Claim Missing Document
Check
Articles

Found 31 Documents
Search

Negative Impact of Noise Exposure on the Mean Number of Neurons in the Frontal Lobe of Adult Wistar Rats Evayanti, Luh Gde; Astini, Dewa Ayu Agung Alit Suka; Sumadewi, Komang Trisna; Witari, Ni Putu Diah; Wijaya, Putu Austin Widyasari; Ekayanti, Ni Wayan Sri; Ekayani, Ni Wayan Diana
Jambura Medical and Health Science Journal Vol 5, No 1 (2026): Jambura Medical and Health Science Journal
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jmhsj.v5i1.32905

Abstract

Introduction: Noise exposure can induce oxidative stress and alter neurotransmitter dynamics within the nervous system. This oxidative stress is also associated with structural changes in the layers of the cerebrum. However, the effects of noise exposure on neuronal populations remain inadequately understood. This study aims to quantify the mean number of neurons in the frontal lobe of Wistar rats subjected to noise exposure.Methods: This study utilized an experimental design characterized by a randomized post-test only control group framework. A total of 30 male Wistar rats were selected through simple random sampling and subsequently divided into two groups: a control group without treatment (C1, n=15) and an experimental group exposed to 95 dB noise (E1, n=15) for four hours daily. Following a two-week exposure period, their brain tissue was excised and preserved in 10% neutral buffered formalin. Histological assessment was conducted using Hematoxylin and Eosin staining to evaluate the mean number of neurons in the frontal lobe. Statistical analysis was performed using the independent T-test.Results: The mean number of neurons was 1053.33 ± 55.529 in the E1 group and 720.167 ± 61.135 in the C1 group. The mean neurons of the frontal lobe of Wistar rats in the E1 group ws lower than the C1 group significantly (P 0.001).Conclusion: Neuronal death in the frontal lobe resulting from noise-induced stress can induce structural alterations within this region, leading to detrimental effects on cognitive function and behavior. Keywords: Frontal lobe, neuron, noise, stress
HUBUNGAN KONSUMSI SUGAR-SWEETENED BEVERAGES DENGAN DURASI MENSTRUASI PADA REMAJA PUTRI Ekayanti, Ni Wayan Sri; Wijaya, Putu Austin Widyasari; Evayanti, Luh Gde; Ekayani, Ni Wayan Diana; Trisnia, Putu Ayunda
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 10 No. 1 (2026): APRIL 2026
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v10i1.56718

Abstract

Konsumsi minuman manis yang tinggi merupakan kebiasaan yang umum pada remaja dan berpotensi memengaruhi berbagai aspek kesehatan, termasuk fungsi reproduksi. Menstruasi merupakan salah satu indikator penting kesehatan endokrin pada remaja putri. Penelitian ini bertujuan untuk menganalisis hubungan antara tingkat konsumsi minuman manis dan durasi menstruasi pada remaja putri. Penelitian ini menggunakan desain cross-sectional dengan melibatkan 76 responden remaja putri yang dipilih menggunakan teknik simple random sampling. Konsumsi minuman manis diukur menggunakan Food Frequency Questionnaire (FFQ) dan dikategorikan menjadi rendah (≤2 kali/minggu), sedang (3–5 kali/minggu), dan tinggi (>5 kali/minggu). Durasi menstruasi dikategorikan menjadi singkat (<3 hari), normal (3–7 hari), dan panjang (>7 hari). Analisis bivariat dilakukan menggunakan uji Chi-square, dengan koreksi Fisher’s exact test pada sel dengan expected count kecil. Kekuatan hubungan dianalisis menggunakan koefisien Cramer’s V. Hasil penelitian menunjukkan adanya hubungan yang signifikan antara tingkat konsumsi minuman manis dan durasi menstruasi pada remaja putri (χ² = 11.82; p = 0.019). Namun kekuatan hubungan tergolong lemah (Cramer’s V = 0.28). Temuan ini menunjukkan bahwa konsumsi minuman manis berpotensi berkontribusi terhadap variasi durasi menstruasi pada remaja putri, meskipun faktor lain kemungkinan memiliki pengaruh yang lebih besar.
CORRELATION OF ANXIETY AND WORKLOAD AMONG HEALTH PROFESSIONALS IN TOURISM AREA IN DENPASAR, BALI Wijaya, Putu Austin Widyasari; Evayanti, Luh Gde; Ekayani, Ni Wayan Diana; Ekayanti, Ni Wayan Sri; Setiabudy, Marta
JURNAL WIDYA MEDIKA Vol. 12 No. 2 (2026): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v12i2.8371

