yum Eryanti Yuni Fatisa Yusmarini Yusmarini