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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Jurnal Silvikultur Tropika (JST) Hemera Zoa Jurnal Veteriner Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biotechnology Majalah Obat Tradisional JSFK (Jurnal Sains Farmasi & Klinis) ARSHI Veterinary Letters FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmu dan Teknologi Kayu Tropis Britain International of Exact Sciences Journal (BIoEx Journal) Jurnal Kedokteran Hewan Jurnal Veteriner dan Biomedis Current Biomedicine Asian Journal of Social and Humanities
IETJE WIENTARSIH
Departement Of Veterinary Clinic Reproduction And Pathology Faculty Of Veterinary Medicine, Bogor Agricultural University, Jl. Raya Dramaga, Bogor, Jawa Barat 16680, Indonesia
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Penyembuhan luka sayatan kulit menggunakan topikal balsamum peruvianum pascaoperasi infark miokardium pada babi domestik (Sus scrofa domestica) Febryanto, Agung; Rahmiati, Dwi Utari; Wientarsih, Ietje; Murtiningrum, Fitria Senja; Iman, Bintang Nurul; Noviana, Deni; Gunanti, Gunanti
Current Biomedicine Vol. 1 No. 1 (2023): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.1.25-32

Abstract

Background: Swine are ideal animal models used for human health and disease research in humans because they have similar anatomy and physiology, one of which is regarding wound healing. Objective: This study aims to determine the effectiveness of balsamum peruvianum on wound healing after myocardial infarction surgery in domestic pigs (Sus scrofa domestica). Methods: The study used five pigs aged 4–5 months, three male and two female. The incision was made using electrocautery in the lateral part of the third and fourth thoracic intercostal spaces, lengthwise from dorsal to ventral. The wound was sutured using Monosyn® 4.0 thread with a subcuticular/intradermal suture pattern. The wound was then given 10% iodine and 10% balsamum peruvianum over the entire surface of the wound twice a day. Recovery was observed on 1st, 4th, 7th, 11th, and 14th days and was scored (grade: 1–4) on macroscopic examination in each pig until day 18th. Results: The observations showed a significant difference in recovery scores on the 11th and 18th days compared to the first day. Conclusion: Topical balsamum peruvianum can be used and is effective for wound healing of skin incisions after myocardial infarction surgery in swine.
Potensi daun kumis kucing dalam meningkatkan hematopoiesis pada kondisi kerusakan ginjal Satyaningtijas, Aryani; Pamungkas, Joko; Sa’diah, Siti; Wientarsih, Ietje; Purnawarman, Trioso; Rini Madyastuti Purwono; Nisa, Khoirun; Nugroho, Radhitya Aryo; Hadiyanti, Cresensia Rara; Tarigan, Ronald
Acta VETERINARIA Indonesiana Vol. 11 No. 3 (2023): November 2023
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.11.3.189-195

Abstract

Kerusakan ginjal berdampak pada proses eritropoiesis karena ginjal merupakan organ utama penghasil eritropoietin (EPO). Tanaman kumis kucing secara turun-temurun sudah digunakan untuk pengobatan gangguan saluran kemih, hipertensi, dan diabetes mellitus. Tanaman ini diketahui mengandung berbagai zat aktif yang bersifat nefroprotektif, seperti flavonoid, tannin, saponin, phenol, serta terpenoid. Penelitian ini bertujuan untuk melihat potensi tanaman kumis kucing untuk memperbaiki profil eritosit pada kondisi kerusakan ginjal yang diinduksi oleh etilen glikol. Sebanyak 35 ekor tikus galur Sprague Dawley jantan berumur 7 bulan dibagi ke dalam 7 kelompok perlakuan dengan pemberian etilen glikol dan atau ekstrak kumis kucing dengan lama permberian yang berbeda. Pemberian ekstrak daun kumis kucing mampu meningkatkan jumlah eritrosit pada tikus serta menekan penurunan jumlah eritrosit saat dan setelah pemberian etilen glikol. Selain itu, pemberian ekstrak kumis kucing juga mampu menurunkan jumlah leukosit serta rasio neutrofil: limfosit yang meningkat akibat induksi etilen glikol. Ekstrak kumis kucing memiliki potensi untuk memperbaiki proses eritropoiesis dan menekan peradangan pada kasus kerusakan ginjal.
Sifat bioavailabilitas implan intravaginal berbahan kitosan-PEG-PCL dalam simulasi cairan vagina dan vagina sapi Yessa, Elma Yuliani; Wientarsih, Ietje; Purwantara, Bambang; Amrozi, Amrozi; Ulum, Mokhamad Fakhrul
ARSHI Veterinary Letters Vol. 7 No. 3 (2023): ARSHI Veterinary Letters - August 2023
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.7.3.57-58

