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PERBEDAAN PENGARUH PAPARAN MUSIK MOZART, BEETHOVEN, DAN CHOPIN SELAMA KEBUNTINGAN TERHADAP INDEKS APOPTOSIS SEL NEURON DI CEREBELLUM Rattus norvegicus BARU LAHIR Dessy Hidayati Fajrin; Hermanto Tri Joewono; widjiati Widjiati
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 10 No 2 (2018): SEPTEMBER
Publisher : NHM PRESS

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Abstract

The efforts that can be done to improvebrain cells in the prenatal period is the provision ofnutrients and good stimulation. Exposure to classicalmusic such as Mozart, Beethoven, and Chopinmusic can increase the wave of brain activity. Duringpregnancy, Mozart music is proven to decrease theapoptosis of neuronal.Analyzing the difference of apoptosisneuronal of cerebrum and cerebellum of newbornbaby of Rattus norvegicus that are exposed to theMozart, Beethoven, and Chopin music, and that isnot exposed to music during pregnancy.Laboratory experimental research, posttestonly control group design. Subjects were femalepregnant Rattus norvegicus, grouped into 4 randomgroups: 1 control group and 3 treatments groups;with 6 samples each. Subjects were super ovulated,and 65 dB intensity of music is played for an hour at20.00-21.00 on the subjects on 10th day ofpregnancy. On 20th day of pregnancy, the motherswas dissected using SC technique. 2 heaviestnewborn babies of Rattus norvegicus were taken.Statistical test concluded there wassignificant differences of apoptosis neuronal ofcerebellum of newborn babies of Rattus norvegicusamong the exposure to Mozart, Beethoven, andChopin music, and without the exposure to musicwith value of p=0,033 in cerebellum.In conclution, the exposure of Mozart’smusic during pregnancy perform expression ofBDNF cerebellum in the offspring-rat was higherthan exposed Beethoven’s music, Chopin and notexposed to music.
PERBEDAAN PENGARUH PAPARAN MUSIK MOZART, BEETHOVEN DAN CHOPIN SELAMA KEBUNTINGAN TERHADAP JUMLAH SEL NEURON DI CEREBELLUM Rattus norvegicus BARU LAHIR Herlina Alvianti N; Hermanto Tri Joewono; widjiati Widjiati
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 10 No 2 (2018): SEPTEMBER
Publisher : NHM PRESS

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Abstract

Efforts could be made to improve humanresources that have intelligence required apositive relationship between health and goodeducation quality, one of the efforts to improvehuman resources requires good brain qualitysince the phase of conception. Classical musichas been shown to boost brain function andhuman intellectual optimally believed to have thebest stimulating effect on babies. Cellularexposure to Mozart affects the number of moreneuronal cells. Analyze the number of cerebrumand cerebellum neuronal cells of newborn Rattusnorvegicus between the exposed to Mozart music,Beethoven, Chopin and not exposed to musicduring pregnancy. This research was anexperimental research with posttest only controlgroup design. The sample was divided into fourgroups randomly, non-exposed, Mozart musicexposure group, Beethoven music exposuregroup, Chopin music exposure group, exposed for1 hour during the night after Rattus norvegicuswas pregnant on day-10 with an intensity of 65 dBand a distance of 37 cm from the rat cage. On the20th day of the pregnant mother of Rattusnorvegicus was sacrificed and selected two ofRattus norvegicus's babies with the greatestweight and then the brains of Rattus norvegicus'sbabies were decapitated and brain dissection tocount the number of neuronal cells withHemotoxyln-Eosin staining. The statistical resultsshowed that the number of neurons of cerebellumcells in the Mozart group differed significantly fromBeethoven, Chopin and not exposed to music withp <0.05. The number of neuronal cells ofcerebellum of the newborn Rattus norvegicus whoexposed to Mozart music during pregnancyproved higher than that exposed to Beethovenmusic, Chopin and not exposed to music.
PERBEDAAN PENGARUH PAPARAN MUSIK MOZART, BEETHOVEN DAN CHOPIN SELAMA KEBUNTINGAN TERHADAP EKSPRESI BRAIN DERIVED NEUROTROPHIC FACTOR DI CREBELLUM RATTUS NORVEGICUS BARU LAHIR Pitria Permatasari; Hermanto Tri Joewono; widjiati Widjiati
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 10 No 2 (2018): SEPTEMBER
Publisher : NHM PRESS

