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All Journal Teknosains: Media Informasi Sains dan Teknologi Nature: National Academic Journal of Architecture Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Kreativitas PKM Jurnal Riset Kefarmasian Indonesia Jurnal Inovasi Pendidikan dan Sains Yumary: Jurnal Pengabdian kepada Masyarakat J-REMI : Jurnal Rekam Medik dan Informasi Kesehatan Narra J Abdimas Langkanae TIMPALAJA: Architecture Student Journal Journal of Educational Sciences Ittishal : Jurnal Komunikasi dan Media
Marwati Marwati
Teknik Arsitektur, Universitas Islam Negeri Alauddin, Makassar
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Phytochemical profiling and enzyme inhibitory activity of Sterculia populifolia DC stem bark extract and fractions against elastase and tyrosinase Khairi, Nur; Nursamsiar, Nursamsiar; Utami, Novi F.; Marwati, Marwati; Nur, Syamsu; Indrisari, Maulita; Kursia, Sukriani
Narra J Vol. 5 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i3.1778

Abstract

The demand for natural ingredients in cosmetic and medical applications is steadily increasing, particularly for anti-aging and skin-lightening products. Sterculia populifolia DC, a member of the Sterculia genus, is known to contain diverse bioactive compounds such as flavonoids, phenolics, and terpenoids, which may offer pharmacological benefits. The aim of this study was to evaluate the anti-aging potential of S. populifolia stem bark extract and its solvent-partitioned fractions through enzyme inhibition assays coupled with phytochemical profiling. The stem bark was extracted using 96% ethanol via maceration, followed by sequential liquid-liquid partitioning with n-hexane, ethyl acetate, n-butanol, and water. Phytochemical constituents were characterized using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The inhibitory activities of the extract and fractions against tyrosinase and elastase enzymes were evaluated using spectrophotometric assays, with kojic acid and quercetin as positive controls, respectively. IC₅₀ values were calculated to quantify enzyme inhibition potency. LC-MS/MS analysis revealed key bioactive compounds, including 4-[(E)-(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol, isofraxidin, and (22E)-ergosta-4,6,8(14),22-tetraen-3-one. Among the tested samples, the ethanol extract exhibited the most potent activity, with an IC₅₀ of 93.35 µg/mL for elastase inhibition and 133.15 µg/mL for tyrosinase inhibition—classified as strong and moderate activity, respectively. Collectively, these findings demonstrate that S. populifolia stem bark extract possesses promising anti-aging and depigmenting properties, supporting its potential development as a natural bioactive ingredient in cosmetic and skincare formulations.
Co-Authors A. Eka Oktawati Aiyi Asnawi Aldi Septyadi Arsyad Alexandra, Francisca Diana alfiah alfiah Allamanda Chatartica M. Amin, Burhanuddin Andi Herniwati Anggyasti, Anggyasti Anton Rahmadi Anton, Ulfa Aulianti Apriani, Fira Arief Rahman Wahid Arifin, Muhammad Zuhri Asrianingsih, Asrianingsih Asruni, Asruni Burhanuddin Burhanuddin Chomaero, Zety Eddy, Syaiful Etiwati, Etiwati Fadly, Nurul Fahmyddin A'raaf Tauhid Fatimah, Andi Nurauliah Firman Firman Gufron, Ahmad Hamja, Ulfa Idin Handayani, Bekti Hapzi Ali Harmin, Harmin Hikma, Nurul I Made Agus Widiana Putra Ida Syamsul Ikrama, Ikrama Irma Rahayu, Irma Ismail B Arifin, Ismail B Jaya Dwi Putra, Jaya Dwi Juliana, Selti Kasmawati, Henny Khairi, Nur Kinasih, Alifia Sekar Wana Kurnia, Anti LA ODE SYUKUR, LA ODE M, Suhardi Maqfirah Putri, Dian Marua, Irwansyah Usman Massarappi, M. Mugny A Maulita Indrisari, Maulita Milawati Milawati Minatik, Alfa Mirdawati, Mirdawati Moedjiherwati, Trijani Muasyarah, Hasanatul Muhammad Ainun Najib Muhammad Ajwad Muzdar Muhammad Ali Akbar, Muhammad Ali Muhammad Attar Muhammad Irsan Amrullah, Muhammad Irsan Mukhlishah Sam Murphi, Maghfiroh Realis Musdar, Muh. Ajwad Mustafa, Fajari Ningsi, Sitti Nurna Nurjannah, Andi Nursamsiar Nursamsiar Nursyam Nursyam Nurul fadillah, Nurul Octavianti, Maria P Purwanto Panggulu Ahmad Ramadhani Pattinggi, Patricia Pradana, Lae Alexander Pratama, Azwar Rahim, Amirudin Ramadhani, Suci Q. Rasdyana Rasdyana Resti Resti Reva Maria Valianti, Reva Maria Rohmah, Miftakhur Safruddin Juddah Sahidin, La Ode Sami, Fitriyanti J. Sarjito, Muhammad Sam Putra Yasashi Sasa Margapita Satriandika, Baso Setiyadi, Rahmat Siddiq, Syahril Silvi, May Sitaturrohmah, Sitaturrohmah Sri Andriani Sri Langgeng Ratnasari Sri Suryana Dinar, Sri Suryana Sukriani Kursia, Sukriani Sutriani Sutriani Sya'baan, Andi Muh. Ruum Syahrir, Muhammad Zulkarnain Syam, Nuramin Syamsiar, Syamsiar Syamsu Nur, Syamsu Taufik Arfan Thamrin, Nurul Fatimah Udayani, Ni Wayan Umar, Abdul Utami, Novi F. Wahidin, Rahmat Wahyudi, Didi Wasilah Wasilah Yassir, Budiman Yulian Andriyani Yunus Yunus Zalili Sailan Zulkarnaen Zulkarnaen Zulkarnain AS Zulkarnain AS, Zulkarnain