Abstract

Health professionals bear high moral responsibilities and face various workplace concerns, such as the risk of disease transmission, the challenge of interacting with diverse patients, the complexity of patient management, and high patient volumes in several health facilities. Previous studies have indicated that high workloads can influence stress levels and disrupt bodily homeostasis. It is hypothesized that healthcare workers with high workloads also exhibit higher levels of anxiety. Consequently, this study aims to determine the relationship between workload and anxiety levels among healthcare professionals, especially those who have been working in the tourism area in Denpasar. This study utilized a cross-sectional method involving healthcare workers in Denpasar employed in outpatient clinics, with data analyzed using Spearman’s correlation test. The instruments employed were the Hamilton Anxiety Rating Scale and the National Aeronautics and Space Administration Task Load Index (NASA-TLX) questionnaire. The results demonstrated that workload has a significant relationship with anxiety among healthcare workers (p = 0.003) with a strong correlation (r = 0.521). These findings are supported by the mechanism of stress hormone secretion via the HPA-axis when individuals encounter work-related stressors or high workloads. In the long term, this condition triggers psychological disorders and anxiety.
Hubungan antara Status Gizi dengan Perkembangan Kognitif pada Anak Usia 6-24 Bulan Putu Ayu Kevin Komala Dewi Mahayuna Putri; Anak Agung Oka Lely; Luh Gde Evayanti
Aesculapius Medical Journal Vol 1 No 1 (2021): October
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.1.1.2021.1-7

Abstract

Abstrak Perkembangan kognitif adalah kemampuan dalam berpikir, mengeksplorasi, dan memecahkan suatu masalah. Perkembangan otak anak dipengaruhi oleh jumlah asupan gizi yang dikonsumsi untuk mempertahankan keseimbangan metabolisme tubuh. Asupan gizi yang baik dapat berkontribusi positif dalam perkembangan otak sehingga mengoptimalkan perkembangan kognitif anak. Penelitian ini bertujuan untuk mengetahui hubungan antara status gizi dan perkembangan kognitif anak yang berumur 6-24 bulan. Penelitian menerapkan metode analitik dengan pendekatan cross- sectional. Besarnya sampel pada penelitian yakni 67 partisipan dipilih dengan concecutive sampling yang memenuhi kriteria inklusi serta eksklusi di wilayah kerja Puskesmas Gianyar I dari Maret 2021 hingga Mei 2021. Variabel pada penelitian ini adalah status gizi dan perkembangan kognitif. Status gizi dinilai atas dasar Indeks Massa Tubuh sesuai umur (IMT/U) dan perkembangan kognitif di nilai dengan capute scales. Analisis data mempergunakan uji fisher exact menggunakan SPSS tipe 26 dimana p < 0,05. Hasil penelitian menunjukkan anak berstatus gizi baik mempunyai perkembangan kognitif yang baik (93,3%). Sedangkan suspek gangguan perkembangan kognitif lebih banyak ditemukan pada anak berstatus gizi tidak baik (85,7%). Terdapat hubungan antara status gizi dan perkembangan kognitif yang bermakna (p = 0,000). Status gizi yang baik mampu mengoptimalkan perkembangan kognitif anak. Kata kunci: status gizi, perkembangan kognitif, anak usia 6-24 bulan Abstract [The Relationship between Nutritional Status with Cognitive Development in Children Aged 6-24 Month] Cognitive development is the ability of thinking, exploring, and solving a problem. Brain development in human’s body is affected by the amount of nutrients that is intake to keep balance of body’s metabolism. Good nutrition intake can contribute positively to the brain development, and it also optimizing the children’s cognitive development. The purpose of this study was to know a correlation between nutritional status and cognitive development in children aged 6-24 months. This study used an analytical method and a cross sectional approach. The sample size of the study was 67 in which it was selected by using the consecutive sampling based on the inclusion and the exclusion criteria in the work area of Puskesmas Gianyar I from March 2021 to May 2021. The research variables were the nutritional status and the cognitive development. The nutritional status was evaluated from Body Mass Index according to age (BMI/U) and the cognitive development was assessed by using the capute scales. The data was analysed by fisher exact test with SPSS type 26 in which the p value is <0.05. In this study, it was found that children with good nutritional status had good cognitive development (93.3%). Meanwhile, suspected cognitive development disorders were found in children with poor nutritional status (85.7%). There is a significant relationship between nutritional status and cognitive development (p = 0.000). A good nutritional status will optimize children's cognitive development. Keywords: nutritional status, cognitive development, children aged 6-24 month
Pelatihan Pembuatan Alat Permainan Edukatif (APE) Sederhana Asri Prima Dewi AA Ayu; Dewa Ayu Agung Alit Suka Astini; Putu Ayunda Trisnia; Komang Trisna Sumadewi; Luh Gde Evayanti; Putu Diah Witari; Fransiscus Fiano Anthony Kerans; Ida Kurniawati
Warmadewa Minesterium Medical Journal Vol. 4 No. 1 (2025): Januari 2025
Publisher : Warmadewa University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmmj.4.1.2025.67-70