Abstract

Penelitian ini bertujuan untuk merancang dan mengevaluasi bioavailabilitas implan intravaginal yang terbuat dari poli-ymer kitosan-polietilen glikol (PEG)-polikaprolakton (PCL) yang dapat terbiodegradasi dalam cairan simulasi vagina (SVF) dan vagina sapi. Implan dibuat menggunakan teknik peleburan dan pencetakan dengan 26 formulasi berbeda. Selanjutnya implan direndam dalam 40 mL SVF pada suhu 37,8℃ dan diamati perubahan morfologi implan setiap hari hingga hari ke 5. Implan yang bertahan hingga hari kelima diuji ketersediaannya lebih lanjut pada vagina sapi dan diamati setiap hari selama 2 minggu. Uji perendaman pada hasil SVF menunjukkan bahwa implan dengan kandungan PEG 75-85% lebih cepat meleleh dibandingkan implan dengan kandungan PEG 20-72%. Implan yang mengandung 1-10% PCL terkikis lebih cepat di SVF dibandingkan implan yang mengandung 22-80% PCL. Implan yang mengandung kitosan dapat tetap stabil di SVF lebih lama dibandingkan implan tanpa kitosan. Uji bioavailabilitas pada vagina sapi menunjukkan bahwa implan 21-23 bertahan hingga hari ke 10, sedangkan implan 24-26 dikeluarkan dari vagina sapi selama pengujian. Implan 21-23 merupakan formulasi yang menjanjikan untuk pengembangan implan intravaginal yang dapat terbiodegradasi. Dengan menyesuaikan komposisi kitosan (antara 14-18 berat%), PEG (maksimum 72 berat%), dan PCL (minimal 20 berat%), implan intravaginal mampu meningkatkan ketersediaan hayati cairan vagina dan vagina yang disimulasikan. ternak
Effect of Bosswelic Acid On Hematological Parameters In Sprague Dawley Rats (Rattus novergicus) Induced By Cyclophosphamide Lingga Surya Maret Daulay; Ietje Wientarsih; Anita Esfandiari; Lina Noviyanti Sutardi; Nuzul Asmilia
Asian Journal of Social and Humanities Vol. 2 No. 5 (2024): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i5.239

Abstract

Chemotherapy drug “cyclophosphamide (SP)” can trigger oxidative stress that causes hematotoxicity and myelotoxicity, therefore an agent that can suppress the negative effects of cyclophosphamide is needed. Boswellic acid is an herbal medicine that has anti-oxidant and anti-inflammatory effects. The aim of this study was to determine the effect of boswellic acid (BA) in hematology parameter rats induced by cyclophosphamid. Animal were allocated in to six groups, each group consists of 5 rats, the KS: healthy group, KSP: cyclophosphamide group; KSD: comparison group, and BA groups (K1;K2;K3). The treatment groups were given cyclophosphamide (SP) at dose of 150 mg/kg body weight (BW) i.p. The BA groups (K1,K2,K3) were given BA at dose of 250 mg/kg BW orally for 6 consecutive days and SP on day 1 (K1), day 4 (K2), day 6 (K3). The results showed that BA administration (K2 and K3) can help increase/maintain the amount of hematological parameters including hemoglobin, hematocrit, and erythrocytes. Administrating BA for 6 days consecutively before SP (K3) has shown best results on hematological parameters than the others including the comparison group. These results suggest that BA may have a potential herbal therapeutic agents that can mitigate cyclophosphamide-induced hematotoxicity manifestations.
Potensi Tanaman Alpukat (Persea americana Mill) dalam Bidang Dermatologi Sebayang, Shalina; Rayendra, Raendi; Wientarsih, Ietje; Priosoeryanto, Bambang Pontjo
Jurnal Veteriner dan Biomedis Vol. 2 No. 2 (2024): September
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.2.2.79-85.

