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All Journal Buletin Udayana Mengabdi E-Jurnal Medika Udayana WMJ (Warmadewa Medical Journal) Biology, Medicine, & Natural Product Chemistry JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) WICAKSANA: Jurnal Lingkungan dan Pembangunan Journal of Health Sciences PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Sewaka Bhakti Aesculapius Medical Journal Warmadewa Minesterium Medical Journal Indonesian Journal of Cancer Jurnal Sehat Indonesia (JUSINDO) Community Services Journal (CSJ) Physical Therapy Journal of Indonesia Jambura Medical and Health Science Journal Jurnal Pelayanan Hubungan Masyarakat Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Luh Gde Evayanti
Universitas Warmadewa
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Noise Exposure-Induced Functional Anatomical Changes: Impact on Superoxide Dismutase, Tumor Necrosis Factor-Alpha, and Adiponectin Suka Astini, Dewa Ayu Agung Alit; Luh Gde Evayanti; Sri Ratna Dewi
JURNAL KESEHATAN LINGKUNGAN Vol. 18 No. 1 (2026): JURNAL KESEHATAN LINGKUNGAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v18i1.2026.1-9

Abstract

Introduction: Environmental noise is a non-auditory stressor that can trigger inflammatory and oxidative responses in the body. Continuous noise exposure is associated with increased production of pro-inflammatory cytokines and reactive oxygen species (ROS). This can disrupt the body's cellular balance. This study aimed to determine the effects of chronic noise exposure on serum superoxide dismutase (SOD), tumor necrosis factor-alpha (TNF-α), and adiponectin levels in wistar rats. Methods: This study used a laboratory based experimental design, involving twenty-four adult male Wistar rats. The rats were randomly divided into two groups: a control group and a treatment group. The treatment group was exposed to 95 dB noise for four hours daily for 14 consecutive days, while the control group received no exposure. SOD, TNF-α, and adiponectin levels were determined using ELISA. The independent t-test was used for statistical analysis. Results and Discussion: TNF-α was significantly higher (p < 0.05) and adiponectin was significantly lower (p < 0.05) in the treatment group than in the control group. SOD levels did not differ significantly across groups (p > 0.05). Noise exposure causes metabolic and inflammatory disruptions, as evidenced by the rise in TNF-α and fall in adiponectin, but the SOD levels remain unchanged, suggesting a limited antioxidant response. Conclusion: An inflammatory response and decreased adiponectin were caused by noise exposure at 95 dB for 14 days, suggesting a possible risk of metabolic dysfunction. Nonetheless, the stability of SOD levels indicates that enzymatic antioxidant action is maintained in these circumstances.
Negative Impact of Noise Exposure on the Mean Number of Neurons in the Frontal Lobe of Adult Wistar Rats Evayanti, Luh Gde; Astini, Dewa Ayu Agung Alit Suka; Sumadewi, Komang Trisna; Witari, Ni Putu Diah; Wijaya, Putu Austin Widyasari; Ekayanti, Ni Wayan Sri; Ekayani, Ni Wayan Diana
Jambura Medical and Health Science Journal Vol 5, No 1 (2026): Jambura Medical and Health Science Journal
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jmhsj.v5i1.32905

Abstract

Introduction: Noise exposure can induce oxidative stress and alter neurotransmitter dynamics within the nervous system. This oxidative stress is also associated with structural changes in the layers of the cerebrum. However, the effects of noise exposure on neuronal populations remain inadequately understood. This study aims to quantify the mean number of neurons in the frontal lobe of Wistar rats subjected to noise exposure.Methods: This study utilized an experimental design characterized by a randomized post-test only control group framework. A total of 30 male Wistar rats were selected through simple random sampling and subsequently divided into two groups: a control group without treatment (C1, n=15) and an experimental group exposed to 95 dB noise (E1, n=15) for four hours daily. Following a two-week exposure period, their brain tissue was excised and preserved in 10% neutral buffered formalin. Histological assessment was conducted using Hematoxylin and Eosin staining to evaluate the mean number of neurons in the frontal lobe. Statistical analysis was performed using the independent T-test.Results: The mean number of neurons was 1053.33 ± 55.529 in the E1 group and 720.167 ± 61.135 in the C1 group. The mean neurons of the frontal lobe of Wistar rats in the E1 group ws lower than the C1 group significantly (P 0.001).Conclusion: Neuronal death in the frontal lobe resulting from noise-induced stress can induce structural alterations within this region, leading to detrimental effects on cognitive function and behavior. Keywords: Frontal lobe, neuron, noise, stress
Short-Chain Fatty Acids and Neurodegeneration in Alzheimer's Disease: A Narrative Review Sumadewi, Komang Trisna; Astini, Dewa Ayu Agung Alit Suka; Evayanti, Luh Gde; Manuaba, Ida Ayu Laxmi Ananda Dewi; Dewi, Ni Made Gita Kusuma
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.498