Abstract

Anak – anak identik dengan dunia bermain. Bermain merupakan salah satu media anak untuk mengembangkan kreativitas dan belajar termasuk melatih sel otaknya untuk mempelajari hal baru yang berkaitan dengan kognitif anak. Pada era teknologi saat ini, penggunaan ponsel pintar semakin berkembang dan marak digunakan pada kalangan anak usia dini. Dampak yang ditimbulkan oleh penggunaan ponsel pintar pada anak usia dini tidak sedikit yang menunjukkan efek buruk seperti penurunan motorik dan sensorik anak, gangguan pada hubungan sosial dan perilaku bahkan penurunan kognitif anak. Permainan edukatif anak yang tersedia pada lingkungan disekitar anak akan dapat membantu pengalihan anak dalam menggunakan ponsel pintar. Dengan menggunakan bahan dan alat yang ada di sekitar kita, permainan edukatif juga dapat dibuat dengan mudah. Posyandu merupakan wadah kegiatan ibu dan anak di wilayah cakupannya yang memiliki kegiatan rutin seperti pemantauan tumbuh kembang anak. Anak biasanya dibawa ke posyandu untuk dimonitor tumbuh kembangnya dan biasanya anak bermain disela kegiatan tersebut. Kader posyandu juga berperan menyampaikan informasi dan edukasi terkait tumbuh kembang anak. Banjar Tengah Blahbatuh memiliki posyandu yang mengadakan kegiatan rutin setiap bulannya. Banjar ini juga memiliki jumlah balita yang cukup banyak. Berdasarkan informasi yang didapat, penggunaan ponsel pintar di kalangan balita pada banjar ini tergolong cukup banyak. Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah untuk menyediakan pelatihan kepada kader posyandu Banjar Tengah Blahbatuh terkait pembuatan alat permainan edukatif (APE) sederhana yang dapat digunakan dan diterapkan di wilayahnya. Hasilnya menunjukkan bahwa kader posyandu lebih memahami alat permainan edukatif (APE) dan lebih sering menggunakannya.
The Differences of 10% Neutral Buffered Formalin, 4% Paraformaldehyde, and Bouin Solution in Newborn Rat Brain Luh Gde Evayanti; Ni Putu Diah Witari; Komang Trisna Sumadewi; A.A.Ayu Asri Prima Dewi; Fransiscus Fiano Anthony Kerans; Dewa Ayu Agung Alit Suka Astini
WMJ (Warmadewa Medical Journal) Vol 9 No 1 (2024): May 2024
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.9.1.9180.1-4

Abstract

Rats are widely used in the study of embryological development of the central nervous system and its congenital disorders. Therefore, tissue fixation is very important in obtaining a good picture of the central nervous system, especially in newborn rats. This study aims to determine the difference in fixation using a solution of 10% neutral buffered formalin, 4% paraformaldehyde, and Bouin solution in the brain tissue of newborn rats. This experimental study used a post-test only controlled-group design with 18 newborn rats aged zero day. After randomization, the pups were grouped into 3 treatment groups, namely: fixation with 10% neutral buffered formalin solution (P1, n = 6), and fixation with 4% paraformaldehyde solution (P2, n = 6), and fixation with Bouin solution (P3, n = 6). Assessment using Hematoxylin Eosin staining, and analyzed by blinding based on the histology of the cerebral tissue (cell nucleus staining, cytoplasmic staining, staining clarity, uniformity of staining). Five cerebrum fields were examined. Data analysis used Kruskall Wallis test and post hoc Mann Whitney test using SPSS. The result was a significant difference in the histology of the brain tissue of newborn rats with the fixation of a solution of 10% neutral buffered formalin, 4% paraformaldehyde and Bouin solution (p = 0.001). Brain tissue fixation using 10% neutral buffered formalin solution showed better quality of histological pictures compared to 4% solution of paraformaldehyde solution and Bouin solution (p <0.05).
Pemberdayaan Satgas Gotong Royong Berbasis Desa Adat Dalam Pencegahan COVID-19 di Banjar Serongga Pondok, Tabanan Putu Nita Cahyawati; A. A. Sri Agung Aryastuti; Luh Gde Evayanti
WICAKSANA: Jurnal Lingkungan dan Pembangunan Vol. 4 No. 2 (2020)
Publisher : Lembaga Penelitian, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wicaksana.4.2.2020.1-6

