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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Kebidanan Althea Medical Journal Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Majalah Obstetri dan Ginekologi Public Health of Indonesia Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Penelitian Kesehatan Suara Forikes Health Notions Jurnal Keperawatan Muhammadiyah Amerta Nutrition Care : Jurnal Ilmiah Ilmu Kesehatan Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan NURSING UPDATE JURNAL ILMIAH ILMU KEPERAWATAN Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology Jurnal Abdi Masyarakat Indonesia Asian Journal of Health Research Strada Jurnal Ilmiah Kesehatan (SJIK) JURNAL KEPERAWATAN
Hermanto Tri Joewono
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Airlangga University
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Number of Glia Cells in the Cerebrum and Cerebellum of Newborn Rats After Administration of Mackerel Fish Oil During Pregnancy Nur Cholila; Widjiati Widjiati; Hermanto Tri Joewono
Jurnal Kebidanan Vol 13, No 1 (2024): February 2024
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jk.13.1.2024.35-40

Abstract

Omega 3 intake during pregnancy can support fetal brain growth and development. Omega 3 plays an important role in making neuron cell membranes and glia and protecting nerve cells. Mackerel is a source of omega 3 which is abundant and easily accessible to the people of Indonesia. The purpose of this study was to analyze the effect of mackerel oil intake on the number of glial cells (astrocytes, oligodendrocytes, and microglia) of the cerebrum and cerebellum of newborn rats. This research was a true experimental design with a post-test only control group. A total of 30 pregnant rats were randomized into 3 groups, namely the control group (K1), mackerel oil (K2), and omega 3 supplements (K3). Each group was given treatment on days 1-17 of pregnancy. On the 18th day, the termination was carried out. 3 newborn rats were taken from each parent and made preparations from brain tissue. Hematoxylin-Eosin test to assess the number of glial cells. The results showed the highest mean±SD number of glial cells (astrocytes, oligodendrocytes, and microglia) in the cerebrum and cerebellum was the highest in the mackerel oil group (174,460±33,777; 21,080±6,937; 11,300±2,090), and (156,280 ±34,980; 22,260±4,302; 11,060±2,383). ANOVA test showed a significant difference in the number of glial cells in the cerebrum and cerebellum between groups with a p-value <0.05. The results of this study can be concluded that the administration of mackerel oil during pregnancy can increase the number of glial cells (astrocytes, oligodendrocytes, and microglia) in the cerebrum and cerebellum of newborn rats.
The Ratio of Bax And Bcl-2 in the Cerebrum of Newborn Rattus Novergius Given Mackerel Oil During Pregnancy Mikra Latisfian; Widjiati Widjiati; Hermanto Tri Joewono; Siti Nur Kholifah; Ali Medina
Jurnal Kebidanan Vol 12, No 2 (2023): August 2023
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jk.12.2.2023.177-186

Abstract

The quality of a nation is determined by nutritional intake during pregnancy. Pregnancy is the right time to prepare the brain's potential optimally, one of which is the intake of mackerel oil which is rich in omega-3. Omega-3 fatty acids can stimulate gene expression and nerve activity, increase synaptogenesis and neurogenesis, and prevent apoptosis. This study aims to analyze the intake of mackerel oil during pregnancy to the ratio of Bcl-2 / Bax in the cerebrum. This research is a true experiment with a posttest-only control group design. 30 pregnant Rattus norvegicus mothers aged 2-3 months were divided into 3 groups, namely the control group (K), the mackerel fish oil group (P1), and the omega-3 supplement group (P2). This research was conducted at the Experimental Animal Cages and Pathology Laboratory, Faculty of Veterinary Medicine, Airlangga University. The mean Bcl-2 / Bax cerebrum ratio was 1.127 ± 0.342 (K), 3.928 ± 1.984 (P1), and 2.526 ± 1.122 (P2). The ANOVA test on the Bcl-2 / Bax ratio in the cerebrum showed a significant difference with a p-value of 0.000. The Bcl-2 / Bax ratio in the cerebrum of Rattus norvegicus newborns treated with mackerel oil on Rattus norvegicus mothers during pregnancy showed higher results than the other groups.
Effect of Mackerel Oil During Pregnancy on Synapsin Expression in Newborn Rattus Novergius Cerebrum Siti Nur Kholifah; Widjiati Widjiati; Hermanto Tri Joewono; Ali Medina; Mikra Latisfian
Jurnal Kebidanan Vol 12, No 2 (2023): August 2023
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jk.12.2.2023.169-176