Abstract

Penggunaan obat tradisional yang berasal dari tanaman dapat menjadi alternatif untuk mengatasi masalah kulit. Tanaman alpukat (Persea americana Mill.) diketahui memiliki banyak khasiat karena mengandung flavonoid, saponin, tannin, alkaloid, steroid, dan fenol yang merupakan antioksidan yang berperan dalam menangkal radikal bebas, sehingga dapat digunakan sebagai alternatif terapi pada beberapa kelainan kulit, serta menjaga kualitas dan penampilan kulit. Metode yang digunakan oleh penulis adalah kajian literatur dari jurnal nasional maupun internasional. Artikel dan jurnal yang didapat dibaca, ditelaah dan dianalisis untuk memberikan informasi baru yang relevan. Hasil penelusuran didapatkan bahwa tanaman alpukat, baik dari daging buah, daun, biji dan kulit memiliki khasiat dalam bidang dermatologi, diantaranya yaitu sebagai antibakteri pada antijerawat, antijamur, tabir surya, agen pemutih, pelembab kulit, dan antiaging. Dapat disimpulkan bahwa tanaman alpukat dapat digunakan sebagai alternatif untuk mengatasi berbagai masalah kulit, walaupun masih harus dilakukan penelitian lebih lanjut untuk menggali lebih banyak manfaat lain dari tanaman alpukat dalam bidang dermatologi. Kata kunci: Alpukat, Persea americana Mill, dermatologi.
Penambatan Molekuler Senyawa Bioaktif Tanaman Metang terhadap Reseptor Estrogen Alfa sebagai Antikanker Agus Saputra; Ietje Wientarsih; Lina Novianti Sutardi; Mohamad Rafi; Silmi Mariya
Acta VETERINARIA Indonesiana Vol. 12 No. 3 (2024): November 2024
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.12.3.203-210

Abstract

Breast cancer is a common health problem in women and causes a high mortality rate. Cancer cells can grow and metastasize to other organs and related to estrogen and estrogen receptor alpha (ERα). The search for plant-based bioactive compounds that are antagonistic to ERα is currently being carried out using an in silico approach. Lunasia amara blanco is a medicinal plant that contains quinolone alkaloid compounds and has been known to inhibit DNA Topoisomerase II. This study aims to predict the interaction of lunacrine, graveoline, lunine, lunacridine, and lumarine compounds on the estrogen receptor alpha (ERα) (PDB 1SJ0) by in silico method. Docking will be done with PyRex 0.8 and the result visualization will be done with the BIOVIA Discovery Studio Visualizer. Base on the results of molecular docking, graveoline and lunine compounds have bond energies of -8.4 and -8.0 kcal/mol, approaching the native ligan of tamoxifen, which is -9.7 kcal/mol. The type of interaction with amino acids affects the bond energy. The amino acid residues that formed interactions with all the test compounds were Ala350, Leu387, Met388, Phe404, and Ile424. The stability of the binding of tamoxifen and graveoline is also thought to be due to the amino acids Asp351 and Cys530. The interaction of the two amino acids is not found in other compounds and the interactions formed are in the form of hydrogen bonds or hydrophobicity. Lunamarine has the lowest bond energy and make interactions with different amino acids
Edible Bird’s Nest Extract Reduced Expression of Senescence Markers in Bone Marrow Mesenchymal Stem Cells Elfita, Lina; Wientarsih, Ietje; Sajuthi, Dondin; Bachtiar, Indra; Darusman, Huda Shalahudin
JSFK (Jurnal Sains Farmasi & Klinis) Vol 8 No 1 (2021): J Sains Farm Klin 8(1), April 2021
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.8.1.19-26.2021