Abstract

The COVID-19 pandemic is affecting all elements of Indonesian society. Lack of knowledge, lack of readiness, and insufficient allocation of funds make the prevention of this disease a challenge for the entire community. Social distancing, limiting all activities outside the home, using masks, hand sanitizers and disinfectants are all efforts that can be made to prevent the spread of this disease. Banjar Serongga Pondok is one of the traditional Banjar which is quite consistent in implementing these things. The residents of Banjar Serongga Pondok have indeed tried to reduce all activities outside the home, but it is undeniable that there are still residents who have not been able to implement this properly. Therefore, a special task force was formed called the Satgas Gotong Royong Berbasis Desa Adat as the driving force for all COVID-19 virus prevention activities in Banjar. The routine efforts that usually they do are spraying disinfectant liquid every Sunday. However, the limitations of disinfectant fluids and budget constraints in the implementation of these activities made it difficult to carry out the activities. The condition, exacerbated by the scarcity of masks, also made it difficult for the task force to work for residents. Based on these problems, the service is focused on providing information related to COVID-19, providing masks, hand sanitizers, and disinfectants to the COVID-19 Task Force in Banjar Serongga Pondok. The activity was started by giving a speech by Kelian Adat Banjar Serongga Pondok, remarks by the head of the activity organizer, material delivery and discussion, the delivery of assistance, and assistance in the implementation of disinfection. This program is expected to help the task force's work program continuity in preventing the transmission of COVID-19, especially in Banjar Serongga Pondok.
Hubungan Kadar Asam Urat Terhadap Kejadian Sindrom Koroner Akut di RSUD Sanjiwani Gianyar Tahun 2018-2019 I Gusti Lanang Agung Wiradinata; I Gede Bagus Gita Pranata Putra; Luh Gde Evayanti
Aesculapius Medical Journal Vol 2 No 1 (2022): Juni
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.2.1.2022.21-25

Abstract

Sindrom Koroner Akut (SKA) merupakan manifestasi klinis dari Penyakit Jantung Koroner dengan spektrum NonST Elevation Miocard Infark (NSTEMI), ST Elevation Miocard Infark (STEMI) dan Unstable Angina Pectoris (UAP). Salah satu faktor predisposisi yang memicu disfungsi endotel pada SKA yaitu hiperurisemia. Penelitian ini bertujuan untuk mengetahui hubungan kadar asam urat dengan kejadian SKA di RSUD Sanjiwani. Penelitian ini menggunakan desain analitik dengan pendekatan cross-sectional. Data diambil dari rekam medis pasien diagnosis SKA tahun 2018-2019. Sebanyak 69 sampel diperoleh dengan metode purposive sampling berdasarkan kriteria inklusi dan eksklusi. Kedua variable di uji menggunakan pearson chi-square (p < 0,05) dengan Statistical Package for Social Science (SPSS) versi 23. Berdasarkan analisis didapatkan bahwa kadar asam urat tidak berhubungan dengan kejadian SKA pada pasien rawat inap di RSUD Sanjiwani pada tahun 2018-2019 (p = 0,717). Asam urat dapat berperan sebagai cardioprotector melalui mekanisme penghambatan stress oksidatif.
Karakteristik Kejang Demam pada Anak di RSUD Tabanan pada Tahun 2021-2022 Kadek Ayu Alit Sintyawati; Ni Kadek Elmy Saniathi; Luh Gde Evayanti
Aesculapius Medical Journal Vol 3 No 3 (2023): October
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.3.3.2023.427-436

Abstract

Febrile seizures are common emergency case of children between 6 months-5 years. During 2021 this cases is the most common pediatric diseases in RSUD Tabanan. Risk factors for febrile seizures in the hospitals have not been studied. This research aims to identify the characteristics of febrile seizures. This descriptive study used cross-sectional design with 145 samples selected by total sampling. Data were obtained from medical records of pediatric hospitalized in 2021-2022. The frequency distribution analysis used SPSS 25. According this study showed that febrile seizures mostly occurred in children aged 6-24 months (75.9%), predominantly in boys (62.8%) with a temperature of 38-40°C (95.2%). The most common diagnosis was simple febrile seizures (95.9%), with duration <15 minutes (95.9%), no family history of seizures (87.6%), and without recurrence (76.6%). The most common comorbid disease was acute respiratory infection (62.8%), while the lowest non-infectious disease was diabetes (0.7%). Hemoglobin and leukocyte levels were within the normal range, namely 54.5% and 75.9%. Most patients had nutritional status except good nutritional status (40.7%), did not get exclusive breastfeeding (26.9%), and had length of stay ≥3 days (82.1%). It can be concluded that febrile seizures mostly occur in boys aged 6-24 months with a temperature of 38-40°C, SFZ <15 minutes in duration is more frequent, without a history of recurrence. This seizure is commonly accompanied by ARI with normal hemoglobin and leukocyte levels. Most patients have nutritional status except good nutritional status, do not get exclusive breastfeeding, and have a length of stay ≥3 days.
Perbedaan Pencapaian Kompetensi Farmakoterapi pada Ujian OSCE Mahasiswa FKIK Universitas Warmadewa Semester 7 dan 8 Adelia Putri Mas; Rima Kusuma Ningrum; Luh Gde Evayanti
Aesculapius Medical Journal Vol 5 No 1 (2025): February
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.5.1.2025.24-30