Abstract

The increase in the number of cells indicates a good synapse function, so that it can be linked to human intelligence. The rapid rate of synaptogenesis, myelination occurs in the first 1000 days of life. The public has not realized the importance of nutrition during pregnancy which contributes to the intelligence of the baby that will be born later. One of them is mackerel oil which contains omega 3. This study aims to analyze the effect of mackerel oil during pregnancy on synapsin expression in the cerebrum. This type of research is true experimental with a posttest-only control group design. The research samples were 30 pregnant Rattus norvegicus mothers aged 2-3 months. The 3 groups were randomly divided namely the control group (K1), the mackerel fish oil treatment group (K2), and the treatment group who were given omega-3 supplements (K3). This research was conducted at the Experimental Animal Cages and Pathology Laboratory, Faculty of Veterinary Medicine, Airlangga University. ANOVA test results on synapsin expression in the cerebrum showed that there was a significant difference with a p-value of 0.000. Synapsin expression in the cerebrum of newborn Rattus norvegicus which was given mackerel oil in the mother of Rattus norvegicus during pregnancy showed higher results than other groups.
Effect of Administration of Mackerel Oil During Pregnancy on the Expression of Brain Derived Neurotrophic Factor (BDNF) in the Cerebrum of Newborn Mice Sofiyanti Miftakhurohmah; Widjiati Widjiati; Hermanto Tri Joewono
Jurnal Kebidanan Vol 13, No 1 (2024): February 2024
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jk.13.1.2024.67-72

Abstract

Omega 3 contained in mackerel oil extract is an important constituent of neuron cell walls and the raw material for building fetal brain cells. DHA and EPA in omega 3 regulate BDNF synthesis through a p38-MAPK dependent mechanism. BDNF has a role in regulating cell survival and programming cell death (apoptosis) in the brain. This study aims to determine the effect of giving mackerel oil during pregnancy on BDNF expression in the cerebrum of newborn rats. Posttest research design only control group with true experimental type. A sample of 30 rats with 10 each per group. The first group was the control group (K), the second group was mackerel oil (P1), and the third group was omega 3 supplements (P2). BDNF expression examination methods with immunohistochemistry. The data were analyzed analytically with ANOVA and continued with post hoc LSD. There was a significant difference in the expression of BDNF cerebral newborn rats between groups with a value of p = 0.000 (2.780 ± 0.52 in the control group, 3.670 ± 0.36 in the mackerel oil group, and 3.670 ± 0.45 in the omega 3 supplement group ) . The conclusion of this study was that the group given mackerel oil extract had a higher BDNF cerebral expression than the other groups.
The Womb: Beyond a Waiting Room – Nurturing the Future Generation Hermanto Tri Joewono
Asian Journal of Health Research Vol. 3 No. 3 (2024): Volume 3 No 3 (December) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i3.203

Abstract

In the intricate journey of human development, the womb emerges not merely as a waiting room, but as one of the best places to lay the foundation for the growth of the human brain and human. Pregnancy, far from being solely a period of preparing for childbirth, unfolds as a golden opportunity to shape the next generation in profound ways.
Pengaruh Pengetahuan, Pendidikan, Pendapatan, dan Usia Pernikahan terhadap Kejadian Anemia Defisiensi Besi pada Ibu Hamil di Kota Taiz-Yaman: The Effect of Knowledge, Education, Income, and Marriage Age on Iron Deficiency Anemia in Pregnant Women in Taiz City-Yemen Ali, Lamia A. S.; Joewono, Hermanto Tri; Fatmaningrum, Widati; Thabit, Riyadh A. S.; Almothana, Hebah H. M.; Alsoufi, Fardous G.; Abdullah, Aya Ali; Al-Qadhi, Tasnim Mohammed; Hajj, Suha Ali Al; Ahmed, Samar A. A.; Alselwi, Sarah A. D.; Thabet, Habib; Mohammed, Haitham T. S.; Andriani, Linda
Amerta Nutrition Vol. 8 No. 3SP (2024): AMERTA NUTRITION SUPPLEMENTARY EDITION Special 4th Amerta Nutrition Conferenc
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v8i3SP.2024.1-6