Abstract

Background: Alzheimer Disease remains the most prevalent cause of dementia worldwide, representing a major and escalating global health challenge. Objective: This study aims to examine the role of short chain fatty acids in the pathogenesis and progression of Alzheimer Disease within the framework of the microbiota gut brain axis. Methods: The research employed a qualitative design with a descriptive approach through a narrative literature study. Data were collected through systematic searches of peer reviewed scientific articles published between 2015 and 2026, focusing on gut microbiota dysbiosis, short chain fatty acids, neuroinflammation, amyloid pathology, and cognitive decline in Alzheimer Disease. Document analysis was conducted using thematic identification, data reduction, conceptual categorization, and inductive interpretation to generate a comprehensive synthesis of the evidence. Results: The findings indicate that Alzheimer Disease is consistently associated with reduced abundance of short chain fatty acid producing bacteria and altered circulating and fecal short chain fatty acid profiles, which are linked to impaired blood brain barrier integrity, microglial activation, increased neuroinflammation, amyloid beta accumulation, and tau pathology. Mechanistic insights demonstrate that short chain fatty acids regulate inflammatory signaling pathways, epigenetic modulation, mitochondrial bioenergetics, and metabolic homeostasis. Conclusion: In conclusion, short chain fatty acids function as key metabolic mediators in Alzheimer Disease and represent promising targets for preventive and therapeutic strategies, contributing to a systems biology perspective and supporting microbiome based precision approaches in cognitive health management.
HUBUNGAN KONSUMSI SUGAR-SWEETENED BEVERAGES DENGAN DURASI MENSTRUASI PADA REMAJA PUTRI Ekayanti, Ni Wayan Sri; Wijaya, Putu Austin Widyasari; Evayanti, Luh Gde; Ekayani, Ni Wayan Diana; Trisnia, Putu Ayunda
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 10 No. 1 (2026): APRIL 2026
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v10i1.56718

Abstract

Konsumsi minuman manis yang tinggi merupakan kebiasaan yang umum pada remaja dan berpotensi memengaruhi berbagai aspek kesehatan, termasuk fungsi reproduksi. Menstruasi merupakan salah satu indikator penting kesehatan endokrin pada remaja putri. Penelitian ini bertujuan untuk menganalisis hubungan antara tingkat konsumsi minuman manis dan durasi menstruasi pada remaja putri. Penelitian ini menggunakan desain cross-sectional dengan melibatkan 76 responden remaja putri yang dipilih menggunakan teknik simple random sampling. Konsumsi minuman manis diukur menggunakan Food Frequency Questionnaire (FFQ) dan dikategorikan menjadi rendah (≤2 kali/minggu), sedang (3–5 kali/minggu), dan tinggi (>5 kali/minggu). Durasi menstruasi dikategorikan menjadi singkat (<3 hari), normal (3–7 hari), dan panjang (>7 hari). Analisis bivariat dilakukan menggunakan uji Chi-square, dengan koreksi Fisher’s exact test pada sel dengan expected count kecil. Kekuatan hubungan dianalisis menggunakan koefisien Cramer’s V. Hasil penelitian menunjukkan adanya hubungan yang signifikan antara tingkat konsumsi minuman manis dan durasi menstruasi pada remaja putri (χ² = 11.82; p = 0.019). Namun kekuatan hubungan tergolong lemah (Cramer’s V = 0.28). Temuan ini menunjukkan bahwa konsumsi minuman manis berpotensi berkontribusi terhadap variasi durasi menstruasi pada remaja putri, meskipun faktor lain kemungkinan memiliki pengaruh yang lebih besar.
Co-Authors A A I Ayesa Febrinia Adyasputri A.A.Ayu Asri Prima Dewi Aanak Agung Ayu Asri Prima Dewi Anak Agung Ayu Asri Prima Dewi Anak Agung Oka Lely Anak Agung Sri Agung Aryastuti Anthony Kerans, Fransiscus Fiano Arthayasa, I Gede Ngurah Bagus Astini, Dewa Ayu Agung Alit Suka Astuti, Ni Luh Putu Vina Juni budiapsari, putu indah Cahyawati, Putu Nita Desak Putu Oki Lestari Dewa Ayu Agung Alit Suka Astini Dewa Ayu Ratna Juwita Dewi, A.A.Ayu Asri Prima Dewi, Anak Agung Ayu Asri Prima Dewi, Ni Made Gita Kusuma Ekayani, Ni Wayan Diana Ekayanti, Ni Wayan Sri Fransiscus Fiano Anthony Kerans Fransiscus Fiano Anthony Kerans I Gede Bagus Gita Pranata Putra I Gede Suranaya Pandit I Gusti Lanang Agung Wiradinata Ida Kurniawati Ida Kurniawati, Ida IGNP Sana Kadek Ayu Alit Sintyawati Kerans, Fransiscus Fiano Anthony Kirana, Ni Made Asthi Pramesti Komang Trisna Sumadewi KT Sumadewi Made Dharmesti Wijaya Maharani, Ni Putu Ayu Dian Manuaba, Ida Ayu Laxmi Ananda Dewi Ni Kadek Elmy Saniathi Ni Luh Putu Indiani Ni Putu Diah Witari Ni Wayan Armerinayanti, Ni Wayan NPD Witari Pande Ayu Naya Kasih Permatananda Perdana, I Gede Sukma Okta Pratiwi, I Gusti Agung Istri Mas Dianti Prima Dewi, A.A.A Asri Putra, Adi Pratama Putu Ayu Kevin Komala Dewi Mahayuna Putri Sari, Ni Luh Putu Eka Kartika Sri Ratna Dewi Sueta, Made Agus Dwianthara Suka Astini, Dewa Ayu Agung Alit Sumadewi, Komang Trisna Trisnia, Putu Ayunda Utari, Putu Nadya Asti Wijaya, Putu Austin Widyasari Witari, Ni Putu Diah