Abstract

Pharmacotherapy is a sub-discipline of pharmacology that studies the treatment of diseases through the use of medications. The use of drugs is considered rational when patients receive medications that suit their needs, for an adequate period of time, and at the most affordable cost for both the patient and society. Prescription writing falls under the competency of healthcare physicians, meaning that doctors are required to master the proper and correct way of writing prescriptions. The Objective Structured Clinical Examination (OSCE) is part of an assessment system aimed at evaluating the clinical competencies and skills of students objectively and systematically. This study aims to determine the differences in the achievement of pharmacotherapy competency during the OSCE among 7th and 8th-semester students of the Faculty of Medicine and Health Sciences, Warmadewa University. The method used in this research is a descriptive-analytic method to identify the relationship between variables through a cross-sectional approach. The target population in this study consists of all medical students of the Faculty of Medicine and Health Sciences at Warmadewa University who meet the inclusion and exclusion criteria. Data collection was based on OSCE scores from the 2019 cohort. A dependent t-test was then conducted, followed by determining Cohen's d. The dependent t-test results showed that the average OSCE scores in pharmacotherapy competence in the 7th and 8th semesters were significantly different, with a p-value of 0.000. This improvement from the 7th to the 8th semester reflects a deeper mastery of more complex pharmacotherapy scenarios.  
Co-Authors A A I Ayesa Febrinia Adyasputri A.A.Ayu Asri Prima Dewi Aanak Agung Ayu Asri Prima Dewi Adelia Putri Mas Agus Santosa Anak Agung Ayu Asri Prima Dewi Anak Agung Ayu Asri Prima Dewi Anak Agung Oka Lely Anak Agung Sri Agung Aryastuti Angga Priyana Asri Prima Dewi AA Ayu Astini, Dewa Ayu Agung Alit Suka Astuti, Ni Luh Putu Vina Juni budiapsari, putu indah Cahyawati, Putu Nita Desak Putu Oki Lestari Dewa Ayu Agung Alit Suka Astini Dewa Ayu Ratna Juwita Dewi, A.A.Ayu Asri Prima Dewi, Anak Agung Ayu Asri Prima Ekayani, Ni Wayan Diana Ekayanti, Ni Wayan Sri Fransiscus Fiano Anthony Kerans Gede Rizky Wismaya Pradipha I Gede Bagus Gita Pranata Putra I Gede Suranaya Pandit I Gusti Lanang Agung Wiradinata I Wayan Sudiarta I Wayan Sudiarta Ida Kurniawati Ida Kurniawati Ida Kurniawati, Ida IGNP Sana Kadek Ayu Alit Sintyawati Kadek Ayu Alit Sintyawati Komang Trisna Sumadewi KT Sumadewi Ni Kadek Elmy Saniathi Ni Luh Putu Indiani Ni Putu Diah Witari Ni Putu Diah Witari, Ni Putu Ni Wayan Armerinayanti, Ni Wayan Ni Wayan Diana Ekayani NPD Witari Pande Ayu Naya Kasih Permatananda Perdana, I Gede Sukma Okta Prima Dewi, A.A.A Asri Putra, Adi Pratama Putu Ayu Kevin Komala Dewi Mahayuna Putri Putu Diah Witari Ratna Juwita Rima Kusuma Ningrum Sagung Putri Permana Lestari Murdhana Putere Sari, Ni Luh Putu Eka Kartika Setiabudy, Marta Sri Ratna Dewi Sri Ratna Dewi Sueta, Made Agus Dwianthara Suka Astini Dewa Ayu Agung Alit Suka Astini, Dewa Ayu Agung Alit Sumadewi, Komang Trisna Trisnia, Putu Ayunda Wijaya, Putu Austin Widyasari