Abstract

Background: Iron Deficiency Anemia (IDA) is one of the most common types of nutritional anemia in pregnant women and is the most dangerous to the mother and fetus; This is because the need for iron for both the mother and the fetus increases gradually during pregnancy and reaches its highest levels at the end of pregnancy. Objectives: The study aimed to identify the effect of education, income, and age of marriage on the anemia of pregnant women in Taiz City-Yemen. Methods: The study was carried out utilizing a quantitative design (Descriptive study). From 3rd November 2023, until 30th January 2024. A simple random selection procedure is used to choose six of Taiz City's 10 primary healthcare facilities.101 pregnant women between the ages of 18 and 42 took part in the study. Results: The findings showed that the low knowledge levels (0-35%) had low Hb levels (9.3 mg/dL) when compared with higher knowledge levels (> 50%) with Hb levels (9.92 mg/dL). Furthermore, those Lower marriage age (<20 Years) had low Hb levels (9.46 gm/dL) when compared to marriage age (>25) with Hb levels (10.81 mg/dL). On the other hand, lower education levels were associated with low Hb levels (8.18 mg/dL) when compared to higher education levels. Conclusions: Findings demonstrated that lower knowledge levels, younger marriage age, lower education, and lower income were associated with lower hemoglobin levels. These factors were linked to a higher prevalence of anemia. Improved education and income levels can lead to better knowledge and management of anemia.
A Study on Predicting High Achievers among Medical Students in the 4th Semester Faculty of Medicine Universitas Airlangga Hermanto Tri Joewono; Herawati, Lilik; Ummah, Fithriyah Cholifatul; Handayani, Samsriyaningsih; Chandra, Cecilia Felicia; Hasan, Helmia; Rejeki, Purwo Sri; Sakina; Heryana, Achmad Yuniari; Kuswandi, Dedi
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.223

Abstract

Introduction Student-centered learning (SCL) is based on students' needs, capacities, and other characteristics, making the method more personalized. This study aimed to analyze new questionnaires to categorize 4th-semester medical faculty students based on their characteristics. Understanding these characteristics could make the teaching and learning process more effective, potentially reducing the number of students retaking exams. Material and Methods: Subjects were 4th semester students who agreed to enroll and self-fulfilled the questionnaire. High achievers are defined as high expectations and consistent high performance (GPAs). Validity and reliability of each item were analyzed by statistical calculations accordingly. GPA in the next semester was used as threshold to confirm the participant's categorization. Results: The study commenced in March 2022, with 107 participants with Grade Point Averages (GPAs) available. The study demonstrated that the questionnaires had high validity and reliability (p-value < 0.005; Pearson Correlation Coefficient and Cronbach alpha). Among the participants, 3 (2.8%) were classified as high achievers, while 3 (28%) were categorized as low achievers. Notably, 44.86% of participants reported their passions as unrelated to medicine, while 5.61% were uncertain of their passions. Regarding vocation, 8.2% cited parental influence, and 10.3% felt their educational progress was not within their control. Conclusion: The questionnaires had high validity and reliability in item analysis. There were 2,8% of participants predicted as High Achievers and Low Achievers. Refinements of items and score presentation are needed. Follow-up activities should be given to the low achievers to prevent becoming retakers.
The Effect of Mackerel Oil During Pregnancy on Apoptotic Index in the Cerebrum of Newborn Rattus Norvegicus Ali Madinah; Widjiati Widjiati; Hermanto Tri Joewono; Siti Nur Kholifah; Mikra Latisfian
STRADA : Jurnal Ilmiah Kesehatan Vol. 10 No. 1 (2021): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v10i1.540