Abstract

Edible bird’s nest (EBN) is often consumed as a health food due to its suggested health benefits, including anti-aging effects, however the mechanism is still unknown. This study investigated the effect of EBN extract using long term expansion bone marrow-derived mesenchymal stem cells (BMMSCs) as an aging model. Passage 5 (P5) and passage 8 (P8) BMMSCs were treated with EBN extract, and their proliferation, senescence-associated β-galactosidase (SA-β-Gal) activity, and expression of p16INK4a were analyzed. Treatment of BMMSCs with EBN extract decreased population doubling time (PDT) in P5 but not in P8 BMMSCs. In P5 BMMSCs, 200 ppm EBN extract increased BMMSCs proliferation, with PDT reduced by 27.6%. However, 200 ppm EBN extracts did not affect P8 BMMSCs proliferation, although it increased BMMSCs viability. Treatment of P5 and P8 BMMSCs with 200 ppm EBN extract decreased SA-β-Gal activity by 54.8% and 47.1% of the control, respectively (P<0.05). Levels of p16INK4a expression were 5.4-fold lower in P5 BMMSCs treated with 200 ppm EBN extract compared to control (P<0.05). Similarly, treatment of P8 BMMSCs with 200 ppm EBN extract reduced p16INK4a mRNA level by 7.9-fold compared to the control (P<0.05). In order to investigate the pathway of EBN extract inhibition, we further analyzed IL-6 and NF-κB1 expression. Treatment of P5 and P8 BMMSCs with 200 ppm EBN extract reduced IL-6 mRNA levels by 7.9-fold and 2.1-fold of control, respectively (P<0.05). We found that 200 ppm EBN extract reduced NF-κB1 mRNA level approximately 2.4-fold both in P5 and P8 BMMSCs (P<0.05). Thus, EBN extract reduces markers of senescence, indicated by decreased SA-β-Gal activity and p16INK4a mRNA level, and this correlated with reduced messenger RNA levels of the pro-inflammatory factor IL-6 and the transcription factor NF-κB1.
Cytotoxicity of Ethyl Acetate Extract of Avocado Seeds (Persea americana Mill.) on Mouse Melanoma B16F10 Cell Line Sebayang, Shalina; Mariya, Silmi; Rayendra, Raendi; Wientarsih, Ietje; Priosoeryanto, Bambang Pontjo
HAYATI Journal of Biosciences Vol. 32 No. 2 (2025): March 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.2.405-413

Abstract

Artificial whitening agents available in the market can cause damage to melanocytes; therefore, a safe and naturally derived skin-whitening agent is needed. Avocado seeds (Persea americana Mill.) are often discarded as waste but possess numerous health benefits. One of the compounds in avocado seeds is catechin, a flavonoid metabolite. This compound has been reported to exhibit antioxidant activity and inhibit tyrosinase to prevent melanin formation, making it suitable for skin-whitening applications. This study aimed to conduct phytochemical screening, assess antioxidant activity using the DPPH method, analyze catechin content using HPLC, and perform cell viability tests using the MTT method from the ethyl acetate extract of avocado seeds. Phytochemical screening has revealed the presence of flavonoids, saponins, and steroids. The DPPH assay yielded an IC50 value of 89.47±0.73 ppm, indicating an intense antioxidant activity, and HPLC detected 0.09% catechin. The MTT test results yielded cell viability percentages ranging from 80-100% at test concentrations of 0.75-25 ppm, with an IC50 value of 61.7 ppm. In conclusion, our results indicate that the ethyl acetate extract from avocado seeds affects cell viability without toxicity, warranting further testing for tyrosinase inhibition in the mouse melanoma B16F10 cell line.
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN KARI (Murraya koenigii) TERHADAP Staphylococcus aureus, Escherichia coli, dan Pseudomonas sp. R, Rastina; Sudarwanto, Mirnawati; Wientarsih, Ietje
Jurnal Kedokteran Hewan Vol 9, No 2 (2015): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v9i2.2842

Abstract

Penelitian ini bertujuan mengetahui aktivitas antibakteri, konsentrasi efektif, dan pengaruh peningkatan konsentrasi ekstrak etanol daun kari (Murraya koenigii) terhadap daya hambat pertumbuhan bakteri Staphylococcus aureus, Escherichia coli dan Pseudomonas sp. Ekstraksi dilakukan dengan cara maserasi menggunakan pelarut etanol 96%. Pengujian aktivitas antibakteri menggunakan metode difusi agar. Parameter yang diukur adalah besarnya diameter daya hambat yang terbentuk di sekitar kertas cakram. Hasil uji aktivitas antibakteri dianalisis dengan metode one way anova dilanjutkan dengan uji Duncan. Hasil penelitian menunjukkan bahwa konsentrasi ekstrak 12,5; 25; dan 50% telah memberikan aktivitas daya hambat pertumbuhan bakteri uji. Konsentrasi efektif yang dapat menghambat bakteri Staphylococcus aureus dan Escherichia coli pada konsentrasi 50%, sedangkan bakteri Pseudomonas sp. pada konsentrasi 12,5; 25; dan 50%. Peningkatan konsentrasi ekstrak daun kari menunjukkan semakin luas diameter zona hambat pertumbuhan bakterinya. Penghambatan yang terjadi pada bakteri Staphylococcusaureus, Escherichia coli, dan Pseudomonas sp. tersebut, membuktikan bahwa daun kari mengandung senyawa aktif yang bersifat antibakteri, seperti flavonoid, fenol, alkaloid, dan saponin.
Effect of Bosswelic Acid On Hematological Parameters In Sprague Dawley Rats (Rattus novergicus) Induced By Cyclophosphamide Maret Daulay, Lingga Surya; Wientarsih, Ietje; Esfandiari, Anita; Sutardi, Lina Noviyanti; Asmilia, Nuzul
Asian Journal of Social and Humanities Vol. 2 No. 5 (2024): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i5.239