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Abstract

r 2015 was ranked 113 out of 188 countries.Education would be needed to raise HDI’s rank. Oneprinciple component of education is the quality of thebrain. BDNF expression in the brain was affected bymany stimuli. Mozart classical music had aneurobiological effect which had ability to increaseBDNF. Whereas, other classical musics such asBeethoven and Chopin had never been studied. Thisstudy aims to cerebellum’s BDNF expression in theoffspring of Rattus norvegicus that ere exposed tothe Mozart , Beethoven, Chopin during pregnancy.The method used is pure laboratoryexperiment with posttest only control group design.The variables measured were BDNF expression inthe brain. The samples were divided into 4 groups ofeach 6 rats.The results showed that significantdifferences in BDNF expressions between controlgroup and Mozart (p=0,023; p<0,05), betweenMozart group and Chopin (p=0,003). There were nostatistically detected differences between controlgroup and Beethoven (p=0,256), control group andChopin (p=0,684), Mozart group and Beethoven(p=0,092) and Beethoven group and Chopin(p=0,292). Based on the above results it can beconcluded that the exposure of Mozart’s musicduring pregnancy had a higher expression of BDNFin the offspring-rat’s cerebellum compare to thosewhich exposed by Beethoven and Chopin’s music.
WHY WE HAVE TO REFORM MIDWIFERY EDUCATION? Esti Nugraheny; Yanti Yanti; Hermanto Tri Joewono
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 11, No 3 (2022): September
Publisher : Asosiasi Institusi Pendidikan Kedokteran Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpki.72654

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Background: Learner, methods and contents are three important parts of the learning variables beside  lecturer, academic environment and patients. Facts and new findings show that we need to reform these learning variables accordingly especially in Obstetrics and Midwifery domainGaps:maternal deaths is still high despite higher number of obstetricians, doctors and midwives; as well asthe government has encouraged an increase in the number of institutions providing midwifery study programs. On the other hand, new paradigm in education has been ordered by the Ministry of Education such as student-centred learning, Outcome-based education, and also other approaches suggested by expert in medical education such as holistic education, bedside teaching, feedback & reflection, and problem based learning. Thus modify educational content and method in obstetrics and midwivery inline with new facts and findings and appropriate methods is necessary.Recommendation: One alternative to modify educational content and methods in midwifery education that can be implemented in clinical learning is the continuity of care approach accompanied by continuous feedback. This approach is proven to be able to reduce maternal mortality and as an effort to synergize education in an effort to achieve government program targets. However, in reality, midwifery education institutions have not fully adopted this approach. So there is a need for leadership commitment to carry out learning reforms with a sustainable curriculum approach, continuous feedback, continuous assessment, continuous midwifery care and continuous supervision so that learning outcomes as outputs and reducing maternal mortality as an outcome can be as expected.
Puasa Selama Kebuntingan terhadap jumlah sel neuron Cereberum dan Cerebellum Rattus norvegicus Baru Lahir Ucik Nurul Hidayati; Hermanto Tri Joewono; Muhammad Miftahussurur; Agus Sulistyono; Martono Tri Utomo; Sulistiawati Sulistiawati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (270.623 KB) | DOI: 10.30742/jikw.v9i1.634

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Fasting by pregnant women causes increasing neurons in the brain. An increasing number of neuron cells will speed up information processing, so it is expected to increasing intelligence. The purpose of this study was to analyze the effect of fasting during pregnancy on the number of new cells of the cerebrum neuron and the newly born Rattus norvegicus cerebellum. The research design was true experimental laboratory posttest only with control group design. Pregnant Rattus norvegicus samples consisted of 3 groups and 1 control group with a total sample of 32 divided by 4; Xo control group without fast treatment, fasting X1 group in 1st trimester (2 days), fasting X2 group in 2nd trimester (2 days), fasting group X3 at TM 3 (2 days). Data analysis using Shapiro – Wilk normality test, followed by ANOVA test and using SPSS for Windows 23 software. The results of statistical analysis showed no significant difference in the number of cerebrum neuron cells in the four groups P = 0.210 (p> 0.05) and there were significant differences in the number of cerebrum neuron cells in the four groups P = 0.032 (p <0.05). The conclusion of this study is there was no difference in the number of neuron cells in cerebrum and cerebellum of Rattus norvegicus newborn in the fasting mother 2 days during trimester I, II dan III of pregnancy. There was a difference in the number of neuron cells in the new cerebellum of Rattus norvegicus fasting for 2 days during trimester III of pregnancy, and there were differences the effect of the number of neuron cell in cerebellum of Rattus norvegicus in all groups.
DIFFERENCES OF MATERNAL SOCIODEMOGRAPHIC CHARACTERISTICS WITH SPONTANEOUS PRETERM BIRTH AMONG HOSPITALS IN INDONESIA: A COMPARATIVE STUDY Herman, Sriyana; Santoso, Budi; Djoewono, Hermanto Tri
Public Health of Indonesia Vol. 4 No. 4 (2018): October - December
Publisher : YCAB Publisher & IAKMI SULTRA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.62 KB) | DOI: 10.36685/phi.v4i4.215