Abstract

This study is a true experiment with a posttest-only control group design. 30 pregnant Rattus norvegicus aged 2-3 months were randomly divided into 3 groups, namely the control group (K), the mackerel oil treatment group (P1), and the omega-3 supplements group (P2). The experimental animals were acclimatized and superovulated. The treatment was given at day 1-17 of pregnancy. 3 newborn Rattus norvegicus with the criteria of the largest, medium, and lightest body weight were taken from each parent to be made preparations on the 18th day. Examination of preparations carried out by immunohistochemistry. The mean ± SD of the apoptosis index in the cerebrum were 4.93 ± 0.87 (K), 2.53 ± 0.45 (P1), and 3.72 ± 0.54 (P2). The results of statistical tests showed that there was a significant effect on the apoptotic index in the cerebrum of newborn Rattus norvegicus between groups with p-value <0.05.
Pengaruh frekuensi paparan stresor cahaya saat kebuntingan terhadap jumlah dendrit dan ekspreis mTorc1 otak mencit (Mus musculus) baru lahir Dwi Puji Wijayanti; Hermanto Tri Joewono; Widjiati Widjiati
Jurnal Keperawatan Vol 17 No 1 (2019): Jurnal Keperawatan Volume 17 No 1
Publisher : STIKES Insan Cendekia Medika Jombang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35874/jkp.v17i1.471

Abstract

Latar Belakang : Pada stres prenatal akan memicu peningkatan kadar CRH dan kortisol maternal. ini akan meningkatkan jumlah CRH dan kortisol pada janin dan menurunkan ekspresi 11β-HSD2 di plasenta. Meningkatnya kadar CRH akan meningkatkan aktifitas glukokortikoid yang akan menurunkan Growth Factors,juga akan mempengaruhi ekspresimTORC1 sebagai mekanisme pertahanan sel. GH, dan IGF-1 sedangkan menurunnya ekspresi 11β-HSD2 pada akhirnya akan menyebabkan perkembangan organ yang tak seimbang. Tujuan.Untuk mengetahui pengaruh frekuensi paparan stresor cahaya selama kebuntingan terhadap jumlah dendrit dan ekspresi mTORC1 anak mencit (Mus musculus). Metode : Penelitian ini merupakan penelitian eksperimen dengan post test only group design. Jumlah dendrit diukur dengan Golgy Cox hasil rerata jumlah dendrit dalam 5x lapangan pandang. Ekspresi mTORC1diukur dengan indeks skala Remelle . Analisis data menggunakan uji Post Hoc dengan tingkat kemaknaan 95% (0,05). Hasil : Hasil penelitian menunjukkan adanya perbedaan rerata jumlahdendrit yang signifikan antara kelompok kontrol (22.30) dan kelompok perlakuan 2 (7.55 ) lebih rendah. Hal yang serupa juga didapatkan padaekspresimTORC1. Terdapat perbedaan yang berarti padaekspresimTORC1. kelompok kontrol (1.14) dan kelompok perlakuan 2 (4.28) lebih tinggi. Selain itu, didapatkan juga hubungan (p < 0,05) antara jumlah sel dendrit danekspresimTORC1 otak anak mencit baru lahir dengan menggunakan korelasiPearson. Hasil uji korelasi Pearson didapatkan nilai signifikansi 0,068 dengan p < 0,05 dan nilai korelasi 0,338 dengan arah korelasi negative Kesimpulan : Jumlah dendrit pada kelompok perlakuan1 dan 2 lebih rendah dibandingkan kelompok kontrol, sedangkan ekspresi mTORC1 pada kelompok perlakuan1 dan 2 lebih tinggi dibandingkan kelompok kontrol.
PUASA PADA KEBUNTINGAN TRIMESTER 1, 2 DAN 3 RELATIF AMAN DILIHAT PADA INDEKS APOPTOSIS SEL NEURON OTAK RATTUS NORVEGICUS BARU LAHIR Wati, Yunita Kholilaili Saras; Joewono, Hermanto Tri; Miftahussurur, Muhammad
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 9, No 2 (2021): EDITION JULY 2021
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v9i2.1388