Abstract

Chemotherapy drug “cyclophosphamide (SP)” can trigger oxidative stress that causes hematotoxicity and myelotoxicity, therefore an agent that can suppress the negative effects of cyclophosphamide is needed. Boswellic acid is an herbal medicine that has anti-oxidant and anti-inflammatory effects. The aim of this study was to determine the effect of boswellic acid (BA) in hematology parameter rats induced by cyclophosphamid. Animal were allocated in to six groups, each group consists of 5 rats, the KS: healthy group, KSP: cyclophosphamide group; KSD: comparison group, and BA groups (K1;K2;K3). The treatment groups were given cyclophosphamide (SP) at dose of 150 mg/kg body weight (BW) i.p. The BA groups (K1,K2,K3) were given BA at dose of 250 mg/kg BW orally for 6 consecutive days and SP on day 1 (K1), day 4 (K2), day 6 (K3). The results showed that BA administration (K2 and K3) can help increase/maintain the amount of hematological parameters including hemoglobin, hematocrit, and erythrocytes. Administrating BA for 6 days consecutively before SP (K3) has shown best results on hematological parameters than the others including the comparison group. These results suggest that BA may have a potential herbal therapeutic agents that can mitigate cyclophosphamide-induced hematotoxicity manifestations.
Co-Authors A.S. Satyaningtijas Agus saputra Ahmad Kurniawan Amrozi Andriyanto . ANGGARA ALDOBRATA Anita Esfandiari April Hari Wardhana April Hari Wardhana April Hari Wardhana Aswin Rahadian Aulia Andi Mustika Bambang Pontjo Priosoeryanto Bambang Purwantara Bayu Febram Bayu Febram Bayu Febram Prasetyo Bayu Febran Prasetyo Chandra Utami Wirawati Chatarina Umbul Wahyuni D R Agungpriyono Deded Sarip Nawawi Deni Noviana Denny Widaya Lukman Dian Firnanda Dodi Darmakusuma Dodi Darmakusumah Dondhin Sajuthi Dondin Sajuthi Dwi Utari Rahmiati Eko Agus Srihanto Erni H Purwaningsih Erni H Purwaningsih Esti Dhamayanti Eva Harlina Farra Sasmita Febryanto, Agung Fikri Hanifah Gunanati Soedjono Gunanti . Hadiyanti, Cresensia Rara Hr. Sjarif, Sulistyantie Huda Shalahudin Darusman I Nyoman Jaya Wistara I Putu Kompiang Ikrar Trisnaning Hardi Utami Iman, Bintang Nurul Indra Bachtiar Indra Bachtiar Irma Maulani Hamzah Istifharany Wahyudina Joko Pamungkas Khoirun Nisa L N Sutardi Lina Elfita Lina Elfita Lina Novianti Sutardi Lina Noviyanti Sutardi Lingga Surya Maret Daulay M. Rafi M. Yanuar J. Purwanto Madyastuti, Rini Maret Daulay, Lingga Surya Maulani Hamzah, Irma Meilisa Lidya Margarita Miranti Fardesiana Putri MIRNAWATI SUDARWANTO Mirnawati Sudarwanto Mokhamad Fakhrul Ulum, Mokhamad Muhammad Bintang Murtiningrum, Fitria Senja Nisa, Nunik Nida Choerun Nopen Meisaroh Nova P. Sulistyawati Nugroho, Radhitya Aryo Nuzul Asmilia Nuzul Asmilia Rahmawati Januar Rahminiwati, Min Rastina R, Rastina Rastina Rastina Rayendra, Raendi Rita Kartika Sari Rizal Arifin Akbari Ros Sumarny Sajuthi, Dondhin Sa’diah, Siti Sebayang, Shalina Setyo Widodo Setyo Widodo SILMI MARIYA Silmi Mariya Subangkit, Mawar Sudarwanto, Mirnawati Bachrum Sulistyantie Hr. Sjarif Sus Derthi Widhyari Tarigan, Ronald TATI NURHAYATI Tika Aryanti Trioso Purnawarman Tyas Ayu Lestari Upik Kesumawati Hadi Vetnizah Juniantito Wiwin Winarsih Yessa, Elma Yuliani