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All Journal ACTA VETERINARIA INDONESIANA Media Kedokteran Hewan Indonesian Journal of Tropical and Infectious Disease Jurnal Medik Veteriner Jurnal Abdi Insani Ovozoa: Journal of Animal Reproduction Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat journal of Basic Medical Veterinary Buletin Pengabdian
Ira Sari Yudaniayanti
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Journal : Jurnal Medik Veteriner

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Evaluation and Its Impact of SARS-CoV-2 Inactivated Vaccine Candidate in K18-hACE2 Mice A'la, Rofiqul; Rantam, Fedik Abdul; Wijaya, Andi Yasmin; Susilowati, Helen; Kuncorojakti, Suryo; Diyantoro, Diyantoro; Aswin, Ahmad; Rahmahani, Jola; Suwanti, Lucia Tri; Lukiswanto, Bambang Sektiari; Yudaniayanti, Ira Sari; Setiawan, Boedi
Jurnal Medik Veteriner Vol. 8 No. 1 (2025): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol8.iss1.2025.54-62

Abstract

The COVID-19 pandemic caused by SARS-CoV-2 requires effective vaccines to be developed. This study aimed to assess the impact of a SARS-CoV-2 inactivated vaccine candidate in k18-hACE2 mice by monitoring their body weight, immune activation, and inflammatory cytokines including IL-4, IL-6, TNF-α, and IFN-γ. The study utilized k18-hACE2 mice expressing the human angiotensin-converting enzyme 2 (hACE2) receptor. The mice were administered the inactivated vaccine candidate compared with sham and vehicle. Body weight was monitored, and serum samples were collected to measure IL-4, IL-6, TNF-α, and IFN-γ levels using ELISA. Data were evaluated using SPSS statistical analysis software. The administration of the SARS-CoV-2 inactivated vaccine candidate in k18-hACE2 mice did not result in significant changes in body weight compared to the control group. Furthermore, the levels of IL-4, IL-6, TNF-α, and IFN-γ were significantly reduced in the vaccinated mice compared to the control group, suggesting a dampening effect on the inflammatory response. This study demonstrates that the SARS-CoV-2 inactivated vaccine candidate has a minimal impact on the body weight of k18-hACE2 mice. Nevertheless, it successfully regulates the levels of IL-4, IL-6, TNF-α, and IFN-γ, suggesting its safety and beneficial impact. These findings contribute to understanding the vaccine's efficacy and safety profile in vaccine development.
Novel Surface Marker for the Prospective Mesenchymal Stem Cell Characterization from Rabbit Visceral Adipose Tissue Kuncorojakti, Suryo; Yudaniayanti, Ira Sari; Susanti, Lina; Susilawati, Helen; Aswin, Ahmad; Diyantoro, Diyantoro; Rodprasert, Watchareewan
Jurnal Medik Veteriner Vol. 8 No. 1 (2025): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol8.iss1.2025.1-9

Abstract

Rabbit as a laboratory animals play an important role in bridging basic research to clinical application. The exploration of rabbit mesenchymal stem cell (MSC) is still facing an obstacle regarding the standardization of characterization of MSC. This study is aimed to explore the novel candidate of rabbit MSC surface marker as an effort to establish the goal standardization of rabbit MSC. Three 2-month-old male White New Zealand rabbits weighing 2 kg were used as visceral rabbit adipose derived mesenchymal stem cell (Rab-ADMSC) donors. The cells were characterized according to their morphology characteristic, clonogenic and three-lineage differentiation capacity. Flow cytometry was used to evaluate the MSC surface markers of Rab-ADMSC against CD81, CD29, CD34 and CD45. The results of this study revealed that the Rab-ADMSC posses characteristic of MSC according to their morphology and differentiation capacity. It can be concluded that CD81 surface marker can be proposed as a stable alternative candidate marker for rabbit MSCs. This data is supported by other phenotypic characteristics of MSCs, both in morphology and in the ability of visceral Rab-ADMSCs to differentiate into adipogenic, osteogenic, and chondrogenic lineages.
Co-Authors A'la, Rofiqul Abdul Samik, Abdul Adikara, Yuanara Augusta Rahmat Al arif, Mohammad Anam Aswin, Ahmad Bambang Sektiari Lukiswanto Billa, Lutfiah Annisa Boedi Setiawan Cahya, Rizka Wulan Diyantoro Diyantoro, Diyantoro Eduardus Bimo Aksono Herupradoto Eka Pramyrtha Hestianah, Eka Pramyrtha Estoepangestie, Agnes Theresia Soelih Fatin Fadhilah Hasib Fedik Abdul Rantam Fidyah Fitrawati, Fidyah Hadiah Fitriyah Haeriah Hani Plumeriastuti Helen Susilowati, Helen Hidanah, Sri Hisyam, Mirza Atikah Madarina Immelda, Kicky Hanis Ivanalee, Angela Swasti Iwan Sahrial Hamid Kadek Rachmawati Karo-karo, Desniwaty Khairullah, Aswin Rafif Kuncorojakti, Suryo Kusnoto Kusnoto, Kusnoto LINA SUSANTI Lucia Tri Suwanti, Lucia Tri Ma'ruf, Anwar Mafruchati, Maslichah Mahdi, Daffa Amanul Mardatillah, Meidy Miarsono, Sigit Mirni Lamid Niken Hastuti, Apriliwiyani Nusdianto Triakoso Panggabean, Rosenna Tiara Poedji Hastutiek Prastika, Dinda Dwi Primarizky, Hardany Putri, Desak Ketut Sekar Cempaka Putrianirma, Rizki R.T.S Adikara, R.T.S Adikara Rahmadhani, Nurmitasari Rahmahani, Jola Rahmawati, Kadek Ratna Damayanti Rochmah Kurnijasanti Rodprasert, Watchareewan Rohmah, Siti Nur Rosyada, Zulfi Nur Amrina Sabdoningrum, Emy Koestanti Santoso, Kuncoro P. Saputro, Amung Logam Sardjana, I Komang Wiarsa Soeharsono Soeharsono Soeharsono Sofyan, Miyayu Soneta Sri Mumpuni Sudjono, Budi Santoso Suherni Susilowati Sukmanadi, M Susilawati, Helen Suwarno Suzanita Utama Theresia, Sis Wisnuarti Wahyudi, Nurul Tri Warsito, Sunaryo Hadi Wibawati, Prima Ayu Widiyatno, Thomas Valentinus Widya Paramita Lokapirnasari Wijaya, Andi Yasmin Wiwik Misaco Yuniarti Wurlina, W Yudhana, Aditya Yunita, Maya Nurwartanti Yunus, Muchammad