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Background: Maternal sociodemographic characteristics can be used to prevent preterm birth.Objective: To identify differences in maternal sociodemographic characteristics with spontaneous preterm birth among hospitals in East Java, Indonesia.Methods: This was a descriptive study with comparative design in 134 mothers who experienced preterm birth at eight hospitals. Data were analyzed using Independent samples t-test.Result: Sixteen variables were significantly different in maternal sociodemographic characteristics with spontaneous preterm birth among eight hospitals, namely: gestational age (CI 95%:10.97-0.02, p <0.049), maternal age (CI 95%:0.46-11.03, p <0.035), smoking (CI 95%:9.98-19.01 p <0.001), Edinburgh Postnatal Distress Scale (EPDS) (CI 95%:6.90-17.09, p <0.001), the fetus mobile (CI 95%:2.41-11.58, p <0.006), the number of visits during pregnancy (CI 95%:5.63-14.36, p <0.001), history of premature (CI 95%:7.76-15.73, p <0.001), history of disease (CI 95%:9.02-18.97, p <0.001), history of abortion (CI 95%:9.34-18.65, p <0.000), height (CI 95%:9.66-18.83, p <0.001), BMI (CI 95%:0.75-11.74, p <0.029), Mid Upper Arm Circumference (MUAC) (CI 95%:2.53-12.96, p <0.007), periodontal infection by (CI 95%:6.04-15.45, p <0.001), bleeding in young and old pregnancy (CI 95%:7.71-17.28, p <0.001), anemia status (CI 95%:2.30-10.19, p <0.004) and BV status (CI95%:9.05-20.45, p <0.001).Conclusion: There were significant disparities in maternal sociodemographic characteristics with preterm birth among hospitals. Our findings can be used as the basic data for future research in an effort to prevent premature birth disorders based on maternal sociodemographic characteristic.
WIDOWER'S AGE AND NUMBER OF CHILDREN AFFECT PARENTING STYLE AND REMARRIAGE DECISION Frisilia Octaviana Yolanda; Hermanto Tri Joewono; Dwi Aprilawati
Majalah Biomorfologi Vol. 32 No. 1 (2022): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v32i1.2022.29-34

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Highlight:1. The widow will outsource childcare to other people, such as the widow's mother, stepmother, aunt, or other relatives who believe they know more about childcare after the wife's death.3. There was a significant relationship between widower's age and the number of children affecting parenting style and remarriage decision.Abstract:Background: The high maternal mortality ratio automatically represents the highest number of widowers in Indonesia. The change of status from a husband to a widower does not rule out the possibility of being able to change his role and function in the family. Objective: To describe that the widower's age and the number of children have an impact on the parenting style and the desire to remarry. Materials and Methods: This study was an observational study with a cross-sectional design. Husbands who had been left by their wives for two years or more owing to maternal death and had one or more children before the wife's maternal death were the subjects of this study. Widower's age, as well as kid's parenting patterns before the death of the mother were recorded. This study was likewise subjected to an ethics review and relied on informed consent. Results: Widowers who had one child before their wife's death and decided to remarry accounted for 7 subjects (87.5%), while those who did not remarry accounted for 5 (31.3%). On the association between a widower's age and child-rearing practices, there were two respondents (40%) who chose to entrust their children's care to someone else or not to be cared by themselves. Conclusion: There was a significant relationship between widower's age and the number of children and the parenting style and remarriage decision. Single parents who decided to remarry were single parents at a relatively younger age.
PROPORTION OF HBsAg AND HBeAg POSITIVE IN MATERNAL PATIENTS AND THEIR HBsAg POSITIVES BABIES WITH IMMUNOPROPHYLAXIS OF HBV IMMUNIZATION IN Dr. SOETOMO GENERAL HOSPITAL, SURABAYA Tanadi, Melina Rosita; Lusida, Maria Inge; Joewono, Hermanto Tri
Indonesian Journal of Tropical and Infectious Disease Vol. 6 No. 4 (2017)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (318.881 KB) | DOI: 10.20473/ijtid.v6i4.1372

