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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Sains dan Teknologi Farmasi Indonesian Journal of Pharmaceutical Science and Technology CHEMPUBLISH JOURNAL Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Ilmu Kefarmasian Indonesia Journal of Telenursing (JOTING) Jurnal Peduli Masyarakat Community Development Journal: Jurnal Pengabdian Masyarakat MEDIC MEdical Dedication Yayasan Cita Cendikiawan Al Khwarizmi SCIENCE : Jurnal Inovasi Pendidikan Matematika dan IPA Jurnal Bio-Geo Material Dan Energi Jurnal Abdimas Kartika Wijayakusuma Indonesian Journal of Biological Pharmacy Journal of Pharmaceutical Care and Sciences Jurnal Karya Abdi Masyarakat Jurnal Ilmiah Ilmu Terapan Universitas Jambi Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Riset Informasi Kesehatan Jurnal Pengabdian Harapan Ibu (JPHI) Journal of Pharmaceutical and Sciences. Prosiding Seminar Nasional Unimus Jurnal Abdimas Kesehatan Indonesian Journal of Jamu Galen: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Farmasi Udayana
Uce Lestari
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Journal : CHEMPUBLISH JOURNAL

 1 
The Activity Test of Transdermal Patch Formulations From Ethanol Extract of Java Chili (Piper Retrofractum Vahl.) as an Analgesic in Male Mice Luthfiyyah, Annisa; Elisma; Lestari, Uce; Naufal Nabillah Putra; Istiazah Putri Sisva; Johan Hasyim Nugroho; Aulia Tria Yustika
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.38136

Abstract

Pain is an unpleasant sensory and emotional experience caused by actual or potential tissue damage. Java chili (Piper retrofractum Vahl.) is an Indonesian plant known for its secondary metabolites, including piperine, pipernonalin, guineensine, and essential oils. Among these, piperine is the primary compound with potential analgesic properties. This study evaluates the analgesic effects of transdermal patches containing ethanol extract of Java chili using the writhing test and macrophage count in acetic acid-induced mice. The patches were formulated with different concentrations of the active ingredient: F1 (1g extract), F2 (2g extract), and F3 (3g extract). The results show that increasing the ethanol extract concentration significantly alters the physical characteristics of the patches, including shape, thickness, color, and durability. In the analgesic test, the macrophage count in the negative control group was 29.33 ± 0.57. In contrast, the treatment groups showed a concentration-dependent reduction: F1 (20.00 ± 1.73), F2 (13.00 ± 3.00), and F3 (7.33 ± 1.15). The positive control group exhibited the lowest macrophage count (3.66 ± 1.15). These findings indicate that transdermal patches containing Java chili ethanol extract possess significant analgesic potential, with higher concentrations yielding stronger effects.
Pengembangan Mouth Nanospray Minyak Atsiri Biji Jintan Hitam (Nigella sativa L.) : Sifat Fisik, Stabilitas, dan Aktivitas Antibakteri Rahayu, Milda; Hariyani, Septi; Lestari, Uce
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.48881

Abstract

Halitosis is one of the oral health problems that is quite high in prevalence and can reduce the quality of life of sufferers. This study aims to formulate and evaluate the physical quality, characteristics of nanoparticles, and antibacterial activity of mouth nano spray containing black cumin essential oil (Nigella sativa L.). The formulation is made in four variations of essential oil concentration (F1 0.25%; F2 0.5%; F3 1%; F4 1.5%) using the nanoemulsion method. Physical quality evaluation included organoleptic, pH, homogeneity, and viscosity tests, while nanoparticle characterization was carried out using a Particle Size Analyzer (PSA). Antibacterial activity was tested against Streptococcus mutans using disc diffusion method. The results show that all formulas have good physical properties with a liquid, clear, and homogeneous form. The pH value is in the range of 6–6.7 which corresponds to the pH of the mouth. The PSA test on F3 yielded a particle size of 42.7 nm with a PDI of 0.6, but a potential zeta value of –5.6 μV indicated low electrostatic stability. The antibacterial activity test showed that F2, F3, and F4 had strong inhibition with inhibition zone diameters of 11.78 mm, 11.57 mm, and 13.10 mm, respectively, higher than positive controls (8.39 mm). Based on these results, the F4 formula with a concentration of 1.5% provides the most optimal antibacterial activity.
Co-Authors Abdullah Muhammad Faathir Ade Adriadi Aditya Gufashar Afifah Hulwah Agraini, Agraini Agus Syarif Amalia Nasution, Riska Andhini Aurellyta Ridwan Andriani, Annisa Anis Yohana Chaerunisaa, Anis Yohana Annisa Luthfiyyah Ardi Novra Astuti, Novita Tri Aulia Tria Yustika Az-Zahra, Ajeng Aprina Azkianti, Erin Baehaqi Brata, Andy Damris, M. Dehan Fahresta Delfina, Rahmanda Ayu Deswinar Darwin Diah Riski Gusti Dwisari Dillasamola Efendi, M. Rifki Elisa, Novia Elisma Elisma Elisma Erlianti, Karina Faizar Farid Fashelia Azizaturrahmah Fathnur SaniK Fitri, Khairunnisa Rizkia Fitrianingsih Fitrianingsih Griselta, Eugenia Gultom, Dame Roida Habib Shidiq Akbar Hariyani, Septi Havizur Rahman Herawati, Ariana Ida Ayu Putu Sri Widnyani Ihsan, Mahya Indra Lasmana Tarigan Intan Lestari Istiazah Putri Sisva Istiqomah Malinda Iva Rama Fitria Jamhari Jamhari Jelly Permatasari Johan Hasyim Nugroho Kaipur, Prago Larisa Aurellia Vilonia Lismiati, Lismiati Luri Mekeama Lusi Octaviana M. Rifqi Efendi Madyawati Latief Maharini, Indri Maisyarah, Intan Timur Mardiana, Lia MAYANG KUSUMA DEWI, MAYANG KUSUMA Milda Rahayu Muhaimin Muhaimin Muhaimin Muhammad Abdul Najib Muhammad Aidi Satryo Muhammad Fazly Muhammad Rahil Dief Nadhira Yuri Maharani Najwa, Shinta Nalinda, Elba Annisa Nasela, Tiara Naufal Nabillah Putra Neldi, Vina Novia Tri Astuti Novita Sari Permatasari, Jelly Permatasari, Jelly Puspa Dwi Pratiwi Putri Maya Sari Putri, Kresentia Rahayu, Milda Rahmadhani, Syarima Rahmadona, Tasha Rahman, Havizur Rahman, Havizur Rahman, Havizur Resti Widyastuti Revis Asra Riki Saputra, Riki Romi Kurniadi S, Lusiana Estiana Sadli, Nurul Kamilah Sani K, Fathnur Saniya De Nafisa Santi Perawati Santi Perawati, Santi Saquro, Abdan Sari, Eza Permata Septi Hariyani Septima, Nurul Rizqan Siagian, Martha Veronica Helena Suci, Ulan Syamsurizal Syamsurizal - - Syarli, Silviera TIANA MILANDA Vaseline, Quichtylichta Vika Permata Gustam Vina Neldi Widya Faizatul Zuhri Widyastuti, Resti Yudistio Arnoza Yufri Aldi Yuliana Yuliana Yuliana Yuliana Yulianis Yulianis Yuliawati Yuliawati Zainini Arraysa Zozy Aneloi Noli