Abstract

Fasting in pregnancy that can increase neural network activity in the brain region and produce BDNF secretions that seek survival pathways will produce pro survival / anti apoptosis in cerebral neuron cells and the cerebellum. The aim of this study to analyze the effect of fasting during pregnancy on the index of apoptosis of cerebral neuron cells and the cerebellum of the newly born Rattus norvegicus. This research was using Experimental laboratory studies that were correct with the post test study design were only the control group design using experimental animals Rattus norvegicus at the Pathology Laboratory of the Faculty of Medicine, Airlangga University Surabaya which were collected into 3 research groups (1st, 2nd, and 3rd trimesters) and 1 control group . Each group consisted of 6 Rattus norvegicus mothers. The brain dissection of the newborn Rattus norvegicus child was taken and the apoptotic index was calculated using the Immunohistochemical Tunnel method. and discuss with the Immunoreactive Score (IRS). The results of the Kruskal wallis analysis were expressed as the Cerebrum apoptosis index in all four groups (p 0.05). Most apoptosis in the cerebrum was in the first trimester (3.9) and lowest in the second trimester (1.5). The results of the cerebellar apoptosis index analysis by the Kruskall wallis test proved that the most cerebellar apoptosis in the first trimester (4.87) and the lowest in the second trimester (1.33). Conclusion there is no difference between the 1,2 th trimester and 3 in the control of the cerebrum and cerebellum
Co-Authors Abdullah, Aya Ali Achmad Zam Zam Aghasy Agnes Krisylva Agus Sulistyono Agustina Hidayati Agustina Mar&#039;atus Sholichah Ahmed, Samar A. A. Al-Qadhi, Tasnim Mohammed Aldika Akbar, Muhammad Ilham Ali Madinah Ali Medina Ali Medina Ali, Lamia A. S. Almothana, Hebah H. M. Alselwi, Sarah A. D. Alsoufi, Fardous G. Amila, Ukhti Mukminah ilmi Amishinta, Ancha Ayu Amishinta, Ancha Ayu Ancha Ayu Amishinta Andita Hapsari Andriani, Linda Aprilawati, Dwi Askandar Tjokroprawiro Ayu Putri Yani Binta Dwi Novitasari Chandra, Cecilia Felicia Dedi Kuswandi Dessy Hidayati Fajrin Diana Estu Rumahastuti Dwi Budi Santoso Dwi Nurdi Puspita Sari Dwi Puji Wijayanti Ecccita Raheestyningtyas Eka Fitriani Sujitno Eka Nasrur Maulana Eko Budi Koendhori, Eko Budi Ernawati Ernawati Esti Nugraheny Fajrin, Dessy Hidayati Fitria Desky Frisilia Octaviana Yolanda Gatut Hardianto, Gatut Hafiza Amadhin Rusti Hajj, Suha Ali Al Harry Mangasi Binsar Panjaitan Hasan, Helmia Henky Mohammad Masteryanto HERAWATI, LILIK Herlina Alvianti N Herlina Puji Angesti Herman, Sriyana Heryana, Achmad Yuniari Jihanifa Hega Salsabiila Jimmy Yanuar Anas Khanisyah Erza Gumilar Khasanah, Rima Nur Laksana, Muhammad Ardian Cahya Margarita Maramis, Margarita Maria Inge Lusida Martono Tri Utomo Mikra Latisfian Mikra Latisfian Mikra Latisfian Mohammed, Haitham T. S. Muhammad Adrianes Bachnas Muhammad Miftahussurur Muhdi, Nalini Nabeel Usama Okbah Nareswari Imanadha Cininta Marcianora Naura Ega Kahayani Nur Cholila Nur Laila Faizah Nurvy Alief Aidillah Nyna Puspa Ningrum Okta Margarita Susiana Pamarga Priyambodo Pitria Permatasari Pudji Lestari PUNGKY MULAWARDHANA, PUNGKY Rejeki, Purwo Sri Risa Etika, Risa Sabrina Kemala Hapsari Sakina Samsriyaningsih Handayani Siti Nur Kholifah Siti Nur Kholifah Siti Nur Kholifah Sofiyanti Miftakhurohmah Sonea Venugopal Sulistiawati Sulistiawati Sulistiawati Sulistiawati Tanadi, Melina Rosita Thabet, Habib Thabit, Riyadh A. S. Ucik Nurul Hidayati Ukhti Mukminah ilmi Amila Ummah, Fithriyah Cholifatul Wardhana, Manggala Pasca Wati, Yunita Kholilaili Saras Widati Fatmaningrum Widjiati Widjiati w Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati, Widjiati Widjiati, DR Widjiati, DR Windhu Purnomo Wironegoro, Rio Yaner, Nurul Ramadhani Yanti Yanti Yasyviena Za’ima Elnabila Yulia Putri Permatasari Zumroh Hasanah