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Hepatitis B Virus (HBV) can be transmitted vertically from mother to her baby. Mothers with HBsAg and HBeAg positives have more risk of transmitting HBV to her baby rather than HBsAg positives only. The aim of this study is to determine the proportion of maternal patient with HBsAg and HBeAg positives and their HBsAg positives babies with immunoprophylaxis of HBV immunization. This study was performed by analytical observation using medical records in 2013-2014 at Obstetric and Gyn ecology Department, Dr. Soetomo Hospital. The samples were all maternal patients (3796) during that period and also their babies from HBsAg positives mothers. Unfortunately, several original medical records were not available. Thirty two (0,85%) out of 3781 maternal patients were found to be HBsAg positives, and three (9,37%) of 32 patients with HBsAg positives were HBeAg positives. From 32 mothers who were positive HBsAg, 22 complete medical records of their babies were found and all of them (100%) had been given Hepatitis B Immunoglobulin (HBIG) and hepatitis B vaccine less than twelve hours after birth. In three cases of the babies from HBeAg positives mothers which had been given prophylaxis properly, two cases each of which was with caesarean and spontaneous delivery were HBsAg negatives. Interestingly, the other one which born with spontaneous delivery was found to be HBsAg positives. Further study in this HBsAg positives baby, especially in analyzing its HBV DNA is needed. The epidemiology of hepatitis B in maternal patients, especially that with complete and neat data needs further research.
Number of Glia Cells in the Cerebrum and Cerebellum of Newborn Rats After Administration of Mackerel Fish Oil During Pregnancy Nur Cholila; Widjiati Widjiati; Hermanto Tri Joewono
Jurnal Kebidanan Vol 13, No 1 (2024): February 2024
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jk.13.1.2024.35-40

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Omega 3 intake during pregnancy can support fetal brain growth and development. Omega 3 plays an important role in making neuron cell membranes and glia and protecting nerve cells. Mackerel is a source of omega 3 which is abundant and easily accessible to the people of Indonesia. The purpose of this study was to analyze the effect of mackerel oil intake on the number of glial cells (astrocytes, oligodendrocytes, and microglia) of the cerebrum and cerebellum of newborn rats. This research was a true experimental design with a post-test only control group. A total of 30 pregnant rats were randomized into 3 groups, namely the control group (K1), mackerel oil (K2), and omega 3 supplements (K3). Each group was given treatment on days 1-17 of pregnancy. On the 18th day, the termination was carried out. 3 newborn rats were taken from each parent and made preparations from brain tissue. Hematoxylin-Eosin test to assess the number of glial cells. The results showed the highest mean±SD number of glial cells (astrocytes, oligodendrocytes, and microglia) in the cerebrum and cerebellum was the highest in the mackerel oil group (174,460±33,777; 21,080±6,937; 11,300±2,090), and (156,280 ±34,980; 22,260±4,302; 11,060±2,383). ANOVA test showed a significant difference in the number of glial cells in the cerebrum and cerebellum between groups with a p-value <0.05. The results of this study can be concluded that the administration of mackerel oil during pregnancy can increase the number of glial cells (astrocytes, oligodendrocytes, and microglia) in the cerebrum and cerebellum of newborn rats.
The Ratio of Bax And Bcl-2 in the Cerebrum of Newborn Rattus Novergius Given Mackerel Oil During Pregnancy Mikra Latisfian; Widjiati Widjiati; Hermanto Tri Joewono; Siti Nur Kholifah; Ali Medina
Jurnal Kebidanan Vol 12, No 2 (2023): August 2023
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jk.12.2.2023.177-186

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The quality of a nation is determined by nutritional intake during pregnancy. Pregnancy is the right time to prepare the brain's potential optimally, one of which is the intake of mackerel oil which is rich in omega-3. Omega-3 fatty acids can stimulate gene expression and nerve activity, increase synaptogenesis and neurogenesis, and prevent apoptosis. This study aims to analyze the intake of mackerel oil during pregnancy to the ratio of Bcl-2 / Bax in the cerebrum. This research is a true experiment with a posttest-only control group design. 30 pregnant Rattus norvegicus mothers aged 2-3 months were divided into 3 groups, namely the control group (K), the mackerel fish oil group (P1), and the omega-3 supplement group (P2). This research was conducted at the Experimental Animal Cages and Pathology Laboratory, Faculty of Veterinary Medicine, Airlangga University. The mean Bcl-2 / Bax cerebrum ratio was 1.127 ± 0.342 (K), 3.928 ± 1.984 (P1), and 2.526 ± 1.122 (P2). The ANOVA test on the Bcl-2 / Bax ratio in the cerebrum showed a significant difference with a p-value of 0.000. The Bcl-2 / Bax ratio in the cerebrum of Rattus norvegicus newborns treated with mackerel oil on Rattus norvegicus mothers during pregnancy showed higher results than the other groups.
Co-Authors , Ernawati Abdullah, Aya Ali Achmad Zam Zam Aghasy Agnes Krisylva Agus Sulistyono Agustina Hidayati Agustina Mar&#039;atus Sholichah Ahmed, Samar A. A. Al-Qadhi, Tasnim Mohammed Aldika Akbar, Muhammad Ilham Ali Madinah Ali Medina Ali Medina Ali, Lamia A. S. Almothana, Hebah H. M. Alselwi, Sarah A. D. Alsoufi, Fardous G. Amila, Ukhti Mukminah ilmi Amishinta, Ancha Ayu Amishinta, Ancha Ayu Anas, Jimmy Yanuar Ancha Ayu Amishinta Andita Hapsari Andriani, Linda Aprilawati, Dwi Askandar Tjokroprawiro Ayu Putri Yani Bachnas, Muhammad Adrianes Binta Dwi Novitasari Chandra, Cecilia Felicia Dedi Kuswandi Dessy Hidayati Fajrin Diana Estu Rumahastuti Dwi Budi Santoso Dwi Nurdi Puspita Sari Dwi Puji Wijayanti Ecccita Raheestyningtyas Eka Fitriani Sujitno Eka Nasrur Maulana Eko Budi Koendhori, Eko Budi Ernawati Ernawati Esti Nugraheny Fajrin, Dessy Hidayati Fitria Desky Frisilia Octaviana Yolanda Gatut Hardianto, Gatut Hafiza Amadhin Rusti Hajj, Suha Ali Al Harry Mangasi Binsar Panjaitan Hasan, Helmia Henky Mohammad Masteryanto HERAWATI, LILIK Herlina Alvianti N Herlina Puji Angesti Herman, Sriyana Heryana, Achmad Yuniari Jihanifa Hega Salsabiila Jimmy Yanuar Anas Khanisyah Erza Gumilar Khasanah, Rima Nur Laksana, Muhammad Ardian Cahya Margarita Maramis, Margarita Maria Inge Lusida Martono Tri Utomo Mikra Latisfian Mikra Latisfian Mikra Latisfian Mohammed, Haitham T. S. Muhammad Adrianes Bachnas Muhammad Miftahussurur Muhdi, Nalini Nabeel Usama Okbah Nareswari Imanadha Cininta Marcianora Naura Ega Kahayani Ningrum, Nyna Puspa Nur Cholila Nur Laila Faizah Nurvy Alief Aidillah Nyna Puspa Ningrum Okta Margarita Susiana Pamarga Priyambodo Pitria Permatasari Pudji Lestari PUNGKY MULAWARDHANA, PUNGKY Raheestyningtyas, Ecccita Rejeki, Purwo Sri Risa Etika, Risa Sabrina Kemala Hapsari Sakina Samsriyaningsih Handayani Siti Nur Kholifah Siti Nur Kholifah Siti Nur Kholifah Sofiyanti Miftakhurohmah Sonea Venugopal Sulistiawati Sulistiawati Sulistiawati Sulistiawati Tanadi, Melina Rosita Thabet, Habib Thabit, Riyadh A. S. Ucik Nurul Hidayati Ukhti Mukminah ilmi Amila Ummah, Fithriyah Cholifatul Wardhana, Manggala Pasca Wati, Yunita Kholilaili Saras Widati Fatmaningrum Widjiati Widjiati w Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati, Widjiati Widjiati, DR Widjiati, DR Windhu Purnomo Wironegoro, Rio Yaner, Nurul Ramadhani Yanti Yanti Yasyviena Za’ima Elnabila Yulia Putri Permatasari Zumroh Hasanah